Clinical trials: Illness, Critical
Respiratory Failure
Multi-center Evaluation of the NEMO Gauge to Aid in Correct Positioning of the Endotracheal Tube
The aim of this study is to verify the safety and accuracy of an FDA-approved device called the NEMO™ Gauge to aide in the proper positioning of the endotracheal tube (ETT), inserted in the lungs of patients admitted to the…
- Trial name
- NCT02787681
- Testing
- NEMO Gauge
- Where
- 3 sites in United States
- Volunteers
- 71 people
- Sponsor
- Loma Linda University
Critically Ill, Ethics
Barriers in the Process of Achieving Informed Consent From Critically Ill Patients
The study will explore barriers in the process of achieving informed consent from critically ill patients
- Conditions
- Critically Ill, Ethics, Informed Consent, Study Recruitment
- Trial name
- NCT03405766
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Oslo University Hospital
Anemic, Critically Ill Patients
Efficacy of Enteral Iron Supplementation in Critical Illness
The purpose of this study is to investigate the efficacy of enteral iron supplementation for improving anemia, decreasing the risk of blood transfusion, and decreasing mortality in patients who are hospitalized in the intensive…
- Trial name
- NCT00450177
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Critical Illness, Selenium Deficiency
The Prognostic Impact of Selenium On Critical Surgical Patients
Selenium is an important trace element for human for its multiple roles such as the antioxidant activity. Previous evidences showed that critically ill patients may benefit from selenium supplement but the dose and results are…
- Conditions
- Critical Illness, Selenium Deficiency, Trace Element Deficiency, Acute Abdomen
- Trial name
- NCT04662242
- Testing
- Selenium Supplement, normal saline
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Troponin, Critical Care
Prognostic Value of Elevated Troponins in Critical Illness Study: A Pilot Study
Troponins are sensitive and specific markers of cardiac injury. Critically ill patients frequently have elevated troponins. In this population, distinguishing patients with elevated troponins from those with myocardial infarction…
- Conditions
- Troponin, Critical Care, Myocardial Infarction
- Trial name
- PRO-TROPICS (NCT02285686)
- Volunteers
- 251 people
- Sponsor
- McMaster University
Critically Ill
Coated Devices to Decrease Infection in the Intensive Care Unit
Pilot explanatory, randomized, open label, controlled trial. Critically ill patients which will demand placement of invasive devices for organ support (endotracheal tube, central venous catheter and urinary Foley catheter) will…
- Trial name
- CRITIC (NCT03868241)
- Testing
- Coated devices, Control
- Where
- 6 sites in Brazil
- Volunteers
- 103 people
- Sponsor
- Hospital do Coracao
Acute Respiratory Failure, Critical Illness
"VARIABLE-PSV" Study
Variable PSV is a new ventilatory mode which delivered a pressure support "variable" from 0 to 100% variation of the set PSV level.This study aimed to compare the ventilatory behavior, sleep quality and gas exchange between…
- Conditions
- Acute Respiratory Failure, Critical Illness, Ventilation Weaning
- Trial name
- NCT01580956
- Testing
- VARIABLE-PSV ventilatory mode, STANDARD-PSV ventilatory mode
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
Cerebral Bleeding in COVID-19 ARDS Patients on Veno-venous ECMO
Critically ill patients with severe acute respiratory distress syndrome (ARDS) sometimes require treatment with veno-venous extracorporeal membrane oxygenation (ECMO) to support gas exchange.
- Conditions
- Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication, Corona Virus Infection
- Trial name
- NCT04853953
- Testing
- Incidence of bleeding complications in ARDS patients on veno-venous ECMO
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Covid19, Critically Ill
Risk Factors for Mortality for COVID-19 Admitted to an Intensive Care Unit
Studying clinical characterization of critically ill COVID-19 patients in a single center Studying Risk factors for Day 28 Mortality in COVID-19 patients admitted to intensive care unit
- Trial name
- ICUCOVID-KK (NCT04805645)
- Testing
- No intervention (Retrospective Cohort Observational)
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- Clinical Research Centre, Malaysia
Intensive Care Units (ICUs)
Body Lateralization and Its Effects on Respiratory Drive, Ventilation, and Pulmonary Aeration in Critically Ill Patients
The goal of this quasi-experimental study is to investigate how different body positions, performed through Automatic Lateralization Therapy, affect respiratory drive, ventilation, and pulmonary aeration in critically ill adult…
- Trial name
- LATLUNG (NCT07323472)
- Testing
- Automatic Lateralization Therapy, Supine Positioning
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Pernambuco
Feeding, ICU
mNEED: a Multicentre, Cluster-randomized, Controlled Trial
Project Name: Improved Feeding Regimen for Critically Ill Patients (mNEED) Based on Feeding Intolerance Prediction Model Solution version number and version date: Version 5.0; 2024.12.16 Informed consent version number and…
- Trial name
- mNEED (NCT06827275)
- Testing
- Feeding process
- Where
- 2 sites in China
- Volunteers
- 2,250 people
- Sponsor
- The First Hospital of Jilin University
Critical Illness
Body Positioning and Pulmonary Aeration During Mechanical Ventilation
The present randomized crossover clinical trial aims to evaluate the influence of different body postures on pulmonary aeration among mechanically ventilated critically ill patients.
