Clinical trials: IgG4-related Disease
Autoimmune Diseases
Withdraw Drug in Stable IgG4-Related Disease
Evaluation and prediction of relapse risk after glucocorticoid or immunosuppressant withdrawal in patients with stable IgG4 related disease: a prospective cohort study from china.
- Trial name
- NCT04124861
- Testing
- Drug free, IS monotherapy and GC combined with IS
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Peking Union Medical College Hospital
Lupus Nephritis, IgG4-related Disease
Safety and Efficacy of PRG-2311 for Refractory Lupus Nephritis and IgG4-Related Disease
A Clinical Study on the Safety and Effectiveness of CD19/BCMA Chimeric Antigen Receptor T Cells in the Treatment of Refractory Lupus Nephritis and IgG4-Related Disease.
- Trial name
- NCT06497361
- Testing
- PRG-2311
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Rheumatoid Arthritis, Lupus Erythematosus, Systemic
Meir Medical Center Rheumatologic Biobank
Serum, synovial fluid and skin biopsies from patients will be collected to the biobank with rheumatoid diseases. These samples will later be used for clinical and basic research, following approval of each specific study by the…
- Conditions
- Rheumatoid Arthritis, Lupus Erythematosus, Systemic, Systemic Sclerosis, IgG4-related Disease
- Trial name
- NCT03473912
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Meir Medical Center
IgG4-related Disease
Belimumab Treatment for IgG4-related Disease
Even though glucocorticoid is the current first line medication for IgG4-RD, it is well accepted in the field that excessive dosage of GC, especially accumulative dosage, is associated with increasing organ damage.
- Trial name
- NCT04660565
- Testing
- Prednisone and Belimumab, Prednisone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
IgG4-Related Diseases
A Study on the Effect of MRD Detected by FAPI PET / CT on the Recurrence of IgG4-RD
This study intends to use the new technology of fibroblast activation protein PET / CT to study whether the tiny residual lesions detected by 68Ga-FAPI PET / CT are related to the recurrence of IgG4-RD in patients with IgG4-RD…
- Trial name
- NCT07104058
- Testing
- 68Ga-FAPI PET / CT
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Luo Yaping
IgG4-related Disease, Aortic Aneurysm
A Laboratory Scan of Patients With Aortic Aneurysms to IgG4 Levels in the Blood
IgG4 Related Disease is a multi-systemic fibroenophilic disease that includes a basket of recently discovered medical conditions.
- Trial name
- NCT03267875
- Testing
- Blood Test
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Meir Medical Center
Immunoglobulin G4 Related Disease
Open Label Two-Arm Study to Evaluate Rilzabrutinib in IgG4-Related Disease Participants
This is a Phase 2a, multi-center, open-label, two-arm study of approximately 25 patients with active IgG4-related disease (IgG4-RD).
- Trial name
- NCT04520451
- Testing
- rilzabrutinib, Glucocorticoids
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 27 people
- Sponsor
- Principia Biopharma, a Sanofi Company
IgG4 Related Disease
A Phase 3 Study of Obexelimab in Patients With IgG4-Related Disease
This study aims to examine the efficacy and safety of obexelimab for the prevention of flare of IgG4-related disease (IgG4-RD)
- Trial name
- INDIGO (NCT05662241)
- Testing
- Obexelimab
- Where
- 65 sites in United States, Argentina and 13 more
- Volunteers
- 194 people
- Sponsor
- Zenas BioPharma (USA), LLC
Primary Sclerosing Cholangitis, IgG4-related Sclerosing Cholangitis
Multicenter Observational Study of PSC and IgG4-SC in China
The investigators aimed to collect demographic features and clinical outcomes in patients diagnosed with PSC and IgG4-SC by utilizing participants database from multiple medical centers across Mainland China.
