Clinical trials: IVF, open to volunteers
IVF, Infertility, Female
Effect of Tadalafil on Endometrial Thickness and Frozen Embryo Transfer Outcomes
investigate the effect of different vasodilators as Tadalafil in women with unexplained infertility using IVF
- Trial name
- NCT07499804
- Testing
- Tadalafil 5mg, estradiol valerate 2 mg
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Embryo Transfer, IVF
Effect of Pentoxyfilline on Endometrial Thickness and Frozen Embryo Transfer Outcomes
The aim of this work was to investigate the effect of different vasodilators as pentoxifylline in women with unexplained infertility using IVF
- Conditions
- Embryo Transfer, IVF, Infertility
- Trial name
- NCT07499817
- Testing
- pentoxifylline 400 mg, (control)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
IVF Outcomes
HELIOS Advanced: Human Oocyte Illumination to Enhance Development
Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well.
- Trial name
- HELIOS-A (NCT07425080)
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Columbia University
IVF, Infertility Treatment
Biomarkers of Endometrial Receptivity
Analysis of proteins from cervical mucus will be done in patients undergoing infertility treatment (fresh or frozen embryo transfer). Cervical mucus will be analysed for potential new biomarkers of endometrium receptivity.
- Conditions
- IVF, Infertility Treatment, Fertility Disorders, Embryo Transfer
- Trial name
- BIOMER (NCT04619524)
- Testing
- Cervical mucus will be collected from patients undergoing IVF, Cervical mucus will be collected from patients undergoing transfer of cryopreserved embryos
- Where
- 3 sites in Czechia
- Volunteers
- 476 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Advanced Age, Recurrent Pregnancy Loss(RPL)
Noninvasive Implantation Potential vs Morphology-Based Selection in IVF Single Blastocyst Transfer
Background: Morphology-based embryo selection cannot detect aneuploidy, which is common in advanced maternal age and recurrent pregnancy loss.
- Conditions
- Advanced Age, Recurrent Pregnancy Loss(RPL), Infertility (IVF Patients), Sequence Analysis
- Trial name
- NICSAI-SBT-RCT (NCT07461077)
- Testing
- NICS-AI, Morphology group
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility (IVF Patients), Artificial Intelligence (AI)
AI-Driven Model Impact on Patient Engagement in Medically Assisted Reproduction
Infertility is a globally significant medical condition, profoundly impacting individuals and couples both emotionally and physically.
- Trial name
- NCT07087171
- Testing
- Artificial intelligence-Machine learning report with accurate personalized probabilities of having a live birth rate
- Where
- Portugal
- Volunteers
- 774 people
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Ovarian Aging, IVF Outcome
The ROAR Study: Reactive Oxygen Species and Reproduction
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative…
- Conditions
- Ovarian Aging, IVF Outcome, Oxidative Stress
- Trial name
- ROAR (NCT06831019)
- Testing
- Oxidative stress markers
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
IVF, In Vitro Fertilization
The Effect of a Four-Week Hatha Yoga Intervention to Improve Quality of Life, Anxiety, and Depressive Symptoms in Individuals Undergoing Assisted Reproductive Technology (ART) Treatment
The goal of this clinical trial is to learn if a four-week yoga program works to improve quality of life in people undergoing IVF (In Vitro Fertilization).
- Conditions
- IVF, In Vitro Fertilization, Quality of Life (QOL), Anxiety
- Trial name
- NCT07415850
- Testing
- Yoga
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Villanova University
Infertility (IVF Patients), Embryo Morphokinetics
IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols
The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol.
- Conditions
- Infertility (IVF Patients), Embryo Morphokinetics, Progestins Primed Ovarian Stimulation
- Trial name
- NCT07409493
- Testing
- Progestin-Primed Ovarian Stimulation, Antagonist protocol for IVF
- Where
- Vietnam
- Volunteers
- 148 people
- Sponsor
- Hanoi Medical University
Infertility, Female, Infertility, Male
Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing
The goal of this observational study is to discern if there is a relationship between timelapse imagery of human oocytes/embryos and PGT results.
- Conditions
- Infertility, Female, Infertility, Male, Infertility, IVF
- Trial name
- NCT06419127
- Testing
- Timelapse incubation and PGT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Gattaca Genomics
IVF
Non-Invasive Preimplantation Genetic Screening for Aneuploidies and Clinical Outcomes in Egg Donation Patients
Preimplantation genetic testing for aneuploidies (PGT-A) is commonly used in IVF but requires embryo biopsy and shows limited benefit in egg donation cycles.
