Clinical trials: IVF, open to volunteers
Assisted Reproductive Technology
Family Foundations for Individuals Pregnant Via ART
The purpose of this study is to help expectant mothers build a coparenting bond and improve communication with a support person (co-caregiver).
- Trial name
- NCT06770972
- Testing
- Family Foundations
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Fertility Preservation, Cancer Remission
Long-term Evaluation of Fertility Preservation Options in Women in Cancer Remission or Haematological Pathology
Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity. Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment.
- Conditions
- Fertility Preservation, Cancer Remission, Reproductive Outcomes, Reproductive Health
- Trial name
- FERT-ISSUES (NCT07312058)
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Oocyte Retrieval for IVF
Virtual Reality Hypnosis as Sedation During Oocyte Retrieval: Effect on Propofol Consumption
An egg retrieval is performed during an IVF course. This painful procedure is performed using sedation to ensure patient comfort.
- Trial name
- VRH-IVF (NCT07104409)
- Testing
- virtual reality hypnosis device
- Volunteers
- 72 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
IVF Outcome
Trigger Timing in Ovarian Stimulations
The use of antagonist ovulation stimulation program is increasing year by year, because of its convenience, flexibility, and prevention effect of ovarian hyperstimulation syndrome.
- Trial name
- NCT04163133
- Testing
- 1～2 days later trigger than regular timing
- Where
- China
- Volunteers
- 834 people
- Sponsor
- Peking University Third Hospital
Reproductive Issues, Subfertility
A Novel Integrative Non-invasive Embryo Selection Approach for IVF Based on MK-RS Analysis
During assisted reproductive technology treatment, embryo selection is an important process that may affect the clinical pregnancy rate.
- Conditions
- Reproductive Issues, Subfertility, IVF
- Trial name
- NCT05896709
- Testing
- MK-RS
- Where
- Hong Kong
- Volunteers
- 176 people
- Sponsor
- Chinese University of Hong Kong
Adenomyosis, IVF
Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients
This randomized clinical trial aims to assess the comparative effectiveness of two distinct endometrial preparation protocols for frozen embryo transfer (FET) among women with adenomyosis undergoing IVF/ICSI.
- Conditions
- Adenomyosis, IVF, Frozen Embryo Transfer
- Trial name
- FET-ADE (NCT06239376)
- Testing
- GnRHa+AI - AC, Artificial cycle
- Where
- Vietnam
- Volunteers
- 222 people
- Sponsor
- Mỹ Đức Hospital
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility (IVF Patients), Oocyte Competence
The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture
This study aims to assess the effect of age of the male partner and the reproductive ability of sperm prepared via sperm selection devices (Zymot) compared to routine embryologist selected sperm after density gradient…
- Conditions
- Infertility (IVF Patients), Oocyte Competence, Sperm DNA Fragmentation, Paternal Age
- Trial name
- EPIC (NCT06629766)
- Testing
- Microfluidic sperm separation device, Density grade centrifugation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes
IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women
Assisted Reproductive Technologies (ART) aim to increase success rates while minimizing patient risks. For women with high AFC or PCOS, conventional IVF carries a high risk of OHSS (Ho et al., 2019).
- Conditions
- Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes, Fresh Embryo Transfer
- Trial name
- SAIGON-PTC (NCT07171970)
- Testing
- IVM-Fresh (No gonadotropin + Fresh embryo transfer), IVF-FET (GnRH-Antagonist - Agonist Trigger - Frozen embryo transfer)
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Mỹ Đức Hospital
Infertility, Infertility (IVF Patients)
Growth Hormone and Dehydroepiandrosterone Role in Vitro Fertilization
The goal of this study is to evaluate the role of Somatropin and Dehydroepiandrosterone (DHEA) on ovarian reserve parameters and intracytoplasmic sperm injection (ICSI) outcome in poor ovarian responder.
- Trial name
- NCT07323329
- Testing
- Somatropin (4IU for 1 month) plus, folic acid 400 mcg per day., DHEA plus folic acid 400mcg per day, control group
- Where
- Egypt
- Volunteers
- 165 people
- Sponsor
- Beni-Suef University
IVF
Ubiquinone vs. Ubiquinol Supplementation
The objective of this study is to determine if ubiquinol will result in improved reproductive outcomes in older women at a reduced oral dose compared to current standard treatment with ubiquinone.
