Clinical trials: ICU Mortality
Sepsis
Serum Albumin Ratios Can Improve Sepsis Mortality Prediction
Sepsis remains a leading cause of mortality in hospitalized patients, despite advancements in critical care. Existing clinical scores for predicting sepsis outcomes often lack generalizability and complexity, hindering accurate…
- Trial name
- NCT06640504
- Testing
- serum albumin, C-Reactive Protein, Serum procalcitonin
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Hyperglycemia, Critically Ill Patients
Impact of 2 Blood Glucose Levels on Hospital Mortality in Patients Admitted in ICU
During hospitalization in the intensive care unit (ICU), the occurrence of a blood glucose imbalance is frequent and associated with increased mortality.
- Trial name
- INSUREA (NCT00591071)
- Testing
- Strict glycemic control, Conventional glycemic control
- Where
- 2 sites in France
- Volunteers
- 440 people
- Sponsor
- Poissy-Saint Germain Hospital
Traumatic Brain Injury (TBI) Patients, Intracranial Pressure
Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI
The role of nonselective beta adrenergic blocker as antistress agent in severe traumatic brain injury
- Conditions
- Traumatic Brain Injury (TBI) Patients, Intracranial Pressure, Intensive Care Unit, Mortality
- Trial name
- NCT06870370
- Testing
- propranolol, normal saline IV
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Mortality
LODS Role in Predicting 30-day Mortality Outcome in ICU
LODS score for deceased ICU patients within 30 days is higher than survived ICU patients
- Trial name
- NCT03930160
- Testing
- Logistic Organ Dysfunction System Score
- Where
- Indonesia
- Volunteers
- 439 people
- Sponsor
- Universitas Indonesia
Acute Renal Failure
Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients
The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e.
- Trial name
- CONVINT (NCT01228123)
- Testing
- RRT for acute kidney failure using the CVVH method, RRT for acute kidney failure using the IHD (intermittent HD)
- Where
- Germany
- Volunteers
- 252 people
- Sponsor
- Charite University, Berlin, Germany
Frailty, Frailty At Older Adults
ASSESSMENT of FRAILTY AS a PROGNOSTIC FACTOR for MORTALITY, DISABILITY, and QUALITY of LIFE AFTER ICU ADMISSION
Between 30% and 40% of elderly patients (over 70 years old) who require hospitalization and treatment in Intensive Care Units (ICU) exhibit a state of frailty.
- Trial name
- FG-UCI (NCT06793462)
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Critical Illness, Intensive Care Unit
Intensive Care Unit Activity in France From the National Database Between 2013 and 2019
Using data from the French National Uniform Hospital Discharge Database (systematically collecting administrative and medical information related to all hospitalized patients in France for care reimbursement purposes), the…
- Trial name
- ICU_ACTIVITY (NCT05353023)
- Where
- France
- Volunteers
- 1,594,801 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Intensive Care Unit Syndrome, Mechanical Ventilation Complication
Ketamine Infusion as Sedative Analgesic in Severe ARDS
To evaluate whether ketamine is a safe sedative-analgesic agent to be used in an intensive care unit (ICU) setting as compared to traditionally used agents such as propofol, opioids, and midazolam
- Conditions
- Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
- Trial name
- KISS (NCT04818827)
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Interfaith Medical Center
Sepsis - to Reduce Mortality in the Intensive Care Unit
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis
Sepsis is a severe, life-threatening condition caused by an abnormal host response to infection, which includes systemic inflammation, oxidative stress, and increasing organ dysfunction.
- Trial name
- NCT07655791
- Testing
- Nicotinamide 1000 mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Traumatic Brain Injuries, Brain Injuries,Traumatic
Doppler Ultrasonography Parameters and Mortality in Traumatic Brain Injury
The purpose of this study is to find out whether blood flow measurements of the brain and neck arteries, obtained with bedside Doppler ultrasonography are associated with neurological outcome and survival in adult patients with…
- Trial name
- NCT07890259
- Testing
- Transcranial and Carotid Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Inonu University
Infectious Disease
Prevalence and Associated Mortality of Infections by Multidrug-Resistant Organisms in Adults Intensive Care Units
Observational 24-hr point prevalence study with longitudinal follow-up at 164 ICUs in Argentina. All adult patients (aged ≥18 years) at a participating ICU on November 24-28, 2023 with 60- day follow-up, were included.
