Clinical trials: ICU Ill Patients
Sepsis, Respiratory Failure
The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit
We sought to determine if there is a benefit to using an insulin drip to control hyperglycemia in the surgical critical care unit for patients who undergo general and vascular surgery.
- Conditions
- Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
- Trial name
- NCT00282594
- Testing
- Novolin R (human recombinant Insulin)
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Genesys
Critical Illness, Dysphagia
Detection of Neuromuscular Complications in Critically Ill Patients
Dysphagia and the intensive care unit-acquired weakness (ICU-AW) are common and outcome-relevant neuromuscular complications in critically ill patients, especially after prolonged mechanical ventilation, sepsis and multi-organ…
- Conditions
- Critical Illness, Dysphagia, Intensive Care Unit Acquired Weakness, Neuromuscular Diseases
- Trial name
- NMCiCIP (NCT04541602)
- Where
- Germany
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Rostock
Red Blood Cell Transfusions, Sex Differences
Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes
Red blood cell (RBC) transfusions are selected based upon matching donor and recipient blood group: donor and recipient sex are not considered when selecting blood for transfusion.
- Conditions
- Red Blood Cell Transfusions, Sex Differences, Health Services, Critically Ill Intensive Care Unit Patients
- Trial name
- SexMATTERS RCT (NCT06840756)
- Testing
- Sex-mismatched red blood cell transfusions, Sex-matched red blood cell transfusions
- Where
- 8 sites in Canada
- Volunteers
- 11,082 people
- Sponsor
- Michelle Zeller
Critically Ill
Ultrasound of the Diaphragm in ICU Patients
Diaphragmatic dysfunction is an important complication of mechanical ventilation. Critically ill patients admitted in a teaching hospital intensive care unit will be evaluated with diaphragm ultrasound to investigate predictors…
- Trial name
- NCT01952262
- Testing
- diaphragm ultrasound
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Vita-Salute San Raffaele
Oral Cancer, Hypopharyngeal Cancer
Acupuncture Effect on Digestion in Critically Ill Post-Operative Oral and Hypo-pharyngeal Cancer Patients
Background: Head and neck cancer patients are in high risk to suffer from malnourishment, a risk that increase in postoperative condition and with the use of enteral nutrition (EN).
- Trial name
- NCT03934294
- Testing
- Specific acupuncture group, Metoclopramide 10mg, Non-specific acupuncture group
- Where
- Taiwan
- Volunteers
- 28 people
- Sponsor
- China Medical University Hospital
Critical Illness, Transportation Accidents
Intra-Hospital Transport of Critically Ill Patients in Intensive Care Unit
Intra-hospital transport is a frequent procedure in the ICU, involving patients with the highest severity scores. Although some studies estimate the rate of adverse events to be around 33% during intra-hospital transport…
- Conditions
- Critical Illness, Transportation Accidents, Intensive Care Unit
- Trial name
- TIGRHOU (NCT06455696)
- Where
- France
- Volunteers
- 645 people
- Sponsor
- French Society for Intensive Care
Critical Illness, Enteral Nutrition
Trial of Enteral Glutamine on Intestinal Permeability in Critically Ill Patients
Glutamine-induced recovery in intestinal barrier function by reducing bacterial translocation was demonstrated in previous studies.
- Conditions
- Critical Illness, Enteral Nutrition, Intestinal Permeability
- Trial name
- NCT03113240
- Testing
- Glutamin, Maltodextrin
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University
Pharmacokinetics of Avycaz in ICU Patients
A Study of Avycaz (Ceftazidime/Avibactam) Pharmacokinetics/Pharmacodynamics (PK/PD) in Critically Ill Patients
The purpose of this study is to analyze the PK/PD of AvyCaz in critically ill patients in the Intensive Care Unit (12). This study will include medical and post-surgical patients who develop an infection where Avycaz can be…
- Trial name
- NCT02822950
- Testing
- Ceftazidime/avibactam
- Volunteers
- 10 people
- Sponsor
- Michigan State University
Acute Kidney Injury, ICU Patients
Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy
The objective of this study is to evaluate the effectiveness of a modified continuous renal replacement therapy (CRRT) protocol in maintaining electrolyte balance in adult patients with acute kidney injury (AKI) admitted to the…
- Conditions
- Acute Kidney Injury, ICU Patients, Continuous Renal Replacement Therapy (CRRT), Electrolytes
- Trial name
- CRRT (NCT07514650)
- Testing
- continuous renal replacement therapy
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Intensive Care (ICU) Myopathy, Intensive Care Unit Acquired Weakness
Effect of Neurophysiological Facilitation Techniques in Intensive Care Patients
The aim of this study was to investigate the effect of neurophysiological facilitation techniques on respiratory and functional levels in intensive care patients.
