Clinical trials: IBD-Inflammatory Bowel Disease
Ulcerative Colitis
A Study To Evaluate The Safety And Efficacy Of PF-06826647 In Participants With Moderate To Severe Ulcerative Colitis
The purpose of this study is to evaluate efficacy and safety of PF-06826647 in moderate to severe ulcerative colitis
- Trial name
- NCT04209556
- Testing
- PF-06826647 100 mg QD, PF-06826647 300 mg QD, PF-06826647 600 mg QD
- Where
- 24 sites in United States
- Sponsor
- Pfizer
Ulcerative Colitis, Crohn's Disease
Epidemiology of Ulcerative Colitis and Crohn's Disease in Non Jewish Israel Population
The aim of the present study was to describe the incidence and prevalence of IBD in non Jewish Israel population
- Trial name
- NCT00815061
- Where
- Israel
- Sponsor
- Rabin Medical Center
IBD-Inflammatory Bowel Disease, UC - Ulcerative Colitis
Impact of Therapeutic Intervention on Quality of Life in Patients With Ulcerative Colitis
This study is therefore postulated as a clear alternative that evaluates patients´quality of life, and recognises fecal calprotectin as an inflammatory marker.
- Trial name
- CAVI_CU (NCT05271773)
- Where
- 10 sites in Spain
- Volunteers
- 234 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Crohn's Disease
Psychology of Crohn's Disease
The purpose of this study is to determine whether emotional processing and somatic dissociation influence IBS-like symptoms in Crohn's Disease patients.
- Trial name
- NCT01573078
- Testing
- Questionnaire
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Crohn Disease
Effect of Biologic Therapy on Surgical Outcomes for Perforated Crohn's Patients
crohn's disease patients who present by intestinal perforation as the first presentation are hard to deal with. Surgical techniques as anastmosis or diversion stoma and active course of the disease may greatly affect the quality…
- Trial name
- NCT06511921
- Testing
- early biologic therapy, late biologic therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Ulcerative Colitis, Crohn's Disease
Evaluation of Health Costs and Resource Utilization
Utilization of health resources in a testing based strategy versus an empiric dose escalation strategy to manage Crohn's disease and Ulcerative Colitis in subjects with loss of response to infliximab or adalimumab.
- Trial name
- Test-NoTest (NCT01960426)
- Testing
- Measurement of drug (Adalimumab/Infliximab), Intensify treatment with the existing drug
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Western Ontario, Canada
Inflammatory Bowel Disease, Iron Deficiency Anemia
EffiCacy and sAfEty of Low doSe orAl iRon for Anaemia in IBD
Iron deficiency anaemia (IDA) is common in inflammatory bowel disease (IBD). However, although iron is commonly prescribed, the amount of elemental iron needed to achieve clinical efficacy, and the optimal method of…
- Trial name
- CAESAR (NCT06321887)
- Testing
- Ferrous fumarate syrup 2.5ml/70mg (22.5mg elemental iron), Ferrous fumarate syrup 2.5ml/70mg(45mg elemental iron), Ferrous fumarate syrup 2.5ml/70mg (90mg elemental iron)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Inflammatory Bowel Disease, Ulcerative Colitis
Evaluate if Response to Infliximab or Adalimumab May be Regained With an Immunomodulator
The immunogenicity of anti-tumor necrosis factor alpha (anti-TNF) therapy in inflammatory bowel disease (IBD) is an important cause of loss of response to therapy that may lead to escalation of dose or discontinuation of therapy.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease
- Trial name
- NCT02413047
- Testing
- Azathioprine, 6 mercaptopurine, Methotrexate
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Indiana University
Crohn Disease (CD)
DB-3Q for the Treatment of Medically Refractory Crohn's Disease
This research study is studying DB-3Q as a possible treatment for medically refractory Crohn's disease. The purpose of this study is to research and evaluate safety and effectiveness of the administration of bone marrow…
- Trial name
- NCT07625293
- Testing
- DB-3Q
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Direct Biologics, LLC
Inflammatory Bowel Disease
A Brief Intervention to Improve Adherence in Teens With Inflammatory Bowel Disease
This project will test if a phone intervention can improve the medicine-taking behavior of teens with IBD. The investigators will study teens who are taking medicine by mouth.
- Trial name
- PHONE (NCT01237847)
- Testing
- 2 Family-based problem solving phone sessions, 4 Family-based problem solving phone intervention sessions, Wait list comparison group
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Rosalind Franklin University of Medicine and Science
Multiple Sclerosis, Colitis, Ulcerative
A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics (PD) of GSK3888130B in Healthy Participants
This is a first time in human study designed to assess the safety, tolerability, pharmacokinetics and PD of GSK3888130B over a range of dose levels in healthy participants.
