Clinical trials: Illness, Critical
Acute Gastrointestinal Injury, Critical Illness
Correlation Between Acute Gastrointestinal Injury and Venous Return in Critical Ill Patients
Currently, altered intestinal blood flow in critically ill patients has been a hot research topic in recent years. In 2022, studies on acute mesenteric ischemia were published in top journals in critical care medicine [Crit Care…
- Trial name
- NCT06667297
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Septic Shock
Temporal Changes of Lactate in CLASSIC Patients
This study aim to examine if randomization to different treatment strategies had any effect on the time to normalization of lactate in intensive care patients treated for septic shock.
- Trial name
- NCT05629780
- Testing
- Resuscitation fluid
- Where
- Sweden
- Volunteers
- 777 people
- Sponsor
- Karolinska University Hospital
Bacterial Infections
Pharmacokinetics of Ceftazidime-avibactam Among Critically-ill Patients Receiving CVVHDF
Ceftazidime-avibactam is used for treatment of invasive Gram-negative bacterial infections among critically ill patients, including those on continuous venovenous hemodiafiltration .
- Trial name
- NCT04358991
- Testing
- Ceftazidime-avibactam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
COVID-19
A Clinical Trial of Mycobacterium w in Critically Ill COVID 19 Patients
The trial is randomized, blinded, two arms, active comparator controlled, clinical trial to evaluate the safety and efficacy of Mycobacterium w in combination with standard care as per hospital practice versus standard care alone…
- Trial name
- NCT04347174
- Testing
- Suspension of heat killed (autoclaved) Mycobacterium w
- Where
- 4 sites in India
- Volunteers
- 40 people
- Sponsor
- Cadila Pharnmaceuticals
Anxiety
Music for Anxiety in Critically Ill Patients
Rationale: Anxiety is common in critically ill patients, and has likely become more prevalent in the recent decade due to the imperative of the recent PADIS guidelines to use low levels of sedation and strive for wakefulness.
- Trial name
- RELACS (NCT04796389)
- Testing
- Music
- Where
- 3 sites in Netherlands
- Volunteers
- 104 people
- Sponsor
- Erasmus Medical Center
Cross Infection (Hospital-Acquired Infections), Critical Illness
Probiotics for Preventing ICU-Acquired Infections in Critically Ill Patients: A Pilot Study
This pilot randomized clinical trial investigated the effect of probiotic supplementation on the incidence of intensive care unit-acquired infections (ICU-AIs) in critically ill patients.
- Conditions
- Cross Infection (Hospital-Acquired Infections), Critical Illness, Probiotic Intervention
- Trial name
- NCT07144124
- Testing
- Biopro-max 8 Billion Probiotics (Bioserv Healthcare)
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Acute Respiratory Infection, Sepsis
Capnodynamic Monitoring of Cardiorespiratory Function in Critically Ill Patients
Capnodynamic monitoring has the potential to offer continuous and non-invasive measurements of heart and lung function in patients requiring ventilation in an intensive care setting.
- Conditions
- Acute Respiratory Infection, Sepsis, Postoperative Respiratory Distress
- Trial name
- PROFICIENT (NCT05082168)
- Testing
- Capnodynamic monitoring
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- South West Sydney Local Health District
Intubation, Pulmonary Ventilation
Immuno Nutrition by L-citrulline for Critically Ill Patients
The main objective of this study is to demonstrate that the only administration of L-citrulline, can improve immune functions in critically ill patients at high risk of nosocomial infection.
- Trial name
- Immunocitre (NCT02864017)
- Testing
- Enteral nutrition, L-Citrulline
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- Rennes University Hospital
Critical Illness, Acute Kidney Injury
Outcomes of Critically Ill Patients With Severe Acute Kidney Injury Requiring Renal Replacement Therapy
This study assess the vital status, renal function and renal recovery of patients admitted to intensive care unit and requiring renal replacement therapy for acute kidney failure.
- Trial name
- PROVEER (NCT02897310)
- Where
- France
- Volunteers
- 245 people
- Sponsor
- University Hospital, Brest
Sepsis
Rezafungin Pharmacokinetics in Patients on ECMO
Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary life-support for critically ill patients where blood is extracted from the vascular system and circulated by a mechanical pump while it is oxygenated and…
- Trial name
- NCT06329518
- Testing
- Rezafungin
- Sponsor
- Hartford Hospital
Difficult Intubation in ICU, Strictly More Than Two Laryngoscopies
Difficult Intubation in Intensive Care
Difficult intubation is associated with a worse outcome in intensive care unit (ICU). New videolaryngoscope devices are proposed to improve airway management in ICU patients.
