Clinical trials: IL6
Major Depressive Disorder
Neutralizing Interleukin (IL)-6
The proposed study aims to establish the feasibility and safety of subcutaneous tocilizumab, a monoclonal antibody (mAb) against interleukin (IL)-6 receptor, in adults with Major Depressive Disorder (MDD) and evidence of…
- Trial name
- NCT07493317
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Periodontal Diseases
YKL-40 and IL-6 Levels in Periodontal Disease
The primer aim of the study was to investigate saliva and gingival crevicular fluid (GCF) YKL-40 and also interleukin-6 (IL-6) levels in chronic periodontitis pathogenesis.
- Trial name
- NCT03507868
- Testing
- Nonsurgical periodontal therapy
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zeynep Pinar KELES
Human Immunodeficiency Virus (HIV)
Vitamin D3 Supplementation in Patients With HIV: Effects on Interleukin-6 Levels and CD4 Counts
This study aims to evaluate the effect of Vitamin D3 supplementation on inflammatory markers and immune status in patients with HIV who are receiving antiretroviral therapy.
- Trial name
- NCT07553052
- Testing
- Vitamin D3, Antiretroviral (ARV) medications
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Sebelas Maret
Interleukin-6
Effectiveness of the Cytokine Hemadsorption on Sepsis
In this prospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock.
- Trial name
- NCT05057455
- Testing
- cytokine hemadsorption
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Biruni University
Inflammation, Somatization
Mindfulness Meditation: Alleviating Symptoms and Inflammation in Nurses
Background: Nurses have experienced several stressors, the most important of which are increased workloads, long shifts, patients' negative results, some patients not responding to treatment, death at high rates, late detection…
- Trial name
- NCT06635278
- Testing
- Mindfulness meditation
- Where
- Jordan
- Volunteers
- 102 people
- Sponsor
- Jordan University of Science and Technology
Metastatic Breast Cancer
IL-6 and IL-8 Level of Blood and Pleural Effusion During Chemotherapy in Metastatic Breast Cancer
Change of IL-6 and IL-8 level in blood and pleural effusion before and after chemotherapy correlate with the prognosis of the disease
- Trial name
- NCT01543126
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Fudan University
Pyrexia
Pyrexia Management Using an IL-6 Antibody in BRAF+ Melanoma Patients Treated with Dabrafenib/ Trametinib +/- Immunotherapy
The study examines the development of fever after administration of Actemra (tocilizumab) in patients who have fever and other cytokine release symptoms (headache, nausea, palpitations, low blood pressure) due to cancer therapy…
- Trial name
- Nov IIT- Pyrex (NCT04652258)
- Testing
- Actemra
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Oral Lichen Planus
Evaluation of Efficacy and Safety of add-on Tofacitinib in Patients With Oral Lichen Planus
Many of the patients with oral lichen planus (OLP) either fail to achieve complete remission or experience frequent relapses with conventional topical corticosteroid therapy, which is currently the mainstay of treatment.
- Trial name
- NCT07131813
- Testing
- Tofacitinib 5 mg BID and Triamcinolone ointment
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Flap Monitoring, Inflammation
Effect of Dexmedetomidine on Microsurgery Reconstruction in Cancer Patient
This double-blinded randomized controlled trial aims to investigate the effect of intraoperative dexmedetomidine administration on early flap viability and microvascular integrity in cancer patients undergoing elective…
- Conditions
- Flap Monitoring, Inflammation, Thrombosis, Oxidative Stress
- Trial name
- DEXFLAP (NCT06993740)
- Testing
- NaCl 0,9%, Dexmedetomidine
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Dharmais National Cancer Center Hospital
Diagnostic and Predictive Value
Diagnostic and Prognostic Value of Combination Biomarkers in the Critically Ill Patient With Sepsis.
Sepsis is a common cause for morbidity and mortality in critically ill patients. With the development of medical skills, the mortality is still remain very high.
- Trial name
- NCT01687010
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Jianfeng Xie
Opioid Use
Assessing the Impact of Opioid-Free Anesthesia Using the Modified Mulimix Technique.
The effective management of post-operative pain in the setting of bariatric surgery presents significant hurdles for both anesthesiologists and surgeons.
- Trial name
- Mulimi (NCT06216210)
- Testing
- opioid-FREE anesthesia., opioid-CONTAINING anesthesia.
