Clinical trials: Illness, Critical
Cardiac Output, Low
Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease
Babies having heart surgery often have problems after surgery with their blood pressure and getting enough blood to their bodies.
- Trial name
- Corti (NCT00590018)
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Baylor College of Medicine
COVID-19 Disease
Systematic Assessment of SARS-CoV-2 Neurotropic Capacity in Modestly and Critically Ill Patients, and Patients Who Died From COVID-19
This study is to analyze the microglia reaction or direct neurotropic effects of CNS COVID-19 in pathogenesis and brain stem dysfunction in critically ill patients.
- Trial name
- NCT04472013
- Testing
- Data collection from lumbar puncture, Data collection from blood draw, CNS magnetic resonance imaging (MRI) imaging
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Basel, Switzerland
Thoracic Diseases
Design and Evaluation of Mobile X-ray for Rapid and Accurate Diagnosis of Thoracic Disease
Computed tomography (CT) is the most accurate test for evaluating patients with thoracic disease. However, access to CT is limited due to long wait times and for the sickest patients in Hospital who cannot be transported from the…
- Trial name
- NCT02391896
- Testing
- Dual energy and tomosynthesis xray
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Clinical Reasoning, Critical Illness
The Effect of Case-Based Education on the Development of Nursing Students' Clinical Reasoning Skills
Aim: This study was conducted to determine the effect of case-based education on the development of clinical reasoning skills of nursing students in critical illnesses.
- Trial name
- NCT05504824
- Testing
- Case-based education
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ankara University
Sepsis, Septic Shock
Impact of the Introduction of a Performance Improvement Program on the Initial Management of Sepsis and Septic Shock in Adults in the Emergency Department: a Before-and-after Study (IPA-SOS)
The goal of this observational study is to evaluate if a performance improvement program can improve the initial management of sepsis and septic shock in adults at Brest University Hospital.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Emergency Medicine
- Trial name
- IPA-SOS (NCT06657625)
- Testing
- Sepsis Performance Improvement Program
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Brest
Respiratory Muscle Weakness, Mechanical Ventilation Weaning
Progressive Pressure Support Reduction as Inspiratory Muscle Endurance Training in Mechanically Ventilated Patients
Mechanical ventilation causes rapid diaphragm muscle atrophy, detectable within 18 hours of ventilator support, which is a major contributor to weaning failure and prolonged ICU stay.
- Conditions
- Respiratory Muscle Weakness, Mechanical Ventilation Weaning, Physiotherapy, Endurance Training
- Trial name
- inspira-rct (NCT07689110)
- Testing
- Progressive Pressure Support Reduction (IRT-PS), Standard ICU Care
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
Acute Kidney Injury, Critical Illness
Renal Resistive Index as a Predictor of Acute Renal Impairment in High-risk Patients
To study the ability of RRI, measured by bedside Doppler ultrasound, in detecting acute kidney injury in high-risk patients admitted to surgical intensive care unit, Aswan university hospital, compared with renal biomarkers and…
- Trial name
- NCT06386796
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Aswan University
Hypernatremia, Critically Ill
Continuous Venovenous Hemofiltration Versus Conventional Treatment for Acute Severe Hypernatremia
The patients with severe hypernatremia who received conventional treatment are often undertreated. Continuous venovenous hemofiltration (CVVH) can effectively remove solute or water from circulation system.
- Trial name
- NCT02449382
- Testing
- continuous venovenous hemofiltration, Control group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Air Force Military Medical University, China
Liver Diseases, Liver Cirrhosis
Sepsis, Endothelial Function, and Lipids in Critically Ill Patients With Liver Failure (the SELLIFA Study)
The purpose of the study is to determine the role of new biomarkers in the diagnosis of sepsis in critically-ill patients with liver failure and to correlate the prognosis of these patients with parameters of endothelial function…
- Conditions
- Liver Diseases, Liver Cirrhosis, Sepsis, Critical Illness
- Trial name
- SELLIFA (NCT00488917)
- Where
- Belgium
- Volunteers
- 167 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Intracerebral Hemorrhage, Critically Ill
Early Multimodal Neuromonitoring For Spontaneous Intracerebral Hemorrhage (ICH)
The investigators intend to assess the predictive value of early (first 48 hours) multimodal neuromonitoring parameters concerning late survival in critically ill intracerebral hemorrhage (ICH) patients.
