Clinical trials: ICH - Intracerebral Hemorrhage
Hemorrhagic Stroke, Intracerebral Hemorrhage (ICH)
Efficacy, Safety and Tolerability of BAF312 Compared to Placebo in Patients With Intracerebral Hemorrhage (ICH).
This is a randomized, placebo-controlled, subject and investigator-blinded study to evaluate efficacy, safety and tolerability of BAF312 in participants with intracerebral hemorrhage (ICH)
- Trial name
- NCT03338998
- Testing
- BAF312 solution, BAF312 tablet
- Where
- 11 sites in United States
- Volunteers
- 32 people
- Sponsor
- Novartis Pharmaceuticals
Intracerebral Hemorrhage
A Study to Evaluate the Safety, Tolerability and the Effects of Ixodes Ricinus-Contact Phase Inhibitor (Ir-CPI) in Adult Patients With Spontaneous Intracerebral Haemorrhage
The purpose of the study is to provide a first assessment of safety, tolerability and efficacy of Ir-CPI, administered on top of standard-of-care, on secondary brain injury in patients with spontaneous intracerebral haemorrhage.
- Trial name
- BIRCH (NCT05970224)
- Testing
- Ir-CPI
- Where
- 8 sites in Belgium
- Volunteers
- 23 people
- Sponsor
- Bioxodes S.A.
Intracerebral Hemorrhage
Statins In Intracerbral Hemorrhage
The SATURN trial aims to determine whether continuation vs. discontinuation of statin drugs after spontaneous lobar intracerebral hemorrhage (ICH) is the best strategy; and whether the decision to continue/discontinue statins…
- Trial name
- SATURN (NCT03936361)
- Testing
- Statins
- Where
- United States
- Volunteers
- 1,456 people
- Sponsor
- Beth Israel Deaconess Medical Center
Stroke, Intracerebra Hemorrhage
APEX-STROKE EAGLE Domain (EAGLE)
In this domain of APEX-STROKE, participants with acute spontaneous supratentorial intracerebral haemorrhage (ICH) who meet the domain-specific eligibility criteria will be randomised to either an early surgical bundle or…
- Trial name
- EAGLE (NCT07790354)
- Testing
- Early surgical bundle, Guideline-Based Standard Care
- Volunteers
- 878 people
- Sponsor
- Fudan University
Ischemic Stroke, Intracerebral Hemorrhage
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke.
- Conditions
- Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular
- Trial name
- DISCOVERY (NCT04916210)
- Where
- 31 sites in United States
- Volunteers
- 8,000 people
- Sponsor
- Massachusetts General Hospital
Stroke
Long Term Outcome After Hemorrhagic Stroke Surgery
The investigators retrospectively reviewed all patients with neurosurgical operations for hemorrhagic stroke (intracerebral hemorrhage) between 1999 and 2008.
- Trial name
- NCT01409252
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Chinese University of Hong Kong
Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral
Spleen Volume Change Predicts 45-Day Mortality in Neurocritical Care: A Prospective Cohort Study
This study investigates whether changes in spleen size over 72 hours can help predict the risk of death within 45 days in patients who were admitted to the emergency department with a type of bleeding in the brain called…
- Conditions
- Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral, Neurocritical Care, Acute Brain Injury
- Trial name
- SCOPE (NCT07132996)
- Testing
- POCUS-based Splenic Volume Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Transcranial Ultrasound With Sonolucent Cranioplasty, TUSC
Transcranial Ultrasound Via Sonolucent Cranioplasty After Minimally Invasive Intracerebral Hemorrhage Evacuation
Postoperative rebleeding is a major limitation of surgical evacuation for intracerebral hemorrhage (ICH). While computed tomography (CT) is the standard of care for postoperative hematoma cavity monitoring, CT requires…
- Trial name
- TUSC MIS (NCT05538286)
- Testing
- ClearFit implant, transcranial ultrasonography through sonolucent cranioplasty
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Intracranial Hemorrhages
Minimal Invasive Surgical Intracerebral Hemorrhage Removal
This is a feasibility study trial to determine whether hyperacute (≤8 hour) mechanical Minimal Invasive Surgical (MIS) management is feasible and secondarily improves outcome in patients with spontaneous supratentorial…
- Trial name
- HEALME (NCT05138341)
- Testing
- Minimally invasive surgical (MIS) intracranial hemorrhage Evacuation
- Volunteers
- 16 people
- Sponsor
- The Ottawa Hospital
Ischemic Stroke, Intracerebral Hemorrhage
Evaluating the Safety and Efficacy of Telemedicine Neurology Assessments on a Mobile Stroke Unit
The goal of this clinical trial is to compare a telemedicine neurologist staffing model to a traditional on-board model in patients being assessed for suspected acute stroke on a mobile stroke unit.
