Clinical trials: Illness, Critical
Protein Malnutrition
Comparison of Clinical Outcomes According to High-protein Provision in Critically Ill Patients After Abdominal Surgery
Protein malnutrition in critically ill patients is a global concern due to its association with prolonged hospital stays, and higher morbidity rates.
- Trial name
- NCT06458387
- Testing
- Active protein supplementation, Conventional protein supplementation
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Seoul St. Mary's Hospital
Sepsis, Critical Illness
Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children
Multiple organ failure (MODS) is still the leading cause of death in children in ICU. The treatment of MODS is mainly organ function monitoring and organ replacement therapy.
- Conditions
- Sepsis, Critical Illness, MODS
- Trial name
- CELS (NCT03654287)
- Testing
- Treatment
- Where
- China
- Sponsor
- Guoping Lu
Ventilator Associated Pneumonia, Critical Care
Delayed Antibiotic Therapy in Non-severe Ventilator Acquired Pneumonia (VAP)
This retro-prospective monocentric observational study compare the impact of the implementation of a restrictive (delayed) versus aggressive (immediate) antibiotic strategy for Ventilator Acquired Pneumonia suspicion without…
- Conditions
- Ventilator Associated Pneumonia, Critical Care, Antibiotic Therapy
- Trial name
- DELAVAP (NCT05205525)
- Testing
- Restrictive antibiotic strategy, Aggressive antibiotic strategy
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Nantes University Hospital
Critical Illness, Respiratory Failure
Intubation Checklist in the Intensive Care Unit
This retrospective study aims to explore whether the introduction of a preprocedural checklist for intubation in the intensive care unit (ICU) is associated with a lower incidence of intubation-related complications.
- Conditions
- Critical Illness, Respiratory Failure, Unconsciousness
- Trial name
- CHECC (NCT06791317)
- Testing
- Checklist
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Respiratory Failure, Acute Hypoxemic Respiratory Failure
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen…
- Conditions
- Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia
- Trial name
- NCT06501118
- Testing
- Education, Epic notification alert
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- University of Colorado, Denver
Acute Kidney Failure Stage 3, Continuous Renal Replacement Therapy (CRRT)
Effect of High Versus Standard Protein Intake in Critically Ill Patients With Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
During critical illness, patients experience a hypercatabolic state. This hypercatabolic state causes muscle wasting in patients, resulting in intensive care unit acquired weakness (ICU-AW).
- Trial name
- PROTEIN-CRRT (NCT07596043)
- Testing
- High protein group, Standard protein group
- Where
- Thailand
- Volunteers
- 56 people
- Sponsor
- Chulalongkorn University
Thermal Hyperalgesia, Anxiety
A Randomized, Double-Blind Study of Placebo vs. Ketamine For Use During Dressing Changes in Critically Ill Burn Patients
Burn-related pain is severe and often difficult to manage. Healthcare workers struggle with keeping burn patients comfortable, especially when these patients undergo dressing changes of their burn wounds of their skin since these…
- Conditions
- Thermal Hyperalgesia, Anxiety, Pain
- Trial name
- NCT02336308
- Testing
- Ketamine
- Where
- United States
- Sponsor
- University of Colorado, Denver
Vitamin D Deficiency, Critical Illness
Early Vitamin D3 Supplementation for Critically Ill Patients
There are no clear international guidelines for dosing vitamin D based on deficiency severity. Therefore, a new clinical trial is needed to evaluate the benefits of early vitamin D supplementation in maintaining sufficient levels…
- Trial name
- NCT05937789
- Testing
- Vitamin D3, Medium Chain Triglycerides (MCT)
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- National Taiwan University Hospital
Critical Illness
The Role of NEMS for Post ICU Rehabilitation
The purpose of this study is to investigate the role of NEMS as a rehabilitation tool for muscle weakness following critical illness.
- Trial name
- NCT01717833
- Testing
- NEMS
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Athens
Deglutition Disorders, Critical Illness
Swallowing Difficulties in ICU Patients [Synkebesvær Hos Intensivpatienter]
Swallow disorders or dysphagia related to mechanical ventilation affects between 1,300 and 2,000 patients in Danish intensive care units every year and increases aspiration, pneumonia and risk of dying.
