Clinical trials: Illness, Chronic
Complex Patient, Multimorbidity
Pursuing the Triple Aim in Hotspotters: Identification and Integrated Care
Hotspotters are patients with complex care needs, defined by problems in multiple life domains and high acute care use. These patients often receive mismatched care, resulting in overuse of care and increased healthcare costs.
- Conditions
- Complex Patient, Multimorbidity, Psychosocial Problem, Chronic Disease
- Trial name
- NCT05878054
- Testing
- Proactive, integrated and personalised care
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Leiden University Medical Center
COPD Exacerbation
COPD Care Model on Clinical and Patient-Reported Outcomes
This study is the first to evaluate a unique integrated care model for COPD which uses a validated clinical frailty indicator to set care goals and guide health care in hospital and in the community.
- Trial name
- NCT03332394
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Ottawa Hospital Research Institute
Vascular Diseases, Peripheral Artery Disease
RECCORD (Recording Courses of Vascular Diseases) Registry
The RECording COurses of vasculaR Diseases registry (RECCORD registry) is an observational, prospective, multicentre, all-comers registry platform.
- Conditions
- Vascular Diseases, Peripheral Artery Disease, Claudication, Critical Limb Ischemia
- Trial name
- RECCORD (NCT03448029)
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Deutsche Gesellschaft für Angiologie, Gesellschaft für Gefäßmedizin e.V.
Chronic Pancreatitis, Diabetes
The Characteristics of Blood Glucose Profile and the Changes of Hormones in PPDM-C Population
The purpose of this study was to explore the characteristics of blood glucose spectrum, changes of endocrine/exocrine pancreatic function and the correlation between them in patients with PPDM-C.
- Trial name
- NCT06826729
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Pulmonary Disease, Chronic Obstructive
Physical Exercise and Responses Measured by HIF-1 in COPD
Despite being considered a potentially preventable disease, COPD is classified as one of the respiratory problems with the highest prevalence and socioeconomic impact.
- Trial name
- ECOPDHIF-1 (NCT04955977)
- Testing
- Physical exercise program, Health education in COPD
- Where
- Colombia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Leukemia
Dasatinib Combination Therapy With the Smoothened (SMO) Inhibitor BMS-833923 in Chronic Myeloid Leukemia (CML)
The purpose of the study is to determine the safety and tolerability of the combination of BMS-833923 plus dasatinib in patients with chronic myeloid leukemia.
- Trial name
- NCT01218477
- Testing
- Dasatinib, BMS-833923
- Where
- 12 sites in United States, Canada and 5 more
- Volunteers
- 33 people
- Sponsor
- Bristol-Myers Squibb
End-Stage Renal Disease
L-Carnitine in Peritoneal Dialysis
The development of glucose-sparing strategies able to provide an efficacious ultrafiltration profile represents one of the modern goals of peritoneal dialysis therapy.
- Trial name
- NCT00922701
- Testing
- L-carnitine
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Iperboreal Pharma Srl
Chronic Hepatitis B, Chronic Hepatitis C
Assessment of Liver FIBROsis by Real-time Tissue ELASTography in Chronic Liver Disease
This is a multi-center cross-sectional study in which the Real-time Tissue Elastography® measurements will be collected prospectively from patients with chronic hepatitis B or C virus presenting for liver biopsy.
- Trial name
- FIBROELAST (NCT01360879)
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Kindai University
Chronic Obstructive Pulmonary Disease (COPD)
Study Evaluating Preference, Satisfaction and Ease of Use of Inhalers in Chronic Obstructive Pulmonary Disease (COPD) Diagnosed Patients
Preference study: Genuair vs HandiHaler inhalers in COPD patients.
- Trial name
- NCT01385696
- Testing
- Genuair® (Almirall S.A.), HandiHaler® (Boehringer Ingelheim's)
- Where
- 4 sites in Germany, Netherlands
- Volunteers
- 130 people
- Sponsor
- Almirall, S.A.
