Clinical trials: IOL
Cataract, Lens Opacities
Clinical Study to Investigate Outcomes of Trifocal Toric IOL POD FT in Asian Eyes
Prospective, controlled, single-surgeon, single-center clinical study to compare visual acuity outcomes to data obtained in a similar study by the same principal investigator on the trifocal IOL POD F (study no.
- Conditions
- Cataract, Lens Opacities, Presbyopia
- Trial name
- NCT03844828
- Testing
- IOL implantation experimental
- Where
- Philippines
- Volunteers
- 100 people
- Sponsor
- Beaver-Visitec International, Inc.
Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma
Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas
The purpose of this study is to evaluate how safe and effective the combination of two different drugs (brentuximab vedotin and rituximab) is in patients with certain types of lymphoma.
- Conditions
- Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma
- Trial name
- NCT01805037
- Testing
- brentuximab vedotin, rituximab, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Cataracts
AcrySof® IQ ReSTOR® +2.5 D Multifocal Intraocular Lens (IOL) Model SN6AD2 [SV25T0] in Japan
The purpose of this study is to evaluate safety and effectiveness of AcrySof® IQ ReSTOR® +2.5 D Multifocal IOL Model SN6AD2 [SV25T0] in Japanese cataract patients.
- Trial name
- NCT01605877
- Testing
- AcrySof® IQ ReSTOR® +2.5 D Multifocal IOL Model SN6AD2 [SV25T0]
- Where
- 2 sites in Japan
- Volunteers
- 70 people
- Sponsor
- Alcon Research
Cataract, Lens Opacities
Multicentric Clinical Study on Isatis TF Trifocal Intraocular Lens
The study will be a multicentric, prospective open-label ethics committee approved clinical study to investigate safety, visual outcomes, contrast sensitivity and rotational stability after bilateral implantation of Isatis TF IOL…
- Trial name
- NCT04465344
- Testing
- Implantation of trifocal IOL, Isatis TF (device under investigation), Implantation of monofocal IOL, Isatis (control device)
- Where
- 7 sites in Czechia, Spain
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Cutting Edge SAS
Cancer
BCX-1777 in Treating Patients With Refractory Cancer
RATIONALE: BCX-1777 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: Phase I trial to study the effectiveness of BCX-1777 in treating patients who have refractory cancer.
- Trial name
- NCT00073944
- Testing
- forodesine hydrochloride
- Where
- United States
- Sponsor
- BioCryst Pharmaceuticals
Cataract, Lens Opacities
Clinical Study to Evaluate Clinical Outcomes of LuxSmart IOL as Compared With LuxGood IOL
This study is a multicentric, prospective, randomised, controlled, post-market clinical follow up (PMCF) study to investigate safety, visual outcomes and contrast sensitivity after bilateral implantation of either LuxSmart IOLs…
- Trial name
- NCT06105190
- Testing
- Implantation of premium monofocal IOL, LuxSmart (device under investigation), Implantation of monofocal IOL, LuxGood (control device)
- Where
- 8 sites in Austria, Czechia and 4 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Cutting Edge SAS
Chronic Myeloproliferative Disorders, Leukemia
Bone Marrow Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00005804
- Testing
- cyclophosphamide, allogeneic bone marrow transplantation, radiation therapy
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Cataracts
Comparison of Corneal Aberrations and Visual Outcomes in AcrySof IQ Toric Patients Versus Limbal Relaxing Incision (LRI) Patients
A prospective evaluation of postoperative corneal aberrations and visual parameters in patients assigned to either an AcrySof IQ Toric intraocular lens (IOL) group or a group implanted with a SN60WF IOL and having concomitant…
- Trial name
- NCT00929747
- Testing
- Toric, Limbal Relaxing Incision
- Where
- United States
- Sponsor
- Alcon Research
Cataract Senile
Evaluation of the Extended Depth of Focus After Bilateral Implantation of Hydrophobic IOLs
This will be a prospective observational, ethics committee approved study where patients undergoing routine cataract surgery will have bilateral implantation of the intraocular lens (LuxSmart, Bausch \& Lomb).