- Trial name
- ICU-Swallow (NCT04428749)
- Testing
- Yale Swallow Protocol, FEES (fiberoptic endoscopic evaluation of swallowing)
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Hospitalsenheden Vest
Necrotizing Enterocolitis
Application of Transcriptome Sequencing Combined With Family-Based Whole Genome Sequencing in Improving Precise Diagnosis of Critically Ill Newborns in Northeast China
Background: Birth defects and genetic diseases are major threats to infant health. Many genetic diseases present atypically in newborns, who often have critical conditions, rapid progression, and high mortality.
- Trial name
- NCT06990334
- Testing
- Whole genome sequencing analysis
- Volunteers
- 1,000 people
- Sponsor
- The First Hospital of Jilin University
Liver Cirrhosis
Impact of Continuous Renal Replacement Therapy on Systemic Hemodynamics and Lactate Clearance in Critically Ill Cirrhotics With Septic Shock.
Consecutive critically ill cirrhotics with septic shock and AKI who give written informed consent will be included in this prospective study.
- Trial name
- NCT04949178
- Testing
- No intervention
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Delirium, Critical Illness
Pain Assessment in the Intensive Care Unit
Pain assessment using self-report scales (Visual Analogue Scale, Numerical Rating Scale), is recommended in the general population, however it is not always possible in patients with altered neurological status such as sedated…
- Trial name
- NCT01628185
- Testing
- Repositioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Chicago
COVID-19, Critical Illness
Analysis of Mortality of Critically Ill Patients With COVID-19
The recent pandemic of the COVID-19 disease has caused a national health emergency due to its severity and the clinical and social consequences of the disease. Crude mortality in Spain is 9.2%.
- Conditions
- COVID-19, Critical Illness, Effectiveness, Outcome, Fatal
- Trial name
- NCT04379258
- Where
- Spain
- Volunteers
- 868 people
- Sponsor
- Hospital Universitario Getafe
Bacterial Infection, Critically Ill
Study of Tigecycline Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy(CRRT)
The aim of this study is to determine the Pharmacokinetics/Pharmacodynamics(PK/PD) of tigecycline in critical ill patients undergoing continuous renal replacement therapy（CRRT）and examine whether the dosage needs adjustment.
- Trial name
- NCT02931526
- Testing
- Tigecycline
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Hyperglycemia
Association Between Blood Glucose Indicators and Heart Rate Variability in Non-diabetic Critically Ill Patients
Heart rate variability (HRV) is a simple way to check how well the body's automatic nervous system is working. It does this by looking at how the heart rate changes in the electrocardiogram.
- Trial name
- NCT07198308
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
Pneumonia, Ventilator-Associated Healthcare-associated Pneumonia Respiration, Artificial
Combined Strategy Using Automated Subglottic Secretion Drainage and Continuous Cuff Pressure Monitoring to Prevent Microaspiration: a Multicenter Randomized Controlled Trial.
This trial will study the impact of a combined strategy to prevent microaspiration of oropharyngeal secretions or gastric content using automated subglottic secretion drainage and/or continuous cuff pressure monitoring.
- Trial name
- cosmic (NCT07555236)
- Testing
- Combined strategy, Automated subglottic secretion drainage, Automated continuous cuff pressure monitoring
- Volunteers
- 800 people
- Sponsor
- University Hospital, Lille
Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients
This prospective, blinded observational clinical study was aimed to determine the effect of hyperhydration and muscle loss measured by Bioelectrical impedance vector analysis (BIVA) on mortality.
- Conditions
- Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Lung Ventilator, Hyperhydration
- Trial name
- NCT05991778
- Testing
- Bioelectrical impedance vector analysis (BIVA), Blood and urine analysis, cumulative water balance
- Where
- Czechia
- Volunteers
- 61 people
- Sponsor
- University Hospital Ostrava
Critically Ill Severe Bronchiolitis
Helmet Continuous Positive Airway Pressure Support for Severe Bronchiolitis in PICUs
Binary randomized peep level of Helmet CPAP (1-0). The first patient enrolled will be assign to treatment 1 (10 cmH2O peep level), independently from its BSS.
- Trial name
- NCT02977585
- Testing
- 10 cmH2O peep
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
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