Clinical trials: Illness, Critical
Covid19, Pediatric ALL
Pediatric Intensive Care and COVID-19
In this prospective longitudinal cohort the investigators reported the clinical, and biological characteristics of all critically ill patients admitted in the pediatric intensive care unit (PICU) of Bicêtre Hospital during the…
- Conditions
- Covid19, Pediatric ALL, Infection, Critical Illness
- Trial name
- CLOVIS (NCT04544878)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Acute Respiratory Failure
Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults
This study will compare the sensitivity and specificity of waveform capnography versus colorimetric carbon dioxide detection to identify tracheal placement of the endotracheal tube during intubation of critically ill adults.
- Trial name
- WAVE (NCT06934876)
- Testing
- Colorimetric carbon dioxide (CO2) detection, Waveform capnography
- Where
- 9 sites in United States
- Volunteers
- 2,092 people
- Sponsor
- Brian Driver
Critical Illness Myopathy
NLRP3 Inflammasome and Physical Therapy in ICU-Acquired Weakness
The goal of this clinical trial is to study whether physical therapy can reduce NLRP3 inflammasome activation and muscle atrophy in patients with critical illness myopathy (CIM).
- Trial name
- PT-NLRP3-CIM (NCT07017517)
- Testing
- Motomed Letto® servo-assisted cycling + standard physiotherapy, Standard physiotherapy
- Where
- 3 sites in Chile
- Volunteers
- 24 people
- Sponsor
- University of Chile
Covid19, Critical Illness
Sex Hormone Dysregulations Are Associated With Critical Illness in COVID-19 Patients
Males develop more severe SARS-CoV-2 infection related disease outcome than females. Herein, sex hormones were repeatedly proposed to play an important role in Covid-19 pathophysiology and immunity.
- Trial name
- HAM-SEX-C19 (NCT04979091)
- Testing
- Sex Hormones
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anemia, Post ICU Syndrome
Iron Deficiency at ICU Discharge
IRON-RECOVERY is a prospective, multicenter, observational cohort study designed to determine the prevalence of iron deficiency at intensive care unit (ICU) discharge and to evaluate its association with post-ICU clinical…
- Conditions
- Anemia, Post ICU Syndrome, Red Blood Cell Transfusions, Iron Deficiencies
- Trial name
- IRON-ICU (NCT07781540)
- Testing
- transferrin saturation
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 462 people
- Sponsor
- Università degli Studi di Ferrara
Critical Illness, Brain Injury
Adverse Events During Physical Therapy in Neurocritical ICU Patients
The goal of this observational study is to identify the clinical, neurological, hemodynamic, and respiratory variables associated with the occurrence of adverse events during physical therapy interventions in adult neurocritical…
- Conditions
- Critical Illness, Brain Injury, Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT07901140
- Testing
- Physical Therapy Intervention
- Where
- 2 sites in Mexico
- Volunteers
- 47 people
- Sponsor
- Hospital H+ Queretaro
Brainstem Response
Use of BRASS in Sedated Critically-ill Patients as a Predictable Mortality Factor
Sedation is used for 30 to 70 % of all intensive care unit (ICU) patients. Deep sedation can be used for lot of disease like acute respiratory distress syndrome, septic shock.
- Trial name
- BRASS-ICU (NCT03835091)
- Testing
- BRASS score
- Where
- France
- Volunteers
- 110 people
- Sponsor
- CHU de Reims
Critically Ill
Microcirculation in Spontaneous Breathing Trial
Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients.
- Trial name
- NCT04711590
- Testing
- Microcirculation examination
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- National Taiwan University Hospital
Cryotherapy Effect
Evaluation of Efficacy of Cryotherapy for Skin Anesthesia During Arterial Puncture
the purpose of this study is to evaluate the cryotherapy effect by vapocoolant spray to reducing pain during puncture for artérial blood gas
- Trial name
- SNOW (NCT03973385)
- Testing
- Cryotherapy
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Versailles Hospital
Critically Ill
Therapeutic Monitoring of Vancomycin in Critical Ill Patients: a Registry
Vancomycin is a glycopeptide antibiotic that is the first line antibiotics for the treatment of serious gram-positive infections involving methicillin-resistant Staphylococcus aureus (MRSA).