- Trial name
- LuxSmart (NCT04523558)
- Testing
- Implantation of LuxSmart hydrophobic IOLs (Bausch + Lomb) in both eyes
- Where
- Czechia
- Volunteers
- 33 people
- Sponsor
- Gemini Eye Clinic
Cataract, Presbyopia
Clinical Investigation of the Visual Outcomes and Safety of a Trifocal Intraocular Lens (IOL) in a Korean Population
The purpose of this study is to confirm the effectiveness of the investigational lens in a Korean population, especially for visual performance, quality of vision, and subject satisfaction with the visual outcome, as well as the…
- Trial name
- NCT03268746
- Testing
- AcrySof IQ PanOptix Multifocal IOL
- Where
- 4 sites in South Korea
- Volunteers
- 52 people
- Sponsor
- Alcon Research
Presbyopia
Visual Outcomes After Presbyopic Lens Exchange
Evaluation of mean preoperative and postoperative Corrected distance visual acuity (CDVA) after Refractive Lens Exchange in presbyopic patients
- Trial name
- RELAX (NCT03790592)
- Testing
- trifocal IOL
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Carl Zeiss Meditec AG
Dry Eye
SAS 1: Develop Ocular Disease (OSD) Diagnostic, Algorithms, and Management Protocols for Cataract Surgery
Patient: Tear film issues resulting in poor visual outcomes are a major cause of dissatisfaction after cataract surgery. There is no universal best preoperative algorithm for managing the ocular surface prior to surgery.
- Trial name
- NCT07323264
- Where
- Singapore
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Louis Tong
Cataract
Comparison Between a Toric Monofocal and Multifocal Intraocular Lens
The primary objective of the study is to observe the rotational stability of the implant 30 minutes, one day, 6 weeks, 6 months and 12 months after the implant surgery.
- Trial name
- NCT04907318
- Testing
- Cataract surgery
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Beaver-Visitec International, Inc.
The Comparison of IOL Formulas in Eyes With PCE≥15um Undergoing Cataract Surgery
Comparison of IOL Formulas in Eyes With PCE≥15µm
The goal of this observational study is to evaluate the long-term refractive outcomes of advanced intraocular lens (IOL) power calculation formulas in cataract patients with posterior corneal elevation (PCE ≥ 15 μm).
- Trial name
- NCT07346456
- Testing
- Intraocular lens calculation formulas
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Cataract, Refractive Error
A Comparative Study of TECNIS Symfony Plus IOL and a Trifocal IOL
This is a multicenter, prospective, randomized, subject- and evaluator-masked, bilateral-implant study conducted at up to 15 sites worldwide.
- Trial name
- NCT04156737
- Testing
- TECNIS Symfony plus IOL Model ZHR00V, Trifocal Intraocular lens
- Where
- 5 sites in New Zealand, Philippines and 1 more
- Volunteers
- 205 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Cataract
Surgeon Experience ReSTOR A +4 Intraocular Lens (IOL)
To collect visual outcome data post AcrySof ReSTOR Aspheric +4 implantation from surgeons throughout the United States.
- Trial name
- NCT00733512
- Testing
- ReSTOR
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Alcon Research
Posterior Capsule Opacification, Pseudophakia
IOL Position and Refractive Change After Nd:YAG Laser Posterior Capsulotomy
After cataract surgery, the thin natural membrane that holds the artificial lens in place can slowly turn cloudy. This is called posterior capsule opacification. It makes vision blurry and can cause glare.
- Conditions
- Posterior Capsule Opacification, Pseudophakia, Refractive Errors
- Trial name
- YAG-IOL-POS (NCT07802145)
- Testing
- Nd:YAG laser posterior capsulotomy, Anterior segment swept-source OCT, Swept-source optical biometry
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Vienna Hospital Association
Microspherophakia
The Efficacy of a 6-point Transscleral Suture Fixation of a 3-looped Haptics PC-IOL Implantation Through Scleral Pockets for Surgical Management for Microspherophakia
By comparing the preoperative data and postoperative data of 9 patients of microspherophakia, we concluded that the 6-point transscleral suture fixation of a 3-looped haptics posterior chamber intraocular lens (PC-IOL) through…
- Trial name
- NCT04447157
- Volunteers
- 9 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cataract
Visual Outcomes After Cataract Surgery: Multifocal AcrySof® IQ ReSTOR® Intraocular Lenses Versus Monofocal Intraocular Lenses
The purpose of this study is to assess and compare visual outcomes of the AcrySof® IQ ReSTOR® +3.0 D intraocular lens (IOL) to a commercially available monofocal IOL in cataract patients.
- Trial name
- NCT01290068
- Testing
- AcrySof® IQ ReSTOR® +3.0 D Multifocal IOL, AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL, Monofocal IOL
- Volunteers
- 208 people
- Sponsor
- Alcon Research
Cataract
Visual Performance of an Extended Depth of Focus IOL in an Emmetropic or Monovision Modality
Comparison of the visual performance of a refractive extended depth of focus intraocular lens in an emmetropic or monovision modality
- Trial name
- NCT06624826
- Testing
- Emmetropic modality, Monovision modality
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA