Clinical trials: ICU-acquired Muscle Weakness
ICU Acquired Weakness
Evaluation of FDY-5301 in Major Trauma Patients in ICU
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of FDY-5301 compared to placebo in major trauma ICU patients at risk of intensive care unit acquired weakness (ICUAW)
- Trial name
- NCT04430283
- Testing
- FDY-5301
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- Faraday Pharmaceuticals, Inc.
Muscle Weakness, Critical Illness
Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes
Elderly patients who experience a prolonged ICU stay are at high risk for developing post intensive care unit syndrome (PICS), a serious medical condition manifested by loss of muscle mass, weakness, malnutrition and…
- Conditions
- Muscle Weakness, Critical Illness, Sarcopenia
- Trial name
- ExPrEs (NCT02509520)
- Testing
- MPR and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Intensive Care Unit Acquired Weakness
The Effect of Inspiratory Muscle Training on Diaphragmatic Function in Mechanically Ventilated Patients
In this study, the effect of inspiratory muscle training on diaphragmatic functions will be investigated radiologically in mechanically ventilated patients.
- Trial name
- NCT05303623
- Testing
- Conventional Physiotherapy, Conventional Physiotherapy+ inspiratory muscle training, inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Demiroglu Bilim University
ICU Acquired Weakness, Diaphragmatic Injury
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients
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- Trial name
- NCT04565002
- Testing
- Transcutaneous Electrical Diaphragmatic Stimulation
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Centro Universitário Augusto Motta
Critical Illness, PICS
ICU Follow-up After Prolonged Intensive Care Stay
Treatment in the intensive care unit (ICU) for more than five days often leads to chronic physical, cognitive and psychological complaints, such as post-traumatic stress disorders, muscle weakness, depression, anxiety and…
- Conditions
- Critical Illness, PICS, Post Intensive Care Syndrome
- Trial name
- PINA (NCT04186468)
- Testing
- ICU follow-up clinic
- Where
- 3 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Otto-von-Guericke University Magdeburg
Ventilator Weaning
Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients
Difficult ventilatory weaning is associated with a 20% mortality rate. 40% of these patients will develop intensive care unit (ICU)-acquired neuromyopathy, associated with reduced cough strength and a 4-fold increase in the risk…
- Trial name
- PHYSIO WEAN (NCT06499389)
- Testing
- Systematic and early intensive instrumental respiratory physiotherapy for patients undergoing difficult ventilatory weaning, Protocolized standard-of-care respiratory physiotherapy
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
ICU Acquired Weakness, Sepsis
ICU Combined Assessment of Cardio-Respiratory Exercise
This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness/dysfunction or…
- Conditions
- ICU Acquired Weakness, Sepsis, Shock, Critical Illness
- Trial name
- ICU-CARE (NCT06193980)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba
Intensive Care Unit Acquired Weakness, Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)
Functional Assessment in Critically Ill Patients
This longitudinal, prospective observational study aims to evaluate functional status in critically ill adult patients in the Intensive Care Unit using the Chelsea Critical Care Physical Assessment Tool (CPAx).
- Trial name
- NCT07191743
- Where
- Brazil
- Volunteers
- 186 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Intensive Care Unit Acquired Weakness, Critical Illness
Locomotor Muscle Oxygenation and Activation During Acute Interval Compared to Constant-load Bed-cycling Exercise
Up to 60% of patients admitted to the Intensive Care Unit (ICU) with a prolonged stay in the ICU develop complications such as intensive care unit acquired weakness (ICUAW) characterized by limb and respiratory muscle weakness.
- Trial name
- NCT05279547
- Testing
- Constant-load bed-cycling exercise, Interval bed-cycling exercise
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
Critical Illness
Physical Therapist Inter-Rater Reliability in Neuro-Muscle Ultrasound in Critically Ill Patients
The goal of this observational study is to evaluate the feasibility and inter-rater reliability of muscle and peripheral nerve ultrasound for the early detection of ICU-acquired weakness (ICU-AW) in critically ill patients.
