Clinical trials: IMPLANTATION
Bleeding, Implants
Treatment of Unfavorable Bleeding Patterns in Contraceptive Implant Users
The etonogestrel (ENG) subdermal contraceptive implant (ENG implant) is a highly effective method of preventing pregnancy, but it has bleeding side effects that make it unappealing for many women.
- Conditions
- Bleeding, Implants, Breakthrough Bleeding
- Trial name
- Tamoxifen/BTB (NCT02903121)
- Testing
- Tamoxifen, Tamoxifen (open label)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Ecchymosis, Adverse Anesthesia Outcome
Comparison of Lidocaine With and Without Adrenaline for Reducing Ecchymosis
This randomized, double-blinded controlled trial evaluates whether lidocaine with adrenaline reduces bruising (ecchymosis) more effectively than lidocaine without adrenaline among women undergoing contraceptive implant insertion…
- Conditions
- Ecchymosis, Adverse Anesthesia Outcome, Complications Associated With Device, Bleeding
- Trial name
- CLEAR (NCT07897201)
- Testing
- 1% Lidocaine with adrenaline, 1% Lidocaine
- Where
- Thailand
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Aortic Valve Disease, Aortic Valve Stenosis
Evaluation of the Viability and Safety of Early Discharge Protocol After TAVI Implantation
Evaluation of the safety and efficacy of early discharge (24 hours) after transfemoral transcatheter aortic prosthesis implantation (TAVI).
- Conditions
- Aortic Valve Disease, Aortic Valve Stenosis, Heart Valve Diseases
- Trial name
- FAST TRACK (NCT05758909)
- Testing
- TF TAVI
- Where
- 13 sites in Spain
- Volunteers
- 585 people
- Sponsor
- Fundación EPIC
Severe to Profound Sensorineural Hearing Loss
Correlations Between Subjective and Objective Responses to Cochlear Implant Stimulation
Cochlear implants have been used for several decades, with major technological advances. However, adjustment can be difficult for patients who have to get used to a new sound that is electrical rather than acoustic.
- Trial name
- CRSOSIC (NCT07371299)
- Testing
- Objective electrophysiological measures (eCAP, eABR, eSRT)
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Immediate Implant
Evaluation of Cross-linked Collagen Membrane With and Without Silk Fibroin Around Immediate Dental Implants
Comparative evaluation of cross-linked collagen membrane with and without silk fibroin around Immediate Dental Implants -Randomized controlled trial.
- Trial name
- NCT06552065
- Testing
- collagen with silk fibroin membrane, cross linked collagen membrane
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Fertility Disorders
Assessment of the New Automated Vitrification System "GAVI" for Early Cleaved Embryos Cryopreservation
The meta-analysis comparing the cryopreservation of human embryos by vitrification or slow-freezing suggested that more well design studies as randomized trials are necessary to identify the most successful method for…
- Trial name
- GAVI (NCT03478592)
- Testing
- reference technique, vitrification technique
- Where
- France
- Volunteers
- 423 people
- Sponsor
- University Hospital, Toulouse
Tooth Loss, Surface Treatment
Effect of Different Loading Protocols on Photofunctionalized Implants in the Posterior Maxilla
This randomized clinical trial evaluates different loading protocols for UV-photofunctionalized dental implants in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow
- Conditions
- Tooth Loss, Surface Treatment, Immediate Dental Implant Loading, Implant Loading
- Trial name
- PHOTOLOAD (NCT07700914)
- Testing
- Immediate loading of UV-photofunctionalized dental implants, Early loading of UV-photofunctionalized dental implants, Conventional loading of UV-photofunctionalized dental implants
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Contraception
Effectiveness of Prolonged Use of IUD/Implant for Contraception
This study will evaluate LNG-IUD and Etonogestrel (ENG) Implant users who are willing to use their contraception beyond the end of the FDA-approved duration.
- Trial name
- EPIC (NCT02267616)
- Testing
- Etonogestrel Implant
- Where
- 2 sites in United States
- Volunteers
- 1,076 people, healthy volunteers welcome
- Sponsor
- Indiana University
Geographic Atrophy Due to Age-Related Macular Degeneration
A Study to Evaluate the Safety and Effect of TO-O-1007 Intravitreal Implant in Subjects With Geographic Atrophy
This study will evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of TO-O-1007, a biodegradable sustained-release intravitreal implant, for the treatment of Geographic Atrophy (GA) secondary to…
- Trial name
- NCT07668804
- Testing
- TO-O-1007 (low-dose), TO-O-1007 (high-dose)
- Where
- 3 sites in Australia
- Volunteers
- 31 people
- Sponsor
- Theratocular Biotek Co.
