Clinical trials: IBD-Inflammatory Bowel Disease
Crohn's Disease
Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis
This study proposes a randomized prospective study comparing the Kono-S anastomosis to the standard side-to-side anastomosis.This will be a multi-center randomized prospective trial.
- Trial name
- NCT03256240
- Testing
- side-to-side functional end anastomosis, Kono-S analstomosis
- Where
- 15 sites in United States, Belgium and 4 more
- Volunteers
- 600 people
- Sponsor
- Weill Medical College of Cornell University
Colitis, Ulcerative
An Efficacy and Safety Study of Golimumab in Participants With Ulcerative Colitis
The purpose of this study is to assess the effects (good and bad) of golimumab (CNTO 148) therapy in participants with active ulcerative colitis (UC) (sores in the colon).
- Trial name
- NCT00488774
- Testing
- Golimumab 1 mg per kg, Golimumab 2 mg per kg, Golimumab 4 mg per kg
- Where
- 108 sites in United States, Australia and 20 more
- Volunteers
- 291 people
- Sponsor
- Janssen Research & Development, LLC
Inflammatory Bowel Diseases
A Prospective Study on the Incidence and Risk Factors Related to Infection in Patients With Inflammatory Bowel Disease
The purpose of this study is to determine the incidence and risk factors related to Infection in patients with Inflammatory Bowel Disease (IBD)
- Trial name
- INFEII (NCT02904590)
- Where
- 24 sites in Spain
- Volunteers
- 1,204 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Insomnia, Ulcerative Colitis
Piloting an Insomnia Treatment in Patients With Ulcerative Colitis
The goal of this clinical trial is to learn if telehealth-based Cognitive Behavioral Therapy for Insomnia (CBT-I) adapted for Ulcerative Colitis (UC) works to treat insomnia in adults with UC.
- Trial name
- RISE-UC (NCT07428629)
- Testing
- CBT-I UC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Crohn Disease
Description of Perianal Lesions in a Cohort of Crohn's Disease Patients
The perianal lesions (LAP) specific for Crohn's disease have been reported in 1938, six years after the first cases of luminal disease.
- Trial name
- LAPCROHN (NCT02899013)
- Testing
- No intervention
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Abdominal Pain, Rectal Bloodloss
Head-to-head Comparison of Two Fecal Biomarkers to Screen Children for IBD
RATIONALE: A substantial proportion of children and teenagers with suspected inflammatory bowel disease (IBD) referred for endoscopy do not have the disease.
- Conditions
- Abdominal Pain, Rectal Bloodloss, Diarrhea, Inflammatory Bowel Disease
- Trial name
- CACATU (NCT02197780)
- Where
- 19 sites in Belgium, Netherlands
- Volunteers
- 355 people
- Sponsor
- University Medical Center Groningen
Colon Cancer, Colon Polyp
Virtual Incision Robotically Assisted Surgical Device Use in Minimally Invasive Colectomy
For patients with colon polyps (clumps of cells in the lining of the colon) treatment often requires removal of the affected portion of the colon.
- Conditions
- Colon Cancer, Colon Polyp, Diverticular Diseases, Inflammatory Bowel Diseases
- Trial name
- NCT04703829
- Testing
- VI-RASD use in minimally invasive right or left colectomy, Right or Left colectomy
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Virtual Incision Corporation
Crohn Disease Haemorrhagic Rectocolitis
Study of the Impact of a Physical Activity Programme on the Quality of Life of Patients With Inflammatory Bowel Disease
Regular physical activity at a mild to moderate intensity can control inflammation in general and intestinal inflammation in particular during IBD.
- Trial name
- APMICI (NCT05099653)
- Testing
- physical activity
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Raincy Montfermeil Hospital Group
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Study of Single and Multiple Ascending Doses of CM551 in Healthy Participants
This is a randomized, double-blind, placebo-parallel controlled phase I study to evaluate the safety and tolerability of single and multiple doses of CM551 in healthy participants
- Trial name
- NCT07900945
- Testing
- CM551
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Keymed Biosciences Co.Ltd
Crohn Disease
Clinical Study Comparing PillCam® Crohn's Capsule Endoscopy to Ileocolonoscopy (IC) Plus MRE for Detection of Active CD in the Small Bowel and Colon in Subjects With Known CD and Mucosal Disease.
This study will evaluate the efficacy of capsule endoscopy (CE) versus ileocolonoscopy (IC) plus MRE for detection of active Crohn's disease (CD) in the small bowel in subjects with known CD and mucosal disease.