- Trial name
- VCMTDMinCI (NCT02896218)
- Testing
- Pharmacists consultation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Critically Ill
TEAM: A Trial of Early Activity and Mobility in ICU
Patients in the intensive care unit (ICU) traditionally receive bed rest as part of their care. They develop muscle weaknesses even after only a few days of mechanical ventilation that may prolong their time in ICU and in…
- Trial name
- TEAM-RCT (NCT01927510)
- Testing
- Early mobilisation
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 50 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
ICU Acquired Weakness
Evaluation of Diaphragmatic Function and Quadriceps Muscle Thickness in Patients Receiving High Protein Nutrition
Different Protein Doses' Effect on Diaphragmatic Function and Quadriceps Thickness
- Trial name
- NCT06025760
- Testing
- patients who will receive 2 gm protein/kg/day will be evaluated by ultrasound for diaphragmatic function and quadriceps muscle thickness
- Volunteers
- 32 people
- Sponsor
- Zagazig University
Critical Illness Myopathy, Critical Illness Polyneuropathy
Improved Recovery of Walking in Acquired Muscle Weakness
The aim of Re-Walk-Easy is to evaluate the effects of rehabilitation based on electrical stimulation on the motor performance of critically ill patients.
- Trial name
- Re-Walk-Easy (NCT06786390)
- Testing
- Rehabilitation protocol: FES, Rehabilitation protocol without FES
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Critically Ill, Acute Lung Injury
Respiratory Mechanics and Pleural Effusion
The investigators aim to compare the respiratory mechanics in acute lung injury (ALI)/acute respiratory diseases syndrome (ARDS) patients with and without pleural effusion.
- Conditions
- Critically Ill, Acute Lung Injury, ARDS
- Trial name
- NCT00258518
- Testing
- mechanical ventilation/CT Scan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Policlinico Hospital
Respiratory Failure, Acute Hypoxemic Respiratory Failure
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen…
- Conditions
- Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia
- Trial name
- NCT06501118
- Testing
- Education, Epic notification alert
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- University of Colorado, Denver
Acute Kidney Injury
Transition of Acute Kidney Injury to Chronic Kidney Disease
Acute kidney injury is a complex clinical syndrome,associated with high short and long- term morbidity and mortality in critical ill patients.Acute kidney injury outcomes may vary from a complete resolution to a partial or…
- Trial name
- NCT04101110
- Testing
- Renal biopsy
- Where
- Egypt
- Volunteers
- 252 people
- Sponsor
- Assiut University
Critical Care Patient; Lower Digestive Tract Disorder;, Colon Lesions;
Acute Non-mechanical Lower Digestive Tract Disorders Should Distinguish Whether Colonic Lesions or Not in Critically Ill Patients
The purpose of the study is to investigate acute non-mechanical lower digestive tract disorders should distinguish whether colonic lesions or not in critically ill patients
- Trial name
- NCT01919060
- Volunteers
- 69 people
- Sponsor
- Nanjing PLA General Hospital
Ventilator Associated Pneumonia
Risk Factors of Ventilator-Associated Pneumonia in Critically Ill Population of Alexandria
The aim of the study is to compare cases of ventilator-associated pneumonia with matched controls of mechanically ventilated patients to identify any relevant independent risk factors for ventilator-associated pneumonia.
- Trial name
- NCT07116382
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Suez Canal University
Critical Illness
The Impact of Higher Positive End Expiratory Pressure on Patient-Ventilator Asynchrony
Patient-ventilator asynchrony is known to frequently occur during lung protective ventilation in patients with ARDS. Previous clinical studies showed that patient-ventilator asynchrony was associated with worse outcome in ICU.
- Trial name
- NCT04951960
- Testing
- Higher PEEP setting, Lower PEEP setting
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Osaka University
Sepsis
Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis
Procalcitonin is a promising marker of sepsis in critically ill patients. Procalcitonin have better diagnostic accuracy compared to White blood cell count and C - reactive protein.
- Trial name
- NCT03506152
- Testing
- Serum Procalcitonin
- Where
- Pakistan
- Volunteers
- 103 people
- Sponsor
- Aga Khan University
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