Opioid Dependency
A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addiction
Probuphine (buprenorphine implant) is an implant placed just below the skin containing buprenorphine (BPN). BPN is an approved treatment for opioid dependence. This study will confirm the efficacy of Probuphine vs.
- Trial name
- NCT01114308
- Testing
- Probuphine (buprenorphine implant), Buprenorphine
- Where
- 20 sites in United States
- Volunteers
- 287 people
- Sponsor
- Titan Pharmaceuticals
Breast Cancer Female
Delayed Breast Reconstruction by Prepectoral Implant After Lipo-preparation (RM2prepec)
Breast implants associated with the installation of a complementary matrix (of dermal or synthetic origin), showed satisfactory results in term of post-operative follow-up but also aesthetic outcomes.
- Trial name
- RM2prepec (NCT04343820)
- Testing
- Breast reconstruction
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut Cancerologie de l'Ouest
Osteoarthritis, Hip, Cardiovascular Diseases
Effects of Remote Ischaemic Preconditioning in Cemented Hip Arthroplasty.
Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. Cemented hip arthroplasty is mainly indicated for elderly patients with poor bone quality and multiple comorbidities.
- Conditions
- Osteoarthritis, Hip, Cardiovascular Diseases, Bone Cement Implantation Syndrome, Kidney Diseases
- Trial name
- PRINCIPAL (NCT06323018)
- Testing
- Remote Ischemic Preconditioning
- Where
- Estonia
- Volunteers
- 200 people
- Sponsor
- University of Tartu
Coronary Disease
Platelet Reactivity After Cessation of Clopid in the Setting of Coronary Stent Implantation I: PRACTICE I
Single center randomized parallel group study to determine if: 1. there is a temporary increase in platelet reactivity after abrupt discontinuation of clopidogrel due to a potential rebound phenomenon. 2.
- Trial name
- PRACTICE I (NCT00684359)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medstar Health Research Institute
Osteoarthritis, Hip, Hip Disease
Multicenter Study for Robotic Arm-assisted THA 4.0 System: Hip Spine Relationship
The current study is a multi-center study to assess precision and accuracy of the robotic system with new software.
- Trial name
- NCT04646096
- Testing
- MAKO THA 4.0 System
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- American Hip Institute
Endometriosis
Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients
This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation.
- Trial name
- NCT07182643
- Testing
- Endometrial fluid, Endometrial biopsy, Follicular fluid
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Peri-Implantitis, Peri-implant Mucositis
Antiseptic Effects on the Dental Implant Internal Surface Microbiome
Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Implant Infection, Dental Implant Failed
- Trial name
- NCT05024760
- Testing
- Chlorhexidine, Hydrogen Peroxide
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Madigan Army Medical Center
Dental Implantation, Peri-Implant Soft Tissue Deficiency
Volume-Stable Collagen Matrix vs. Connective Tissue Graft for Peri-Implant Soft Tissue Defects
Peri-implant soft-tissue defects will be treated with either a volume-stable collagen matrix (VCMX; test group) or an autogenous connective tissue graft (CTG; control group) following implant placement in patients with a single…
- Conditions
- Dental Implantation, Peri-Implant Soft Tissue Deficiency, Soft Tissue Augmentation
- Trial name
- NCT07782125
- Testing
- Connective tissue graft, Volume-stable collagen matrix
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ankara University
Breast Implant
Safety Follow-up Study in Subjects With Silicone Gel-filled Breast Implants as Compared Both to Saline-filled Breast Implants and to National Norms
Ten year safety study examining rates of rare adverse events, child bearing issues, effects of mammography, MRI compliance and results, and long-term benefit of silicone-filled breast implants.
- Trial name
- BIFS (NCT00443274)
- Testing
- NBIR - US National Breast Implant Registry, 410 Arm, BIFs - Breast Implant Follow-Up Study
- Where
- United States
- Volunteers
- 56,460 people
- Sponsor
- Allergan
Dental Implant, Tooth Extraction
Soft Tissue Volume Changes After Immediate Implants With Two Different Techniques
The aim is to comparatively evaluate the soft tissue volume changes that occur after tooth extraction and immediate dental implant placement using two different surgical techniques.
- Conditions
- Dental Implant, Tooth Extraction, Bone Resorption
- Trial name
- NCT04803110
- Testing
- Dental implant placement after tooth extraction
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Aula Dental Avanzada
Embryo Implantation
Effect of Dilatation and Curettage on the Endometrial Receptivity
Effect of dilatation and curettage on the endometrial receptivity and pregnancy outcome in patients with recurrent implantation failure
- Trial name
- NCT03485235
- Testing
- D&C, ICSI
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Ain Shams University