Clinical trials: IRIS
Myocardial Infarction
IRI-EXPLORE: A Study to Test Whether BI 765845 Helps People Who Have Had a Heart Attack
This study is open to adults aged 18 and over who have just had a heart attack. The purpose of this study is to find out whether a medicine called BI 765845 helps people who have had a heart attack.
- Trial name
- IRI-EXPLORE (NCT06139328)
- Testing
- BI 765845
- Where
- 53 sites in Australia, Canada and 12 more
- Volunteers
- 160 people
- Sponsor
- Boehringer Ingelheim
Immune Reconstitution Inflammatory Syndrome, Leukoencephalopathy, Progressive Multifocal
Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS)
The objectives of this study are to explore the effects of administering high-dose corticosteroids to participants who developed progressive multifocal leukoencephalopathy (PML) while on natalizumab as measured by time-course…
- Trial name
- IRIS (NCT01211665)
- Testing
- Methylprednisolone, Prednisolone
- Where
- 3 sites in United States, Germany
- Volunteers
- 3 people
- Sponsor
- Biogen
HIV, Stigma, Social
Using the Ending Self-Stigma Intervention to Reduce Internalized Stigma Among People Living With HIV Who Use Substances
The goal of this clinical trial is to test an intervention to reduce stigma among people living with HIV who use opioids and cocaine.
- Conditions
- HIV, Stigma, Social, Substance Use
- Trial name
- IRIS (NCT05704764)
- Testing
- Ending Self Stigma for Persons living with HIV and Use Substances
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Friends Research Institute, Inc.
Metastatic Biliary Tract Carcinoma, Metastatic Colorectal Carcinoma
Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer
This phase I/II trial studies the side effects and best dose of liposomal irinotecan and rucaparib when given together with fluorouracil and leucovorin calcium and to see how well they work in treating patients with pancreatic…
- Conditions
- Metastatic Biliary Tract Carcinoma, Metastatic Colorectal Carcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma, Metastatic Malignant Digestive System Neoplasm
- Trial name
- NCT03337087
- Testing
- Fluorouracil, Irinotecan Sucrosofate, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Academic and Community Cancer Research United
Aphakia Due to Trauma, Eye; Rupture, Traumatic, With Loss of Intraocular Tissue
Clinical Outcomes of Implantationof Black Diaphragm Intraocular Lens in Complete Aniridia and Aphakia Due to Posttraumatic Eye Rupture
Purpose: To assess long-term outcomes of implantation of black diaphragmintraocular lens (BD IOL) in postraumatic aniridia and aphakia due to eye rupture.
- Conditions
- Aphakia Due to Trauma, Eye; Rupture, Traumatic, With Loss of Intraocular Tissue, Aniridia
- Trial name
- NCT03581864
- Where
- Poland
- Volunteers
- 14 people
- Sponsor
- Medical University of Lublin
Surgery, Liver Metastases
Improved Recovery by Iron Following Surgery With Blood Loss, the IRIS-trial
The aim of the study is to investigate if iv iron formulation improve recovery after surgery with blood loss. Post-operative anaemia is a common debilitating condition after major surgery due to a combination of preoperative iron…
- Conditions
- Surgery, Liver Metastases, Liver Cancer, Pancreas Cancer
- Trial name
- IRIS (NCT05744219)
- Testing
- Ferric carboxymaltose
- Where
- Sweden
- Volunteers
- 338 people
- Sponsor
- Jon Unosson
Meibomian Gland Dysfunction, Cataract
Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures
The development of optical coherence tomography (OCT) and its application for in vivo imaging has opened entirely new opportunities in ophthalmology.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation
- Trial name
- NCT03461978
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Arthritis, Juvenile Rheumatoid, Uveitis
The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis
Current treatment modalities for uveitis associated with juvenile rheumatoid arthritis have not been beneficial in the juvenile population.
- Trial name
- NCT00001614
- Testing
- Chicken type II collagen
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Eye Institute (NEI)
Kaposi Sarcoma, Human Immunodeficiency Virus
Impact of Valganciclovir on Severe IRIS-Kaposi Sarcoma Mortality: an Open-label, Parallel, Randomized Controlled-trial.
Kaposi sarcoma (KS) has an unpredictable course, patients with disseminated KS starting combined Antiretroviral Therapy can develop Immune Reconstitution Syndrome (IRIS), with a severe clinical presentation and high mortality…
- Conditions
- Kaposi Sarcoma, Human Immunodeficiency Virus, Immune Reconstitution Syndrome
- Trial name
- NCT03296553
- Testing
- Valganciclovir, Antiretroviral Combinations
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- National Institute of Cancerología
Intraoperative Floppy Iris Syndrome
Retrobulbar Injection of Anesthesia Versus Healon 5 in the Management of Intraoperative Floppy Iris Syndrome
In this study, the investigators plan to compare the incidence and complications of intraoperative floppy iris syndrome (IFIS) during cataract surgery in patients taking tamsulosin (Flomax) and treated with retrobulbar injection…
- Trial name
- NCT00627913
- Testing
- Healon 5 injection, Retrobulbar anesthetic injection
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Penn State University
Glaucoma, Open-Angle, Pseudoexfoliation Glaucoma
Optimal Treatment Protocol for Selective Laser Trabeculoplasty - Repeat Trial
Glaucoma is a common eye disease that can lead to blindness. The only known way to reduce the rate of disease progression is by reducing the pressure in the eye (the intraocular pressure, IOP).
