Clinical trials: Illness, Critical
Pain
Validation of "Escala de Conductas Indicadoras de Dolor" ESCID Scale for Measuring Pain in Critically Ill Patients
Pain is an unpleasant and important stress factor, and a potentially harmful experience for critically ill patients. Pain is harder to evaluate in non-communicative patients, who can´t report their own pain.
- Trial name
- ESCID-MQ (NCT01744717)
- Testing
- Pain measurement
- Where
- Spain
- Volunteers
- 286 people
- Sponsor
- Puerta de Hierro University Hospital
Sepsis, Obstructive Shock
Use of Renin Versus Lactic Acid as Tissue Perfusion Biomarkers for Mortality Prediction in Hypotensive Critically Ill Patients
Measurement of Whole Blood Lactate Concentrations Whole blood lactate concentrations will be measured at the time of study enrollment and at 24, 48, and 72 hours.
- Conditions
- Sepsis, Obstructive Shock, Critical Illness, Hypotensive
- Trial name
- NCT05810415
- Testing
- Renin levels and lactic acid levels
- Where
- 2 sites in Egypt
- Volunteers
- 84 people
- Sponsor
- Al-Azhar University
Respiratory Failure, Critical Illness
Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation
Sedation is frequently required in critically ill patients admitted to the intensive care unit (ICU), including those receiving non-invasive respiratory support such as high-flow nasal cannula (HFNC), non-invasive ventilation…
- Trial name
- CALM-ICU (NCT07536750)
- Where
- China
- Volunteers
- 1,680 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Traumatic Brain Injury
Efficacy of Lung and Inferior Vena Cava Sonography for Fluid Optimization
Traumatic brain injury (TBI) is a leading cause of death and disability in trauma patients. As the primary injury cannot be reversed, management strategies must focus on preventing secondary injury by avoiding hypotension and…
- Trial name
- NCT05400343
- Testing
- Standard care (control group), US-guided fluid management (active group), Standard ICU Care
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Critical Illness, Septic Shock
Microcirculatory Alterations in Critical Disease: New Ultrasound Technology
Aim of this study is (1) to test and further develop a new non-invasive ultrasound method, and (2) to gain new insight into microcirculatory alterations during critical disease, particularly in critical septic shock patients.
- Trial name
- SepCease (NCT03311568)
- Testing
- ultrasound for microcirculatory assessment
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Acute Kidney Injury, Acute-On-Chronic Liver Failure
Risk Factors for Acute Kidney Injury in Critically Ill Patients With Acute-on-Chronic Liver Failure
Acute kidney injury (AKI) is one of the most important factors associated with increased mortality in patients with acute-on-chronic liver failure (AoCLF).
- Trial name
- NCT04525625
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Institutul Clinic Fundeni
Critical Illness
Renal Replacement Anticoagulant Management
Observational comparative effectiveness study of individual patient data using interrupted time series analysis techniques of linked data sources to establish clinical and health economic effects of moving from systemic heparin…
- Trial name
- RRAM (NCT03545750)
- Where
- United Kingdom
- Volunteers
- 85,000 people
- Sponsor
- Intensive Care National Audit & Research Centre
Delirium
Melatonin for Prevention of Delirium in Critically Ill Patients
The purpose of this study is to determine the feasibility of conducting a randomized controlled trial (RCT) with melatonin for prevention of delirium in critically ill adult patients.
- Trial name
- MELLOW-1 (NCT02615340)
- Testing
- Melatonin
- Where
- 3 sites in Canada
- Volunteers
- 69 people
- Sponsor
- Mount Sinai Hospital, Canada
Sepsis
Rezafungin Pharmacokinetics in Patients on ECMO
Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary life-support for critically ill patients where blood is extracted from the vascular system and circulated by a mechanical pump while it is oxygenated and…
- Trial name
- NCT06329518
- Testing
- Rezafungin
- Sponsor
- Hartford Hospital
Critical Illness
Antibiotic Regimens Tailored by Clinical Pharmacist Suppored by Intensivist Enhanced Rational Use of Antibiotics
adding pharmaceutical services to patient care and changing the professional activity of pharmacists from drug-focused to patient-oriented care,in the current study, clinical pharmacists will be assigned to monitor…
- Trial name
- NCT04931914
- Testing
- Clinical pharmacy sharing in the patient care regimen
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- University of Alexandria
Critical Care
Neutrophil Lymphocyte Ratio as a Predictor of Outcome in Critically Traumatic Patients
Neutrophil lymphocyte ratio NLR is an important index that evaluate the inflammatory status . It is a cost effective and readily available , and simply calculated , so that why investigators try to use it as a predictor of short…
- Trial name
- NCT02749487
- Testing
- Neutrophil Lymphocyte Ratio
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Intra-Abdominal Hypertension, Critical Illness
Intra-Abdominal Pressure Changes During Continuous Renal Replacement Therapy in Critically Ill Patients
This prospective observational study will evaluate changes in intra-abdominal pressure in critically ill adult patients receiving continuous renal replacement therapy in the intensive care unit.
