Clinical trials: IBS, open to volunteers
Irritable Bowel Syndrome
Well-being in IBS: Strengths and Happiness (WISH) 2.0
The purpose of this study is to examine the feasibility, acceptability, preliminary effects, and candidate gut-brain mechanisms of an optimized positive psychology (PP) intervention for patients with irritable bowel syndrome…
- Trial name
- NCT06866106
- Testing
- Positive Psychology (PP) Intervention, Educational Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Irritable Bowel Syndrome
Digestive Enzyme Formulation Intervention in IBS Patients Who Previously Clinically Responded to Mediterranean LFD
Irritable bowel syndrome (IBS) is a highly prevalent chronic functional gastrointestinal disorder. The cardinal symptoms include abdominal pain, flatulence, bloating, and changes in bowel habits related to stool frequency and…
- Trial name
- NCT06749613
- Testing
- digestive enzymes
- Where
- 2 sites in Greece
- Volunteers
- 40 people
- Sponsor
- Attikon Hospital
Irritable Bowel Syndrome, Food Sensitivity
Brachyspira and Intestinal Allergy-like Immune Reactions in Patients With Irritable Bowel Syndrome (IBS)
The aim of this study is to define local immune responses in the GI tract to food antigens in IBS patients, with and without Brachyspira infection, using advanced imaging.
- Trial name
- NCT06413004
- Testing
- Elimination and re-introduction of CLE or COLAP positive food item(s)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Magnus Simrén
IBS, Diarrhea Predominant
Transcutaneous Electrical Acustimulation for IBS-D: A Multicenter Study
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent abdominal pain and altered bowel habits.
- Trial name
- NCT07425145
- Testing
- Portable stimulator
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First People's Hospital of Foshan
ME/CFS, IBS - Irritable Bowel Syndrome
The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This clinical study aims to evaluate the use of i3.1 probiotic in participants who meet the Institute of Medicine (Canadian Consensus Criteria) case definition for ME/CFS and who may or may not be diagnosed with irritable bowel…
- Trial name
- NCT06211062
- Testing
- Floradapt Intensive GI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nova Southeastern University
IBS - Irritable Bowel Syndrome, Post Infection Syndrome
Gut Microbiome in Patients With Post-infectious Irritable Bowel Syndrome
Observational, multicenter, prospective study aimed at characterizing the gut microbiome in patients with post-infectious irritable bowel syndrome (PI-IBS) using whole genome sequencing (WGS).
- Trial name
- MicroRestore (NCT07517029)
- Where
- Italy
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Irritable Bowel Syndrome
Defining Objective Markers of Compliance for Dietary Therapies in IBS
This research will investigate if a specific marker in your stool or urine can be used to track changes in your carbohydrate intake including fructo-oligosaccharide and mannitol intake
- Trial name
- NCT07494968
- Testing
- Diet A - elimination diet, Diet B - healthy eating diet
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Michigan
IBS (Irritable Bowel Syndrome), IBS-D (Diarrhea-predominant)
Saccharomyces Boulardii CNCM I-745 in Irritable Bowel Syndrome
This is a double-blind, randomized (group assignment by chance), placebo-controlled, multicenter trial which will be conducted over a 13.5-months period The main objective of the research is to demonstrate the efficacy of…
- Conditions
- IBS (Irritable Bowel Syndrome), IBS-D (Diarrhea-predominant), IBS, Mixed Symptoms
- Trial name
- BoWell Sb252 (NCT07168434)
- Testing
- Saccharomyces Boulardii 250 MG
- Where
- 10 sites in Portugal, Spain
- Volunteers
- 406 people
- Sponsor
- Biocodex
Functional Gastrointestinal Disorders (FGIDs), Irritable Bowel Syndrome (IBS)
Mechanism of FODMAP Restriction on FGID Patients
Brief Summary : The goal of this clinical trial is to investigate the effects of differing FODMAP diets on gut microbiota, gut barrier function, symptom severity, quality of life, and psychological status in FGID patients.
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Irritable Bowel Syndrome (IBS), Functional Dyspepsia
- Trial name
- BRIDGE (NCT07000227)
- Testing
- Low FODMAP diet, Gentle FODMAP diet, Traditional Dietary Advice
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Irritable Bowel Syndrome (IBS-C)
Trans Auricular Vagal Nerve Stimulation in Patients With IBS-C
This study evaluates the efficacy and safety of transcutaneous auricular vagus nerve stimulation (ta-VNS) in adults with constipation-predominant irritable bowel syndrome (IBS-C).
- Trial name
- NCT07662083
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- West Virginia University
Irritable Bowel Syndrome (IBS), Microbiome
SIMBA in Irritable Bowel Syndrome (IBS)
This study is intended to characterize longitudinal changes in the small intestinal microbiome following rifaximin treatment in participants with Irritable Bowel Syndrome (IBS) over a 12 week period.