- Conditions
- Intracerebral Hemorrhage, Critically Ill, Intracranial Pressure, Cerebral Perfusion Pressure
- Trial name
- NCT05501613
- Testing
- Multimodal Neuromonitoring
- Where
- Portugal
- Volunteers
- 65 people
- Sponsor
- Universidade do Porto
Critical Illness, Intensive Care (ICU) Myopathy
Early Goal-Directed Nutrition in ICU Patients - EAT-ICU Trial
An increasing number of patients survive critical illness and intensive care, but describe having impaired physical function several years after discharge as a consequence of extensive loss of muscle mass.
- Conditions
- Critical Illness, Intensive Care (ICU) Myopathy, Muscle Wasting, Loss of Physical Function
- Trial name
- EAT-ICU (NCT01372176)
- Testing
- Early Goal-Directed Nutrition, ASPEN-guidelines
- Where
- Denmark
- Volunteers
- 203 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ventilator Associated Pneumonia
Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to…
- Trial name
- NCT04527276
- Testing
- Oral care with 0,12% Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Medeniyet University
Critically Ill, Acute Respiratory Distress Syndrome
the Influence of Tidal Volume to Lung Strain
Measure the lung strain in different tidal volume in ADRS patients to find the relationship between tidal volume and lung strain and find the most suitable tidal volume for each patient.
- Trial name
- NCT01864668
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Zhongda Hospital
Metabolic Acidosis; Critically Ill Patients; Organ Dysfunction
Risk Potential for Organ Dysfunction Associated With Sodium Bicarbonate Therapy (SBT) in Critically Ill Patients
This study aimed to investigate whether hemodynamic status before SBT contributed to the effect of sodium bicarbonate infusion on the risk of neonatal organ dysfunction and mortality in critically ill patients with early…
- Trial name
- NCT04953013
- Testing
- sodium bicarbonate
- Where
- China
- Volunteers
- 664 people
- Sponsor
- Peking University Third Hospital
Mechanical Ventilation, Pulmonary Rehabilitation
Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.
This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.
- Conditions
- Mechanical Ventilation, Pulmonary Rehabilitation, Intensive Care Units (ICUs), Quality of Life (QOL)
- Trial name
- REPOrt (NCT07093125)
- Where
- Italy
- Volunteers
- 2,400 people
- Sponsor
- Universita degli Studi di Genova
Critically Ill
Central Venous Pressure and Right Atrial Pressure Measurements in Supine, Semi-recumbent and Trendelenburg Position
Intensive care is directed towards patients with severe illness or risk of serious outcomes following, for example, surgery. Central venous pressure (CVP) is an important part of the hemodynamic assessment of patients in surgery…
- Trial name
- NCT06705374
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Vastra Gotaland Region
Critical Illness
Evidence-Based Tele-Emergency Network Grant Program
The purpose of this study is to determine the impact of an existing tele-emergency care network on quality of care, appropriateness of care utilization, patient safety (medication errors), and cost effectiveness compared to…
- Trial name
- NCT02877810
- Testing
- Telemedicine, Telephone
- Where
- United States
- Volunteers
- 696 people
- Sponsor
- University of California, Davis
Systemic Inflammatory Response Syndrome (SIRS)
Myostatin and Irisin Levels in Predicting the Outcome of Patients With Systemic Inflammation: A Prospective Observational Study
Systemic inflammatory response syndrome (SIRS) is associated with severe metabolic stress that can lead to rapid breakdown of skeletal muscle and the development of stress-related malnutrition.
- Trial name
- NCT07476391
- Where
- Czechia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Critical Illness, ICU Patients
Intensive Care Unit Rehabilitation Protocols
The aim of this study was to investigate the effects of NMES combination applied in addition to bicycle ergometry on mobility, functional status, muscle strength and hemodynamic responses in ICU patients.
- Trial name
- ICU-Rehab (NCT07179718)
- Testing
- neuromuscular electrical stimulation, bicycle ergometer
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Hacettepe University
Critical Illness
Topical Application of Silver Nanoparticles and Oral Pathogens in Ill Patients
The purpose of this study is to determine whether oral topic silver nanoparticles are effective to reduce potential pathogen microbial loads in mechanical ventilation patients.
- Trial name
- NCT02761525
- Testing
- silver nanoparticles
- Volunteers
- 50 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
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