- Trial name
- NCT06555575
- Testing
- Ubiquinone 200 Mg Oral Capsule, Ubiquinol 100 MG Oral Capsule
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Trio Fertility
Repeated IVF Failure, Microbiota
The Role of the Physiological Endometrial Microbiota in Assisted Reproduction Outcomes
The goal of this observational study is to investigate the influence and contribution of the normal composition and balance of the endometrial microbiota on the achievement of embryo implantation and the maintenance of pregnancy…
- Trial name
- no exist (NCT07606053)
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Assisting Nature
Emotional Freedom Technique
Effect of Emotional Freedom Techniques on Fatigue, Hopelessness, and Perceived Stigma in Women With Unsuccessful IVF Experience
In this study, it is planned to provide nursing care to women with an experience of unsuccessful IVF treatment by combining Emotional Freedom Technique (EFT) with the principles developed in line with the philosophy of Levine's…
- Trial name
- NCT07477665
- Testing
- Emotional Freedom Technique
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Infertility, Female, Infertility, Male
Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing
The goal of this observational study is to discern if there is a relationship between timelapse imagery of human oocytes/embryos and PGT results.
- Conditions
- Infertility, Female, Infertility, Male, Infertility, IVF
- Trial name
- NCT06419127
- Testing
- Timelapse incubation and PGT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Gattaca Genomics
Diminished Ovarian Reserve (DOR)
Testing Herbal Pretreatment For IVF Success In Women With Low Ovarian Reserve
The goal of this clinical trial is to learn if a traditional Chinese herbal pretreatment can improve pregnancy outcomes in infertile women with diminished ovarian reserve (DOR) who are undergoing in vitro fertilization (IVF) or…
- Trial name
- PRIME (NCT07347340)
- Testing
- Bushen Tongzhi Formula
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Peking Union Medical College Hospital
Vitrification, Egg Donor
Validation of Donor Oocytes Semi-automated Vitrification
Oocyte vitrification is an effective method of freezing which has been authorized in France since 2011. The arrival of this technique has led to real improvements in the survival rate of oocytes after warming compared to that…
- Conditions
- Vitrification, Egg Donor, Fertility, Assisted Reproductive Technology
- Trial name
- GAVIDO (NCT06238570)
- Testing
- Gavi, Merck® (automated vitrification instrument), Vitrolife system
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility and Miscarriage
A Multicenter, Prospective, Randomized Controlled Clinical Study on the Effect of Hysteroscopic Uterine Septum Resection on IVF-ET Outcomes in Infertile Patients With Non-recurrent Miscarriage
This study aims to evaluate the impact of hysteroscopic transcervical resection of the septum (TCRS) on fertility in infertile women without recurrent miscarriage, primarily assessing its effect on subsequent IVF-ET outcomes.
- Trial name
- NCT07611656
- Testing
- Transcervical resection of septum
- Where
- China
- Volunteers
- 236 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Cancer, Cancer in Pregnancy
ProspectiveFemaleAYA - Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, the evidence-based knowledge on the prevalence and risk factors for gonads impairment, including infertility, following cancer and numerous cancer treatment regimen has significantly increased.
- Conditions
- Cancer, Cancer in Pregnancy, Infertility, In Vitro Fertilisation (IVF) Treatment
- Trial name
- FemFertilAYA (NCT07622420)
- Volunteers
- 3,000 people
- Sponsor
- Karolinska Institutet
Oocyte Retrieval for IVF, Pain
Analgesic Effect of TENS-WAA Combined With Tramadol Hydrochloride During Oocyte Retrieval Surgery
This study is a single-centre randomised controlled trial. It aimed to evaluate the efficacy and safety of transcutaneous electrical nerve stimulation based on wrist-ankle acupuncture theory(TENS-WAA) combined with tramadol…
- Trial name
- NCT07212127
- Testing
- Transcutaneous Electrical Nerve Stimulation based on Wrist-Ankle Acupuncture theory（TENS-WAA)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University
PCOS, Glucose Metabolism Disorder
Study of Time-restricted Eating (TRE) to Clinical Pregnancy Rate in PCOS Women With Glucose Metabolism Disorder Via IVF/ICSI
Investigate the effect and mechanism of time-restricted eating (TRE) on the clinical pregnancy rate in women with PCOS and glucose metabolism disorder via IVF/ ICSI.
- Conditions
- PCOS, Glucose Metabolism Disorder, IVF Outcome
- Trial name
- NCT06666933
- Testing
- Time restricted eating, Metformin
- Where
- China
- Volunteers
- 254 people
- Sponsor
- RenJi Hospital