Clinical trials: IBD-Inflammatory Bowel Disease
Ulcerative Colitis
Personalised Prediction of Disease Course in Ulcerative Colitis Using Multimodal Machine Learning - Part of the Presager Project
In patients achieving clinical remission following a flare, artificial intelligence can reliably predict a new flare within the next 12 months utilizing clinical and objective information at day 0 and week 8.
- Trial name
- Presager II (NCT05479617)
- Testing
- Deep learning model
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Crohn's Disease
The Crohn's Therapy, Resource, Evaluation, and Assessment Tool Registry
The purpose of this study is to evaluate the long-term clinical, economic and humanistic outcomes of various treatment regimens, including infliximab, in Crohn's disease in real world medical practice.
- Trial name
- TREAT (NCT00553176)
- Testing
- No intervention
- Volunteers
- 6,273 people
- Sponsor
- Janssen Biotech, Inc.
Ulcerative Colitis
TOFACITINIB vs TOFACITINIB WITH MESALAMINE IN ULCERATIVE COLITIS
All the trials using tofacitinib for maintenance of remission in UC have allowed the use of concomitant therapies except glucocorticoids.
- Trial name
- NCT06625450
- Testing
- Tofacitinib, Tofacitinib plus mesalamine
- Volunteers
- 75 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Crohn's Disease
Comparison of Endoscopy and Diffusion-weighted Enterography-MRI for the Diagnosis of Crohn's Disease Recurrence Following Ileocolic Resection: a Pilot Study
Nearly three-quarters of patients with Crohn's disease have small bowel involvement and 80% of them will have complications that will require a surgical procedure, usually an ileocolonic resection with ileocolonic anastomosis.
- Trial name
- MRI-CROHN (NCT02867540)
- Testing
- MRI enterography
- Where
- France
- Volunteers
- 40 people
- Sponsor
- CHU de Reims
Ulcerative Colitis
First-In-Human Study of BBT-401-1S Following Single and Multiple Ascending Doses in Healthy Volunteers
This clinical trial is the first-in-human study of BBT-401-1S. The purpose of this phase 1 study is to assess the safety and tolerability of single and multiple ascending oral doses of BBT-401-1S in healthy adult subjects.
- Trial name
- NCT03482648
- Testing
- BBT-401-1S, Single dose, BBT-401-1S, Multiple doses
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bridge Biotherapeutics, Inc.
Inflamatory Bowel Disease
Construction and Validation of a Predictive Model for the Efficacy of Different Biologics in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a group of chronic progressive gastrointestinal diseases that can recur throughout life and for which there is no cure.
- Trial name
- NCT07181525
- Testing
- anti-cytokine antibodies, anti-integrin antibodies
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Crohn's Disease, IBD
Open-label Extension Study of Brazikumab in Crohn's Disease
The purpose of Study D5271C00002 (Legacy #3150-303-008) is to permit participants in D5271C00001 (Legacy #3150-301-008) to receive open-label brazikumab in Study D5271C00002 (Legacy #3150-303-008).
- Trial name
- INTREPID OLE (NCT03961815)
- Testing
- Brazikumab Induction Dose, Brazikumab Maintenance Dose
- Where
- 15 sites in United States, Germany and 3 more
- Volunteers
- 18 people
- Sponsor
- AstraZeneca
Crohn's Disease, Ulcerative Colitis
Comparative Effectiveness of Biologics or Small Molecule Therapies in Inflammatory Bowel Disease (IBD)
The purpose of this study is to assess effectiveness of vedolizumab versus ustekinumab in patients with Crohn's disease and vedolizumab versus tofacitinib in patients with ulcerative colitis, after non-response to anti-tumor…
- Trial name
- COMPARE (NCT04852666)
- Where
- 2 sites in United States
- Volunteers
- 465 people
- Sponsor
- University of North Carolina, Chapel Hill
Rectal Cancer, Colon Cancer
Perfusion Assessment in Laparoscopic Left Anterior Resection
The purpose of this study is to demonstrate that NIR fluorescence angiography using the PINPOINT Endoscopic Fluorescence Imaging System ("PINPOINT System" or "PINPOINT") can assess viability of colon tissue during laparoscopic…
- Conditions
- Rectal Cancer, Colon Cancer, Crohn's Disease, Polyp
- Trial name
- PILLAR II (NCT01560377)
- Testing
- PINPOINT Endoscopic Fluorescence Imaging System
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- Novadaq Technologies ULC, now a part of Stryker
Inflammatory Bowel Diseases, Hepatitis B
Intra-dermal With Topical Imiquimod Pretreatment Versus Intra-muscular Hepatitis B Vaccination in IBD Patients
Inflammatory bowel disease (IBD) has witnessed a rising incidence globally and in Hong Kong, an area where chronic hepatitis B (CHB) remains endemic.