- Trial name
- MSU-TELEMED (NCT05991310)
- Testing
- Telemedicine Assessment by Remote Neurologist, In-Person Assessment by an Onboard Neurologist
- Where
- Australia
- Volunteers
- 270 people
- Sponsor
- Melbourne Health
Primary Disease or Condition Being Studied, or Focus of the Study
Neuropsychiatric Symptoms in Spontaneous Intracerebral Hemorrhage Survivors
Compared to the United Kingdom and the United States, Spontaneous non-traumatic intracerebral hemorrhage (ICH) is more common among people in Taiwan.
- Trial name
- NCT05620810
- Testing
- neuropsychiatric symptoms
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Treatment of Spontaneous Intracerebral Hemorrhage
Safety and Efficacy of Stereotactic Aspiration Plus Urokinase in Deep Intracerebral Hemorrhage Evacuation
This is a nationwide, multicenter, open-label, randomized controlled trial of early minimally invasive treatment for deep-seated spontaneous cerebral hemorrhage (dICH).
- Trial name
- STAPLE-dICH (NCT04686877)
- Testing
- STAPLE
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Traumatic Brain Injury, Intracerebral Hemorrhage
Clinical Decision Support System for Early Mobilization in the Neuro-ICU
This study aims to evaluate the feasibility, safety, and user acceptability of a tablet- and smartphone-based Clinical Decision Support System (CDSS) designed to guide early mobilization for patients with severe neurological…
- Conditions
- Traumatic Brain Injury, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Spontaneous, Acute Ischemic Stroke
- Trial name
- CDSS-EM-ICU (NCT07685145)
- Testing
- Clinical Decision Support System (CDSS) for Early Mobilization
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- National Taiwan University Hospital
Coma, Stroke
Short-term Cervical Spinal Cord Stimulation in Patients With Disorders of Consciousness After Intracerebral Hemorrhage
Disorders of consciousness (DOC) refers to the persistent loss of consciousness after 28 days in patients with brain injury caused by trauma, stroke, or hypoxia. It includes coma, vegetative state, and minimally conscious state.
- Trial name
- SCS-ICH (NCT05922644)
- Testing
- SCS, Conventional
- Where
- China
- Volunteers
- 344 people
- Sponsor
- Beijing Tiantan Hospital
Hypertension
IV Double and Triple Concentrated Nicardipine for Stroke and ICH
Hypertension (high blood pressure) can often cause neurological worsening in patients with stroke, intracerebral hemorrhage and subarachnoid hemorrhage.
- Trial name
- NCT00325793
- Testing
- Nicardipine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- OSF Healthcare System
Stroke Hemorrhagic
DTI-guided Minimally Invasive Hematoma Evacuation for Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating disease with high early mortality, unfavorable neurological outcomes, and high cost of care.
- Trial name
- GLAMOR (NCT05891509)
- Testing
- Minimally Invasive Hematoma Evacuation, Best Medical Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongming Qiu
Intraventricular Hemorrhage, Intracerebral Hemorrhage
The Natural History of Procalcitonin in Hemorrhagic Stroke
Approximately 12% of strokes in the United States are hemorrhagic.1 Hemorrhagic stroke can lead to multiple complications including fever that is not infectious.
- Trial name
- NCT01498705
- Testing
- Procalcitonin level
- Where
- United States
- Sponsor
- CAMC Health System
Intracerebral Hemorrhage, Stroke
Chongqing Intracerebral Hemorrhage Study
The Chongqing intracerebral hemorrhage study is a multi-center, prospective, observational study led by professor Qi Li from Chongqing Medical University. Professor Peng Xie will be the senior consultant for the study.
- Conditions
- Intracerebral Hemorrhage, Stroke, Hematoma
- Trial name
- NCT03085472
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Intracerebral Hemorrhage
Recovery and Outcomes From Stroke
The investigators will perform follow-up on 500 cases of deep and lobar intracerebral hemorrhage to perform advanced neuroimaging before 45 days post stroke, and evaluations of motor and cognitive function at baseline, 3 months…
- Trial name
- ROSE (NCT04007757)
- Where
- 8 sites in United States
- Volunteers
- 500 people
- Sponsor
- State University of New York at Buffalo
Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage
The Anaesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury
Cortical spreading depolarisations are pathological depolarisation waves that occur frequently after severe acute brain injury and has been associated with poor outcome.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage, Traumatic Brain Injury
- Trial name
- KETA-BID (NCT05095857)
- Testing
- S-ketamine
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet