Clinical trials: ICU, open to volunteers
Sedation Complication
multipaRameter mOnitoring systeM for sedAtion iNThe ICu
The administration of sedation in Intensive Care Units (ICU) is a vital and complex task, essential for the well-being of critically ill patients.
- Trial name
- ROMANTIC (NCT06667869)
- Testing
- Sedative
- Where
- 2 sites in Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Acute Respiratory Failure, Caregiving Stress
Investigating Dyadic Expectations About ARF Survivorship (IDEAS)
The purpose of this observational study is to understand how adults who survive acute respiratory failure (ARF) and the people (usually family) who support ARF survivors after returning home think about the first 6 months of…
- Conditions
- Acute Respiratory Failure, Caregiving Stress, Mental Health Issue
- Trial name
- IDEAS (NCT06401239)
- Testing
- Dyadic expectations about the ARF survivor's perceived health 6 months after hospital discharge, Self-efficacy, Concordant expectations/shared appraisal of ARF survivor's health 6 months after hospital discharge
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Johns Hopkins University
Eye Tracking, ICU
Eye-Tracking Interactive Agent in Non-verbal ICU Patients
The goal of this clinical trial is to determine whether an eye-tracking interactive agent can ameliorate communication impairments and reduce the incidence of complications among non-verbal patients in the intensive care unit…
- Conditions
- Eye Tracking, ICU, Communication Barriers, Non-Verbal Communication
- Trial name
- NCT07429695
- Testing
- eye-tracking interactive agent, conventional techniques
- Volunteers
- 54 people
- Sponsor
- Shanghai Zhongshan Hospital
Bed Sores
Evaluating the Impact of Vitamin D Supplementation on Healing Bed Sores in ICU.
To study the value of vitamin D supplementation on healing bed sores in ICU patients.
- Trial name
- NCT07813975
- Testing
- Enteral Vit-D 3 (cholecalciferol)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Maha Salah
Vital Signs
Validation of Continuous Monitoring of Vital Signs in Children With a Connected Patch
Small connected devices monitoring vital signs do not exist in children although they could be very useful to monitor patients once they have left the pediatric intensive care unit (PICU) in order to early identify patients at…
- Trial name
- VITALPICU (NCT04627766)
- Testing
- Monitoring with VT-Patch (Connected device manufactured by VitalTracer)
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- St. Justine's Hospital
Analgesia, Lidocaine
Evaluation of the Analgesia by Serratus Plane Block During Pleural Drainage in Intensive Care Unit.
Pleural drainage under local anesthesia is a frequent practice in resuscitation, experienced as an unpleasant and painful event for patients.
- Conditions
- Analgesia, Lidocaine, Intensive Care Unit
- Trial name
- SERRATUS (NCT03984656)
- Testing
- lidocaine treatment, serratus plane block treatment
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Colistin Adverse Reaction
Colistin Dosage Prsonalization Approach
A few studies have evaluated higher doses or the administration or a loading dose, which is routine in adults, in pediatric patients, and reported improved colistin exposure without an increased risk of nephrotoxicity The main…
- Trial name
- NCT06472271
- Testing
- Polymyxin e
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mahmoud I Mostafa
TBI (Traumatic Brain Injury)
Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury
The overarching goal of this pilot study is to assess the feasibility and safety of transcutaneous auricular neurostimulation (tan) in ICU patients with TBi and to determine the effect of tan on serum markers of inflammation.
- Trial name
- tAN-TBI (NCT06467708)
- Testing
- Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN)
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Texas Southwestern Medical Center
Out-Of-Hospital Cardiac Arrest
REmote COnditioning in Out-of-Hospital Cardiac Arrest
Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia.
- Trial name
- RECO-OHCA (NCT06306625)
- Testing
- Remote ischemic conditioning, No remote ischemic conditioning
- Where
- 14 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury, Fluid Overload
Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients
Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes.