- Conditions
- Glaucoma, Open-Angle, Pseudoexfoliation Glaucoma, Ocular Hypertension
- Trial name
- OSLT-R (NCT05159960)
- Testing
- SLT
- Where
- 2 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Vastra Gotaland Region
Ciliary Body and Choroid Melanoma, Medium/Large Size, Ciliary Body and Choroid Melanoma, Small Size
Cixutumumab in Treating Patients With Metastatic Melanoma of the Eye
This phase II trial studies how well giving cixutumumab works in treating patients with metastatic melanoma of the eye. Monoclonal antibodies, such as cixutumumab, can block tumor growth in different ways.
- Conditions
- Ciliary Body and Choroid Melanoma, Medium/Large Size, Ciliary Body and Choroid Melanoma, Small Size, Iris Melanoma, Metastatic Intraocular Melanoma
- Trial name
- NCT01413191
- Testing
- Cixutumumab, Laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Neovascular Glaucoma, Type 2 Diabetes
Observation of Iris Blood Flow Via OCTA in Diabetic Neovascular Glaucoma
The goal of this observational study is to quantify iris blood flow via non-invasive eye scanning for evaluating ocular lesions in adults aged 18 years and older, including healthy volunteers, patients with type 2 diabetes…
- Trial name
- NCT07722910
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Qilu Hospital of Shandong University
Metastatic Melanoma, Unresectable Melanoma
Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma
The purpose of this first in human study is to evaluate the feasibility, safety, and efficacy of administering TBio-4101 (tumor infiltrating lymphocytes [TIL]) after receiving a lymphodepleting chemotherapy regimen and before…
- Conditions
- Metastatic Melanoma, Unresectable Melanoma, Acral Melanoma, Mucosal Melanoma
- Trial name
- NCT05628883
- Testing
- TBio-4101, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Chronic Mental Disorders
A Study of Engagement in the "Résonance(s)" Musical and Experiential Immersion Program Among Patients With Mental Disorders - IRIS
The objective of this exploratory, interventional, single-center study without a control group is to examine participation in the "Résonance(s)" musical and experiential immersion program among patients aged 18 to 60 with a…
- Trial name
- IRIS (NCT07762079)
- Testing
- Scales and neuropsychological testing
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Federation Regionale de Recherche en Psychiatrie et Sante Mentale Occitanie
Glaucoma, Primary Open Angle Glaucoma
Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma
Glaucoma is a progressive optic neuropathy with retinal ganglion cell loss which leads to visual field loss. Open-angle glaucoma is the most common form of glaucoma.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- TES-GPS (NCT06682962)
- Testing
- Transcorneal electrical stimulation (TES) with the OkuStim 2 System
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Okuvision GmbH
Solid Tumors, ER/PR Positive Breast Cancer
MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment
This is a Phase I study to understand the biodistribution of MM-398 and to determine the feasibility of using Ferumoxytol as a tumor imaging agent.
- Conditions
- Solid Tumors, ER/PR Positive Breast Cancer, Triple Negative Breast Cancer, Metastatic Breast Cancer With Active Brain Metastasis
- Trial name
- NCT01770353
- Testing
- Ferumoxytol, MM-398
- Where
- 7 sites in United States
- Volunteers
- 45 people
- Sponsor
- Ipsen
Pseudoexfoliation Syndrome
Optical Low Coherence Reflectometry Enables Preoperative Detection of Zonular Weakness in Pseudoexfoliation Syndrome
The purpose of the study was to evaluate optical ocular components in patients with pseudoexfoliation syndrome using optical low coherence reflectometry.
- Trial name
- NCT01298895
- Where
- Croatia
- Volunteers
- 224 people
- Sponsor
- General Hospital Sveti Duh
Metastatic Colorectal Cancer
Cap/Iri Plus Cetuximab Compared to Cap/ox Plus Cetuximab in Patients With Metastatic Colorectal Cancer.
A randomized phase II-study to evaluate the safety and efficacy of capecitabine plus irinotecan plus cetuximab compared to capecitabine plus oxaliplatin plus cetuximab in first-line treatment of patients with metastatic…
- Trial name
- NCT00254137
- Testing
- capecitabine, irinotecan, oxaliplatin
- Volunteers
- 92 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Pseudoexfoliation, Pseudoexfoliation Syndrome
Cataract Surgery in Patients With Pseudoexfoliation and Pseudoexfoliation Glaucoma
The study aims to document the effect cataract surgery has on the pseudoexfoliation and pseudoexfoliation glaucoma eye. Details such has patient history, history of possible glaucoma, intraocular pressure, status of the eye…
- Conditions
- Pseudoexfoliation, Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma, Cataract
- Trial name
- PHACOPXG (NCT04590651)
- Testing
- Cataract surgery, Cataract surgery with extra anterior chamber angle aspiration
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Peeter Kuddu