Clinical trials: Illness, Chronic
Mental Disorders, Chronic Disease
Online Access to Clinical Treatment Notes for Outpatients
This study investigates the feasibility and impact of patient access to clinical notes written by their healthcare providers-a concept known as Open Notes.
- Conditions
- Mental Disorders, Chronic Disease, Primary Health Care, Outpatients
- Trial name
- OpenNOTES (NCT07135726)
- Testing
- Patient Portal-Based Access to Clinical Notes
- Volunteers
- 1,092 people
- Sponsor
- Julian Schwarz
Chronic Periodontitis
1% Alendronate Gel in Treatment of Chronic Periodontitis Among Smokers
Locally delivered Alendronate (ALN) have potent inhibitory effect on bone and increases new bone formation in chronic periodontitis patients Till date no study has reported the effect of local delivery of ALN in chronic…
- Trial name
- NCT02168543
- Testing
- Alendronate
- Volunteers
- 46 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Neuropathy Demyelinating
Posturography-Neuropathy
If the classification between hereditary and acquired neuropathy is often easy, there is no completely specific marker allowing the distinction between the two etiologies.
- Trial name
- PONE (NCT04154540)
- Testing
- Motion analysis
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Lille
Anemia
A Phase 2a Study To Evaluate The Pharmacokinetics, Safety, Efficacy, Tolerability, And Pharmacodynamics of Sotatercept (ACE-011) for the Correction of Anemia in Subjects With End-stage Renal Disease on Hemodialysis.
This is the first study in hemodialysis subjects with anemia to evaluate the pharmacokinetics, safety, efficacy, tolerability, and pharmacodynamics of sotatercept (ACE-011)
- Trial name
- NCT01146574
- Testing
- Sotatercept
- Where
- 24 sites in United States
- Volunteers
- 50 people
- Sponsor
- Celgene
Chronic Hepatitis C Virus
A Study to Evaluate the Efficacy and Safety of Quadruple Therapy (VX-222, Telaprevir,Peginterferon-Alfa-2a, Ribavirin) in Subjects With Chronic Hepatitis C With Compensated Cirrhosis
The purpose of this study is to evaluate the safety and efficacy of a quadruple regimen (VX-222, telaprevir, pegylated interferon, and ribavirin)in subjects with hepatitis C with cirrhosis.
- Trial name
- NCT01516918
- Testing
- VX-222, telaprevir, ribavirin
- Where
- 43 sites in United States, Canada and 3 more
- Volunteers
- 103 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Brain and Central Nervous System Tumors, Breast Cancer
Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma
RATIONALE: Giving antibiotics may be effective in preventing or controlling early infection in patients receiving chemotherapy for solid tumors or lymphoma.
- Conditions
- Brain and Central Nervous System Tumors, Breast Cancer, Extragonadal Germ Cell Tumor, Infection
- Trial name
- NCT00005590
- Testing
- levofloxacin
- Where
- United Kingdom
- Sponsor
- Cancer Research Campaign Clinical Trials Centre
Myelogenous Leukemia, Chronic
Phase II Study of SCH66336, A Farnesyltransferase Inhibitor in Chronic Myelogenous Leukemia (CML)
The goal of this research is to see if giving the drug SCH66336 by mouth can improve the disease in patients with chronic or accelerated phase CML. The safety of this treatment will also be studied.
- Trial name
- NCT00038597
- Testing
- SCH66336
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- M.D. Anderson Cancer Center
Disability Physical, Chronic Conditions, Multiple
Physical Activity and Social Engagement for Persons With Disabilities in an Underserved Community
Using a community-based participatory approach, this project aims to evaluate the feasibility, acceptability, and preliminary efficacy of two technology-driven group activity programs on socioemotional health and physical…
- Conditions
- Disability Physical, Chronic Conditions, Multiple, Aging
- Trial name
- NCT05247242
- Testing
- Lakeshore Online Fitness (Online), Get Active with Virtual Reality (VR)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia
Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer
This clinical trial studies massage therapy given by caregiver in treating quality of life of young patients undergoing treatment for cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, Angioimmunoblastic T-cell Lymphoma, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative
- Trial name
- NCT01053494
- Testing
- massage therapy, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Hepatitis B
A Cohort Study in Korean Patients With Chronic Hepatitis B (CHB) Receiving Pegylated Interferon
The current proposed study aims to bring answers following issues: the antiviral efficacy and safety profiles in Korean Chronic Hepatitis B (CHB) patients who are mostly infected with solely genotype C HBV, a proper duration of…
- Trial name
- NCT01531166
- Testing
- pegylated Interferon-alpha 2a
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Yonsei University
Hyperkalemia
Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)
The purpose of this study is to assess the effects of patiromer compared with placebo on serum K+ in HF patients.
- Trial name
- DIAMOND (NCT03888066)
- Testing
- Patiromer
- Where
- 415 sites in United States, Argentina and 19 more
- Volunteers
- 1,195 people
- Sponsor
- Vifor Pharma, Inc.