- Trial name
- NCT05282576
- Testing
- NPF Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Saglik Bilimleri Universitesi
Pain, Pain Management
Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustments
Both severe pain and opioid therapy are associated with negative effects. The experience of pain is common in the intensive care unit, but it is highly individual and difficult to assess, as patients are often unable to…
- Conditions
- Pain, Pain Management, Critical Illness
- Trial name
- INVISIBLE (NCT07473115)
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Mechanical Ventilation, Intensive Care (ICU)
Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients
RATIONALE Lung-protective ventilation using a lower respiratory rate (RR) is an appealing strategy to reduce ventilation intensity, which may require permissive hypercapnia.
- Trial name
- PERMISS pilot (NCT07077174)
- Testing
- Permissive lung-protective ventilation, Conventional lung-protective ventilation
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 56 people
- Sponsor
- Reinier de Graaf Groep
Critical Illness
Feasibility Study on Implementing Consultation-based High-quality Palliative Care Services in Intensive Care Units
Critically ill patients in intensive care units (ICUs) receive life-sustaining treatments aimed at restoring or maintaining organ function.
- Trial name
- NCT06490835
- Testing
- High-quality palliative care through consultation-based palliative care services in the ICU
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Critical Illness, ICU
Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study
This multicentric randomized controlled trial aims to evaluate whether indirect calorimetry (IC)-guided nutritional support improves patient-centered outcomes in critically ill adult patients compared to standard formula-based…
- Trial name
- OPTICal (NCT07343440)
- Testing
- Indirect Calorimetry Group, Control Group - Formula-Based Group
- Where
- 3 sites in Switzerland
- Volunteers
- 356 people
- Sponsor
- HEIDEGGER CP
Anti-Mullerian Hormone Deficiency
Ovarian Reserve in Intensive Care Patients
Gastrointestinal, pulmonary, nephrological, cardiac, neurologic and psychological effects in critically ill patients followed in the intensive care unit have been shown in the literature.
- Trial name
- NCT06999291
- Testing
- Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)
- Volunteers
- 75 people
- Sponsor
- Haseki Training and Research Hospital
Hyperglycemia
Fat Based Enteral Nutrition for Blood Glucose Control in ICU
In this randomized, double-blind clinical trial, eligible hospitalized ICU patients with EN will be included. Patients will be divided into two groups.
- Trial name
- NCT02584907
- Testing
- High Fat Enteral Nutrition
- Where
- Iran
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Anemia
A Study to Observe the Causes and Treatment of Anemia in Critically Ill Children
The purpose of this study is to determine the incidence of anemia and blood transfusions and management of these in critically ill children
- Trial name
- NCT00211055
- Volunteers
- 1,201 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Restraint, Physical, Intensive Care Units
Implementation of Physical Restraints Clinical Practice Guidelines for Critically Ill Patients Using the CAN-IMPLEMENT Framework
Physical restraints (PR) are widely used in ICU around the world. Many institutions have suggested that the use of PR should be reduced.
- Conditions
- Restraint, Physical, Intensive Care Units, Practice Guideline, Health Plan Implementation
- Trial name
- NCT04476355
- Testing
- Select and Tailor implementation interventions
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Critical Illness
Oral Care to Reduce Mouth and Throat Infections in Critically Ill Patients
This study will evaluate whether a program of systematic oral care can help prevent hospital-acquired respiratory infections in patients in intensive care units.
- Trial name
- NCT00078663
- Testing
- Oral Care
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Mortality Prediction
28-day Mortality Prediction for Critically Ill Patients in the Intensive Care Unit: Physician-nurse vs. Score
There are several scores for predicting mortality within 28 days in the intensive care unit, including APACHE 2, MPM 2 and MODS.
- Trial name
- NCT06665529
- Testing
- 28-day mortality prediction by ICU staff and mortality scores
- Where
- Israel
- Sponsor
- Meir Medical Center