Clinical trials: IVF Poor Responders
Infertility, Female
Protocols of IVF/ICSI in Poor Responders
Comparing two ovarian induction protocols in poor responders in IVF/ICSI cycles
- Trial name
- NCT04356105
- Testing
- Minimal stimulation protocol, Microflare protocol, IVF/ICSI cycle
- Where
- 2 sites in Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infertility
Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders
This is a prospective, randomized clinical trial to compare the efficiency and safety of mild stimulation and controlled ovarian stimulation protocol on the treatment of POR.
- Trial name
- POR (NCT01926210)
- Testing
- mild stimulation protocol, controlled ovarian stimulation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Huang Rui
Infertility
Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART)
This is a Phase 3, randomized, controlled, single-blind, multicenter, parallel-arm trial to assess the safety and efficacy of Pergoveris® (recombinant human follicle stimulating hormone [r-hFSH]/recombinant human luteinising…
- Trial name
- ESPART (NCT02047227)
- Testing
- Pergoveris®, GONAL-f®, Recombinant human chorionic gonadotrophin (r-hCG)
- Where
- Germany
- Volunteers
- 939 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Poor Ovarian Reserve, Infertility (IVF Patients)
Drospirenone-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol in Poor Ovarian Responders Undergoing Freeze-All IVF/ICSI
Participants will: Take either drospirenone (a daily pill) or the standard daily injection during their ovarian stimulation cycle, alongside their regular fertility hormone injections Undergo egg retrieval, with all resulting…
- Trial name
- PPOS (NCT07736261)
- Testing
- Drospirenone drug, Cetrorelix 0.25 mg
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmed Saad
Female Infertility Due to Diminished Ovarian Reserve
Microflare Protocol in Poor Responders
The effect of use of the microflare down regulation protocol on the outcome of the IVF/ICSI cycles in poor responders
- Trial name
- NCT02185326
- Testing
- Growth hormone (Norditropin, Novo nordisk)
- Where
- Egypt
- Volunteers
- 145 people
- Sponsor
- Woman's Health University Hospital, Egypt
Poor Responders
Comparison of Treatment Modalities in Poor Responders Undergoing IVF
The accurate identification and efficient management of poor responders remains one of the most enigmatic challenges in assisted reproductive technology (ART).
- Trial name
- NCT02158689
- Testing
- Letrozole, human menopausal gonadotropin (hMG)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ercan Bastu
Infertility
Low-dose GH Supplementation Increases Clinical Pregnancy Rate
The objective of this study is to assess whether a low dose of GH supplementation (0.5 IU/day) increases clinical pregnancy rates in women with a history of POR who failed to become pregnant in two previous IVF cycles.
- Trial name
- NCT02359695
- Testing
- Growth Hormone
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Centro de Infertilidad y Reproducción Humana
Infertility, Female
Can Antioxidants Affect Pregnancy Rate in Patients With Expected Low Number of Egg Retrieval in IVF Cycles?
The aim of the study is to evaluate the effect of antioxidants on IVF outcome in infertile patients undergoing IVF who are expected to produce low number of eggs compared to a control group.
- Trial name
- NCT03085030
- Testing
- Antioxidant Formula
- Where
- Egypt
- Volunteers
- 593 people
- Sponsor
- Cairo University
Poor Responders, IVF
Clomiphene Citrate Plus Gonadotropins and GnRH Antagonist Versus Flexible GnRH Antagonist Protocol Versus Microdose GnRH Agonist Protocol in Poor Responders Undergoing IVF
Poor ovarian response to stimulation in IVF cycles is a challenging and frustrating condition, due to its poor prognosis in terms of chances of pregnancy and live births.
- Conditions
- Poor Responders, IVF, Clomiphene Citrate, GnRH Agonist
- Trial name
- NCT02201914
- Testing
- Clomiphene citrate, Daily FSH and LH plus Cetrorelix, Triptorelin plus daily FSH anh LH
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Bioroma
Infertility, Female
Transdermal Testosterone for Poor Responder Patients Undergoing Controlled Ovarian Stimulation Prior to IVF
This study evaluates the efficacy of pre- IVF treatment with transdermal testosterone to enhance ovarian response in poor responders.
- Trial name
- NCT03078569
- Testing
- Testosterone gel
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Subfertility
Transdermal Testosterone Pretreatment in Poor Responders Undergoing IVF
Ιt has been suggested that the accumulation of androgens in the micro milieu of the primate ovary, plays a critical role in early follicular development and granulosa cell proliferation.