- Trial name
- SIMPACT (NCT07882953)
- Testing
- Rifaximin (drug), fluid biopsy capsule
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of Calgary
Irritable Bowel Syndrome, Diarrhea-Predominant (IBS-D), Recurrent Clostridioides Difficile Infection (rCDI)
A Flexible Clinical Trial to Test if Freeze-dried Fecal Microbiota Therapy Helps Treat Diarrhea-predominant Irritable Bowel Syndrome or Prevent Recurring C. Difficile Infections.
The goal of this clinical trial is to learn if oral lyophilized fecal microbiota therapy (ORAL-LYO-FMT) helps treat diarrhea-predominant irritable bowel syndrome (IBS-D) and prevent the recurrence of Clostridioides difficile…
- Conditions
- Irritable Bowel Syndrome, Diarrhea-Predominant (IBS-D), Recurrent Clostridioides Difficile Infection (rCDI), Fecal Microbiota Therapy (FMT), Irritable Bowel Syndrome (IBS)
- Trial name
- ORAL-LYO-FMT (NCT06948461)
- Testing
- ORAL-LYO-FMT
- Volunteers
- 63 people
- Sponsor
- PharmaPlanter Technologies Inc
Quiescent Crohn's Disease (CD)
Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease
Many individuals with Crohn's disease continue to experience abdominal pain, bloating, or bowel habit changes even when their inflammation is controlled.
- Trial name
- AIMS-CD (NCT07556718)
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Irritable Bowel Syndrome
IBS Skin Patch Test Food Allergy Study
Participants with IBS are skin patch tested (no needles) to 80 different foods and food additives, compounded for patch testing, in search of food allergies. The testing requires 3 office visits within a 4 or 5 day period.
- Trial name
- NCT06288672
- Testing
- True avoidance diet
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- IBS-80, LLC
Irritable Bowel Syndrome
Reliability of a Food Frequency Questionnaire in the Assessment of Dietary Intake Including FODMAPs in Different Populations, and Relationship With IBS Symptoms and the Degree of Self-assessed Physical Activity
During an online assessment participants will fill in questionnaires evaluating demographic data, psychological variables, the degree of self-assessed physical activity and symptoms of irritable bowel.
- Trial name
- NCT05293769
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Universitair Ziekenhuis Brussel
Irritable Bowel Syndrome (IBS)
Deep Learning-Based Confocal Laser Microendoscopy Feature Atlas Construction and Its Application in Intelligent Diagnosis of Irritable Bowel Syndrome
In this study, the healthy control group and IBS patients are taken as the research subjects, and CLE is applied to image and analyze the enrolled persons respectively, to derive and compare the characteristic microstructural…
- Trial name
- NCT07051226
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Ulcerative Colitis
Naturopathic Approaches to Ulcerative Colitis
Ulcerative colitis (UC) is a long-term condition that causes inflammation in the large intestine. People with UC often have symptoms such as diarrhea, abdominal pain, and fatigue.
- Trial name
- NCT07521904
- Testing
- Naturopathic medicine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National University of Natural Medicine
IBS, Diarrhea Predominant
Phase III Clinical Trial of Changji'an Capsules in the Treatment of Irritable Bowel Syndrome With Predominant Diarrhea (Liver-Qi Invading Spleen Syndrome)
This trial is a randomized, double-blind, placebo-controlled, parallel-group, multicenter Phase III clinical trial. Its purpose is to evaluate the efficacy and safety of Changji'an Capsules in subjects with diarrhea-predominant…
- Trial name
- NCT07610434
- Testing
- Chang Ji'an capsule, Chang Ji'an capsule mimic
- Where
- 29 sites in China
- Volunteers
- 636 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine
Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS)
Enabling Microbiomics- Driven Personalized Nutrition
The goal of this observational research study is to determine how diet contributes to various gastrointestinal related conditions.
- Conditions
- Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), Celiac Disease, Diarrhea
- Trial name
- EMPOWER (NCT06657001)
- Where
- United States
- Volunteers
- 4,001 people
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome (IBS), Pain
Study on Treatment Mechanisms and Efficacy Prediction of Individualized Transcranial Magnetic Stimulation in Adults With Irritable Bowel Syndrome Using Multimodal MRI and High-Throughput Sequencing
The goal of this clinical trial is to explore if "individualized repetitive Transcranial Magnetic Stimulation (TMS)" works to improve symptoms in adults with Irritable Bowel Syndrome (IBS).
- Conditions
- Irritable Bowel Syndrome (IBS), Pain, Depressive Disorder, Major, Moderate
- Trial name
- NCT07345377
- Testing
- Individualized TMS Intervention
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University