Chronic Kidney Disease
Efficacy Trial of N-Acetylcysteine and Sodium Bicarbonate for the Prevention of Contrast-Induced Acute Kidney Injury
Contrast-Induced Acute Kidney Injury(CIAKI) was defined as an absolute increase in serum creatinine of more than or equal to 0.3mg/dl (≥ 26.4 μmol/l), a percentage increase in serum creatinine of more than or equal to 50%…
- Trial name
- PREKIT (NCT01210456)
- Testing
- Physiological Saline, N-Acetylcysteine and Sodium Bicarbonate
- Where
- Japan
- Volunteers
- 458 people
- Sponsor
- Tokushukai Medical Group
Peripheral Artery Disease, Intermittent Claudication
Assessing Best Medical Treatment Patterns of Patients With Symptomatic Peripheral Arterial Occlusive Disease in Germany
This proposed study will be conducted to support real-world-evidence on the extent of best medical treatment for secondary prevention of patients with symptomatic peripheral arterial occlusive disease (PAOD) for prevention of…
- Conditions
- Peripheral Artery Disease, Intermittent Claudication, Critical Limb Ischemia
- Trial name
- NCT03909022
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Lymphocytic Leukaemia (CLL), Small Lymphocytic Lymphoma (SLL)
Phase I/II Open-label Study Evaluating The Safety And Efficacy of Concomitant Administration of Anti-CD19 CAR T-cell Therapy and Lenalidomide in Refractory/Relapsed Chronic Lymphocytic Leukemia Patients.
This is a Phase I/II interventional, open-label treatment study designed to evaluate the safety and efficacy of concomitant therapy with anti-CD19 CAR T-cells and Lenalidomide in adult patients with relapsed/refractory chronic…
- Trial name
- VTB-CLL002 (NCT06762431)
- Testing
- Lenalidomide, Obinutuzumab Injection [Gazyva]
- Where
- Belarus
- Volunteers
- 24 people
- Sponsor
- Vitebsk Regional Clinical Cancer Centre
Chronic Obstructive Pulmonary Disease
Chronic Beta-blockade and Cardiopulmonary Exercise in COPD
What are the differential effects of beta-blockers on lung and heart function during exercise in chronic obstructive pulmonary disease (COPD)? COPD is a major cause of illness and death.
- Trial name
- CPET1 (NCT02380053)
- Testing
- Bisoprolol, Celiprolol
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Dundee
Chronic Obstructive Pulmonary Disease, Emphysema
Cost-Effectiveness of Lung Volume Reduction Surgery
Lung volume reduction surgery (LVRS) has been advanced as a therapy to significantly improve quality of life in patients with COPD, but to date no controlled studies have evaluated the impact of LVRS.
- Trial name
- NCT00013156
- Testing
- Effectiveness of Lung Reduction Therapy
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- US Department of Veterans Affairs
Hepatitis C, Chronic, HIV Infection
Pharmacokinetic Interactions Between Telaprevir and Un-boosted Atazanavir
Hypothesis: the Telaprevir(TVR) plasma levels (750 mg q8h or 1125 mg/12h )will not be affected when co-administered with un-boosted Atazanavir (ATV) 200 mg q12h plus two analogues (NRTIs) in HCV/HIV-co-infected patients.
- Trial name
- NCT01818856
- Testing
- Ritonavir withdrawal, atazanavir 200 mg/12h, Telaprevir interactions
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Arteriovenous Graft
LineMatrix® Biological Vascular Graft for the Creation of Arteriovenous Graft
The study is planned to be conducted at multiple centers, with an intended enrollment of 326 subjects. Protocol-eligible subjects will be randomized in a 1:1 ratio to either the investigational group or the control group.
- Trial name
- NCT07773051
- Testing
- LineMatrix® Biological Vascular Graft, GORE-INTERING®
- Where
- 12 sites in China
- Volunteers
- 326 people
- Sponsor
- Longhua Hospital
Chronic Obstructive Pulmonary Disease
Study of Fluticasone/Formoterol/Glycopyrronium for the Treatment Chronic Obstructive Pulmonary Disease (TRIPLAR)
Several studies have demonstrated the benefits of the LAMA (Long-Acting Muscarinic Antagonists) + LABA (Long-Acting Beta-Agonists) + IC (inhaled corticosteroids) combination in the treatment of chronic obstructive pulmonary…
- Trial name
- TRIPLAR (NCT06234345)
- Testing
- Fluticasone 250mcg/Formoterol 12mcg/Glycopyrronium 25mcg, Comparator - Trimbow®
- Where
- Brazil
- Volunteers
- 1,252 people
- Sponsor
- Eurofarma Laboratorios S.A.
COVID-19, Chronic Lung Diseases
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs
This is study is comprised of three approaches. First, the investigators will conduct a retrospective cohort study to determine factors associated with COVID-19 severity and complications and understand COVID-19 outcomes…
- Trial name
- LAUREL (NCT04628039)
- Where
- 2 sites in United States
- Volunteers
- 622 people
- Sponsor
- VA Office of Research and Development
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