- Trial name
- BLINK (NCT03241368)
- Testing
- Capsule Endoscopy
- Where
- 26 sites in United States, Austria and 1 more
- Volunteers
- 187 people
- Sponsor
- Medtronic - MITG
Ulcerative Colitis
High Definition Versus Chromoendoscopy for Dysplasia Detection in Ulcerative Colitis (UC)
Patients with ulcerative colitis (UC) have an increased risk for colorectal cancer (CRC) compared to the general population. Regular screening by colonoscopy is an internationally recommended cancer prevention strategy.
- Trial name
- NCT02138318
- Testing
- High definition (HD) endoscopy, chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Crohn's Disease
PET/CT to Predict Response to Infliximab Therapy in Patients With Crohn's Disease
The costs and potential complications (side effects) of therapies currently used to treat Crohn's disease could be reduced if a non-invasive test existed that determined which therapies benefit patients and which do not.
- Trial name
- NCT01759017
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Brigham and Women's Hospital
IBD
Regulation of Vitamin D Metabolism by Washed Microbiota Transplantation in Patients With IBD
WMT could effectively induce clinical response and maintain remission in patients with Inflammatory bowel disease (IBD). VD maintains gut microbiota and gut microbiota alter intestinal vitamin D metabolism (VDM),The aim of this…
- Trial name
- NCT04989374
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Crohn Disease
Randomized Trial Comparing Single vs. Maintenance Fecal Microbiota Transplant for Refractory Crohn's Disease in Children
NCT02108821 Primary goal: -To determine the safety of fecal transplant by colonoscopy and retention enemas for induction followed by maintenance retention fecal vs.
- Trial name
- NCT03747718
- Testing
- Fecal Microbiota Transplantation
- Where
- United States
- Sponsor
- Stanford University
Moderate to Severe Crohn's Disease
Phase IIa Study Evaluating AZD7798 in Crohn's Disease
This is a randomised, double-blind, parallel group, placebo-controlled Phase IIa study designed to evaluate the efficacy and safety of AZD7798 in participants with moderate to severe Crohn's disease.
- Trial name
- AMALTHEA (NCT06450197)
- Testing
- AZD7798
- Where
- 116 sites in United States, Argentina and 24 more
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Chronic Mesenteric Ischemia, Median Arcuate Ligament Syndrome
Intestinal Ischemia Biomarker in Patients With Chronic Mesenteric Ischemia
Plasma Alpha glutathione S transferase (Alpha GST) has been previously demonstrated to be raised in patients with chronic mesenteric ischemia (CMI) caused by atherosclerosis and in patients with median arcuate ligament syndrome…
- Conditions
- Chronic Mesenteric Ischemia, Median Arcuate Ligament Syndrome, Crohn Disease, Cholelithiasis
- Trial name
- NCT06468774
- Testing
- Laparoscopic surgery
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Crohn Disease, Ulcerative Colitis
Digital Behavioral Interventions in Inflammatory Bowel Disease
Given the bidirectionality between psychological distress and disease activity in inflammatory bowel disease (IBD), whereby increased psychological distress exacerbates disease activity and vice versa, psychosocial aspects of IBD…
- Conditions
- Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases, Stress, Psychological
- Trial name
- NCT04861597
- Testing
- Internet based cognitive behavioral therapy, Digital mood tracking
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Montefiore Medical Center
Inflammatory Bowel Diseases
Vaccination Practices for Inflammatory Bowel Disease Patients in China With Gastroenterologists
The aim of the current study was to evaluate the knowledge of Chinese gastroenterologists on vaccinating patients with IBD under the assistance of Chinese Crohn's \& Colitis Foundation.
- Trial name
- NCT04948723
- Where
- China
- Volunteers
- 307 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ulcerative Colitis (Disorder), Crohn Disease
Partial Enteral Nutrition to Prevent Weight Loss and Sarcopenia in IBD Patients at Nutritional Risk - SIMBA
This is a multicenter, open-label, randomized two-arm interventional nutritional study evaluating the effects of partial enteral nutrition (LH VIOLA) in patients with Inflammatory Bowel Disease (IBD) at risk of malnutrition.
- Conditions
- Ulcerative Colitis (Disorder), Crohn Disease, Malnutrition or Risk of Malnutrition, IBD
- Trial name
- SIMBA (NCT07433946)
- Testing
- LH VIOLA Supplementation
- Where
- 4 sites in Italy
- Volunteers
- 146 people
- Sponsor
- Lionhealth Srl Società Benefit
Crohn Disease, Infliximab
HLADQA1*05 Genotype and the Efficacy of Treatment With Infliximab in Chinese Population Crohn's Disease
Crohn's disease (CD) is a chronic non-specific inflammatory disease of the intestine. Infliximab (IFX) is a kind of one of the anti-tumor necrosis factor agents (anti-TNF) and is the main clinical treatment drug for Crohn's…
- Trial name
- NCT05813860
- Testing
- Azathioprine, Infliximab
- Volunteers
- 976 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
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