Clinical trials: Illness, Chronic
Bodily Distress Disorder Moderate, Bodily Distress Disorder Severe
Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders
The aim of this multi-center, two-armed, randomized controlled trial is to assess the effect of a novel internet-based therapist-assisted treatment program "One step at a time" designed for the treatment of patients with moderate…
- Conditions
- Bodily Distress Disorder Moderate, Bodily Distress Disorder Severe, Fibromyalgia, Chronic Fatigue Syndrome
- Trial name
- OneSTEP (NCT05525598)
- Testing
- "One step at a time", "Get started"
- Where
- Denmark
- Volunteers
- 166 people
- Sponsor
- University of Aarhus
Chronic Disease, Aging
Compassionate Communities Neighbourhood Program
This study will evaluate a Compassionate Communities-based intervention aimed at reducing social isolation by mobilizing individuals to act on their health and social needs individually, and in collaboration with fellow members…
- Trial name
- WECCC-NHB (NCT03634163)
- Testing
- Neighbourhood exchange, Quality of Life Assessment
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia
Phase 1 Study of CC-486 in Japanese Subjects With Hematological Neoplasms
To identify the maximum tolerated dose (MTD) of oral azacitidine on different treatment schedules in Japanese subjects with hematological neoplasms
- Conditions
- Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Acute Myeloid Leukemia, Multiple Myeloma
- Trial name
- NCT01908387
- Testing
- Oral azacitidine
- Where
- 3 sites in Japan
- Volunteers
- 2 people
- Sponsor
- Celgene Corporation
Pancreatitis, Chronic
Phone-based Smoking Cessation Intervention for Patients With Chronic Pancreatitis.(START)
This study aims to explore whether regular telephone intervention in patients with chronic pancreatitis can improve their smoking cessation rate.
- Trial name
- NCT05940987
- Testing
- Phone-based smoking cessation intervention
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Changhai Hospital
Pancreatic Neoplasms, Biliary Tract Neoplasms
Nonstented Stump-closed vs Duct-to-Mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy
Pancreaticojejunostomy is the key procedure of pancreaticoduodenectomy. The aim of our study is to investigate a new pancreaticojejunal (PJ) anastomosis procedure named "nonstented stump-closed pancreaticojejunostomy" in…
- Conditions
- Pancreatic Neoplasms, Biliary Tract Neoplasms, Pancreatitis, Chronic, Duodenal Neoplasms
- Trial name
- NCT01731821
- Testing
- pancreaticojejunostomy
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Fudan University
Chronic Pancreatitis
Fat Malabsorption in Chronic Pancreatitis
The objective of this study is to evaluate the malabsorption blood test (MBT), stool coefficient of fat absorption (CFA) and stool bomb calorimetry (BC) methods as potential screening or diagnostic tests for reduced exocrine…
- Trial name
- NCT02849704
- Testing
- Creon36™
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Chronic Kidney Disease, Proteinuria
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.
- Conditions
- Chronic Kidney Disease, Proteinuria, Children
- Trial name
- FIONA OLE (NCT05457283)
- Testing
- Finerenone (Kerendia, BAY94-8862)
- Where
- 151 sites in United States, Argentina and 30 more
- Volunteers
- 100 people
- Sponsor
- Bayer
Pulmonary Disease, Chronic Obstructive
Genomic/ Proteomic/ Metabonomic Profiling in Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by progressive airflow obstruction, chronic cough and dyspnoea in advanced stages. We hope to develop a better understanding of lung disease.
- Trial name
- NCT00655694
- Testing
- sputum, blood, urine, exhaled breath, lung function
- Where
- United Kingdom
- Sponsor
- Imperial College London
Chronic Kidney Disease
Efficacy Trial of N-Acetylcysteine and Sodium Bicarbonate for the Prevention of Contrast-Induced Acute Kidney Injury
Contrast-Induced Acute Kidney Injury(CIAKI) was defined as an absolute increase in serum creatinine of more than or equal to 0.3mg/dl (≥ 26.4 μmol/l), a percentage increase in serum creatinine of more than or equal to 50%…
- Trial name
- PREKIT (NCT01210456)
- Testing
- Physiological Saline, N-Acetylcysteine and Sodium Bicarbonate
- Where
- Japan
- Volunteers
- 458 people
- Sponsor
- Tokushukai Medical Group
Chronic Obstructive Pulmonary Disease, Chronic Heart Failure
Using NT-proBNP to Detect Chronic Heart Failure in Patients With Chronic Obstructive Pulmonary Disease
The aim of the present study was to evaluate if the analysis of NT-proBNP might be used as an initial step for the diagnosis of chronic heart failure in patients with COPD in primary health care, and to select patients for a…
- Trial name
- NT-proBNP (NCT01801722)
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Lund University
Chronic Hepatitis C
A Multicenter Treatment Protocol of Daclatasvir (BMS-790052) in Combination With Sofosbuvir for the Treatment of Post-Liver Transplant Subjects With Chronic Hepatitis C
The primary objective of this program is to provide DCV for 24 weeks to be given in combination with SOF to subjects with chronic hepatitis C with decompensated cirrhosis or post-liver transplant subjects with chronic hepatitis C…
- Trial name
- NCT02161939
- Testing
- Daclatasvir (BMS-790052), Sofosbuvir
- Where
- 20 sites in United States
- Sponsor
- Bristol-Myers Squibb
Chronic Obstructive Pulmonary Disease (COPD)
Developing a COPD Case Finding Methodology for Primary Care
The purpose of this qualitative work is to inform the content and structure of a new screening measure for identifying undiagnosed at-risk COPD cases in primary care and support content validity of the measure.