- Trial name
- NMusICU-R (NCT07032870)
- Where
- Chile
- Volunteers
- 37 people
- Sponsor
- University of Chile
Muscle Weakness, Rehabilitation
Efficacy of Different Treatments for the Intensive Care Unit Acquired Weakness
Experimental study that has how to compare the efficacy between conventional rehabilitation, transcutaneous electrostimulation or early mobilization to reduce the time needed to reverse the muscle weakness evaluated by the muscle…
- Trial name
- NCT04613908
- Testing
- neuro muscular electro stimulation, Early Mobilization protocol, standard care or usual rehabilitation
- Volunteers
- 18 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Intensive Care Unit Acquired Weakness
IMT Outcomes in Sufferers of Severe Walking Disabilities and Intensive Care Unit Acquired Weakness
Intensive care unit-acquired weakness (ICU-acquired weakness) may be caused by a variety of different causes. Several studies have shown that ICU-acquired weakness occurs in up to 30% of critically ill patients.
- Trial name
- NCT06210763
- Testing
- Threshold IMT and traditional physical therapy program, traditional physiotherapy program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Critical Illness, Sarcopenia
Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors
Older ICU survivors with ICU acquired weakness (ICUAW) are malnourished, sarcopenic, and functionally debilitated as a consequence of the high burden of comorbidities common in the elderly.
- Conditions
- Critical Illness, Sarcopenia, ICU Acquired Weakness
- Trial name
- ProMoTE (NCT05326633)
- Testing
- MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Maryland, Baltimore
Intensive Care Unit Acquired Weakness
Muscle Effects Of Neuromuscular Electrostimulation In Mechanically Ventilated Patients In An Icu
To prevent the development of ICUAW, both early mobilization and neuromuscular electrical stimulation (NMES) have been shown to prevent muscle atrophy in critically ill patients by preserving muscle mass.
- Trial name
- NCT06409611
- Testing
- neuromuscular electrical stimulation
- Where
- 3 sites in Brazil
- Volunteers
- 22 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Critical Illness, ICU Acquired Weakness
Muscle Evaluation Using Ultrasound in the Critically Ill
Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction. Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay.
- Trial name
- ULTRAMUSCLE (NCT03550222)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Intensive Care Unit Acquired Weakness, Intensive Care Unit Patients
Feasibility and Safety of Early Mobilization and Rehabilitation in Intensive Care Unit Patients
Intensive Care Unit Acquired Weakness (ICU-AW) is a common complication of critical illnesses, occurring in approximately 50% of ICU patients and is strongly associated with increased morbidity, physical impairments, and both…
- Trial name
- NCT06653998
- Testing
- Early mobilization and rehabilitation
- Where
- 4 sites in Colombia
- Volunteers
- 220 people
- Sponsor
- Claudia Aristizábal
Neuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness
Effects of Neuromuscular Electrical Stimulation on Muscle Mass and Strength in Critically Ill Patients After Cardiothoracic Surgery
The purposes of this study are 1) to determine whether neuromuscular electrical stimulation (NMES) is effective in preventing loss of muscle mass and strength and 2) to observe the time variation of MLT and strength from…
- Conditions
- Neuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness, Muscle Wasting, Muscle Loss
- Trial name
- Catastim 2 (NCT02391103)
- Testing
- Compex 3 Professional (CefarCompex Medical AB) stimulator
- Volunteers
- 54 people
- Sponsor
- Medical University of Vienna
Metabolomics, Critical Care
Metabolomics Study on Intensive Care Acquired Muscle Weakness in Polytrauma
In this mono-center pilot trial, polytrauma patients admitted to intensive care will be included. Investigators are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular…
- Conditions
- Metabolomics, Critical Care, Critical Illness, Critical Illness Myopathy
- Trial name
- MIRACLE II (NCT03819959)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Technical University of Munich
Muscle Weakness, Critical Illness
Development of the Italian Version of the ICU Mobility Scale (IMS). Cross-cultural Adaptation, Italian Translation, and Validation Study.
Early mobilisation of the patient admitted to intensive care units (ICUs) is essential to prevent Intensive Care Unit Acquired Weakness (ICUAW).
- Conditions
- Muscle Weakness, Critical Illness, Critical Illness Recovery, Acquired Weakness
- Trial name
- NCT07195942
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Clinico Humanitas
Quality of Life, Post ICU Discharge
Study in Intensive Care Follow-up Programme in Improving Long-term Outcomes of ICU Survivors
Study Hypothesis: Critical illness is associated with long-term medical and psychological sequelae that can impact the professional and private life.
- Trial name
- SUIVI-REA (NCT01796509)
- Testing
- Medical, psychological, social
- Where
- France
- Volunteers
- 545 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris