Clinical trials: IOP
Intraocular Pressure
Quantitative Rise in Intraocular Pressure in Steep Trendelenburg Position
This study analyse the rise in Intraocular Pressure while patient is in surgery in head low position.
- Trial name
- NCT02646033
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Primary Open Angle Glaucoma
IOP Fluctuations in Primary Open Angle Glaucoma Patients Before and After Deep Sclerectomy With Collagen Implant
Primary open angle glaucoma (POAG) is associated with inadequate drainage of the aqueous humor via the trabecular meshwork towards the systemic circulation. This may lead to an increase in IOP and may damage the optic nerve.
- Trial name
- NCT01561001
- Testing
- SENSIMED Triggerfish®
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Sensimed AG
Glaucoma
Intraocular Pressure (IOP) Lowering Efficacy of Transdermal Brimonidine Therapy
The purpose of this study is to evaluate the safety and effectiveness in lowering intraocular pressure (IOP) utilizing an experimental lotion containing 0.1% Brimonidine that is applied to the outside of one eyelid.
- Trial name
- NCT01345448
- Testing
- Brimonidine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Nanduri, Padma, M.D., FACS
Healthy
Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve head (ONH) circulation has been shown in animals and…
- Trial name
- NCT00915226
- Testing
- Suction cup application, Squatting
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Open-Angle Glaucoma
Collection of Blood Specimens From Patients in AL-3789 Studies for Elevated Intraocular Pressure (IOP)
The objective of this study is to obtain blood samples from patients who are or were participants in any Alcon AL-3789 clinical trial.
- Trial name
- NCT00691639
- Testing
- Blood Collection Only
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Alcon Research
Intraocular Pressure and PROSE Lens
Tonometry Precision and Accuracy During PROSE Scleral Lens Wear: A Pilot Study
The goal of this research is to determine the reproducibility of measurements of intraocular pressure (IOP) when a scleral lens is on the eye.
- Trial name
- NCT04308941
- Testing
- Intraocular pressure
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boston Sight
Ocular Hypertension
Effect of Alternate Therapies on Intraocular Pressure in Ocular Hypertension
The purpose of this study is to evaluate the effect of complementary and alternative therapies, specifically alternate nostril breathing and foot reflexology, on intraocular pressure in patients with ocular hypertension.
- Trial name
- NCT02993445
- Testing
- Alternate Nostril Breathing, Foot Reflexology
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Temple University
Ocular Hypertension, Glaucoma
Effects of a Single OMT on Intraocular Pressure (IOP) in Ocular Hypertenive or Glaucoma Suspect Subjects
The hypothesis is that osteopathic manipulative treatment (OMT)will significantly reduce intraocular pressure (IOP) in individuals with ocular hypertension (OHT) and glaucoma suspect patients.
- Trial name
- OMT4OHT (NCT01864642)
- Testing
- osteopathic manipulative treatment (OMT)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Wisconsin, Madison
Uncontrolled Intraocular Pressure
To Assess the Safety and Efficacy of Travacom in Patients With Uncontrolled Intraocular Pressure
This study is a multi-site, unmasked phase IV study. Travacom(R) is a combination topical ocular agent, containing travoprost and timolol, which lower intraocular pressure (IOP) by complementary mechanisms of action.
- Trial name
- NCT01159756
- Testing
- Travacom
- Where
- India
- Volunteers
- 468 people
- Sponsor
- Alcon Research
Glaucoma
The Effect of Body Posture on Intraocular Pressure in Progressive Glaucoma
Glaucoma is a condition where the optic nerve (the nerve responsible for sight) shows progressive damage with characteristic loss of visual field.
- Trial name
- NCT01351779
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Open Angle Glaucoma, Ocular Hypertension
A Study to Investigate the Effect of IOP-lowering With TO-O-1001 Eye Drops in Healthy Subjects and in Patients With Open-Angle Glaucoma or Ocular Hypertension
This is a Phase I/II stage to investigate the safety, tolerability, and ocular hypotensive efficacy of TO-O-1001 in healthy volunteers and patients with Open-Angle Glaucoma or Ocular Hypertension.
- Trial name
- NCT05456724
- Testing
- TO-O-1001
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Theratocular Biotek Co.
Intraocular Pressure, Spinal Anesthesia
Upper Extremity Position and Intraocular Pressure During Spinal Anesthesia: A Randomized Controlled Trial
This prospective randomized controlled trial evaluated the effect of two upper extremity positions on intraocular pressure (IOP) in adult patients undergoing surgery under spinal anesthesia.
- Conditions
- Intraocular Pressure, Spinal Anesthesia, Surgical Positioning
- Trial name
- UEP-IOP (NCT07424417)
- Testing
- Upper Extremity Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Eye Diseases
Anecortave Acetate for Treatment of Steroid Induced Intraocular Pressure (IOP) Elevation
The purpose of this study is to evaluate the safety and efficacy of anecortave acetate depot when administered for the treatment of elevated IOP following treatment with steroids.
- Trial name
- NCT00315640
- Testing
- Anecortave Acetate Sterile Suspension, 6 mg/mL, Anecortave Acetate Suspension Depot, 30 mg/mL, Anecortave Acetate Sterile Suspension, 60 mg/mL
- Where
- 12 sites in United States, Brazil and 6 more
- Volunteers
- 70 people
- Sponsor
- Alcon Research
Glaucoma
Dexmedetomidine as an Additive to Local Anaesthesia to Decrease Intraocular Pressure in Glaucoma Surgery
Nowadays, a number of cases with increased intraocular pressure and glaucoma have been shown a huge increase . This is because of the increase the geriatric population in the community and advanced medical care.
- Trial name
- NCT02846090
- Testing
- Dexmedetomidine to reduce the IOP
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Cairo University
Intraocular Pressure Change in Intravitreal Injection
Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection
To assess the effect of prophylactic antiglaucoma agents in prevention of acute intraocular pressure rise after intravitreal injection.
- Trial name
- NCT02140450
- Testing
- Timolol, Brimonidine, Acetazolamide
- Where
- Iran
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Cataract, Glaucoma
Comparison of Phaco-Trabeculectomy and MSICS-Trab in Cataract and Glaucoma Patients
The goal of this interventional study is to compare the outcomes of two surgical techniques, Phaco-Trabeculectomy and Manual Small Incision Cataract Surgery (MSICS) with Trabeculectomy, in patients with coexisting cataract and…
- Trial name
- NCT06739343
- Testing
- PHACO-Trabeculectomy, MSICS-Trabeculectomy
- Where
- Nigeria
- Volunteers
- 122 people
- Sponsor
- Emeka John Dingwoke
Intraocular Pressure
Clinical Study for TONOREF III Tested to ANSI Z80.10-2014
The primary objective of this clinical study was to show that tonometry values for TONOREF III, as the representative device of the NIDEK tonometer series, were comparable to the predicate device.
- Trial name
- NCT07152808
- Testing
- NIDEK TONOREF III, Haag-Streit Goldmann Manual Tonometer
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Pregnancy
Corneal Biomechanics During Pregnancy
It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child.
- Trial name
- CorvisPreg (NCT04433689)
- Testing
- Non-Contact measurement of corneal properties
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Open-angle Glaucoma, Ocular Hypertension
Double-masked Study of PG324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
To evaluate ocular hypotensive efficacy and safety of PG324 Ophthalmic Solution compared to Netarsudil (AR-13324) Ophthalmic Solution and Latanoprost Ophthalmic Solution.
- Trial name
- NCT02558400
- Testing
- PG324 Ophthalmic Solution 0.02%/0.005%, Netarsudil (AR-13324) Ophthalmic Solution 0.02%, Latanoprost Ophthalmic Solution 0.005%
- Where
- United States
- Volunteers
- 718 people
- Sponsor
- Aerie Pharmaceuticals
Pigmentary Dispersion Syndrome, Pigmentary Glaucoma Patients
Continuous Intraocular Pressure (IOP) Monitoring in Pigmentary Dispersion Syndrome and Pigmentary Glaucoma Patients
This study monitors the intraocular pressure (IOP) over 4 to 6 hours using the SENSIMED Triggerfish® device and Goldmann Applanation Tonometry (GAT) in pigment dispersion syndrome and pigmentary glaucoma patients.
- Trial name
- NCT01253109
- Testing
- SENSIMED Triggerfish
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Sensimed AG