- Trial name
- NCT01961336
- Testing
- Testosterone
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility
Growth Hormone in Poor Responders to IVF Trial
This study (the "Adjuvant Growth Hormone Study") is being done to see the effects of adding Growth Hormone (GH) during fertility treatment (also called in vitro fertilization or IVF).
- Trial name
- NCT01616225
- Testing
- Saizen (Human Growth Hormone), No Saizen Control (Standard IVF Protocol)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Pacific Centre for Reproductive Medicine
Androgen Receptor Gene Overexpression, Normal Responders
Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian Response
AR is a steroid hormone receptor that regulates various genes' expression and affects cellular proliferation and differentiation.
- Conditions
- Androgen Receptor Gene Overexpression, Normal Responders, Poor Ovarian Response, Bologna Criteria
- Trial name
- NCT03433768
- Testing
- Real time PCR
- Volunteers
- 67 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility
Extended High Dose Letrozole Regimen Versus Short Low Dose Letrozole Regimen as an Adjuvant to GnRH Antagonist Protocol in the Management of Poor Responders Undergoing IVF-ET
The aim of this randomized controlled trial is to compare the efficacy of extended high dose letrozole regimen (5 mg /day for the first 5 days of cycle and 2.5 mg/day for the subsequent 3 days ) with short low dose letrozole…
- Trial name
- NCT01219153
- Testing
- Extended high dose letrozole regimen /GnRH antagonist protocol, Short low dose letrozole regimen /GnRH antagonist protocol
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Cairo University
Fertilization
Follicular Flushing
Patients with infertility often undergo in vitro fertilization (IVF) to achieve a pregnancy, which involves ovarian stimulation, monitoring of follicular growth, oocyte retrieval, sperm insemination, embryo culture and embryo…
- Trial name
- NCT01558141
- Testing
- Aspiration without flushing follicles with culture media, Follicular Flushing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Infertility
Dydrogesterone Versus GnRH Antagonist in Poor Responders Undergoing Double Ovarian Stimulation
The aim of this randomized controlled trial is to compare the efficacy and cost-effectiveness of using progestin with GnRH antagonist to prevent premature LH surge in poor responders undergoing double stimulation protocol.
- Trial name
- NCT06212102
- Testing
- Progestin primed ovarian stimulation, GnRH antagonist
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Bedaya Hospital
Unrecognized Condition
Intravascular Laser Irradiation of Blood Use in Poor Ovarian Responders
The aim of this study was to investigate the effects of intravascular laser irradiation of blood on outcomes of in vitro fertilization cycles in poor ovarian responders.
- Trial name
- NCT05873075
- Testing
- Intravascular laser irradiation of blood
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility
Timing of Initiation of Luteal Phase Support in Poor Responders Undergoing IVF/ICSI
It is already known that all stimulated IVF ICSI cycles needs luteal phase support for higher pregnancy rates The current study will focus on evaluating two different starting times of luteal phase support
- Trial name
- NCT03938064
- Testing
- Prontogest 400 mg vaginal pessaries
- Where
- 2 sites in Egypt
- Volunteers
- 520 people
- Sponsor
- Ain Shams Maternity Hospital
Infertility
RCT of Low-dose Clomiphene vs. High Dose Gonadotropin Protocol for IVF Poor Responders
The purpose of this study is compare two commonly-used medication protocols ( low-dose clomiphene citrate and high dose gonadotropin protocols) for the treatment of patients with diminished ovarian reserve (decreased number of…
- Trial name
- CLOVANT (NCT01577199)
- Testing
- Low-dose Clomiphene, High dose gonadotropins
- Sponsor
- Weill Medical College of Cornell University
Infertility
Oestradiol Pre-treatment in an Ultrashort Flare GnRH Agonist/GnRH Antagonist Protocol in Poor Responders Undergoing IVF
To evaluate the effect of oestradiol pre-treatment in a combined ultrashort flare GnRH agonist /GnRH antagonist protocol
- Trial name
- NCT01798836
- Testing
- Oestradiol pre-treatment and combination of GnRH agonist/antagonist protocol, GnRH agonist or antagonist protocol without oestradiol pre-treatment
- Where
- Greece
- Volunteers
- 17 people
- Sponsor
- National and Kapodistrian University of Athens