Chronic Hepatitis C
An Efficacy and Safety Study of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in the Treatment of Chronic Hepatitis C Virus (HCV) Genotype (GT)1, 4, or 6 Infection in Treatment-Naïve Participants Who Are on Opiate Substitution Therapy (MK-5172-062)
This is a 2-part study. The purpose of Part A is to assess the efficacy and safety of grazoprevir (MK-5172) 100 mg in combination with elbasvir (MK-8742) 50 mg for 12 weeks in the treatment of chronic HCV GT1, GT4, or GT6…
- Trial name
- C-EDGE CO-STAR (NCT02105688)
- Testing
- Grazoprevir 100 mg/Elbasvir 50 mg FDC tablet (MK-5172A)
- Volunteers
- 301 people
- Sponsor
- Merck Sharp & Dohme LLC
Heart Failure, Congestive, Kidney Failure, Chronic
N-Acetylcysteine in Heart Failure With Coexistent Chronic Renal Failure
Treatment with n-acetylcysteine in patients with heart failure and chronic renal failure leads to improvements in vascular function and in renal function.
- Trial name
- NCT00532688
- Testing
- N-acetylcysteine
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Bayside Health
Asthma, Coronary Artery Disease
A Study of the Safety and Tolerance of Regadenoson in Subjects With Asthma or Chronic Obstructive Pulmonary Disease
This study is intended to determine the safety and tolerance of regadenoson in subjects with asthma or chronic obstructive pulmonary disease.
- Conditions
- Asthma, Coronary Artery Disease, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00862641
- Testing
- Regadenoson
- Where
- 48 sites in United States
- Volunteers
- 1,009 people
- Sponsor
- Astellas Pharma Inc
Pulmonary Disease, Chronic Obstructive
Effect of GSK1160724 In Healthy Volunteers
GSK1160724 is a potent mAChR antagonist, which is being developed for treatment of chronic obstructive pulmonary disease (COPD)
- Trial name
- NCT00555022
- Testing
- GSK1160724, Tiotropium bromide
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Lung Disease,Obstructive
Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease
In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the…
- Trial name
- NCT02592122
- Testing
- Salbutamol Aerosol, No drugs
- Where
- China
- Volunteers
- 120 people
- Sponsor
- snow
COPD
Physical Activity Enhancement Using Pedometers in COPD
Physical activity is reduced in COPD affecting morbidity and mortality and the usual advice is not good enough to increase the physical activity level.
- Trial name
- NCT01739751
- Testing
- pedometers
- Where
- Chile
- Volunteers
- 90 people
- Sponsor
- University of Chile
Post-Treatment Lyme Disease
Tetracycline Treatment Tolerability Trial
Randomized, double-blind, placebo-controlled study (with a one-week washout period) where subjects receive either 3 months of tetracycline or 3 months of placebo.
- Trial name
- T-4 (NCT05219929)
- Testing
- Tetracycline 500 Mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Healthy, COPD
A Multiple Ascending Dose Study With AZD9164 Given for 13 Days in Healthy Male and Female Subjects and in Patients With Chronic Obstructive Pulmonary Disease
The purpose of this study is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of inhaled AZD9164 following administration of multiple ascending doses in healthy male and female subjects and COPD…
- Trial name
- NCT01016951
- Testing
- AZD9164 Turbuhaler®
- Where
- 2 sites in Sweden
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
Timing of Dilation Tracheostomy in Mechanically Ventilated Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is: to evaluate the optimal time-point for percutaneous dilation tracheostomy in COPD patients in terms of duration on mechanical ventilation, length of stay on ICU and mortality; to evaluate the rate of…
- Trial name
- NCT01021202
- Testing
- Percutaneous dilation tracheostomy
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Periodontitis, End-stage Renal Disease
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications.
- Trial name
- NCT06755372
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Kidney Failure Chronic, Arrhythmias Cardiac
Effects of Marine n-3 Fatty Acids on Heart Rate Variability and Arrhythmias in Patients Receiving Chronic Dialysis
Background: End Stage Renal Disease (ESRD) patients have an extremely high mortality and the leading cause of death is cardiovascular disease which accounts for 50% of all deaths.
- Trial name
- NCT02147977
- Testing
- dietary supplement: n-3 PUFA, olive oil
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- Aalborg University Hospital
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