Clinical trials: Ileus
Small Bowel Obstruction
Early Small Bowel Obstruction Following Laparotomy For Trauma
The formation of intraperitoneal adhesion following abdominal surgery is accepted by clinicians as an inevitable consequence. More than 90% of patients undergoing a surgical procedure in the abdomen will develop intraperitoneal…
- Trial name
- NCT01068340
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- University of Southern California
Hernia, Ventral, Ileus
The Impact of Sugammadex on Ileus After Abdominal Wall Reconstruction
The aim of the study is to determine if the usage of sugammadex would reduce the time to return of bowel function when compared to standard of care (neostigmine/glycopyrrolate) when used for neuromuscular blockade reversal in…
- Trial name
- NCT05985343
- Testing
- Neostigmine / Glycopyrrolate, Sugammadex
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Clayton Petro
Delay in GI Recovery/Postoperative Ileus (POI)
TU-100 for Accelerating GI Recovery After Major Abdominopelvic Surgery (RC & CAWR)
This Phase 2, multicenter, randomized, double-blind, placebo-controlled master protocol study will evaluate the safety and efficacy of TU-100, adjunctive to an Enhanced Recovery After Surgery (ERAS) pathway, for accelerating…
- Trial name
- NCT07765589
- Testing
- TU-100
- Volunteers
- 240 people
- Sponsor
- Tsumura USA
Colon Cancer, Splenic Flexure Mobilization
Surgical Outcomes in Splenic Flexure Cancers: A Multicenter Comparison of Segmental vs. Extended Hemicolectomy (SPARROW Study)
SPARROW Study: Surgical Outcomes in Splenic Flexure Cancer Colonic cancers located at the splenic flexure where the transverse colon turns into the descending colon are uncommon and represent less than 10% of all colorectal…
- Conditions
- Colon Cancer, Splenic Flexure Mobilization, Right Hemicolectomy, Left Hemicolectomy
- Trial name
- SPARROW (NCT07289568)
- Testing
- Colectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Acibadem University
Ileus, Gastrointestinal Dysfunction
Alvimopan as a Rescue Treatment of Postoperative Ileus
This study aims to evaluate the cost effectiveness of Alvimopan as rescue therapy in patients undergoing colorectal or small bowel resection who develop POI, and its safety and effectiveness in reducing LOS and POI duration.
- Trial name
- NCT04405037
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Scott Steele
Abdominal Cancer
Effects of Rocking on Postoperative Ileus Duration Study
Primary Objective: 1. Compare the duration of postoperative ileus (POI) duration (time to first flatus), subjective reports of surgical and gas pain, postoperative pain medication (total milligrams per 24 hours) and postoperative…
- Trial name
- NCT00494806
- Testing
- Rocking Chair Intervention
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- M.D. Anderson Cancer Center
Ileus, Ogilvie Syndrome
Therapeutic Oxygen for Gastrointestinal Atony (TOGA)
This study is a non invasive study to see if 100% oxygen therapy will help to resolve an intestinal obstruction.
- Conditions
- Ileus, Ogilvie Syndrome, Small Bowel Obstruction
- Trial name
- TOGA (NCT03386136)
- Testing
- 100% Oxygen
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Florida
Postoperative Ileus
A Study in Healthy Male Subjects Designed to Assess the Mass Balance Recovery and Pharmacokinetics of 14C TZP-101
A study to investigate the mass balance recovery and pharmacokinetics of 14C TZP-101.
- Trial name
- NCT01668199
- Testing
- TZP-101
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Norgine
Postoperative Ileus
Gastric Volume and Colorectal Surgery
Postoperative ileus (POI) is a serious complication after colorectal surgery. One of its most frequent consequences is the replacement of nasogastric tube because of the vomiting.
- Trial name
- EVOL (NCT04461067)
- Testing
- ultrasonography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Ileus
Subcutaneous Electrical Stimulation in the Prevention of Postoperative Ileus
Assess whether the application of electrical stimulation in patients undergoing subcutaneous colon cancer in a Multimodal Rehabilitation Program (Fast track) decreases the incidence of postoperative ileus, improving the results…
- Trial name
- SESPI (NCT02399605)
- Testing
- Stimulation
- Where
- 2 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Hospital General Universitario Elche
Pain, Postoperative, Anesthesia Complication
Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia
The use of opioid during surgery can cause side effects and may delay hospital discharge. Some studies have shown balanced sparing opioid anesthesia can optimize the side effects and and the time of discharge.