- Trial name
- NCT05463445
- Testing
- Only observation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- RenJi Hospital
IgG4-Related Disease
A Study of IMM0306 in IgG4-Related Disease
The goal of this clinical trial is to learn if IMM0306 works to reduce the risk of disease relapse in participants with IgG4-related disease (IgG4-RD). It will also learn about the safety and tolerability of IMM0306.
- Trial name
- NCT07621939
- Testing
- IMM0306
- Volunteers
- 125 people
- Sponsor
- ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
IgG4-related Disease
Characterizing IgG4-RD With 68Ga-FAPI PET/CT
68Ga-FAPI has been developed as a tumor-targeting agent as fibroblast activation protein is overexpressed in cancer-associated fibroblasts and some inflammation,such as IgG4-related disease.And it might be more sensitive than FDG…
- Trial name
- NCT04125511
- Testing
- 68Ga-FAPI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
IgG4 Related Disease
Tripterygium Wilfordii Plus Prednisone for Active IgG4-Related Disease
The goal of this clinical trial is to learn if tripterygium wilfordii added to prednisone can treat active IgG4-related disease (IgG4-RD) in adults 45 to 80 years of age. Women in the study must be postmenopausal.
- Trial name
- NCT07878585
- Testing
- Prednisone, tripterygium wilfordii
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Peking Union Medical College Hospital
Autoimmune Diseases
Treatment Strategies for IgG4-RD Patients With Internal Organ Involvement
This study has been designed as a 18-month, open-label randomized controlled clinical trial. The study aims to compare the efficacy and safety of two treatment strategies in active IgG4-RD patients with internal organ involvement…
- Trial name
- NCT05789017
- Testing
- Prednisone and Mycophenolate Mofetil, Mycophenolate Mofetil, Leflunomide
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Immunoglobulin G4-Related Disease, Janus Kinase Inhibitors
Tofacitinib in the Treatment of IgG4 Related Diseases
This study is a single centre, open label, randomized controlled study to compare the efficacy and safety between steroids plus tofacitinib and steroids alone in active IgG4-related diseases patients.
- Trial name
- NCT07827469
- Testing
- Tofacitinib 5mg Oral Tablet, Prednisone 5mg
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Peking University People's Hospital
Relapsed/Refractory Systemic Lupus Erythematosus (r/r SLE), Relapsed/Refractory IgG4-Related Disease (r/r IgG4-RD)
A Clinical Study to Evaluate LVIVO-TaVec400 for the Treatment of Relapsed/Refractory Autoimmune Diseases
This is a prospective, single-arm, open-label dose-escalation clinical study to evaluate LVIVO-TaVec400 in the treatment of relapsed/refractory autoimmune diseases.
- Conditions
- Relapsed/Refractory Systemic Lupus Erythematosus (r/r SLE), Relapsed/Refractory IgG4-Related Disease (r/r IgG4-RD), Progressive Multiple Sclerosis (PMS), Relapsed/Refractory Myasthenia Gravis(r/r MS)
- Trial name
- NCT07583030
- Testing
- LVIVO-TaVec400 product
- Where
- 4 sites in China
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
IgG4-related Disease
A Study of Efgartigimod in Patients With IgG4-Related Disease
The goal of this clinical trial is to learn if efgartigimod can treat IgG4-related disease in adults. The main questions it aims to answer are: In patients with IgG4-related disease, does treatment with efgartigimod reduce the…
- Trial name
- NCT07025330
- Testing
- Efgartigimod
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
IgG4-related Disease
Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease
IgG4-related disease is a rare and very recently identified pathology, whose frequency is certainly underestimated. The clinical presentation varies among affected organs, and most often, patients have at least three organ…
- Trial name
- G4-FH (NCT02899039)
- Testing
- extra blood draw samples
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
IgG4-related Disease
Plasmablast Detection From IgG4-Related Disease Patients
IgG4-related disease (IgG4-RD) is an immune-mediated, fibro-inflammatory disease that leads to tissue damage, organ dysfunction and, if untreated, to organ failure.
- Trial name
- NCT03466970
- Where
- 2 sites in Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center