- Trial name
- NCT04176445
- Testing
- Orthostatic board posture, Bedside sitting posture
- Where
- 2 sites in Brazil
- Volunteers
- 19 people
- Sponsor
- Hospital Moinhos de Vento
Invasive Candidiasis, Critically Ill
Pharmacokinetics of Anidulafungin on Intensive Care Unit (ICU)
The objective of this study is to determine whether pharmacokinetic parameters of anidulafungin correlate with disease severity and plasma protein levels in critically ill patients.
- Trial name
- NCT01047267
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
PICS
The Impact of a Bundle of Preventive Measures for Post-intensive Care Syndrome on the Outcome of Critically Ill Patients
This prospective observational cohort study will investigate the impact of a bundle of nine preventive measures (Assessment, prevention and management of pain; spontaneous awaking trial; spontaneous breathing trial; choice of…
- Trial name
- NCT03398707
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Hospital Sao Domingos
Orotracheal Intubation
AI-Integrated 3D-Printed Videolaryngoscope for Orotracheal Intubation in Critically Ill Patients
Background: Orotracheal intubation is an essential procedure in critically ill patients requiring ventilatory support, and the use of videolaryngoscopy is recommended as the gold standard in clinical practice.
- Trial name
- VL-AI (NCT07592702)
- Testing
- Orotracheal intubation using a 3D videolaryngoscope integrated with artificial intelligence (VL-IA)., Commercially available gold-standard videolaryngoscope (VL-C)
- Where
- 4 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of Pelotas
Intensive Care Unit Syndrome, Post-intensive Care Syndrome
Neurological Blood-based Biomarkers and Cognitive Disorders in Critically Ill Survivors.
Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β…
- Conditions
- Intensive Care Unit Syndrome, Post-intensive Care Syndrome, Cognitive Disorder
- Trial name
- COGNISI (NCT05953311)
- Testing
- Blood analysis, Cognitive tests
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University of Liege
Covid-19, Critical Illness
Optimizing Outcomes With Physical Therapy Treatment for IndividuALs Surviving an ICU Admission for Covid-19
Introduction: Survivors of acute respiratory failure develop persistent muscle weakness and deficits in cardiopulmonary endurance combining to limit physical functioning.
- Conditions
- Covid-19, Critical Illness, Post Intensive Care Unit Syndrome, Muscle Weakness
- Trial name
- OPTIMAL (NCT04412330)
- Testing
- ICU Recovery + Physical Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Kentucky
Hyperglycemia
Feasibility Study to Evaluate Safety and Device Performance of the Hospital Glucose Management System (HGMS)
The purpose of this study is to assess safety and device performance of the Medtronic Hospital Glucose Management System (HGMS) for up to 72-hours.
- Trial name
- MAHI (NCT01763567)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Medtronic MiniMed, Inc.
Pneumonia, Ventilator-Associated, Critical Illness
Intubation and Extubation Over 48 Hours Mechanical Ventilation
The purpose of this study is to determine how often ventilator associated pneumonia happens in the current intensive care units, and how types of endotracheal tube affect its occurrence.
- Trial name
- INDEX48 (NCT01123681)
- Testing
- Choice of endotracheal tube
- Where
- 6 sites in Japan
- Volunteers
- 200 people
- Sponsor
- Okayama Research Investigator Organizing Network
Critical Illness, Respiration, Artificial
Conservative Versus Conventional Oxygen Administration in Critically Ill Patients
Oxygen supplementation in the inspired mixture is commonly used in critically ill patients and observational studies highlight that those patients remain hyperoxemic for substantial periods during Intensive Care Unit stay.
- Conditions
- Critical Illness, Respiration, Artificial, Hyperoxia, Hyperoxemia
- Trial name
- NCT04198077
- Testing
- Oxygen
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Modena and Reggio Emilia
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