- Conditions
- Pain, Postoperative, Anesthesia Complication, Nausea, Vomiting
- Trial name
- GALOFF (NCT02953210)
- Testing
- dexter ketamine, Lidocaine Hydrochloride, Fentanyl Hydrochloride
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Meconium Ileus
Impact of Visceral Osteopathic Treatment on Meconium Evacuation in Preterm Infants
Timing of the first and last meconium stool is critical for oral feeding tolerance and proper gastrointestinal function. The time until premature infants pass their first meconium ranges from 1 hour to 27 days (median: 43 hours).
- Trial name
- NCT02140710
- Testing
- Osteopathic treatment
- Where
- Austria
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Postoperative Ileus, Caffeine
Can Coffee/Caffeine Improve Post-Operative Gastrointestinal Recovery
Disruption of the normal gastrointestinal (GI) motility is a well-known consequence of major surgery. The pathophysiology behind this phenomenon is not fully understood but involves the autonomic nervous system as well as a…
- Trial name
- NCT04547868
- Testing
- Coffee, Decaffeinated Coffee, Warm water
- Where
- 3 sites in Canada
- Volunteers
- 174 people
- Sponsor
- Sunnybrook Health Sciences Centre
Post-Operative Ileus
Asimadoline for the Treatment of Post-Operative Ileus
The purpose of this study is to evaluate the safety and efficacy of asimadoline in patients who have undergone a laparoscopic segmental colectomy and determine whether it reduces the time to recovery of bowel function compared to…
- Trial name
- NCT00443040
- Testing
- Asimadoline
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- Tioga Pharmaceuticals
Bowel Ileus, Cesarean Section Complications
Effect of Chewing Gum and Drinking Fennel Tea
Aim: Postoperative ileus after cesarean section is a problem that significantly prolongs hospital stay and increases perioperative costs.
- Trial name
- NCT06403215
- Testing
- Chewing gum group, Fennel tea group, Chewing gum+Fennel tea group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Marmara University
Post-Operative Ileus (POI)
At-Home Bowel Stimulation
Postoperative ileus (POI) is a common complication after ileostomy closure and is associated with patient discomfort, delayed return of bowel function, prolonged hospital stay, and increased healthcare costs.
- Trial name
- NCT07574437
- Testing
- At-home bowel stimulation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The Cleveland Clinic
Rectal Cancer Surgery, Middle and Low Rectal Cancer
Pelvic Floor Peritoneal Closure to Prevent Postoperative Ileus in Mid-Low Rectal Cancer Surgery
The goal of this clinical trial is to determine whether closing the pelvic floor peritoneum during laparoscopic radical resection of mid-low rectal cancer can reduce the incidence of postoperative ileus.
- Conditions
- Rectal Cancer Surgery, Middle and Low Rectal Cancer, Intestinal Obstruction, Ileus
- Trial name
- TOWER-1 (NCT07432542)
- Testing
- Pelvic floor peritoneum reconstruction
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Sun Yat-sen University
Postoperative Ileus
Pilot Study: Anti-inflammatory Effect of Peroperative Stimulation of the Vagus Nerve
Hypothesis: Electrical stimulation of the abdominal vagus nerve has an anti-inflammatory effect and represents a new therapeutic approach to shorten postoperative ileus.
- Trial name
- NCT01572155
- Testing
- Vagus stimulation 1, Vagus stimulation 2
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- KU Leuven
Patient Under Going Colorectal and Stomach Cancer Surgery
Randomized Control Trial on Seprafilm and Guardix in Preventing Ileus
The purpose of the study is to evaluate the efficacy of Seprafilm and guardix in reducing the incidence of bowel obstruction and to evaluate the incidence of all serious adverse events (SAEs) associated with the use of Seprafilm…
- Trial name
- NCT02168426
- Testing
- Guardix, Seprafilm
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Gachon University Gil Medical Center
Postoperative Ileus
Effect of TU-100 in Patients Undergoing Laparoscopic Colectomy
TU-100 is a gastrointestinal drug produced from the three botanical raw materials, Asian ginseng, Zanthoxylum fruit (Japanese pepper), and ginger, based on proprietary aqueous decoction and granulation technology.
- Trial name
- TU100P2T3 (NCT02232893)
- Testing
- Daikenchuto (TU-100)
- Where
- 13 sites in United States
- Volunteers
- 69 people
- Sponsor
- Tsumura USA