- Trial name
- NCT05131971
- Testing
- GSK3888130B
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Colitis, Ulcerative
An Efficacy and Safety Study of Mongersen (GED-0301) in Subjects With Active Ulcerative Colitis
This is a phase 2, open-label, multicenter study to explore the efficacy and safety of oral GED- 0301 in subjects with active UC, defined as a modified Mayo score (MMS) ≥ 4 and ≤ 9 and a Mayo endoscopic subscore≥ 2.
- Trial name
- NCT02601300
- Testing
- GED-0301
- Where
- 36 sites in United States, Bulgaria and 4 more
- Volunteers
- 41 people
- Sponsor
- Celgene
Ulcerative Colitis
Efficacy and Safety of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis
Ulcerative colitis is a disease of the large bowel (colon) and rectum in which the lining of the bowel becomes red and swollen. Over time, patients with this disease may experience acute episodes of diarrhea, rectal bleeding and…
- Trial name
- NCT00151892
- Testing
- SPD476, Asacol
- Where
- 142 sites in United States, Argentina and 26 more
- Volunteers
- 829 people
- Sponsor
- Shire
Graft Vs Host Disease, Inflammatory Bowel Diseases
Precision Diagnostics in Inflammatory Bowel Disease, Cellular Therapy and Transplantation (The PREDICT Trial)
The goal of the Precision Diagnosis in Inflammatory Bowel Disease, Cellular Therapies, and Transplantation (PREDICT) trial is to apply a systems-biology approach to enable precision diagnostics for the key immunologic outcomes…
- Conditions
- Graft Vs Host Disease, Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders
- Trial name
- PREDICT (NCT03369353)
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Boston Children's Hospital
Ulcerative Colitis
Phosphatidylcholine (LT-02) vs. Placebo vs. Mesalamine for Maintenance of Remission in Ulcerative Colitis (PROTECT-2)
The purpose of this study is to prove the superiority of a 48-weeks treatment with 3.2 g/day delayed-release phosphatidylcholine (LT-02) versus placebo for the maintenance of remission in patients with ulcerative colitis (UC)
- Trial name
- PROTECT-2 (NCT02280629)
- Testing
- LT-02, Mesalamine
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Dr. Falk Pharma GmbH
Ulcerative Colitis, Histology Remission
FIT Combining FC for Predicting MH and Histology Remission in UC
Investigaters will perform a clinical trial to asess the abilitiy of qFIT and FC on predicting UC MH and histology remission.
- Conditions
- Ulcerative Colitis, Histology Remission, Fecal Calprotetin, FIT
- Trial name
- NCT05447572
- Testing
- FIT + FC
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Ulcerative Colitis, Crohn's Disease
Eicosapentaenoic Free Fatty Acid and Fecal Calprotectin in Inflammatory Bowel Diseases
The aim of this study is to test Eicosapentaenoic free fatty acid's effects on calprotectin levels in IBD patients in clinical remission.
- Trial name
- NCT02179372
- Testing
- Eicosapentaenoic acid
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Ulcerative Colitis, Protein Metabolism
Metabolic Response to Infliximab in Pediatric Ulcerative Colitis
The metabolic response to ulcerative colitis, including increased proteolysis and lipolysis and changes in energy expenditure, plays a significant role in the resulting malnutrition from which these patients suffer.
- Conditions
- Ulcerative Colitis, Protein Metabolism, Energy Expenditure
- Trial name
- NCT00586807
- Testing
- Stable amino acid isotopes
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (Disorder)
Virtual Versus Dye-based Chromoendoscopy in Inflammatory Bowel Disease Surveillance Colonoscopy
People with inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease affecting the colon, have a higher risk of developing colon cancer over time.
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (Disorder), Crohns Disease, Colorectal Neoplasms
- Trial name
- NCT07089771
- Testing
- Virtual Chromoendoscopy, Dye-Based Chromoendoscopy
- Where
- Sweden
- Volunteers
- 480 people
- Sponsor
- Region Stockholm
Crohn Disease
Treg Immunotherapy in Crohn's Disease
Crohn's Disease (CD) is a condition that causes inflammation of the digestive system or gut. Crohn's can affect any part of the gut, though the most common area affected is the end of the ileum (the last part of the small…
- Trial name
- TRIBUTE (NCT03185000)
- Testing
- TR004 (Treg immunotherapy)
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- King's College London
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