- Trial name
- niPGTAdon (NCT07364526)
- Where
- Spain
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Subclinical Hypothyroidism, Infertility
Levothyroxine Treatment and IVF Outcomes in Women With Subclinical Hypothyroidism: A Target Trial Emulation
Subclinical hypothyroidism (SCH) is defined by elevated thyroid-stimulating hormone (TSH) with normal free thyroxine (fT4) levels.
- Conditions
- Subclinical Hypothyroidism, Infertility, Assisted Reproductive Technology, In Vitro Fertilization (IVF)
- Trial name
- LESI (NCT07257250)
- Where
- 2 sites in Vietnam
- Volunteers
- 900 people
- Sponsor
- Mỹ Đức Hospital
Infertility (IVF Patients), Oocyte Retrieval for IVF
The Role of Follicular Flushing at Oocyte Retrieval
In vitro fertilization (IVF) is the most common method of medically assisted reproduction, involving fertilization of the egg by sperm in a lab.
- Trial name
- FOFLOR (NCT07335016)
- Testing
- follicular flushing, Simple aspiration
- Where
- 2 sites in Greece
- Volunteers
- 75 people
- Sponsor
- Aristotle University Of Thessaloniki
IVF Outcomes
Ovarian Stimulation Outcomes During a GnRH Antagonist Protocol for In-vitro Fertilization When Comparing Trigger Day Decision by Physicians Versus an Artificial Intelligence-based Algorithm.
To compare the number of mature oocytes following a GnRH antagonist in-vitro fertilization stimulation cycle when comparing trigger day timing decision by physicians versus an artificial intelligence-based algorithm
- Trial name
- NCT07110285
- Testing
- Artificial intelligence-based algorithm
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- FertilAI
Infertility, Infertility (IVF Patients)
Growth Hormone and Dehydroepiandrosterone Role in Vitro Fertilization
The goal of this study is to evaluate the role of Somatropin and Dehydroepiandrosterone (DHEA) on ovarian reserve parameters and intracytoplasmic sperm injection (ICSI) outcome in poor ovarian responder.
- Trial name
- NCT07323329
- Testing
- Somatropin (4IU for 1 month) plus, folic acid 400 mcg per day., DHEA plus folic acid 400mcg per day, control group
- Where
- Egypt
- Volunteers
- 165 people
- Sponsor
- Beni-Suef University
Infertility, in Vitro Fertilization (IVF)
Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes
The use of machine learning techniques using an artificial intelligence tool is proposed to analyze clinical data to predict best possible IVF/ART outcomes.
- Conditions
- Infertility, in Vitro Fertilization (IVF), ART
- Trial name
- AI in ART (NCT04255615)
- Testing
- AI to analyze 3 D ultrasound
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
In Vitro Fertilization (IVF), Embryo Transfer
Dual Trigger With HCG and GnRH Agonist on Thawed Modified Natural Cycle Embryo Transfer
Impact of dual trigger using recombinant human chorionic gonadotropin (HCG) and gonadotropin-releasing hormone (GnRH) agonist on thawed modified natural cycle outcomes: an open-label multi-center randomized controlled trial.
- Trial name
- NCT07269392
- Testing
- GnRH agonist
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Infertility (IVF Patients), Infertility Treatment
Ketorolac Use and Fresh Embryo Transfer Outcomes
Ketorolac is a medication often used to relieve pain after surgery. In the past, infertility doctors have been cautious about using ketorolac after egg retrieval for patients planning a fresh embryo transfer (usually done 5 days…
- Conditions
- Infertility (IVF Patients), Infertility Treatment, Post-op Pain, Fresh Embryo Transfer
- Trial name
- NCT07185724
- Testing
- Ketorolac 30 mg IV
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jessica D. Kresowik
Pregnancy Rate IVF, Clinical Pregnancy Rate
Uterine Interstitial Myolisis and Oocytes Retrieval in Single Step: a Pilot Study
The aim of this observational cohort study is to evaluate the pregnancy rate, the ongoing pregnancy rate and the live birth rate of infertile women aged between 18 and 45 years who undergo a single surgical step of oocyte…
- Conditions
- Pregnancy Rate IVF, Clinical Pregnancy Rate, Live Birth Rate
- Trial name
- UIMandOPU (NCT07267754)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- San Carlo Public Hospital, Potenza, Italy
IVF
Progesterone Levels and Frozen Embryo Transfer Outcomes
Frozen embryo transfers (FET) now represent the majority of all embryo transfer cycles, and upwards of 60% live births in United States are now attributable to frozen embryo transfers (1).
- Trial name
- PLATO (NCT07252622)
- Testing
- Blood draw
- Volunteers
- 659 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center