Clinical trials: Illness, Chronic
Hepatitis C, Chronic
Rate and Predictors of Relapse in the Treatment of Hepatitis C (Study P05181)
This is an observational, multicenter, nationwide study where information will be collected on the follow-up of participants with chronic hepatitis C virus (HCV) who have a viral response at the end of treatment with pegylated…
- Trial name
- FAST-4 (NCT00723645)
- Volunteers
- 279 people
- Sponsor
- Merck Sharp & Dohme LLC
Leukemia, Chronic Lymphocytic Leukemia
Mosunetuzumab for CLL MRD Clearance
The goal of this study is to test mosunetuzumab given alone or in combination with a Bruton tyrosine kinase inhibitor (BTKi, such as ibrutinib, acalabrutinib, zanubrutinib, or pirtobrutinib) in participants with CLL (chronic…
- Conditions
- Leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Lymphoma
- Trial name
- NCT07052695
- Testing
- Mosunetuzumab, Ibrutinib, Acalabrutinib
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Inhye Ahn
Chronic Kidney Disease, Dialysis
A Phase III, Multi-Centre, Randomised, Placebo-Controlled Study in Combination With Ca-based P Binders in Patients With Hyperphosphatemia
This study consists of a 4 week run-in period with a Ca based phosphate binder and 12 weeks treatment period by MCI-196 or placebo, (both on Ca based phosphate binder).
- Conditions
- Chronic Kidney Disease, Dialysis, Hyperphosphatemia
- Trial name
- NCT00451295
- Testing
- MCI-196(colestilan(INN), Colestimide(JAN), CHOLEBINE®)
- Where
- 25 sites in Czechia, France and 8 more
- Volunteers
- 6 people
- Sponsor
- Tanabe Pharma Corporation
Type 2 Diabetes Mellitus, Chronic Kidney Disease
Fasiglifam in Type 2 Diabetic Subjects With Chronic Kidney Disease Stage 4 or 5 on Hemodialysis
To evaluate the efficacy of fasiglifam 50 mg once daily compared to placebo on glycemic control as measured by glycosilated haemoglobin (HbA1c) over a 16-week treatment period in participants with Type 2 Diabetes Mellitus (T2DM)…
- Trial name
- NCT02015780
- Testing
- Fasiglifam, Antihyperglycemic therapy
- Where
- 30 sites in United States, Bulgaria and 5 more
- Sponsor
- Takeda
Obesity, Heart Disease
Helping People to Exercise Regularly
This study tests two different incentive mechanisms to induce members of a particular urban senior center to attend more exercise classes.
- Trial name
- NCT01335880
- Testing
- Coupons for use within the next week, Coupons for use within the next 3 months
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Major Depressive Disorder, Hepatitis C, Chronic
Efficacy and Safety of Escitalopram for Prevention of Depression Induced by Peg-Interferon in Hepatitis C Patients
The purpose of this study is to determine whether the use of an antidepressant (escitalopram) can prevent depressive episodes that appear during the treatment with peg-interferon and ribavirin in patients with chronic hepatitis C.
- Trial name
- NCT00166296
- Testing
- Escitalopram
- Where
- 15 sites in Spain
- Volunteers
- 133 people
- Sponsor
- Germans Trias i Pujol Hospital
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Panzyga in CIDP Administered at Different Infusion Rates
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a treatable form of peripheral neuropathy with suspected autoimmune cause.
- Trial name
- Panzyga-CIDP (NCT03166527)
- Testing
- Immune Globulin 10% Intravenous Solution
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Vera Bril
Respiration, Artificial, Critical Illness
Development of a Rehabilitation Strengthening and Mobility Program for Ventilator Dependent Older Patients
As the general population ages and technology advances, many who suffer from catastrophic critical illness (i.e. septic shock, respiratory failure, Acute Respiratory Disease Syndrome) survive only to find themselves severely…
- Conditions
- Respiration, Artificial, Critical Illness, Chronic Disease, Exercise Therapy
- Trial name
- NCT03195127
- Testing
- multimodal physical therapy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Maryland, Baltimore
Covid19, AKI
Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 Infection
The coronavirus (COVID-19) pandemic has created a significant strain on health care resources across the world for managing critically ill patients.
- Conditions
- Covid19, AKI, CKD, ESRD
- Trial name
- NCT04491227
- Where
- 12 sites in United States, Bolivia and 4 more
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Diego
COPD
Novel Predictors of Premature Aging in COPD Patients
•Examine whether COPD is associated with accelerated aging using a biological marker of aging and dermatological score
- Trial name
- NCT06019286
- Testing
- SCINEXA score
- Volunteers
- 100 people
- Sponsor
- Assiut University
End-Stage Renal Disease
Anti-Cytokine Therapy for Hemodialysis InflammatION
Anti-Cytokine Therapy for Hemodialysis InflammatION (ACTION) is a phase II multi-center study to evaluate the safety and tolerability of anakinra, an IL-1 receptor antagonist, for patients treated with maintenance hemodialysis.
