Clinical trials: IVH- Intraventricular Hemorrhage, open to volunteers
Intraventricular Hemorrhage of Prematurity
Research on Prevention, Early Detection, and Clinical Evaluation of Intracranial Hemorrhage in Preterm Infants
1. Establish a reference curve for the lateral ventricular diameter of premature infants and determine the intervention threshold for hydrocephalus after hemorrhage in premature infants based on the reference curve, providing a…
- Trial name
- ROPEDACEOIHIPI (NCT07157020)
- Testing
- ommaya capsule implantation technique
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Intraventricular Hemorrhage Neonatal, Post-hemorrhagic Hydrocephalus
Advanced MRI in IVH
55,000 babies are born prematurely in the UK annually. Bleeding in the fluid spaces of the brain (ventricles) is common after prematurity; in England around 450 babies suffer from severe bleeds every year.
- Trial name
- NCT07412886
- Testing
- Advanced MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Intraventricular Hemorrhage, Subarachnoid Hemorrhage
AFFECT Study for Patients With Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, and Ventriculitis
The goal of this clinical trial is to evaluate efficacy and safety of evacuation of cerebrospinal fluid, blood, and harmful bacteria from the intraventricular, subdural and subarachnoid spaces by Active Controlled Irrigation and…
- Conditions
- Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, Ventriculitis
- Trial name
- AFFECT (NCT05649904)
- Testing
- IRRAflow with Active Fluid Exchange System, External Ventricular Drain
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Ohio State University
Preterm Birth Complication, Neonatal Morbidity and Mortality
Delayed Versus Immediate Cord Clamping in Preterm Birth
The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth.
- Conditions
- Preterm Birth Complication, Neonatal Morbidity and Mortality, Cord Clamping, Delayed Cord Clamping
- Trial name
- PREM-CORD (NCT07699666)
- Testing
- Delayed Umbilical Cord Clamping, Immediate Umbilical Cord Clamping
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Faculty of Medicine of Tunis
Hemorrhage, Premature Infants
NIRS Monitoring in Premature Infants
This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for…
- Conditions
- Hemorrhage, Premature Infants, Newborn, Hydrocephalus
- Trial name
- NCT02601339
- Testing
- ETV/CPC
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Clarify the Therapeutic Differences Between Robot Assisted Endoscopic Clearance and Traditional Puncture and External Drainag
Effect of Minimally Invasive Surgical Assisted by Robots on Intraventricular Hemorrhage
Clarify the therapeutic differences between robot assisted endoscopic clearance and traditional puncture and external drainage, and establish a new minimally invasive surgical diagnosis and treatment strategy for intraventricular…
- Trial name
- NCT06486480
- Testing
- Using robot assisted endoscopy to clear intraventricular hemorrhage
- Volunteers
- 143 people
- Sponsor
- Jin Hu
Intraventricular Hemorrhage, Cerebral Hemorrhage
Early Lumbar Drainage for Intraventricular Hemorrhage
This is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial in Chinese patients with intraventricular hemorrhage (IVH), comparing early lumbar drainage added to standard care with standard care…
- Trial name
- LD-IVH (NCT07625449)
- Testing
- Control treatment plus lumbar drainage, Control treatment schedule
- Where
- 31 sites in China
- Volunteers
- 392 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Intraventricular Hemorrhage of Prematurity
Outcome of Intraventricular Hemorrhage in Preterm Infants
To determine the incidence and grading of IVH among preterm neonates in the NICU. To identify maternal and neonatal risk factors associated with IVH.
- Trial name
- NCT07198360
- Testing
- No intervention
- Volunteers
- 300 people
- Sponsor
- Assiut University
Intraventricular Hemorrhage
rhTNK-tPA Thrombolytic Removal of Intraventricular Hemorrhage
The purpose of this pilot study is to determine the safety and optimal dose of clot lysis with rhTNK-tPA for intraventricular hemorrhage, using stereotactic guidance for extraventricular drain placement.
- Trial name
- NCT06814964
- Testing
- Low dose group, Medium dose group, High dose group
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage, Intracerebral Haemorrhage
International Care Bundle Evaluation in Cerebral Hemorrhage Research
Spontaneous intracerebral haemorrhage (ICH) accounts for approximately 10-15% of all strokes but stands for 50% of stroke-related morbidity and mortality.
- Conditions
- Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke
- Trial name
- I-CATCHER (NCT06429332)
- Testing
- Reversal of Oral anticoagulation within 30 minutes, Early intensive blood pressure lowering, Treatment of pyrexia
- Where
- 54 sites in United States, Australia and 6 more
- Volunteers
- 3,500 people
- Sponsor
- Region Skane
Extreme Prematurity, Intraventricular Hemorrhage
Single-dose Prophylactic INdomethacin in Extremely Preterm Infants
In Canada, about 900 babies each year are born very early (<26 weeks of gestation) and have a high chance of dying or having a serious bleed in the brain.
