Clinical trials: Ileus
Chronic Intestinal Pseudo-obstruction
Efficacy and Safety of Rifaximin for Patients With Chronic Intestinal Pseudo-obstruction: a Phase 2 Trial
The objective of the study is to investigate efficacy and safety of rifaximin (L-105) in patients with chronic idiopathic intestinal pseudo-obstruction(CIIPO) or patients with chronic intestinal pseudo-obstruction (CIPO)…
- Trial name
- NCT04118699
- Testing
- Rifaximin oral tablet
- Where
- Japan
- Volunteers
- 12 people
- Sponsor
- Yokohama City University
Postoperative Ileus
Goal Directed Fluid Therapy and Postoperative Ileus
Despite Goal Directed Fluid Therapy (GDFT) has shown a reduction of hospitalization and overall complications in patients undergoing abdominal surgery, there is a need to address the effect of implementing GDFT on the incidence…
- Trial name
- NCT01818375
- Testing
- Goal Directed Fluid Therapy (GDFT)-Esophageal doppler guided, Standard fluid therapy
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- Gabriele Baldini, MD, MSc, Assistant Professor
Postoperative Ileus
A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy
This study is being conducted to determine whether alvimopan can accelerate recovery of gastrointestinal function following radical cystectomy when compared with a placebo.
- Trial name
- NCT00708201
- Testing
- Alvimopan
- Where
- 20 sites in United States
- Volunteers
- 280 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Colorectal Cancer, Surgery
Trial of Chewing Gum to Reduce Post Operative Ileus in Elective Colorectal Surgery
It is unknown whether post operative chewing gum will reduce post operative ileus. This study is a randomised controlled trial that will determine whether chewing gum three times a day following surgery will reduce post operative…
- Trial name
- NCT02372500
- Testing
- Chewing gum
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Countess of Chester NHS Foundation Trust
Stoma Ileostomy, Stoma Colostomy
Conventional Hand Sewn End-To-End Anastomosis Versus Side-To-Side Anastomosis for Stoma Reversal: A Prospective Study
The goal of this clinical trial is to compare approaches to enterostomy reversal by hand-sewn end-to-end anastomosis versus side-to-side anastomosis (sub-divided into hand-sewn side-to-side anastomosis and stapled side-to-side…
- Conditions
- Stoma Ileostomy, Stoma Colostomy, Anastomosis, Ileus
- Trial name
- NCT05753709
- Testing
- Hand sewn end-to-end anastomosis, Hand sewn side-to-side anastomosis, Stapled side-to-side anastomosis
- Where
- India
- Volunteers
- 38 people
- Sponsor
- Sawai Mansingh Medical College
Post-operative Ileus
G-Tech Feasibility Study for Early Detection of a Post-op Ileus
This feasibility study is for the purpose of determining if the G-Tech Device can differentiate between normal return of GI activity post-operatively and the myoelectric activity in patients who develop a POI.
- Trial name
- GTECHPOI (NCT02673671)
- Testing
- G-Tech Myoelectric recording device
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- G-Tech Corporation
Ileus
A New Approach of Neostigmine in Unavoidable Post Operative Ileus
Postoperative ileus (POI) in the absence of any mechanical obstruction remains a commonly encountered clinical problem.So, this study aimed to show the effective way to decrease the rate of postoperative Ileus (POI).
- Trial name
- NCT00676377
- Testing
- Neostigmine, Saline
- Where
- Iran
- Volunteers
- 3 people
- Sponsor
- Baqiyatallah Medical Sciences University
Ileus, Fusion of Spine
The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus
Postoperative ileus and opioid induced constipation are well-known post-operative complications. Previously, research has shown that using peripherally acting opioid antagonists can help alleviate the condition.
- Trial name
- FusionIleus (NCT03176316)
- Testing
- Naloxone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Loyola University
Obstruction, Cancer
Intravenous Nutrition in Hospitalized Patients: Comparison of Two Oils
Intravenous nutrition is an important therapy for the recovery of many patients. It is indicated when the patients cannot take food by mouth or use their intestines for feeding.
- Conditions
- Obstruction, Cancer, Ileus, Malnutrition
- Trial name
- NCT01943409
- Testing
- Intralipid, ClinOleic
- Where
- Canada
- Volunteers
- 303 people
- Sponsor
- Johane Allard
Ileus, Small Bowel Obstruction
Development of a Patient Reported Outcome Measure for GastroIntestinal Recovery
People who undergo surgery, or develop intestinal obstruction will spend a period of time without normal bowel function. This might extend beyond the normal measures of passage of flatus or tolerance of diet.
