Clinical trials: IBD-Inflammatory Bowel Disease
Crohn's Disease
GSK1605786A in the Maintenance of Remission in Subjects With Crohn's Disease
A randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of two doses (500 mg once daily and 500 mg twice daily) of GSK1605786A in maintaining remission over 52 weeks in adult subjects with Crohn's…
- Trial name
- SHIELD-2 (NCT01316939)
- Testing
- GSK1605786A
- Where
- 256 sites in United States, Australia and 31 more
- Volunteers
- 229 people
- Sponsor
- GlaxoSmithKline
Colitis, Ulcerative
A Study to Investigate the Safety and Tolerability of Multiple Study Interventions in Participants With Moderate to Severe Ulcerative Colitis
This study will look at how safe and tolerable different treatments are for adults who have moderate to severe ulcerative colitis (UC).
- Trial name
- PEGASUS (NCT07747467)
- Testing
- Aletekitug (GSK1070806)
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis (RA), Crohn's Disease (CD)
Ketogenic and Carnivore (Lion) Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis
This study is a randomized controlled clinical trial evaluating whether two therapeutic dietary approaches - a ketogenic diet and a carnivore (lion) diet - can improve quality of life, reduce symptoms, and influence measures of…
- Conditions
- Rheumatoid Arthritis (RA), Crohn's Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07524244
- Testing
- Ketogenic diet, Carnivore (Lion) Diet
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Fuller Research Foundation
Inflammatory Bowel Diseases, Thromboembolism
Inflammatory Bowel Disease and Thromboembolic Events
The main objective was to demonstrate the existence and importance of hypercoagulability in patients with IBD, by determining the prevalence of changes in coagulation parameters and evaluating the impact of these changes on the…
- Conditions
- Inflammatory Bowel Diseases, Thromboembolism, Coagulation Disorder
- Trial name
- NCT05162339
- Testing
- No intervention was made
- Where
- Portugal
- Volunteers
- 149 people
- Sponsor
- Centro Hospitalar Tondela-Viseu
Crohn's Disease
Blood and Stool Molecular Biomarkers Longitudinal Detection Study in Crohn's Disease (CD) Patients
To evaluate the relationship between noninvasive biomarkers (patient serological markers and metagenomic analysis of stool) and disease status as determined by colonoscopy and by clinical symptoms in patients with Crohn's…
- Trial name
- NCT03566407
- Testing
- Colonoscopy
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Prometheus Laboratories
Perianal Fistula Due to Crohn's Disease, Fistula in Ano
Safety of Allogeneic Human Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) to Treat Perianal Fistulas w/ Crohn's Disease
Objectives: Primary: To demonstrate the safety of allogeneic UC-MSCs administered by injection for complex perianal fistulas in patients with Crohn's disease Secondary: To determine the efficacy of a single/multiple allogeneic…
- Trial name
- NCT05039411
- Testing
- PF2020-CELL (UC-MSCs) - Allogeneic Human Umbilical Cord Mesenchymal Stem Cells
- Where
- Malaysia
- Volunteers
- 5 people
- Sponsor
- CryoCord Sdn Bhd
Inflammatory Bowel Diseases
The Impact of Medication Belief on Adherence to Infliximab in Patients With Crohn's Disease
The IFX adherence to CD in China was not high. Medicine concerns may be predictive factor of adherence. By enhancing knowledge and relieving medicine concerns, we may increase patients' adherence to IFX.
- Trial name
- NCT05777616
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Irritable Bowel Syndrome, Crohn Disease
Evaluation of the SIMBA Capsule for Small Intestinal Dysbiosis
The SIMBA Capsule is a small, single-use, ingestible capsule that allows for the non-invasive sampling of small bowel contents using purely mechanical means.
- Conditions
- Irritable Bowel Syndrome, Crohn Disease, Celiac Disease, Ulcerative Colitis
- Trial name
- NCT05633706
- Testing
- fluid biopsy capsule
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Inflammatory Bowel Diseases, Crohn's Disease
The Effect of Diet on Microbial Profile and Disease Outcomes in Patients With Inflammatory Bowel Diseases
This clinical study is designed to evaluate the effect of two dietary patterns, Mediterranean diet and the specific carbohydrate diet on clinical, inflammatory and microbial parameters in patients after pouch surgery and to…
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Dietary Modification
- Trial name
- NCT02858557
- Testing
- Mediterranean diet, Specific Carbohydrate Diet
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Inflammatory Bowel Diseases, Remission
Social and Demographic Determinants of Fatigue in Patients With Inflammatory Bowel Disease in Remission
The aim of this observational study is to identify the social and demographic determinants of fatigue in patients with inflammatory bowel disease in remission.