- Trial name
- ACTION (NCT03141983)
- Testing
- Anakinra
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Hepatitis C, Chronic, Hepatitis C
A Pilot Study of Treating HCV at a Psychiatrist-staffed Outpatient Addiction Clinic
The main purpose of this pilot study is to investigate the safety, effectiveness and tolerability of the study medication in the treatment of people with chronic hepatitis C virus infection who regularly attend a…
- Conditions
- Hepatitis C, Chronic, Hepatitis C, Opiate Dependence
- Trial name
- NCT03235154
- Testing
- sofosbuvir/velpatasvir
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Community Research Initiative of New England
Postcancer Fatigue, Chronic Fatigue Syndrome
Humoral and Cellular Immune Responses After Influenza Vaccination in Patients With Postcancer Fatigue and in Patients With Chronic Fatigue Syndrome
Postcancer fatigue (PCF) is a frequently occurring, severe and invalidating problem, impairing quality of life. Patients with chronic fatigue syndrome (CFS) also suffer from severe fatigue symptoms.
- Trial name
- NCT01651754
- Testing
- Seasonal influenza vaccination
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cardiovascular Diseases, Pulmonary Disease
Improving Physical Activity in Rehabilitation
Cardiac rehabilitation is a programme of exercise and health advice for people recovering from heart disease. Pulmonary rehabilitation is a similar programme for people with chronic lung disease.
- Conditions
- Cardiovascular Diseases, Pulmonary Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- IPAiR (NCT03264924)
- Testing
- IPAIR
- Where
- United Kingdom
- Volunteers
- 82 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Kidney Transplantation, Chronic Kidney Disease
Calcineurin Free Immunosuppression in Renal Transplant Recipients
The main purpose of this study is to obtain preliminary information on the efficacy, safety and cost of two regimens, Rapamycin / MMF / steroid therapy and Cyclosporine A Neoral / MMF / steroid therapy, used in the prevention of…
- Trial name
- NCT00812123
- Testing
- Sirolimus, Cyclosporine A, Prednisone
- Where
- Switzerland
- Volunteers
- 127 people
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Hepatitis C
Phase 2 Study of VX-950, Pegasys®, and Copegus® in Hepatitis C
Study the effectiveness of telaprevir (VX-950) in combination with Pegylated Interferon Alfa 2a (Peg-IFN-alfa-2a) and Ribavirin (RBV) in reducing plasma hepatitis C virus (HCV) ribonucleic acid (RNA) levels
- Trial name
- NCT00336479
- Testing
- Telaprevir, Ribavirin, Pegylated Interferon Alfa 2a
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 263 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Long COVID
Stellate Ganglion Block for Long COVID Symptoms: A Randomized Controlled Trial
This single-center, randomized, controlled, single-blind clinical trial evaluates whether a stellate ganglion block (SGB) using bupivacaine can improve persistent symptoms in adults with long COVID.
- Trial name
- STAR-CO (NCT07374562)
- Testing
- Stellate Ganglion Block (Bupivacaine)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
Pulmonary Disease, Chronic Obstructive
A 6-month Study to Evaluate the Efficacy and Safety of Fluticasone Furoate (FF)/GW642444 Inhalation Powder in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The Purpose of this study is to assess the efficacy and safety of two strengths of the FF/GW642444 Inhalation Powder in subjects with chronic obstructive pulmonary disease (COPD)
- Trial name
- NCT01053988
- Testing
- FF/GW642444 Inhalation Powder, FF Inhalation Powder, GW642444 Inhalation Powder
- Where
- 132 sites in United States, Chile and 8 more
- Volunteers
- 1,031 people
- Sponsor
- GlaxoSmithKline
End Stage Renal Disease
Outcomes of Renal Access Arteriovenous Fistulas for Hemodialysis in Patients With Chronic Renal Failure
End stage renal disease cases has increased significantly in the last decade. There are various treatment modalities which are available for the ESRD patients.
- Trial name
- NCT04386954
- Testing
- observational study
- Where
- India
- Volunteers
- 52 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Stress, Chronic Fatigue
The Effect of the Human Regenerator Jet Device on the Quality of Life of Adult Individuals [HR-QoL]
This cross-over single-blinded study aims to evaluate the effect of a novel cold atmospheric plasma jet-producing device, the Human Regenerator Power Jet device, for individuals who suffer from chronic stress, chronic pain…
- Conditions
- Chronic Stress, Chronic Fatigue, Chronic Pain, Post-COVID / Long-COVID
- Trial name
- HR-QoL (NCT07279272)
- Testing
- Cold Atmospheric Plasma, Atmospheric Air
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Athens
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