Clinical trials: IBD-Inflammatory Bowel Disease
Severe Ulcerative Colitis
Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC)
Up to one third of patients with Ulcerative Colitis (UC) will require hospitalisation for severe disease (ASUC - Acute Severe Ulcerative Colitis), often within the first 12 months of diagnosis.
- Trial name
- ELEVATE-ASUC (NCT03907631)
- Testing
- Standard of care
- Where
- United Kingdom
- Volunteers
- 189 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Ulcerative Colitis, Telemedicine
The Use of Web-app Constant-Care in Patients With Acute Severe Ulcerative Colitis Treated With Rescue Therapy
The primary aim is to evaluate if introduction of eHealth in its form of the web application Constant-Care (https://ibd.constant-care.com) could reduce the length of hospitalization in patients with acute severe Ulcerative…
- Trial name
- NCT04165265
- Testing
- Constant-Care
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Nordsjaellands Hospital
Colitis, Ulcerative, Crohn Disease
Unraveling a Potential Connection Between Bilirubin Metabolism, Gut Microbiota and Inflammatory Bowel Diseases
Inflammatory Bowel Diseases (IBDs) are a set of recurrent inflammatory conditions that include the colon and small intestine. The two principal conditions include Crohn's disease (CD) and ulcerative colitis (UC).
- Trial name
- NCT03841045
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Crohn Disease (CD)
Efficacy of MIrikizumab to Achieve Transmural Healing in patiENTs With Crohn's Disease
Efficacy of Mirikizumab to achieve transmural healing in patients with Crohn's Disease
- Trial name
- EMINENT-CD (NCT07292012)
- Testing
- Mirikizumab - IV, Mirikizumab - SC
- Where
- 8 sites in France
- Volunteers
- 75 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn Disease, Pediatric Crohns Disease
FMT in Pediatric Crohn's Disease
The goal of this study is to evaluate the safety of Fecal Microbiota Transplantation (FMT) in children with Crohn's disease who are in remission. Safety will be the primary endpoint and Pediatric Crohn's Disease.
- Trial name
- FMTPCD (NCT03194529)
- Testing
- FMT
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Los Angeles
Inflammatory Bowel Diseases, Ulcerative Colitis
IBD and Women's Health Wellness Program
Researchers want to understand if a combination of usual medical care along with a wellness program designed for women with Inflammatory Bowel Disease diagnosis will have an effect on quality of life, stress, and disease activity.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT05172557
- Testing
- Wellness Program, Wellness Coaching
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Crohn's Disease
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study, comprised of 3 sub-studies, to evaluate the efficacy and safety of duvakitug in participants with moderately to severely…
- Trial name
- STARSCAPE-1 (NCT07184931)
- Testing
- Duvakitug
- Where
- 461 sites in United States, Argentina and 34 more
- Volunteers
- 980 people
- Sponsor
- Sanofi
Crohn's Disease
A Study of Abatacept in Patients With Active Crohn's Disease
The purpose of this clinical research study is to learn if abatacept can improve signs and symptoms of active Crohn's Disease in patients who have not had an adequate response to other therapies.
- Trial name
- NCT00406653
- Testing
- abatacept
- Where
- 101 sites in United States, Australia and 15 more
- Volunteers
- 451 people
- Sponsor
- Bristol-Myers Squibb
Crohn's Disease
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
The reason for this study is to determine the long-term efficacy and safety of the study drug mirikizumab in participants with Crohn's disease.
- Trial name
- VIVID-2 (NCT04232553)
- Testing
- Mirikizumab
- Where
- 322 sites in United States, Argentina and 30 more
- Volunteers
- 996 people
- Sponsor
- Eli Lilly and Company
Crohn's Disease, Ulcerative Colitis (UC)
Expanded Access to Risankizumab
This is an expanded access program (EAP) for eligible participants with Crohn's Disease (CD). This program is designed to provide access to risankizumab, prior to approval by the local regulatory agency, to patients with the…
- Trial name
- NCT03914261
- Testing
- Risankizumab
- Sponsor
- AbbVie
Colitis, Ulcerative
A Study to Investigate the Efficacy and Safety of GSK1605786 for Treatment of Patients With Active Ulcerative Colitis
GSK1605786 is an oral antagonist specific for the chemokine receptor CCR9 in development for treatment of small bowel and colonic Crohn's disease (CD).