- Conditions
- Extreme Prematurity, Intraventricular Hemorrhage, Morbidity;Newborn
- Trial name
- SPIN (NCT06572917)
- Testing
- Indomethacin
- Where
- 15 sites in United States, Australia and 1 more
- Volunteers
- 500 people
- Sponsor
- University of British Columbia
Intensive Care Unit, Intraventricular Hemorrhage
Prediction of Undesired Obstruction in External Ventricular Drains.
Acute obstructive hydrocephalus often complicates intraventricular hemorrhage (IVH). The insertion of an external ventricular drain (EVD) is typically necessary in order to alleviate intracranial pressure by draining excess…
- Conditions
- Intensive Care Unit, Intraventricular Hemorrhage, External Ventricular Drain
- Trial name
- EVD-OBS (NCT06466811)
- Testing
- Patients of intensive care unit, Patients of surgical intensive care unit
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Nantes University Hospital
Intraventricular Hemorrhage of Prematurity
Safety of Erythropoietin and Melatonin for Very Preterm Infants With Intraventricular Hemorrhage
Very preterm infants are prone to numerous medical complications with lifelong impact. Amongst the most serious neurologically are white matter injury (WMI), intraventricular hemorrhage (IVH) and the subsequent progression to…
- Trial name
- SCEMPI (NCT05617833)
- Testing
- MLT+EPO
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Intraventricular Hemorrhage of Prematurity, Hydrocephalus
Light Therapy Device for Neonatal Intraventricular Hemorrhage Grade 3 and 4
The primary purpose of this study is to serve as a pilot study of the EFIL device treatment feasibility of IVH grades 3,4 to guide development of a larger trial.
- Trial name
- EFIL (NCT06797219)
- Testing
- Low Level Laser Therapy for Intraventricular Hemorrhage of Prematurity
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Rutgers, The State University of New Jersey
Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
Cerebral/Cortical Visual Impairment (CVI) is the leading cause of childhood visual impairment in the United States and other industrialized countries.
- Trial name
- CVI (NCT07275021)
- Testing
- Prospective Clinical and Neurodevelopmental Data Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
ICH - Intracerebral Hemorrhage, IVH- Intraventricular Hemorrhage
Placing External Ventricular Drains Using Assistive Augmented Reality or Image-Based Localization
The goal of this clinical trial is to assess if EVD placement using augmented reality is non inferior to image-guidance systems for assistance in adult patients needing an EVD for spontaneous ICH with IVH or severe TBI.
- Conditions
- ICH - Intracerebral Hemorrhage, IVH- Intraventricular Hemorrhage, TBI Traumatic Brain Injury
- Trial name
- PEARL (NCT07042048)
- Testing
- EVD placement - image-guidance assisted, EVD placement - AR assisted
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cooper Norcross Health
Intracerebral Hemorrhage, Subarachnoid Hemorrhage
Improving Outcomes for Patients With Life-Threatening Neurologic Illness
Background: While the intensive care of patients with life-threatening brain illnesses has advanced tremendously, a large number of therapies are still without proper scientific support.
- Conditions
- Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Intraventricular Hemorrhage, Nontraumatic Haemorrhage
- Trial name
- REACH (NCT04189471)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Maryland, Baltimore
Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD)
The Correlation Between Red Cell Transfusion and Complications of Prematurity
The aim of this clinical trial is to learn if there is a correlation between the erythrocyte transfusion in the early neonatal period in premature infants and early and late complications of prematurity.
- Conditions
- Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD), Enterocolitis, Necrotizing, Intraventricular Hemorrhage Neonatal
- Trial name
- NCT07123948
- Testing
- Wechsler Intelligence Test, performed by educated psychologists
- Where
- Croatia
- Volunteers
- 128 people
- Sponsor
- Clinical Hospital Center Rijeka
Basal Ganglia Hemorrhage, Intraventricular Hemorrhage
RAINBOW-ICH Trial of AI Guided Minimally Invasive Neurosurgery for ICH
Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke, with high rates of death and disability worldwide. Despite advances in medical and surgical care, effective therapeutic options remain limited.
- Conditions
- Basal Ganglia Hemorrhage, Intraventricular Hemorrhage, Brainstem Stroke, Intracranial Hemorrhage, Spontaneous
- Trial name
- RAINBOW-ICH (NCT07205263)
- Testing
- AI-assisted robotic-guided endoscopic hematoma evacuation, Conventional craniotomy, AI-assisted robotic-guided puncture and hematoma evacuation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intraventricular Hemorrhage, Lumbar Drainage
Lumbar Drainage of Intraventricular Hemorrhage
Intracerebral hemorrhage (ICH) is a debilitating and fatal disease, especially when the hemorrhage is also entering the cerebral ventricles leading to acute hydrocephalus.
- Conditions
- Intraventricular Hemorrhage, Lumbar Drainage, External Ventricular Drainage
- Trial name
- DRAIN IVH (NCT06510842)
- Testing
- External drainage of intraventricular hemorrhage
- Where
- 12 sites in Germany
- Volunteers
- 354 people
- Sponsor
- University Hospital Heidelberg