Clinical trials: IgG4-Related Diseases
Autoimmune Diseases
Treatment Strategies for IgG4-RD Patients With Internal Organ Involvement
This study has been designed as a 18-month, open-label randomized controlled clinical trial. The study aims to compare the efficacy and safety of two treatment strategies in active IgG4-RD patients with internal organ involvement…
- Trial name
- NCT05789017
- Testing
- Prednisone and Mycophenolate Mofetil, Mycophenolate Mofetil, Leflunomide
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Rare Diseases, Amyloidosis
Institutional Registry of Rare Diseases
The goal of this observational study is to create a single macro registry system with data collection on common clinical features, grouping the different rare diseases (RD).
- Conditions
- Rare Diseases, Amyloidosis, Sarcoidosis, Phacomatosis
- Trial name
- NCT06573723
- Where
- Argentina
- Volunteers
- 380 people
- Sponsor
- Hospital Italiano de Buenos Aires
IgG4-related Disease
A Prospective Cohort Study of IgG4RD in China
This is an cohort study to investigate the disease course and treatment response of patients with IgG4-related disease.
- Trial name
- NCT01670695
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Autoimmune Disease
18F-FDG PET/CT for IgG4-Related Disease
This is an open-label study to investigate the diagnostic performance of 18F-FDG PET/CT (positron emission tomography/computed tomography) in evaluation of patients with IgG4-related disease.
- Trial name
- NCT01665196
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
IgG4 Related Disease
An Exploratory Clinical Study on the Safety and Efficacy of CD19/BCMA CAR-NK in the Treatment of Relapsed and Refractory IgG4-related Disease
A single arm, open-label pilot study is designed to determine the safety and effectiveness of CD19/BCMA CAR NK cells (KN5601) in patients with IgG4 related diseases.
- Trial name
- NCT07298590
- Testing
- CD19/BCMA CAR NK
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Changhai Hospital
IgG4-RD
Study to Evaluate the Effect of XmAb®5871 on Disease Activity in Patients With IgG4-Related Disease (RD)
The purpose of this Phase 2 study is to investigate the effect of XmAb5871 on IgG4-Related Disease (RD) activity
- Trial name
- NCT02725476
- Testing
- XmAb5871
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Xencor, Inc.
IgG4 Related Disease
A Randomized Controlled Study of the Efficacy and Safety of Lenalidomide in the Treatment of Active IgG4-related Disease
For patients with active proliferative IgG4-RD, we plan to conduct a 52-week prospective randomized controlled trial to compare the efficacy and safety of 5mg lenalidomide plus prednisone, 10mg lenalidomide plus prednisone, and…
- Trial name
- IgG4-RD (NCT07068165)
- Testing
- 5mg lenalidomide, 10mg lenalidomide, Prednisone monotherapy
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Peking Union Medical College Hospital
IgG4-related Disease
Safety and Efficacy of Abatacept in IgG4-Related Disease
This is a Phase 2, single center, proof of concept clinical trial in subjects with active IgG4-Related Disease (IgG4-RD). Approximately 10 subjects with active IgG4-RD will be enrolled into this study.
- Trial name
- NCT03669861
- Testing
- Abatacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Autoimmune Disease
Study of Treatment Response on IgG4 Related Disease (IgG4RD)
This is an open-label randomized controlled trial to compare the efficacy of Prednisone alone and combination therapy of Prednisone and Mycophenolate mofetil in IgG4RD patients.
- Trial name
- NCT02458196
- Testing
- Prednisone, Prednisone and Mycophenolate mofetil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Autoimmune Pancreatitis, IgG4-Related Diseases
Validation of the Odesa Criteria 2026 for Autoimmune Pancreatitis
This ambispective observational study aims to validate the Odesa Criteria 2026 (OC26), a flexible domain-based point scoring system for diagnosing autoimmune pancreatitis.
- Conditions
- Autoimmune Pancreatitis, IgG4-Related Diseases, Pancreatic Cancer, Chronic Pancreatitis
- Trial name
- ОС26 (NCT07536841)
- Testing
- No intervention (observational study)
- Where
- 2 sites in Ukraine
- Volunteers
- 82 people
- Sponsor
- Military Medical Clinical Center of the Southern Region, Ukraine
IgG4-related Disease
Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease
IgG4-related disease is a rare and very recently identified pathology, whose frequency is certainly underestimated. The clinical presentation varies among affected organs, and most often, patients have at least three organ…
- Trial name
- G4-FH (NCT02899039)
- Testing
- extra blood draw samples
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
IgG4 Related Disease
A Phase 3 Study of Obexelimab in Patients With IgG4-Related Disease
This study aims to examine the efficacy and safety of obexelimab for the prevention of flare of IgG4-related disease (IgG4-RD)
- Trial name
- INDIGO (NCT05662241)
- Testing
- Obexelimab
- Where
- 65 sites in United States, Argentina and 13 more
- Volunteers
- 194 people
- Sponsor
- Zenas BioPharma (USA), LLC
IgG4-Related Diseases
A Study on the Effect of MRD Detected by FAPI PET / CT on the Recurrence of IgG4-RD
This study intends to use the new technology of fibroblast activation protein PET / CT to study whether the tiny residual lesions detected by 68Ga-FAPI PET / CT are related to the recurrence of IgG4-RD in patients with IgG4-RD…
- Trial name
- NCT07104058
- Testing
- 68Ga-FAPI PET / CT
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Luo Yaping
IgG4-related Disease
Short-term Glucocorticoid Combined with MMF for IgG4-RD
Comparison of short-term glucocorticoid monotherapy and short-term glucocorticoid combined with MMF in the treatment of IgG4 Related Disease
- Trial name
- NCT06663618
- Testing
- prednison, Mycophenolate mofetil
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Wen Zhang
IgG4 Related Disease, Covid19
Impact of COVID-19 on the Clinical Outcomes and Management of IgG4 Related Disease Patients
Since December 2019, coronavirus disease 2019 (COVID-19), caused by the severe respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected more than 124 million people worldwide as of 23/3/2021.
- Trial name
- IgG4-COVID (NCT04817553)
- Testing
- exposure to COVID19
- Where
- Hong Kong
- Volunteers
- 124 people
- Sponsor
- Chinese University of Hong Kong
Autoimmune Disease
Leflunomide Treatment for IgG4-RD
This study is an open-label randomized controlled trial aiming to investigate whether the efficacy and side effect of Leflunpomide plus glucocorticoid.
- Trial name
- NCT03715699
- Testing
- Prednisone, Prednisone and Leflunomide
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking Union Medical College Hospital
IgG4-related Disease With Eosinophilia
Baricitinib Plus Glucocorticoid for Eosinophilia in IgG4-RD
Evaluation of efficacy and safety of Baricitinib combined with glucocorticoid in patients of IgG4-related disease with eosinophilia.
- Trial name
- NCT05781516
- Testing
- Prednisolone, Baricitinib
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Wen Zhang