Clinical trials: IOL
Cataract
Symfony Intraocular Lens Retrospective Chart Review
Retrospective chart review of patients with pre-existing ocular pathology who underwent cataract surgery with implantation of the Symfony IOL.
- Trial name
- NCT05111106
- Testing
- Symfony IOL
- Volunteers
- 463 people
- Sponsor
- Austin Eye
Cataract
Visual and Patient Reported Outcomes With Clareon TruPlus
This is a prospective, single-site, two-surgeon, single-arm, observational study evaluating the Clareon TruPlus IOL. Subjects will be assessed up to 3 months post-operatively.
- Trial name
- NCT07648355
- Testing
- Clareon TruPlus
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- OVO LASIK + Lens
Glaucoma, Primary Open Angle, Cataract
Investigate, Following Cataract Surgery With IOL in Conjunction With Intracanalicular Dexamethasone Insert
Randomized, controlled treatment with an intracanalicular dexamethasone (0.4mg) insert following cataract surgery with intraocular lens implant (IOL) combined with minimally invasive glaucoma surgery (MIGS), specifically iStent…
- Trial name
- NCT04465864
- Testing
- Intracanalicular Dexamethasone, 0.4 mg insert
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wolstan and Goldberg Eye Associates
Lymphoma, Small Intestine Cancer
BMS-247550 in Treating Patients With Advanced Cancers
Phase I trial to study the effectiveness of BMS-247550 in treating patients who have malignant solid tumors or lymphoma. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Lymphoma, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00006221
- Testing
- ixabepilone
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- National Cancer Institute (NCI)
Cataract
Clinical Investigation of a New Intraocular Lens
The purpose of this clinical trial is to evaluate the safety and effectiveness of the TECNIS Symfony Extended Range of Vision IOL.
- Trial name
- NCT02203721
- Testing
- TECNIS Symfony Extended Range of Vision IOL, Model ZXR00, TECNIS Monofocal IOL, Model ZCB00
- Where
- 15 sites in United States
- Volunteers
- 324 people
- Sponsor
- Abbott Medical Optics
Glaucoma, Cataracts
Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy
The purpose of this study is to compare the safety \& effectiveness of the two types of cataract and glaucoma surgeries. Results from this study may improve the surgical and post surgical management and long term management of…
- Trial name
- NCT00695747
- Testing
- 2 Site procedure- Phacoemulsification/IOL and Trabeculectomy
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Lahey Clinic
Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific
Carbendazim in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of carbendazim in treating patients who have advanced…
- Trial name
- NCT00023816
- Testing
- carbendazim
- Sponsor
- Jonsson Comprehensive Cancer Center
Eye Diseases, Postcataract Aphakia
Investigation of the Safety and Effectiveness of Monofocal Toric Intraocular Lens (IOL)
This study is a prospective, multicenter, randomized, double masked trial comparing an investigational Monofocal Toric intraocular lens (IOL) (PODEYE TORIC CYL 1.5 D) and a commercially available non-toric monofocal IOL.
- Conditions
- Eye Diseases, Postcataract Aphakia, Cataract, Lens Opacities
- Trial name
- NCT06399211
- Testing
- PODEYE TORIC Monofocal IOL, Alcon AcrySof SA60AT Monofocal IOL
- Volunteers
- 261 people
- Sponsor
- Beaver-Visitec International, Inc.
Cataract
Clinical Investigation of the Clareon® Intraocular Lens (IOL)
The objective of this study is to compare visual acuity and adverse event outcomes from the Clareon intraocular lens (IOL) to historical safety and performance endpoint (SPE) rates.
