Clinical trials: IV Iron
Myelodysplastic Syndrome
Evaluation the Effect of Exjade on Oxidative Stress in Low Risk Myelodysplastic Syndrome Patients With Iron Over Load
Certain percentage of MDS patients develop iron overload. Iron is known to participate in intracellular reactions that generate free radicals, inducing oxidative stress and apoptosis, which was found to be increased in MDS…
- Trial name
- NCT00452660
- Testing
- Exjade
- Where
- Israel
- Volunteers
- 21 people
- Sponsor
- Wolfson Medical Center
Hip Fracture, Anemia
IV Iron in Association With Tranexamic Acid for Hip Fracture
It is a prospective randomized controlled study aiming to test if tranexamic acid combined to intravenous iron before and after surgery for hip fracture in elderly can decrease peri-operative red cell transfusion.
- Trial name
- NCT02428868
- Testing
- tranexamic acid (Exacyl®), intravenous iron (Ferroven®), Saline
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Institut Kassab d'Orthopédie
Heart Failure, Left Sided, Anemia, Iron Deficiency
ORal IrON Supplementation With Ferric Maltol in Patients With Heart Failure Carrying Left Ventricular Assist Devices
This is a open-label, uncontrolled, monocenter, phase IV study. The aim of this study is to detect AEs or SAEs with a relative frequency of at least 11.5% in LVAD patients with iron deficiency anemia treated with oral ferric…
- Trial name
- ORION-LVAD-1 (NCT03774615)
- Testing
- Ferric maltol 30 mg (Feraccru®)
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Hannover Medical School
Restless Legs Syndrome, Iron Deficiency Anemia
Pilot Study: Randomized, Placebo-controlled Comparator Trial of IV vs Oral Iron Treatment of RLS With IDA. (IVOR-IDA)
The purpose of the study is to determine the relative effect size of standard IV and oral iron treatment of RLS with Iron deficiency anemia (IDA) and to determine the time course of treatment response.
- Trial name
- NCT02499354
- Testing
- Ferumoxytol intravenous, Ferrous sulfate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Auerbach Hematology Oncology Associates P C
Iron Deficiency Anemia Treatment, Chronic Kidney Disease(CKD)
Compare Efficacy/Safety of Repeat Doses of Ferumoxytol With Iron Sucrose in CKD Subjects With IDA and on Hemodialysis
The objectives of this study are to compare the efficacy and safety of repeat doses of intravenous (IV) ferumoxytol with IV iron sucrose for the treatment of IDA in subjects with hemodialysis-dependent CKD.
- Trial name
- NCT01227616
- Testing
- Ferumoxytol, Iron Sucrose
- Where
- 43 sites in United States, Canada and 1 more
- Volunteers
- 296 people
- Sponsor
- AMAG Pharmaceuticals, Inc.
Heart Failure With Preserved Ejection Fraction, Iron Deficiency
IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency
This randomized, double-blind, placebo-controlled clinical trial evaluates intravenous ferric derisomaltose in older adults with HFpEF and iron deficiency.
- Trial name
- INFUSE-HFpEF (NCT07686692)
- Testing
- Ferric derisomaltose
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Anemia, Leukemia
Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer
RATIONALE: Darbepoetin alfa may cause the body to make more red blood cells. Red blood cells contain iron that is needed to carry oxygen to the tissues.
- Conditions
- Anemia, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00661999
- Testing
- darbepoetin alfa, ferrous sulfate, sodium ferric gluconate complex in sucrose
- Where
- 2 sites in United States
- Volunteers
- 502 people
- Sponsor
- Mayo Clinic
Iron Deficiency Anemia (IDA)
A Study to Characterize the PK and PD Profile of IV FCM in Pediatric Subjects 1-17 Years Old With IDA
This is a Phase II, open-label, non-randomized, multi-center, single arm study to characterize the pharmacokinetic and pharmacodynamics (PK/PD) profile of Ferric Carboxymaltose dosing in pediatric subjects with IDA after…
- Trial name
- NCT02410213
- Testing
- Ferric Carboxymaltose (FCM)
- Where
- 10 sites in Poland, Russia
- Volunteers
- 35 people
- Sponsor
- American Regent, Inc.