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zulekha Hospitals
COVID-19, Hospitalized COVID-19 Patients
LUSZ Treatment Efficacy in Hospitalized COVID-19 Patients
This study aims first to assess the efficacy, safety, and effectiveness of the LUSZ COVID-19 therapy consisting of a comparative study of three different treatment approaches: antiviral, antiretroviral, and immunosuppressive IL-6…
- Trial name
- LUSZ_AVIST (NCT05925140)
- Testing
- Lopinavir / Ritonavir, Remdesivir (RDV), Tocilizumab
- Where
- 2 sites in Lebanon
- Volunteers
- 1,000 people
- Sponsor
- Lebanese University
Lumbar Posterior Decompression
Thoracolumbal Interfascial Plane Block Versus Erector Spinae Plane Block for Lumbar Posterior Decompression Stabilization
This study aimed to found out The Comparison Of Perioperative Analgesia Effectiveness Between Thoracolumbal Interfascial Plane Block with Erector Spinae Plane Block In Lumbar Posterior Decompression and Stabilization.
- Trial name
- NCT04951024
- Testing
- Thoracolumbar interfacial plane (TLIP) Block, Erector Spinae Plane (ESP) Block
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Cellulitis
The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycin
Primary: To determine the influence of daptomycin on inflammatory cytokine (IL-1, TNF and IL-6) for the treatment of complicated cellulitis/erysipela compared with alternative treatment (vancomycin or oxacillin).
- Trial name
- NCT01626560
- Testing
- Daptomycin, Vancomycin
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Evangelico de Curitiba
Rheumatoid Arthritis
Effect of Monoclonal Anti-IL6 Antibody (Tocilizumab) on the Cardiovascular Risk in Patients With Rheumatoid Arthritis
The purpose of this study is to determine whether tocilizumab changes the cardiovascular risk factors on patients with arthritis rheumatoid.
- Trial name
- TOCRIVAR (NCT01752335)
- Testing
- Braquial ecography
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Hospital Universitario de Canarias
Obesity, Periodontitis
Chemerin and Interleukin-6 Levels of Gingival Crevicular Fluid in Obese Individuals Following Periodontal Treatment
The objective in this case-control intervention study, therefore, was to explore the effect of nonsurgical periodontal therapy on the GCF levels of chemerin and IL-6 in patients with chronic periodontitis in order to determine…
- Trial name
- NCT02660814
- Testing
- Non-surgical periodontal treatment, Gingival crevicular fluid collection
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Umut BALLI
Endometrial Receptivity and Success Rate of IVF
Pilot Study on Molecular Quantitation and Sequencing of Endometrial Cytokines Gene Expression and Their Effect on the Outcome of In-vitro Fertilization (IVF) Cycle
Pilot study on molecular quantitation and sequencing of endometrial cytokines gene expression and their effect on the outcome of in-vitro fertilization (IVF) Cycle
- Trial name
- NCT01809509
- Testing
- Endometrial biopsy
- Where
- 2 sites in Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cairo University
Muscle Damage, Athletic Performance
The Combined Effects of Cordyceps and Fartlek Training on Muscle Recovery and Bone Health in Soccer Players
Purpose of the Study:This study aims to evaluate the effectiveness of combining Cordyceps supplementation and fartlek training as a recovery and performance enhancement strategy for soccer players.
- Conditions
- Muscle Damage, Athletic Performance, Oxidative Stress, Inflammation
- Trial name
- COR-FAST (NCT07726979)
- Testing
- Fartlek Training Program, Cordyceps sinensis Supplementation
- Where
- Indonesia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Surabaya State University
Metabolic Syndrome, Overweight
Systematic Review and Meta-analysis of the Differential Effects of DHA and EPA on Inflammation
According to the World Health Organization, cardiovascular diseases (CVDs) are the number 1 cause of death globally. Systemic and local tissue inflammation is now recognized as a key etiological process leading to CVD.
- Conditions
- Metabolic Syndrome, Overweight, Obesity, Chronic Inflammation
- Trial name
- NCT03520556
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Laval University
Ischemic Stroke
Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Posterior Circulation Large Vessel Occlusion Stroke
This is an investigator-initiated phase III clinical trial employing a randomized, double-blind, placebo-controlled design. The primary objective of this study is to investigate the efficacy and safety of an interleukin-6…
- Trial name
- IRIS-3 (NCT07509645)
- Testing
- Tocilizumab
- Where
- 30 sites in China
- Volunteers
- 348 people
- Sponsor
- Capital Medical University