- Trial name
- NCT01658605
- Testing
- GSK1605786
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Sponsor
- GlaxoSmithKline
Crohn's Disease, Ileitis
Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs
Study is designed to show a lack of effect on white blood cells circulating in the spinal fluid.
- Conditions
- Crohn's Disease, Ileitis, Ileo-colonic and Colonic Crohn's Disease, Granulomatous Colitis
- Trial name
- TOSCA (NCT01387594)
- Testing
- lumbar puncture
- Where
- 9 sites in Austria, Belgium and 3 more
- Volunteers
- 49 people
- Sponsor
- Shire
Ulcerative Colitis, Gastrointestinal Disease
Humanized Anti-IL-2 Receptor Monoclonal Antibody in Moderate-to-severe Ulcerative Colitis
The purpose of The PROSPECT Study is to evaluate an investigational medication for the treatment of moderate to severe ulcerative colitis.
- Conditions
- Ulcerative Colitis, Gastrointestinal Disease, Inflammatory Bowel Disease
- Trial name
- NCT00073047
- Testing
- Daclizumab
- Where
- 35 sites in United States, Belgium and 1 more
- Volunteers
- 150 people
- Sponsor
- Facet Biotech
Ulcerative Colitis
Long-term Outcome of Patients With Acute Ulcerative Colitis After First Course of Intravenous Corticosteroids
All episodes of patients with acute UC admitted to Tampere University Hospital and treated with intravenous corticosteroids between January 2007 and January 2016 were identified from patient records and reviewed.
- Trial name
- NCT04564638
- Testing
- Corticosteroid
- Volunteers
- 217 people
- Sponsor
- Tampere University Hospital
Autoimmune Diseases, Epilepsy
VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems
Vagal nerve stimulation is a neurosurgical procedure consisting of implantation of an impulse generator battery with leads placed into the vagus nerve in the neck.
- Conditions
- Autoimmune Diseases, Epilepsy, Autonomic Dysfunction, Inflammatory Bowel Diseases
- Trial name
- VNS-IG (NCT03953768)
- Testing
- Vagal nerve stimulation (VNS)
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Louisville
Ulcerative Colitis
Additive Effect of Probiotics (Mutaflor®) in Patients With Ulcerative Colitis on 5-ASA Treatment.
E.coli Nissle 1917 (Mutaflor®) is equivalent to mesalazine in preventing disease relapse in ulcerative colitis. However, data on ability of E.coli Nissle 1917 (Mutaflor®) to induce remission compared with placebo is limited.
- Trial name
- NCT04969679
- Testing
- E. coli Nissle 1917 (Mutaflor®)
- Where
- South Korea
- Volunteers
- 134 people
- Sponsor
- Kangbuk Samsung Hospital
Crohn's Disease Colon
Mindfulness-Based Stress-Reduction in Patients With Crohn's Disease
A randomized controlled study which aims to improve the quality of life of Crohn's disease adult patients suffering from mild to moderate level of symptoms.
- Trial name
- NCT05085925
- Testing
- Cognitive behavioral mindfulness intervention, Cognitive behavioral mindfulness intervention after 3-month wait list
- Where
- Israel
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Inflammatory Bowel Diseases, Rheumatologic Disease
EFFICACY AND SAFETY OF S.C. INFLIXIMAB IN PATIENTS SWITCHED FROM I.V. FORMULATION OF INFLIXIMAB
Phase-IV, national, multicentric, non-randomized, observational real-life study. The goal of this stud is to investigate the patient's benefits in terms of quality of life and work ability resulting from the switch from…
- Trial name
- NCT05719389
- Testing
- CT-P13
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Radiomics, Multi-omics
Neurophenotype Predicts CD Disease Progression
The goal of this observational study is aimed to develop a novel multimodal neuroimaging-based model to characterize the neurophenotype of Crohn's Disease patients and assess its ability for predicting disease progression, using…
- Trial name
- NCT06452550
- Testing
- Logistic regression (LR) prediction models
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Pouchitis, Inflammatory Bowel Diseases
Faecal Microbiota Transplantation in the Treatment of Chronic Pouchitis
Patients with the chronic bowel disease pouchitis is disabled by bloody diarrhoea and abdominal pain often followed by fever. Pouchitis is an inflammation in a pouch, a reservoir formed by the small intestine in the management of…
- Conditions
- Pouchitis, Inflammatory Bowel Diseases, Ulcerative Colitis
- Trial name
- MicroPouch (NCT04100291)
- Testing
- Faecal microbiota transplantation
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
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