Clinical trials: Illness, Chronic
Chronic Obstructive Pulmonary Disease With Chronic Bronchitis
A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Study Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis
The purpose of the study is to investigate the efficacy of galvokimig versus placebo in the time to the first acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in study participants with moderate-to-severe COPD…
- Trial name
- SCALA (NCT07725939)
- Testing
- Galvokimig
- Where
- 23 sites in United States, China
- Volunteers
- 402 people
- Sponsor
- UCB Biopharma SRL
Cough, Chronic Disease
Internet-Behavioral Cough Suppression Therapy
The goal of this randomized, placebo-controlled, clinical trial is to develop and test the efficacy of an Internet-based behavioral intervention for refractory chronic cough.
- Trial name
- NCT05770401
- Testing
- Internet-Behavioral Cough Suppression Therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Montana
COPD
A Novel Incremental Step Test as an Alternative for the Assessment of Exercise Capacity in Patients With COPD
According to the official guidelines of pulmonary rehabilitation, a structured home-based approach is recommended to answer to the inadequate number of pulmonary rehabilitation services due to the chronic obstructive pulmonary…
- Trial name
- NCT04715659
- Testing
- Performance of step test (number of steps) for the assessment of exercise capacity
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Polytechnic Institute of Porto
Chronic Pancreatitis, Surgery
Robot-assisted Versus Open Lateral Pancreaticojejunostomy for the Treatment of Symptomatic Chronic Pancreatitis (PANACOTTA)
PANACOTTA is a multicenter randomized controlled trial including patients with symptomatic chronic pancreatitis and a dilated main pancreatic duct to either robot-assisted or open lateral pancreaticojejunostomy.
- Conditions
- Chronic Pancreatitis, Surgery, Minimally Invasive Surgical Technique, Robot Surgica
- Trial name
- PANACOTTA (NCT07109180)
- Testing
- Robot-assisted lateral pancreaticojejunostomy, Open lateral pancreaticojejunostomy
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Head and Neck Cancer, Chronic Periodontitis
Estimation of (suPAR) in Chronic Periodontitis With Post-radiotherapy on HNCs Patients
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy (HNC post-RT).
- Conditions
- Head and Neck Cancer, Chronic Periodontitis, Radiotherapy Side Effect
- Trial name
- HNCs (NCT06529588)
- Testing
- Radiation
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al-Maarif University College
Chronic Obstructive Pulmonary Disease
Pain Assessment in Patients With Chronic Obstructive Pulmonary Disease (COPD) Exacerbations.
The prevalence of chronic obstructive pulmonary disease (COPD) is between 8 and 12% of the adult population. This prevalence is expected to increase over the coming decades due to the aging of the population and the continued…
- Trial name
- MorphoCOPD1b (NCT03102970)
- Where
- 2 sites in Canada, France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Pulmonary Disease, Chronic Obstructive
Trial to Determine the Comparability of Ipratropium Bromide Hydrofluoroalkane (HFA)-134a Inhalation Aerosol to ATROVENT® Chlorofluorocarbon (CFC) Inhalation Aerosol, in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The objective of this study was to determine the pharmacokinetic comparability of 84 µg ipratropium bromide HFA-134a inhalation aerosol and 84 µg ATROVENT® CFC Inhalation Aerosol in COPD patients
- Trial name
- NCT02236169
- Testing
- Ipratropium bromide HFA-134a inhalation aerosol, Atrovent CFC inhalation aerosol
- Volunteers
- 30 people
- Sponsor
- Boehringer Ingelheim
Chronic Disease, Exercise
Implementing and Evaluating the Integration of Physical Activity Into a Major Health System and Connecting Patients to Physical Activity Programs.
Multiple case study trial examining the adoption, implementation, and reach of eligible patients visiting participating Prisma Health primary care clinics and receiving a referral to a 12-week evidence-informed physical activity…
- Conditions
- Chronic Disease, Exercise, Physical Activity
- Trial name
- NCT06073041
- Testing
- Invitation to adopt, Onboarding strategies
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
COPD
Implementation of an Evidence Based Smoking Cessation Strategy (SMOCC) for Patients With COPD in Primary Care
A controlled study demonstrated that a smoking cessation protocol in routine primary care, specifically targeted at patients with COPD (SMOCC), doubled the quit rates.
- Trial name
- NCT00294905
- Testing
- Implementation of a combined smoking cessation strategy
- Where
- Netherlands
- Volunteers
- 2,700 people
- Sponsor
- Radboud University Medical Center
Neoplasms, Communication
My Team of Care: a Pilot Randomized Controlled Trial of an Online Communication Tool for Collaborative Care
This project will pilot and test a new online communication tool, Loop, developed within a research framework with participatory and user-centred design. This pilot trial focuses on advanced cancer as an example of complex care.