- Conditions
- Intra-Abdominal Hypertension, Critical Illness, Continuous Renal Replacement Therapy
- Trial name
- NCT07823387
- Testing
- Intravesical Intra-abdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Systemic Inflammatory Response Syndrome
Leptin: a Therapeutic Option for Treating Catabolic States and Malnutrition in Critically Ill Patients
Leptin is a hormone that plays a central role in food intake and energy balance. It is secreted by fat cells, released into the circulation and transported into the central nervous system (brain), where it regulates energy…
- Trial name
- NCT00893932
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Hadassah Medical Organization
Covid19
Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.
Given its anti-viral, anti-oxidative, immune-enhancing, cytokine-modulating, and anticoagulant properties, the investigators hypothesize that Selenium infusion at supranutritional doses for moderately-ill, severely-ill, and…
- Trial name
- SeCOVID (NCT04869579)
- Testing
- Selenium (as Selenious Acid)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- CHRISTUS Health
Critical Illness, Septic Shock
Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study)
This study will test whether giving human albumin to keep the blood albumin level above 3.5 g/dL, in addition to standard care, improves survival in patients with surgical septic shock.
- Trial name
- ALBUS (NCT07212582)
- Testing
- Human Albumin 20% Solution, Standard Care (in control arm)
- Where
- Thailand
- Volunteers
- 304 people
- Sponsor
- Mahidol University
Acute Kidney Injury
Epidemiology and Long Term Outcome of Critically Ill Patients Requiring Renal Replacement Therapy in Southeast Asia and India (InSEA-RRT Registry)
Acute kidney injury is associated with increased short-term and long-term morbidity and mortality. Long-term data is lacking in low to middle-income countries.
- Trial name
- InSEA-RRT (NCT03727997)
- Where
- Thailand
- Volunteers
- 2,315 people
- Sponsor
- Chulalongkorn University
Critical Illness
Influence of Patient/Ventilador Decoupling in Neurocognitive and Psychopathological Sequelae in ICU Patients
Mechanical ventilation (MV) is a vital support tool for critically ill patients. However, it may present several adverse effects, such as the development of cognitive and psychopathological alterations.
- Trial name
- PVI-NCOG (NCT02390024)
- Testing
- Invasive Mechanical Ventilation
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Corporacion Parc Tauli
Simulation of Physical Illness, COVID-19 Respiratory Infection
In Situ Simulation Training in Transferring Critically Ill COVID-19 Patients
This study aimed to determine the role of in situ simulation training during a pandemic by using standard and high-fidelity mannequins to improve interprofessional communication, skills, and teamwork in transferring critically…
- Trial name
- NCT05113823
- Testing
- Simulation Training
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Septic Shock
The Prognostic Role of Tricuspid Annular Plane Systolic Excursion in Critically Ill Patients With Septic Shock
The aim of this study is to evaluate the possible prognostic performance of RV dysfunction, as assessed by TAPSE, in non-cardiac patients with septic shock.
- Trial name
- NCT06008067
- Testing
- tricuspid annular plane systolic excursion (TAPSE)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Critical Illness, Intensive Care Unit Acquired Weakness
PRotEin Provision in Critical IllneSs
Rapid skeletal muscle wasting during critical illness had a detrimental impact on both short and long term outcomes following ICU admission.
- Trial name
- PRECISe (NCT04633421)
- Testing
- PRECISe protocol EN 8g protein/100kcal, PRECISe protocol EN 5g protein/100kcal
- Where
- 10 sites in Belgium, Netherlands
- Volunteers
- 935 people
- Sponsor
- Maastricht University Medical Center
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