Clinical trials: Illness, Critical
Critical Illness, Enteral Feeding Intolerance
Nocturnal Cyclic Enteral Nutrition Infusion Versus Continuous Infusion of Enteral Nutrition
Enteral nutrition is considered the best way to feed those who can´t be fed orally. the standard protocol of administration includes continuous infusion for 24 hours; nonetheless this support is constantly suspended which causes…
- Conditions
- Critical Illness, Enteral Feeding Intolerance, Nutrition Support
- Trial name
- NCT03727165
- Testing
- Continuous enteral nutrition infusion, Cyclic enteral nutrition infusion
- Where
- Colombia
- Sponsor
- Hospital Universitario San Ignacio
Myocardial Infarction, Inflammation
Inflammation in Type 2 Myocardial Infarction
Type 2 myocardial infarction (MI) is defined as myocardial necrosis that results from an imbalance of myocardial oxygen supply and demand.
- Conditions
- Myocardial Infarction, Inflammation, Critical Illness
- Trial name
- NCT02385487
- Where
- United States
- Sponsor
- NYU Langone Health
Brain Injuries, Stroke
Effects of Prolonged and Chronic Critical Illness Induced by Brain Injury on Metabolic State
Brain injuries, including acute stroke (AS) and traumatic brain injury (TBI), are prevalent pathologies with severe consequences.
- Conditions
- Brain Injuries, Stroke, Malnutrition, Critical Illness
- Trial name
- NCT06545825
- Testing
- Standard enteral nutrition
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
Critical Illness, COVID-19 Pneumonia
Acute Kidney Injury in Coronavirus Disease-19 (COVID-19) Patients Admitted to the Intensive Care Unit (ICU)
The aim of this study is to evaluate the rate and outcomes of COVID-19 associated acute kidney injury (AKI) and use of kidney replacement therapy (KRT) in critically ill COVID-19 patients in ICUs in several large hospitals in…
- Conditions
- Critical Illness, COVID-19 Pneumonia, Acute Kidney Injury
- Trial name
- COVID-AKI-B (NCT04997915)
- Testing
- Observational study exploring the epidemiology and outcomes of AKI in critical COVID-19 patients admitted to the ICU
- Where
- 9 sites in Belgium
- Volunteers
- 1,286 people
- Sponsor
- University Hospital, Ghent
Critically Ill, Enteral Nutrition
Prokinetic Drugs and Enteral Nutrition
The purpose of this study is to compare the effect of two drugs that can help in the prevention of regurgitation during the administration of enteral nutrition and define which one is the most effective.
- Trial name
- prokinetics (NCT00916591)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitair Ziekenhuis Brussel
COVID-19
Probe-based Confocal Laser Endomicroscopy in Critically Ill COVID-19 Patients
The study is devoted to the comparative analysis of the data received in patients with COVID-19 lung pathology using the method of probe-based confocal laser endomicroscopy of distal airways and two reference methods: high…
- Trial name
- NCT04451889
- Testing
- miniprobe Alveoflex
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Critical Illness, Recovery Outcomes
UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.
Persistent Critical Illness (PCI) is a condition that affects some patients who remain in the Intensive Care Unit (ICU) for a long time, usually more than 10-14 days. It is estimated to occur in 5-20% of critically ill patients.
- Conditions
- Critical Illness, Recovery Outcomes, Critical Care, Intensive Care, Critical Care
- Trial name
- UPSt_UCI (NCT07510776)
- Where
- 7 sites in Portugal
- Volunteers
- 7,000 people
- Sponsor
- Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa
Critical Illness
Association Between Resuscitation Orders and Mortality in ICU Patients
The hypothesis of the study is that a resuscitation order other than full code is associated with increased mortality among critically ill patients.
- Trial name
- NCT06373068
- Testing
- Resuscitation orders
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Karolinska Institutet
Muscle Weakness
Evaluation of Effectiveness of Combining High Protein Intake With Early Physical Exercise During Critical Illness
Assessment of Effectiveness of combined high protein intake with early physical exercise by ultrasound measurement of rectus femoris muscle thickness in Intensive Care Unite mechanically ventilated patients.
- Trial name
- NCT05877989
- Testing
- Amino Acid, Physical exercise
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Septic Shock
Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis
The norepinephrine and vasopressin for rescue versus early vasopressin for vasopressor dependent sepsis (NoVa) is a phase 3, multicenter, open-label, randomized controlled trial comparing an early vasopressin initiation strategy…
- Trial name
- NoVa (NCT06464510)
- Testing
- Early Vasopressin, Norepinephrine and Vasopressin for Rescue
- Where
- 8 sites in Brazil
- Volunteers
- 2,800 people
- Sponsor
- Hospital do Coracao
Tracheostomy Complications
Comparison Between Bronchoscopy and Real- Time Ultrasound Guided Percutaneous Tracheostomy
Trial is a randomized study to compare between ultrasound guided percutaneous tracheostomy and bronchoscopy guided percutaneous tracheostomy.
- Trial name
- NCT02656719
- Testing
- Ultrasound guided percutaneous tracheostomy, Bronchoscopy guided percutaneous tracheostomy
- Volunteers
- 80 people
- Sponsor
- Aykut Saritas
Vascular Access Devices
Effect of Education of Health Care Workers on the Maintenance of Venous Access Devices
In intensive care units (ICU), critically ill patients require various venous access devices for fluid resuscitation, drug therapy, or renal replacement therapy (RRT).
- Trial name
- NCT04692753
- Testing
- Training and education
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Venous Thromboembolism
Anti Xa Monitoring Low Molecular Weight Heparin on Prevention of Venous Thromboembolism
Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism, is a common cardiovascular disease associated with significant morbidity ranging from painful leg swelling, chest pain, shortness of…
- Trial name
- NCT05382481
- Testing
- Peak value anti-Xa, Trough value anti-Xa, Control Group
- Where
- China
- Volunteers
- 858 people
- Sponsor
- Xuanwu Hospital, Beijing
End-stage Renal Disease
IVC and Lung Ultrasound B-lines Guided Decongestion in Critically Ill ESKD Patients With Heart Failure
The objectives of this trial are to determine whether, in critically ill ESKD patients randomization to fluid removal guided by lung and inferior vena cava ultrasound, compared to standard care, leads to Improved pulmonary…
- Trial name
- NCT06373575
- Testing
- Lung and inferior vena cava ultrasound guidance, Conventional protocol guidance
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Stroke, Diabetic Ketoacidosis
Descriptive Analysis of Near Infrared Spectroscopy in Critically Ill and Injured Pediatric and Neonatal Patients
This study involves looking at Cerebral oximetry measurements in pediatric and neonatal patients who are experiencing a critical illness. Such as Altered mental status, seizures, trauma, sepsis, etc.
- Conditions
- Stroke, Diabetic Ketoacidosis, Increased Intracranial Pressures, Altered Mental Status
- Trial name
- NIRSCI (NCT02950181)
- Testing
- NIRS
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Acute Kidney Injury
Effect of Filter Lifespan in CRRT on New Infections in Critically Ill Patients With AKI
This observational study aims to explore the factors that influence the risk of new infections in critically ill patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) in the UK.
- Trial name
- CRRTinfUK (NCT07903519)
- Where
- United Kingdom
- Volunteers
- 630 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Invasive Mechanical Ventilation, Ventilation-Perfusion Mismatch
Physiological Dead Space and Intensive Care Mortality in Mechanically Ventilated Patients
This study investigates the relationship between physiological dead space and clinical outcomes, specifically mortality and discharge status, in adult patients receiving invasive mechanical ventilation in the intensive care unit…
- Conditions
- Invasive Mechanical Ventilation, Ventilation-Perfusion Mismatch, ICU Mortality, Critical Illness
- Trial name
- IRIS-MAP (NCT06963944)
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Karadeniz Technical University
Candida Sepsis, Candidiasis, Invasive
Early Identification of Candida in Intra-abdominal Candidiasis
Intra-abdominal candidiasis remains the first origin of invasive candidiasis in critically ill patients with a mortality up to 60%. This high mortality is partly related to delay of anti-fungal treatment administration.
- Conditions
- Candida Sepsis, Candidiasis, Invasive, Peritonitis Infectious, Critically Ill
- Trial name
- ICCA (NCT05264571)
- Testing
- calscreener, Metabolic profile, optical microscopy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Critical Illness
Effect of Intensivist Communication on Surrogate Prognosis Interpretation
This study evaluates the effect of physician communication styles on the interpretation of prognosis by family members of chronically-ill patients.
- Trial name
- NCT04239209
- Testing
- Indirect - other patients, Indirect - physiology, Redirection
- Where
- United States
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Critical Illness
Critical Care OptimizatIon of Albumin Ordering
Strong evidence suggests that human albumin solutions should not be used for fluid resuscitation except among patients undergoing therapeutic plasmapheresis and select patients with complications of liver cirrhosis (i.e.
- Trial name
- RATIONALE (NCT04187534)
- Testing
- Albumin Fluid Resuscitation Optimization Intervention, Usual Practice
- Where
- 15 sites in Canada
- Volunteers
- 50,000 people
- Sponsor
- University of Calgary
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