Clinical trials: INDIVIDUALIZED THERAPY
Autistic Disorder
Randomized Study of Intensive One-on-one Behavioral Treatment for Preschool Aged Children With Autism
OBJECTIVES: I. Determine the effectiveness of intensive one-on-one behavioral treatment in the home or neighborhood compared with at home, individualized, parent training in preschool aged children with autism. II.
- Trial name
- NCT00004449
- Testing
- intensive one-on-one behavioral treatment, Individualized in home parent training
- Volunteers
- 102 people
- Sponsor
- University of California, Los Angeles
Pancreas Cancer
Pancreatic Cancer Molecular Sub-classification Using Endoscopic Ultrasound Tissue Core Biopsy Samples
This study evaluated the feasibility and reliability of PDAC molecular subtyping on tissue core biopsies samples acquired under EUS guidance.
- Trial name
- NCT04246710
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Catholic University of the Sacred Heart
Cardiac Surgery, Coronary Artery Bypass Graft CABG
Effects of a Hybrid Model of Cardiac Rehabilitation on Patient Outcomes
Determine if the standard of care at a cardiac rehabilitation center using what the investigators term to be "hybrid model" on the exercise component of cardiac rehabilitation is associated with improved adherence and outcomes.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Graft CABG, Stent, Valve Replacement
- Trial name
- NCT06030115
- Testing
- Exercise Component Of Cardiac Rehabilitation (Hybrid Model) Intensity Recovery Progression Protocol (IRPP)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Good Shepherd Integrated Healthcare Systems
Type 2 Diabetes Mellitus
Traditional Chinese Medicine in Individualized Treatment of Patients With Diabetes Symptoms
Based on the Individualized treatment of diabetes symptoms to evaluate the method of syndrome differentiation treatment of Traditional Chinese medicine.
- Trial name
- NCT01844050
- Testing
- Chinese herbal medicine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Refractory Epilepsy in Children, Refractory Epilepsy
Cannabidiol as add-on Therapy for Children With Refractory Epilepsy (CBD-uN1que), a High-quality Individualized Approach: a Series of N-of-1 Trials
The goal of this clinical trial is to learn if cannabidiol ("CBD-oil") works to treat severe epilepsy in children. It will also learn about the safety of cannabidiol.
- Conditions
- Refractory Epilepsy in Children, Refractory Epilepsy, Epilepsy
- Trial name
- CBD-uN1que (NCT07668856)
- Testing
- Cannabidiol (CBD) oral solution
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
Ovarian Cancer
Individualized Precision Treatment Based on Ovarian Cancer Organoid Model
The research purpose of this study is to use organoid cultured from patients' own ovarian cancer tissues as models, screen potential clinical therapeutic drugs (such as paclitaxel, gemcitabine, etc.) in vitro, formulate…
- Trial name
- NCT05813509
- Testing
- Organoid culture
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Epilepsy
Exploring the Effects of Genetic Variants and Inflammation on Vitamins Supplementation Treatment Outcomes in Epilepsy
The management of patients with epilepsy is focused on controlling seizures, avoiding treatment side effects, and restoring quality of life.
- Trial name
- NCT04488172
- Testing
- Multi-vitamin supplementation
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Cheng-Kung University Hospital
Multiple Sclerosis
Robotic -Assisted Rehabilitation for Multiple Sclerosis: An Adaptive Approach for Individualized Therapy
Therefore, the purpose of this study was to evaluate four-weeks of an upper limb robotic intervention for persons with Multiple Sclerosis.
- Trial name
- NCT07070388
- Testing
- end-effector robotic training
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Michael Holmes
Renal Transplantation
Computer Guided Doing of Tacrolimus in Renal Transplantation
Dosing of tacrolimus is challenging due to the large inter-individual variation in its pharmacokinetics. The investigators have developed a pharmacokinetics population model that can be used to estimate individual doses of…
- Trial name
- OPTIMAL (NCT02010320)
- Testing
- Computer dosing, Standard dose determination
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- University of Oslo School of Pharmacy
Metastatic Hormone-Sensitive Prostate Cancer
A Prospective Study Based on Spatial Multi-omics to Predict the Efficacy of ADT Combined With Second-generation Novel Hormonal Agents in Metastatic Hormone-sensitive Prostate Cancer.
This study plans to enroll patients with newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC) and conduct a prospective, single-center, observational study.
- Trial name
- NCT07795177
- Testing
- ADT plus abiraterone or other ARPIs（apalutamide, enzalutamide, rezvilutamide, darolutamide)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Colorectal Cancer, Colorectal Adenoma
Circulating Tumor DNA in Patients Summoned for Colonoscopy; - a Liquid Biopsy for Detection, Characterization, Individualized Treatment and Follow-up of Colorectal Cancer
CoLiQ is a clinical study designed to evaluate the clinical usefulness of circulating tumor DNA (ctDNA) markers found in blood, as a liquid biopsy for diagnosis, prognosis and follow-up of colorectal cancer.
- Trial name
- CoLiQ (NCT06307938)
- Testing
- liquid biopsy
- Where
- Norway
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Helse Nord-Trøndelag HF
Non-small Cell Lung Cancer
Individualized Chemotherapy Based on BRCA1 and RRM1 mRNA for Advanced Non-small Cell Lung Cancer (NSCLC)
Gemcitabine, docetaxel, CPT-11 and cisplatin are effective in 1st line treatment of advanced non-small cell lung cancer (NSCLC). Platinum-based doublets including gemcitabine, docetaxel or CPT-11 are standard 1st regimens.
- Trial name
- BRAVO (NCT01424709)
- Testing
- Gemcitabine, Docetaxel, CPT-11,Cisplatin, gemcitabine/cisplatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tongji University
Perioperative Anxiety
Individualized Music Versus Propofol for Perioperative Anxiety During Regional Anaesthesia
Perioperative anxiety is common among patients undergoing surgery under regional anaesthesia. Intravenous sedative-hypnotic agents such as propofol are commonly administered to reduce anxiety and improve patient comfort; however…
- Trial name
- NCT07820787
- Testing
- Professionally Prescribed Individualized Music, propofol
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- University of Malaya
Diabetes Mellitus, Type 2
A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)
The main purpose of this study is to compare the benefits and risks associated with the use of 2 treatment strategies to lower blood sugar in participants aged 65 and older with T2DM.
- Trial name
- IMPERIUM (NCT02072096)
- Testing
- Glimepiride, Metformin, Pioglitazone
- Where
- 34 sites in United States, Austria and 3 more
- Volunteers
- 192 people
- Sponsor
- Eli Lilly and Company
Stable Coronary Syndrome, Percutaneous Coronary Intervention
A Novel Strategy For Personalized Long-Term Dual Antiplatelet Therapy (RAPID EXTEND PILOT STUDY)
In patients with heart attacks, the current standard of care is to restore blood flow through percutaneous coronary intervention (PCI). This is done using stents (metal meshes) that opens up blockages.
- Conditions
- Stable Coronary Syndrome, Percutaneous Coronary Intervention, Antiplatelet Therapy, Ticagrelor
- Trial name
- NCT03224923
- Testing
- Ticagrelor 60mg, Clopidogrel 75mg, Aspirin 81 mg
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Suicidality
Enhanced Dialectical Behavior Therapy for Adolescents
Suicide is a leading cause of death and significant concerns for adolescents and young adults. Dialectical Behavior Therapy for Adolescents (DBT-A) is an evidence-based intervention that effectively reduces life-threatening…
- Trial name
- NCT07256496
- Testing
- Enhanced DBT-A
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Compass Behavioral Health