- Trial name
- NCT04083157
- Testing
- Intradermal hepatitis B vaccine with imiquimod, Intramuscular hepatitis B vaccine with aqueous cream
- Where
- China
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong
Colitis, Ulcerative, Crohn Disease
A Study to Evaluate Disease Control and Treatment Pattern in Participants With Moderate to Severe Inflammatory Bowel Disease (IBD) in Real Life Practice
The purpose of this study is to characterize the treatment patterns associated with biologics agents use or non-biological therapy in participants with moderate to severe Ulcerative Colitis (UC) and Crohn's Disease (CD).
- Conditions
- Colitis, Ulcerative, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- INTENT (NCT03532932)
- Where
- 36 sites in Belarus, Kazakhstan and 1 more
- Volunteers
- 1,990 people
- Sponsor
- Takeda
Pouchitis, Ulcerative Colitis
Fecal Microbiota Transplantation (FMT) in the Treatment of Pouchitis
The aim of our study is to investigate the efficacy and safety of fecal microbiota transplantation (FMT) in the treatment of antibiotic dependent chronic pouchitis. This is a double-blinded randomized placebo controlled study.
- Trial name
- NCT03378921
- Testing
- Fecal microbiota transplantation
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Helsinki University Central Hospital
Crohn's Disease, Obesity
Crohn's Disease, Obesity and Disease Severity
The aim of our study is to suggest possible underlying mechanisms for the observed clinical differences in disease severity and behavior of overweight and obese patients with crohn's disease(BMI > 25 kg/m²)as compare to non-obese…
- Trial name
- CROHN_OBESE (NCT00488085)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Ulcerative Colitis
Efficacy and Safety of Oral BT-11 in Ulcerative Colitis
This is a phase 2 randomized, placebo-controlled, double-blind, parallel-group multicenter study with an optional open-label extension (OLE) period.
- Trial name
- NCT03861143
- Testing
- BT-11 (440 mg), BT-11 (880 mg)
- Where
- 16 sites in United States, Bosnia and Herzegovina and 3 more
- Volunteers
- 198 people
- Sponsor
- NImmune Biopharma
Crohn Disease
The Effects of a Mindfulness Based Intervention on IBD Disability
EMBODY (Effects of a Mindfulness Based interventiOn on ibD disabilitY) aims to evaluate the effects of a mindfulness based intervention on a broad number of disease related disability dimensions in patients with Crohn's disease…
- Trial name
- EMBODY (NCT05944068)
- Testing
- midfulness training
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Crohn's Disease
Behavioral Therapy for Crohn's Disease
People living with Crohn's disease (CD) experience psychological and emotional symptoms, in addition to known chronic and disabling physical symptoms, which prevent them from living their life to the fullest (flourishing).
- Trial name
- NCT06512597
- Testing
- Primary Intervention for Combination Therapy - IBD Coping Strategies Program, Time and Attention Control - IBD Support Program
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Crohn Disease, Complex Perianal Fistula
A Study to Check How Often People Treated With Darvadstrocel for Crohn's Disease Are Diagnosed With Cancer
The main aim is to learn about the risk of cancer after treatment with darvadstrocel compared to other standards of care in people with Crohn's Disease (CD).
- Trial name
- NCT04971525
- Where
- 4 sites in France, Germany and 2 more
- Sponsor
- Takeda
Crohn Disease Located in Jejunum or Ileum
Endoscopic Detection of Dysplasia in Crohn 's Disease Patient
Patients with Crohn's disease (CD) have an increased risk of small bowel adenocarcinoma (SBA). Long duration of CD is the main risk factor.
- Trial name
- DYDJI (NCT01180452)
- Testing
- enteroscopy
- Where
- 15 sites in France
- Volunteers
- 107 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Ulcerative Colitis
Beta-1,3/1,6-D-Glucan Ganoderma Lucidum on Ulcerative Colitis
The aim of this study is to determine the efficacy and safety of Beta-1,3/1,6-D-Glucan from mycelium extract of Ganoderma lucidum on ulcerative colitis
- Trial name
- NCT04029649
- Testing
- Beta-1,3/1,6-D-Glucan
- Where
- Indonesia
- Volunteers
- 204 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Ulcerative Colitis
Effect and Mechanism of Baitouweng Decoction for Large Intestine Damp-heat Syndrome of Ulcerative Colitis
Baitouweng Decoction is traditionally used to treat large intestine damp-heat syndrome of ulcerative colitis (UC) by oral administration and rectal enema.The project applicant's invention of transendoscopic entral tubing (TET)…
- Trial name
- NCT06421818
- Testing
- Baitouweng Tang
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Second Hospital of Nanjing Medical University
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