- Trial name
- NCT01880177
- Where
- 4 sites in United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Leukemia
Vaccine Therapy in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia
RATIONALE: Vaccines made from a peptide may help the body build an effective immune response to kill cancer cells. PURPOSE: This phase II trial is studying how well vaccine therapy works in treating patients with chronic phase…
- Trial name
- NCT00428077
- Testing
- bcr-abl peptide vaccine, reverse transcriptase-polymerase chain reaction
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- OHSU Knight Cancer Institute
COPD
COPD Exacerbations
Detecting exacerbations to prevent a severe and / or to early treat an exacerbation is crucial in patients with COPD in order to prevent hospitalization.
- Trial name
- NCT02798575
- Testing
- Astral 150 ventilator
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- RWTH Aachen University
Chronic Obstructive Pulmonary Disease, Lung Diseases, Obstructive
Impact of Multidisciplinary Care, Structured and Targeted on the COPD Patient's Clinical Pathway.
In 2020, chronic obstructive pulmonary disease (COPD) was the 4th leading cause of death worldwide. In France, its annual cost was estimated at 4366 euros per patient, including 25% related to management of exacerbations and 33%…
- Conditions
- Chronic Obstructive Pulmonary Disease, Lung Diseases, Obstructive, Lung Disease Chronic
- Trial name
- OPTI-BPCO (NCT07907601)
- Testing
- COPD targeted pharmaceutical interview and consultation, Respiratory Insufficiency Day Hospitalization, Pulmonary Function Test
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Brain and Central Nervous System Tumors, Breast Cancer
Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Conditions
- Brain and Central Nervous System Tumors, Breast Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT00019019
- Testing
- carboxyamidotriazole, paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Myelodysplastic Syndrome, Leukemia
FTS Study in Patients With Advanced Hematologic Malignancies
Primary Objective: Determining the maximum tolerated dose (MTD) and pharmacokinetics (PK) of FTS (S-Trans, Trans-Farnesylthiosalicylic Acid) after daily oral administration on Days 1 through 21 of a 28-Day cycle to patients with…
- Trial name
- NCT00867230
- Testing
- FTS
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Disease, Lung Diseases, Obstructive
Holistic Wellbeing in COPD: Communication About Sexuality (COSY)
The aim of this study is to assess the effectiveness of a communication intervention about sexuality on quality of life and other outcomes like physical activity, exercise capacity and health status in people with chronic…
- Conditions
- Chronic Disease, Lung Diseases, Obstructive, Respiratory Disease
- Trial name
- NCT05696730
- Testing
- Communication intervention about sexuality in people with COPD
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Pulmonary Disease, Chronic Obstructive
Change in Symptom and Quality of Life in COPD by Budesonide/Glycopyrronium/Formoterol Fumarate Pressurized Metered Dose Inhaler (BGF pMDI)
This study is primarily aimed to investigate whether PROs can be improved after the initiation of BGF pMDI in real world clinical settings.
- Trial name
- EBISU (NCT05219630)
- Where
- 17 sites in Japan
- Volunteers
- 106 people
- Sponsor
- AstraZeneca
Drug Use, Alcohol Use
Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
This study will assess Specialized Community Disease Management (SCDM), an intervention which employs various evidence-based strategies to engage substance using co-morbid patients while in the hospital and follow them into the…
- Conditions
- Drug Use, Alcohol Use, Congestive Heart Failure, Pneumonia
- Trial name
- NCT02059005
- Testing
- Specialized Community Disease Management, Treatment As Usual
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Treatment Research Institute
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