Solid Cancer Metastatic Disease, Lymphoid Disease
Randomized Study Evaluating Agents Stimulants Erythropoiesis (ASE) Associated With Ferric Carboxymaltose (Ferinject ®) in Concomitant or Sequential Patients Treated for Cancer and With Anemia Associated With Functional Iron Deficiency
Anemia in patients with cancer is a common problem associated with an impaired quality of life. Treatment with erythropoiesis stimulating agents (ESA) allows an increase in hemoglobin levels in 40-70% of patients and decreased…
- Trial name
- NCT02213653
- Testing
- ARM A : IV iron + epoietin zeta, ARM B: IV iron + epoietin zeta sequence, ARM C : single epoietin zeta
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Centre Francois Baclesse
Anemia, Arthroplasty, Replacement, Hip
An Intravenous Iron Based Protocol for Preoperative Anaemia in Hip and Knee Surgery - An Observational Study
This observational study follows a cohort of patients scheduled for elective hip- or knee surgery but has preoperative anemia and are treated with Intravenous (IV) iron prior to surgery according to a recently introduced…
- Conditions
- Anemia, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- NCT02385383
- Testing
- Iron-III Isomaltoside 1000, Standard Care
- Where
- 6 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Parkinson Disease, REM Sleep Behavior Disorder
Quantitative Mapping of Substantia Nigra Iron in Parkinson's Disease (Stages I-IV, REM Sleep Behavior Disorder) and Controls
Prospective, single center study to determine whether the current R2* iron mapping method for measuring nigral iron changes in the brain can be significantly improved by using the Quantitative Susceptibility Mapping (QSM) based…
- Conditions
- Parkinson Disease, REM Sleep Behavior Disorder, Healthy
- Trial name
- NCT03675282
- Testing
- (11C)PE2I, Ioflupane
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Myocardial Infarction, Iron-deficiency
An Open Study on the Efficacy of Iron Therapy Using iv Iron Relative to Oral Iron for Increasing LV Systolic Function
The OPERA-MI trial evaluates the effect of i.v. ferric carboxymaltose compared to the effect of oral iron, on left ventricular systolic function.
- Trial name
- OPERA-MI (NCT05309499)
- Testing
- ferric carboxymaltose, ferrous sulphate
- Where
- Russia
- Volunteers
- 298 people
- Sponsor
- Kazan State Medical University
Heart Failure, Iron-deficiency
Effects of IV Iron Replacement on Exercise Capacity in Individuals With Heart Failure
Patients with heart failure with reduced ejection fraction and iron deficiency will be randomized to either receive iron infusion or be in the control group.
- Trial name
- NCT05816265
- Testing
- IV Iron Infusion Group
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Radha Gopalan
Anemia in Chronic Renal Disease
Changes in Iron Markers Following Iron Loading in Hemodialysis Patients
The purpose of this study is to describe alterations of serum ferritin, transferrin saturation, soluble transferrin receptor, % hypochromic erythrocytes, % reticulocytes, reticulocyte hemoglobin content after iron loading in…
- Trial name
- NCT00308490
- Testing
- iron sucrose
- Where
- Greece
- Volunteers
- 160 people
- Sponsor
- Papageorgiou General Hospital
Anemia, Knee Arthropathy
Effect of IV Iron Isomaltoside on Postoperative Anemia in Total Knee Arthroplasty Patients
Postoperative anemia is a frequent complication after total knee arthroplasty, with an incidence of 87%. Iron supplementation is known to be effective in treatment and prevention of postoperative anemia.
- Trial name
- NCT03470649
- Testing
- Iron Isomaltoside 1000
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Hypophosphatemia, Roux-en-Y Gastric Bypass
IV Iron-induced Hypophosphatemia After RYGB
The primary objective of the study is to compare the incidence of hypophosphatemia in RYGB patients treated with intravenous (IV) single dose of iron isomaltoside (Monofer®) or ferric carboxymaltose (Ferinject®).
- Trial name
- IVORY (NCT06350955)
- Testing
- Iron isomaltoside, Iron Carboxymaltose
- Where
- Switzerland
- Volunteers
- 94 people
- Sponsor
- Lucie Favre
Restless Legs Syndrome (RLS)
Intravenous (IV) Iron Preparation (VIT-45) in the Treatment of Restless Legs Syndrome (RLS)
The purpose of this study was to evaluate the safety of 2 dosage regimens of Intravenous (IV) iron Ferric Carboxymaltose (FCM) in comparison to placebo in patients with Restless Legs Syndrome (RLS)
- Trial name
- NCT01382901
- Testing
- Ferric Carboxymaltose (FCM)
- Volunteers
- 45 people
- Sponsor
- American Regent, Inc.
Kidney Failure, Chronic, Anemia, Iron-Deficiency
Comparison Between Effects of Two Iron Preparations on Protein in the Urine
This study will compare the effects of sodium ferric gluconate complex and iron sucrose on urine concentrations of various chemicals including protein
- Trial name
- NCT00534144
- Testing
- iron sucrose injection, USP, sodium ferric gluconate complex in sucrose injection
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 74 people
- Sponsor
- Watson Pharmaceuticals
Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
The goal of this clinical trial is to learn which iron treatment works better for adults with congestive heart failure and low iron levels: intravenous (IV) iron given through a vein or oral (PO) iron taken by mouth.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Iron Deficiency
- Trial name
- IRONICA (NCT07053475)
- Testing
- Ferric Carboxymaltose, Ferrous Sulfate
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Syed Hamza Mufarrih
Anemia, Iron Deficiency, Heavy Menstrual Bleeding
IV Iron vs Oral Iron for Treatment of Anemia in Women With Abnormal Uterine Bleeding
This study investigates whether intravenous (IV) iron [Feraheme (ferumoxytol) injection)] is a better treatment than oral iron pills (ferrous sulfate) for correcting anemia in women who have heavy menstrual bleeding and anemia.
- Trial name
- NCT04205266
- Testing
- Ferumoxytol, Ferrous Sulfate
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University