- Trial name
- Loop (NCT02372994)
- Testing
- Loop
- Where
- 2 sites in Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Follicular Lymphoma, Small Lymphocytic Lymphoma
Idelalisib in Combination With Rituximab for Previously Untreated Follicular Lymphoma and Small Lymphocytic Lymphoma
The primary objective of this study is to evaluate the overall response rate (ORR) and complete response (CR) rate to treatment with idelalisib in combination with rituximab in previously untreated adults with follicular lymphoma…
- Trial name
- NCT02258529
- Testing
- Idelalisib, Rituximab
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Gilead Sciences
Long Covid19, Autonomic Dysfunction
Autonomic Nervous System Affection Due to Post Covid Syndrome
Post-Covid syndrome is defined as symptoms that develop in addition to respiratory symptoms in individuals who have had Covid-19 infection for more than 12 weeks.
- Trial name
- NCT05502094
- Testing
- Heart Rate Variability Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Long COVID, Post COVID-19 Condition
Taurine Supplementation in Adolescents With Post-COVID Condition
The COVID-19 pandemic has swept across the globe, affecting millions of individuals with varying degrees of severity. While many individuals recover from the acute phase of the infection, a significant proportion continue to…
- Conditions
- Long COVID, Post COVID-19 Condition, PASC Post Acute Sequelae of COVID 19
- Trial name
- TaurineLCPeds (NCT07682402)
- Testing
- Taurine
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Chronic Kidney Disease, Chronic Renal Insufficiency
STAAR-1 Clinical Study
To assess the effect of Aranesp on the hemoglobin of CRI subjects who are recombinant human erythropoetin (rHuEPO)-naïve or converting from rHuEPO therapy
- Conditions
- Chronic Kidney Disease, Chronic Renal Insufficiency, Kidney Disease, Pre-dialysis
- Trial name
- NCT00369772
- Testing
- darbepoetin alfa
- Volunteers
- 2,000 people
- Sponsor
- Amgen
COPD, Emphysema
Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease
The aim of this study is to investigate the mechanisms whereby lung function is decreased in COPD. The hypothesis is that in diseases such as COPD, inflammatory cells including neutrophils, macrophages and lymphocytes migrate to…
- Trial name
- NCT00147095
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Heart Failure, Diabetes Mellitus
Remote Multichannel Monitoring of Patients With Chronic DIseAses Using Speech technoLogies Based On Artificial intelliGence
DIALOG is a study to assess the efficacy and safety of remote patient monitoring using virtual operator voice technologies and a business intelligence (BI) system for timely detection, prevention of early complications, worsening…
- Conditions
- Heart Failure, Diabetes Mellitus, Arterial Hypertension, Lymphoproliferative Disease
- Trial name
- DIALOG (NCT06644339)
- Testing
- Voice assistant
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Anemia, Chronic Kidney Disease
A Study of the Efficacy and Safety of MK2578 for the Treatment of Anemia in Patients With Kidney Disease (MK2578-003-AM03-EXT12)
This study will evaluate the efficacy and safety of intravenous MK2578, given as maintenance treatment for renal anemia in chronic kidney disease patients on dialysis who were previously receiving erythropoietin stimulating…
- Trial name
- NCT00924781
- Testing
- MK2578 1mcg for every 600 Units (U) of Epogen® (epoetin alfa) received per week at Baseline, MK2578 1 mcg for every 350 U of Epogen (epoetin alfa) received per week at Baseline, MK2578 1 mcg for every 200 U of Epogen (epoetin alfa) received per week at Baseline
- Volunteers
- 39 people
- Sponsor
- Merck Sharp & Dohme LLC
End-stage Renal Disease
Physical Fitness/Training and Inflammatory Immune Responses in Patients With End-stage Renal Disease
The end-stage renal disease (ESRD) leading two causes of death are cardiovascular diseases and sepsis. Exercise improves low physical fitness, available research concerning its effect on the pro-/anti-inflammatory immune response…
- Trial name
- NCT04949919
- Testing
- aerobic training by a cycle ergometer and Biodex system 4 pro
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Anaemia
Evaluation of Dose Response Relationship, Safety and Efficacy of GSK1278863 in Hemodialysis-dependent Subjects With Chronic Kidney Disease Associated Anemia
This study is intended to evaluate the dose-response relationship of GSK1278863 over the first 4 weeks of treatment and evaluate the safety and efficacy of GSK1278863 over 24 weeks to maintain hemoglobin (Hgb) level in…
- Trial name
- NCT01977482
- Testing
- GSK1278863, rhEPO
- Where
- 107 sites in United States, Australia and 14 more
- Volunteers
- 216 people
- Sponsor
- GlaxoSmithKline
Kidney Transplant, ESRD (End Stage Renal Disease)
Improving Access to Renal Transplantation for Underserved Black Communities
The goal of this clinical trial is to learn whether the African American Transplant Access Program can be successfully replicated at another large kidney transplant program.
- Trial name
- AATAP (NCT06707038)
- Testing
- AATAP intervention
- Where
- United States
- Sponsor
- Northwestern University
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