- Conditions
- Difficult Intubation in ICU, Strictly More Than Two Laryngoscopies, Cormack Grade Three/Four
- Trial name
- NCT01816217
- Testing
- Intubation with The McGrath Mac videolaryngoscope
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Bronchopulmonary Dysplasia (BPD), Premature Births
PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia
The purpose of the study is to learn how safe montelukast may be in premature infants at significant risk for Bronchopulmonary Dysplasia (BPD) and to determine how much and how quickly montelukast moves from the stomach into the…
- Conditions
- Bronchopulmonary Dysplasia (BPD), Premature Births, Critical Illness
- Trial name
- PRISM (NCT07101640)
- Testing
- montelukast 4 mg granule
- Where
- 5 sites in United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Septic Shock, Candidiasis
Candida Host Defense Response After Septic Shock in the Critically Ill
Septic shock is associated with acquired immunoparalysis which is associated with a high risk of nosocomial acquired infection. Nosocomial candidiasis is associated with a 50% rate of mortality but is difficult to diagnose.
- Trial name
- IMMUNOCANDIDA (NCT03136081)
- Testing
- Candidiasis infection occurence
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Traumatic Brain Injury
Efficacy of Lung and Inferior Vena Cava Sonography for Fluid Optimization
Traumatic brain injury (TBI) is a leading cause of death and disability in trauma patients. As the primary injury cannot be reversed, management strategies must focus on preventing secondary injury by avoiding hypotension and…
- Trial name
- NCT05400343
- Testing
- Standard care (control group), US-guided fluid management (active group), Standard ICU Care
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
ICU Length of Stay
Primary Intensivists and Primary Nurses to Decrease Pediatric ICU Length of Stay
This is a randomized control trial of PICU patients admitted for 7 days and expected to remain for at least another 3 days and who have a complex chronic condition.
- Trial name
- PIPRNs (NCT03364933)
- Testing
- Primary intensivist and nurses
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Mechanically Ventilated ICU Patients
The Effect of Sodium Oxybate on Sleep Architecture
The purpose of this study is to determine what effect sodium oxybate has on the functions of sleep in mechanically ventilated, critically ill patients hospitalized in an intensive care unit.
- Trial name
- NCT00744393
- Testing
- sodium oxybate
- Where
- United States
- Sponsor
- Tufts Medical Center
Intensive Care (ICU), Critical Illness
Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin
The goal of this observational study is to learn whether hazardous alcohol consumption, measured objectively by carbohydrate-deficient transferrin (CDT) levels at intensive care unit (ICU) admission, is associated with worse…
- Conditions
- Intensive Care (ICU), Critical Illness, Alcohol Misuse
- Trial name
- IMPACT (NCT07632716)
- Testing
- Carbohydrate-Deficient Transferrin (CDT) Measurement
- Where
- Austria
- Volunteers
- 800 people
- Sponsor
- Medical University of Vienna
Critical Illness, Post Operative Complication
Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial
Patients admitted to the Intensive Care Unit (ICU) after thoracic surgery often experience complications related to immobility, such as muscle weakness, pulmonary issues, and longer recovery times.
- Conditions
- Critical Illness, Post Operative Complication, Thoracic Surgery
- Trial name
- HEART (NCT07220733)
- Testing
- Self-balancing robotic exoskeleton (Atalante X)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wandercraft
Pre-Eclampsia, Hypotension
Inferior Vena Cava Collapsibility Index Guide for Preoperative Fluid Therapy in Preeclampsia
The routine assessment of fluid status depends on clinical evaluation and invasive monitoring. The clinical assessment lacks objectivity and the invasive monitoring carries risks.
- Conditions
- Pre-Eclampsia, Hypotension, Fluid Overload
- Trial name
- NCT06539026
- Testing
- fluid therapy, 300 ml of crystalloid Ringer's solution.
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Septic Shock
ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock
The purpose of this study is to find out whether adult patients admitted to the Intensive Care Unit with septic shock who are given hydrocortisone compared to placebo (a dummy solution), will have an improved rate of survival 90…
- Trial name
- ADRENAL (NCT01448109)
- Testing
- Hydrocortisone, Sterile air filled vial
- Where
- 70 sites in Australia, Denmark and 3 more
- Volunteers
- 3,800 people
- Sponsor
- The George Institute
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