- Trial name
- PREV-AR (NCT06574776)
- Testing
- Observation and collecting data
- Where
- 7 sites in Argentina
- Volunteers
- 1,799 people
- Sponsor
- Hospital Italiano de Buenos Aires
De Novo Hypoxemic Acute Respiratory Failure (hARF)
Impact on Mortality of a Strategy Including Continuous Positive Airway Pressure Plus High Flow Nasal Cannula Oxygen Therapy Versus High Flow Nasal Cannula Oxygen Therapy Alone in Patients With de Novo Acute Hypoxemic Respiratory Failure: a Prospective, Randomized Controlled Trial.
De novo hypoxemic acute respiratory failure (hARF) is one of the main causes of intensive care unit (ICU) admission. In de novo hARF, intubation is associated with a dramatic increase in mortality rate.
- Trial name
- HighCPAP (NCT06213168)
- Testing
- HFNC, CPAP and HFNC
- Where
- 29 sites in France
- Volunteers
- 1,084 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis - to Reduce Mortality in the Intensive Care Unit, Trauma Coagulopathy
ROTEM in Sepsis Trauma Outcome in Intensive Care
This prospective observational study aims to investigate the ability of advanced ROTEM analysis using Principal Component Analysis (PCA) to detect early signs of disseminated intravascular coagulation (DIC) and trauma-induced…
- Trial name
- ROSTIC (NCT06891599)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Stockholm
Intensive Care Unit, Mortality
Analysis of the Evolution of Mortality in an Intensive Care Unit
The intensive care units is of the main components of modern healthcare systems. Formally, its aim is to offer the critically ill health care fit to their needs; ensuring that this health care is appropriate, sustainable, ethical…
- Conditions
- Intensive Care Unit, Mortality, Epidemiology, Respiration, Artificial
- Trial name
- NCT05261607
- Where
- Spain
- Volunteers
- 27,463 people
- Sponsor
- Hospital Universitario Getafe
Critical Illness
RDW:MCHC as a Pragmatic Adjunct to SOFA Score in ICU Mortality Assessment
Critical illness represents a complex pathophysiological state characterized by systemic inflammation, oxidative stress, immune dysregulation, and progressive multiorgan dysfunction.
- Trial name
- NCT07775911
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
In-Hospital Mortality, Number of ICU Readmission
To Survive After ICU Discharge
Many factors before and after ICU stay determine the outcome of patients at ICU discharge, the type of illness, physical dependence and other sequelae can be a trigger for complications in hospital ward which can induce ICU…
- Conditions
- In-Hospital Mortality, Number of ICU Readmission, Number of Warnings On-duty
- Trial name
- NCT02599636
- Testing
- None intervention
- Where
- Spain
- Volunteers
- 1,200 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Covid19; Liver Injury; Mortality
Effect of Liver Injury on Mortality in Coronavirus Disease-2019 Patients Admitted to Intensive Care Unit
In addition to primarily affecting the lungs, coronavirus disease-2019 (COVID-19) disease can also affect many different organs, especially the heart, kidneys, liver and brain.
- Trial name
- NCT04669509
- Testing
- Liver function tests
- Where
- Turkey (Türkiye)
- Volunteers
- 532 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Septic Shock
TOADS Study: TO Assess Death From Septic Shock.
The aim of this study is to assess the causes of death in patients with septic shock in French intensive care units. It is an epidemiologic and descriptive study .
- Trial name
- TOADS (NCT02547467)
- Testing
- epidemiologic study
- Volunteers
- 340 people
- Sponsor
- University Hospital, Angers
Critical Illness
Scoring Systems in ICU and Malnutrition
The objective of the present study was to compare the ability of acute physiology and chronic health evaluation (APACHE) scoring systems with the combination of an anthropometric variable score "adductor pollicis muscle (APM)…
- Trial name
- NCT03318965
- Volunteers
- 304 people
- Sponsor
- Shahid Beheshti University
Sepsis
Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial
Background: Dexmedetomidine, a highly selective arfa2-adrenergic agonist, is known to be a unique sedative agent which causes less acute tolerance, drug addiction and withdrawal compared with gamma-aminobutyrate (GABA) agonists.
- Trial name
- DESIRE (NCT01760967)
- Testing
- Dexmedetomidine
- Where
- Japan
- Volunteers
- 203 people
- Sponsor
- Wakayama Medical University