- Conditions
- Inflammatory Bowel Diseases, Remission, Fatigue
- Trial name
- SOFA (NCT06186999)
- Where
- 4 sites in France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Grenoble
Crohn's Disease, Ulcerative Colitis
An Investigational Study to Test Usability of the Electronic Dosing Equipment Medicpen
This is a study of the electronical dosing tool MedicPen and it's qualities with regards to user friendliness and medication compliance.
- Trial name
- NCT00917514
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Medicpen AB
Crohn Disease (CD), Intestine Ultrasonography
Use of Water Ingestion in Small Intestine Ultrasound
Small Intestine Contrast Ultrasonography (SICUS) is an ultrasound-based method that explores bowel loops, and is able to identify wall thickness, intestinal motility, bowel wall vascularity and complications such as stenosis or…
- Trial name
- NCT07079007
- Testing
- Water
- Where
- Australia
- Volunteers
- 55 people
- Sponsor
- Austin Health
Crohn's Disease
Volatiles in Exhaled Breath and Blood in Crohn's Disease: Validation Cohort
This study evaluates the use of exhaled air analysis as tool to monitor the disease activity in Crohn's Disease (CD). This study is a validation of the previous findings.
- Trial name
- NCT02641171
- Testing
- Specimen sampling
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Crohn Disease
Epidemiological Characteristics and Efficacy Evaluation of Difficult-To-Treat Crohn's Disease
Difficult to treat Crohn's disease (DTT-CD) was defined by the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) in 2023, which refers to CD patients with poor response to drug treatment and poor…
- Trial name
- NCT07364734
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- Xiang Gao
Crohn's Disease
Study To Test Whether PF-00547659 Is Safe And Improves Disease Symptoms In Patients With Crohn's Disease
Adults with Crohn's disease that is clinically active despite conventional treatment will be eligible for this study. Patients may receive one of three doses of PF-00547659 (experimental drug) or placebo (inactive drug).
- Trial name
- OPERA (NCT01276509)
- Testing
- PF-00547659 SC injection
- Where
- 137 sites in United States, Austria and 14 more
- Volunteers
- 265 people
- Sponsor
- Shire
Crohn's Disease
Intralesional Tolerogenic Dendritic Cells in Crohn's Disease Treatment
Intralesional Tolerogenic Dendritic Cells in Crohn's Disease Treatment.
- Trial name
- TolDecCDintra (NCT02622763)
- Testing
- Tolerogenic Dendritic Cells
- Where
- Spain
- Volunteers
- 3 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Healthy Participants, IBD (Inflammatory Bowel Disease)
A Phase I Study of HW201877 in Healthy Subjects
This is a Phase I, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and food effect (FE) of HW201877 in healthy subjects following (1) a single…
- Trial name
- NCT07373457
- Testing
- HW201877 capsules
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Wuhan Humanwell Innovative Drug Research and Development Center Limited Company
Crohn's Disease, Ulcerative Colitis (UC)
Impact of AbbVie Care Patient Support Program on Clinical, Health Economic and Patient Reported Outcomes, in Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis, Psoriatic Arthritis, Psoriasis and Axial Spondyloarthritis, in the Portuguese National Health Service
This study aims to evaluate the impact of AbbVie Care 2.0 on adalimumab's compliance, patient reported outcomes and utilization of health resources over 12 months.
- Conditions
- Crohn's Disease, Ulcerative Colitis (UC), Rheumatoid Arthritis (RA), Psoriatic Arthritis
- Trial name
- IMPROVE (NCT03223012)
- Where
- 15 sites in Portugal
- Volunteers
- 116 people
- Sponsor
- AbbVie
Inflammatory Bowel Disease
Predictors of Mucosal Healing in Inflammatory Bowel Disease (IBD) Patients Treated With Anti-TNF
The aim of this study is to prospectively identify, at diagnosis of the disease, factors predictive of mucosal healing in patients with inflammatory bowel disease treated with anti-TNF.
- Trial name
- NCT01605175
- Where
- Greece
- Volunteers
- 21 people
- Sponsor
- Evangelismos Hospital
Ulcerative Colitis
Phase 2a Study to Evaluate IcBD-01 Enema in Active Ulcerative Colitis Patients
Ulcerative proctitis can lead to considerable morbidity, and the available treatment options are limited. Cannabidiol (CBD), a non-psychotropic ingredient of Cannabis sativa, possesses potent immunomodulatory and…
- Trial name
- NCT06353828
- Testing
- CBD, synthetic form
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- CannaMore Biotechs
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