- Conditions
- Acute Kidney Injury, Fluid Overload, Fluid Overload in Dialysis Patients, Critical Illness
- Trial name
- VINKO (NCT07643597)
- Where
- 10 sites in Brazil, Chile and 5 more
- Volunteers
- 128 people
- Sponsor
- Hospital Las Higueras
Cognitive Load and Task Performance in Rotating Residents
Effect of a Localized ICU AI Teaching Agent on Rotating ICU Residents
This trial is an ongoing single-center, pragmatic, parallel-group randomized controlled superiority trial currently in participant recruiting phase, conducted within intensive care unit teaching wards at Peking Union Medical…
- Trial name
- NCT07692035
- Testing
- ICU-Tutor AI Agent, General-Purpose Large Language Models
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Intensive Care Unit Delirium
Dexmedetomidinine in the Prevention of Postoperative Delirium in the Intensive Care Unit After Cardiac Surgery
This is a prospective, randomized, single blinded, controlled clinical trial designed to compare the clinical effects of sedation with dexmedetomidine versus propofol in patients undergoing cardiac surgery.
- Trial name
- NCT05849597
- Testing
- Dexmedetomidine, Propofol
- Where
- Serbia
- Volunteers
- 200 people
- Sponsor
- University of Novi Sad
Non Bleeding Patients With Thrombocytopenia
Platelet Transfusion Thresholds in Non-Bleeding Patients
This is a study of platelet transfusion thresholds in patients with thrombocytopenia without bleeding and benifits of transfusion in those critically ill patients to prevent bleeding
- Trial name
- NCT07915284
- Testing
- Platlet transfusion
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Moral Injury
Mobile-Based Resilience Intervention for Moral Injury, Compassion Fatigue, and Distress in ICU Nurses
Critical care nurses are routinely exposed to high acuity, mortality, end-of-life decisions, and long rotating shifts, which can lead to moral injury, compassion fatigue (burnout and secondary traumatic stress), and psychological…
- Trial name
- ICU-RESILIENCE (NCT07896447)
- Testing
- Behavioral
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Alexandria University
Organ Failure, Multiple
Impact of Fourier Transform Infrared Spectroscopy (FTIRS) in ICUs
This study will assess the impact of FTIRS typing on the spread of ESBL-E in intensive care units
- Trial name
- ECLA'IR (NCT05872152)
- Testing
- FTIR results
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Caen
Weaning Failure of Mechanical Ventilation
Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit
The goal of this prospective observational study is to evaluate whether left ventricular function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success from mechanical ventilation in adult…
- Trial name
- NCT07075926
- Testing
- Echocardiographic Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Intubation in Intensive Care Units
Delayed Against Rapid Sequence Induction in Adults With Medical Diseases Undergoing Emergency Endotracheal Intubation.
The goal of this clinical trial is to learn if it is feaseble to conduct a superiority trial comparing two methods for endotracheal intubation in critically ill patients.
- Trial name
- DARSITUBE (NCT06940219)
- Testing
- Delayed Sequence Induction, Modified Rapid Sequence Induction
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Leipzig University Medical Center
Frailty, Cognitive Impairment
Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic
This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total…
- Conditions
- Frailty, Cognitive Impairment, Older Adults, Hip Arthroplasty
- Trial name
- ORTOPODCZ (NCT07432009)
- Where
- 7 sites in Czechia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Persistent Pulmonary Hypertension, Mechanical Ventilation Strategies
Pressure Regulated Volume Control Ventilation in Neonates Persistent Pulmonary Hypertension
This study aims to assess the clinical and respiratory outcomes of Pressure-Regulated Volume Control ventilation as compared with patient on pressure-controlled ventilation in neonates with persistent pulmonary hypertension.
- Conditions
- Persistent Pulmonary Hypertension, Mechanical Ventilation Strategies, Neonatal Intensive Care Unit (NICU), Ventilation
- Trial name
- NCT07850908
- Testing
- Pressure-Controlled Ventilation, Group II (Pressure-Regulated Volume Control)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Critical Illness, ICU
Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study
This multicentric randomized controlled trial aims to evaluate whether indirect calorimetry (IC)-guided nutritional support improves patient-centered outcomes in critically ill adult patients compared to standard formula-based…
- Trial name
- OPTICal (NCT07343440)
- Testing
- Indirect Calorimetry Group, Control Group - Formula-Based Group
- Where
- 3 sites in Switzerland
- Volunteers
- 356 people
- Sponsor
- HEIDEGGER CP