- Trial name
- NCT03170154
- Testing
- Clareon aspheric hydrophobic acrylic monofocal IOL
- Where
- 16 sites in United States
- Volunteers
- 376 people
- Sponsor
- Alcon Research
Cataract
Effect of 1.8-mm Steep-axis Clear Corneal Incision on the Posterior Corneal Astigmatism in Candidates for Toric IOL Implantation
we aimed to analyze the effects of cataract surgery using a 1.8-mm steep-axis clear corneal incision (CCI) on the posterior corneal surfaces based on the keratometry from the rotating Scheimpflug imaging device (Pentacam HR) in…
- Trial name
- NCT04924231
- Testing
- astigmatism
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia
CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma
This phase I trial studies the side effects and best dose of CPI-613 (6,8-bis[benzylthio]octanoic acid) when given together with bendamustine hydrochloride and rituximab in treating patients with B-cell non-Hodgkin lymphoma that…
- Conditions
- B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia, Cutaneous B-cell Non-Hodgkin Lymphoma, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue
- Trial name
- NCT02168907
- Testing
- 6,8-bis(benzylthio)octanoic acid, bendamustine hydrochloride, rituximab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences
Cataract, Fuchs Endothelial Corneal Dystrophy
Partial Range Of Field IOLs in DMEK-Enabled Procedures
Study Overview This study aims to evaluate the visual outcomes, quality of vision, and patient satisfaction after receiving an extended range PRoF intraocular lens (IOL) during triple Descemet Membrane Endothelial Keratoplasty…
- Trial name
- PROFIDE (NCT07441616)
- Testing
- combined cataract and lamellar endothelial keratoplasty
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Lens Opacities, Cataract
Clinical Outcomes of an New EDOF IOL (Isopure®)
Single-center, retrospective, open-label observational study aiming to evaluate visual outcomes and patient satisfaction after bilateral implantation of Isopure® EDOF-IOL with a mono-minovision target.
- Conditions
- Lens Opacities, Cataract, Pseudophakia
- Trial name
- NCT05704686
- Testing
- Isopure 1.2.3 intraocular EDOF lens implantation
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- Kristof Vandekerckhove, MD, MBA
Chronic Myeloproliferative Disorders, Leukemia
Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone
RATIONALE: Gathering information about how often methemoglobinemia occurs in young patients receiving dapsone for hematologic cancer or aplastic anemia may help doctors learn more about the disease and plan the best treatment.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00993694
- Testing
- chemotherapy, dapsone, medical chart review
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Vanderbilt University
Cataract, Lens Opacities
PMCF Retrospective Study Outcomes of a Premium Monofocal IOL
Multicentric, retro- / prospective, open-label, observational PMCF study to investigate visual performance, contrast sensitivity and patient satisfaction after mono- or bilateral implantation of Isopure 1.2.3.
- Trial name
- PHY2110 (NCT04874376)
- Testing
- IOL implantation experimental (Isopure 1.2.3.)
- Where
- 6 sites in Spain
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Beaver-Visitec International, Inc.
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases
RATIONALE: Pemetrexed disodium may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Studying samples of cerebrospinal fluid and blood from patients with cancer in the laboratory may help…
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00424242
- Testing
- Pemetrexed
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwestern University
Aphakia, Corneal Astigmatism
Clinical Investigation of the Visual Outcomes and Safety of a Trifocal Toric IOL in an Asian Population
The purpose of this study is to evaluate the clinical performance of the ACRYSOF® IQ PanOptix® Toric Trifocal intraocular lens (IOL) when implanted in the eye following cataract removal in an Asian population.
- Trial name
- NCT04528069
- Testing
- ACRYSOF® IQ PanOptix® Toric Trifocal IOL, Cataract surgery
- Where
- 4 sites in Australia
- Volunteers
- 58 people
- Sponsor
- Alcon Research
Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ
Treating Patients With Recurrent PCNSL With Carboplatin/BBBD and Adding Rituxan To The Treatment Regimen
RATIONALE: Monoclonal antibodies, such as rituximab, can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ, Lymphoma, Thrombocytopenia
- Trial name
- NCT00074165
- Testing
- Rituxan, Cyclophosphamide, Etoposide
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- OHSU Knight Cancer Institute
Contrast Sensitivity
Contrast Sensitivity Assessment in Pediatric Cataract Surgery With IOL Implantation
The study evaluates contrast sensitivity in older children following surgery for lamellar and posterior subcapsular cataracts. Often, pediatric surgeons tend to delay surgery in these children who present beyond the amblyogenic…
- Trial name
- NCT01901744
- Testing
- Cataract Surgery
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Iladevi Cataract and IOL Research Center
Lymphoma, Prostate Cancer
Flavopiridol in Treating Patients With Refractory Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of flavopiridol in treating patients who have refractory…
- Conditions
- Lymphoma, Prostate Cancer, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00019344
- Testing
- alvocidib
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)