- Conditions
- Ileus, Small Bowel Obstruction, Intestinal Failure
- Trial name
- PRO-diGI (NCT05315765)
- Where
- United Kingdom
- Volunteers
- 560 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Postoperative Ileus
Safety and Efficacy of IV Infusion of TZP-101 for POI After Major Open Abdominal Surgery
The purpose of this study is to determine whether TZP-101 is effective in the management of post operative ileus in subjects undergoing major open abdominal surgery (i.e. partial large bowel resection).
- Trial name
- NCT00617552
- Testing
- 5% dextrose in water, TZP-101
- Where
- 27 sites in United States, India and 1 more
- Volunteers
- 267 people
- Sponsor
- Tranzyme, Inc.
Postoperative Ileus
The Effect of Acupoint Application on Postoperative Ileus
This study aims to verify the therapeutical effect and mechanism of acupoint application on postoperative ileus.
- Trial name
- NCT04008667
- Testing
- Acupoint application, Fake acupoint application
- Where
- China
- Volunteers
- 540 people
- Sponsor
- li xiong
Postoperative Ileus
The Effect of Coffee Consumption in Enhancing Recovery of Bowel Function Following Colorectal Surgery.
The effects of coffee have been shown to act as a colonic stimulant. Caffeinated coffee stimulates colonic activity, most notably in the transverse/descending colon, in magnitude similar to a meal, 60% stronger than water, and…
- Trial name
- NCT02639728
- Testing
- Regular Coffee, Decaffeinated coffee, Warm water
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Cedars-Sinai Medical Center
Anesthesia, General Anesthesia
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia
- Trial name
- RUMBLE (NCT04144933)
- Testing
- Acetaminophen, Gabapentin, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Dexamethasone, Ondansetron
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Gallbladder Diseases
Cholecystoduodenal Fistula With and Without Gallstone Ileus
Observative and descriptive study of 10 patients, which were diagnosed with a Cholecystoduodenal fistula, All electronic medical records were retrospectively reviewed.
- Trial name
- NCT03888976
- Testing
- Cholecystectomy
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Tecnologico de Monterrey
Postoperative Ileus
Does Bowel Stimulation Before Loop Ileostomy Closure Reduce Postoperative Ileus?
Postoperative ileus is the most commonly observed morbidity following ileostomy closure. Studies have previously demonstrated that the defunctionalized bowel of a loop ileostomy undergoes a series of functional and structural…
- Trial name
- NCT02559635
- Testing
- Bowel stimulation, Nestle Resource
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- Jewish General Hospital
Acupressure, Post-Op Complication
Effect of Acupressure on Recovery of Bowel Function in Patients Post Cesarean Section
Research objectives To compare the efficacy of acupressure with no acupressure to examine time to first flatus in patient post cesarean section ; Acupressure at ST-36 Zusanli (lateral to anterior crest of tibia, in the tibialis…
- Conditions
- Acupressure, Post-Op Complication, Cesarean Section, Bowel Ileus
- Trial name
- NCT04620850
- Testing
- Acupressure
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Postoperative Ileus
Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section
Postoperative ileus is a perplexing problem for clinical surgeons. It occurs not only after abdominal surgery but also after any surgery that requires general anesthesia.
- Trial name
- NCT05654649
- Testing
- 0.9%sodium chloride, Dexamethasone
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Postoperative Ileus
The Effect of Coffee After Resection of Small Bowel
Post-operative ileus ("post-op ileus") is a condition which can occur after surgery. This means that the bowels stop working correctly and food and liquids will not pass through in the normal manner.
- Trial name
- NCT03143621
- Testing
- Coffee, Water
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Mount Carmel Health System
PIPO
Role of ACTG2 Variants in Smooth Muscle Determination and Function in Pediatric Intestinal Pseudo-obstruction.
The primary objective of this study is to describe the transcriptional impact of R178, R257, R40 or A136 variants of the ACTG2 gene on iPS differentiation mechanisms up to organoids derived from PIPO patient samples versus those…
- Trial name
- SMOOTH-PIPO (NCT06687564)
- Testing
- Biopsy
- Where
- 3 sites in France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Grenoble