Clinical trials: Illness, Critical
Critical Illness, Enteral Nutrition
Early Enteral Feeding and Clinical Outcomes in ICU Patients
This study evaluated the effectiveness of an early enteral feeding protocol in critically ill adult patients admitted to an Intensive Care Unit (ICU).
- Conditions
- Critical Illness, Enteral Nutrition, Intensive Care Unit ICU, Nutritional Support
- Trial name
- EEFP (NCT07131098)
- Testing
- Early Enteral Feeding Protocol, Standard Nutritional Care
- Where
- Palestinian Territories
- Volunteers
- 80 people
- Sponsor
- Loai Muawiah Zabin
Mechanical Ventilation, Infection Prevention
Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units
The goal of the ORACLE study is to evaluate the impact of implementing a standardized oral hygiene bundle on outcomes in critically ill, mechanically ventilated patients.
- Conditions
- Mechanical Ventilation, Infection Prevention, Oral Care, Oral Hygiene, Oral Health
- Trial name
- ORACLE (NCT07129733)
- Testing
- Oral hygiene bundle
- Where
- 6 sites in Brazil
- Volunteers
- 4,800 people
- Sponsor
- Hospital do Coracao
Psycho-educational, Anxiety
The Effect of Bibliotherapy Administered During the Preoperative Period on Vital Signs, Anxiety, and Coping With Illness in Adolescent Patients
This study aimed to evaluate the effects of bibliotherapy administered to adolescent patients in the preoperative period on vital signs, anxiety levels, and coping attitudes using a pretest-posttest controlled experimental…
- Conditions
- Psycho-educational, Anxiety, Illness, Critical
- Trial name
- Bibliotherapy (NCT07126054)
- Testing
- bibliotherapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul Medipol University Hospital
Critical Illness
Impact of Interactive ICU Diary on Psychological Distress
This study investigates the effectiveness of a technology-driven, interactive ICU diary in reducing psychological distress, specifically anxiety, depression, and stress, in ICU patients.
- Trial name
- NCT06512987
- Testing
- technology-driven, interactive ICU diary
- Where
- Taiwan
- Volunteers
- 56 people
- Sponsor
- Taipei Medical University
Heart Failure, ICUAW
Intensive Care Unit-acquired Heart Failure in Critically Ill: the ICU-HF Study
Critically ill patients in intensive care units (ICUs) are exposed to a wide range of complications that can affect long-term morbidity and mortality.
- Trial name
- ICU-HF (NCT07094425)
- Testing
- transthoracic echocardiography
- Where
- 2 sites in Austria, Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Critical Illness
SC2i VIPER: EnVenomation Investigation Pilot to Evaluate Recovery
The purpose of this study is to pilot data for a systematic molecular characterization of pathophysiologic perturbations incurred by snake envenomation and compare this to other inflammatory physiologic states such as trauma and…
- Trial name
- VIPER (NCT03170297)
- Testing
- Research interventions of blood sampling and data collection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Critical Illness, Energy Supply; Deficiency, Severe
GLUCOSAFE 2 - A New Tool for Nutritional Management and Insulin-therapy in the Intensive Care Unit (ICU)
The survival and the outcomes of critically ill patients are strongly influenced by insulin-therapy and nutritional support. The GLUCOSAFE 2 pilot study, aims to test the performance and the security of the new GLUCOSAFE 2…
- Conditions
- Critical Illness, Energy Supply; Deficiency, Severe, Protein Deficiency, Hypoglycemia
- Trial name
- NCT03890432
- Testing
- GLUCOSAFE 2, Local protocol control group with routine care, Historical control group with routine care
- Where
- 2 sites in Switzerland
- Volunteers
- 213 people
- Sponsor
- HEIDEGGER CP
Critical Illness, ICU Acquired Weakness
Optimised Nutritional Therapy and Early Physiotherapy in Long Term ICU Patients (NutriPhyT Trial)
Due to medical advances and quality of care, mortality in adult intensive care units (ICUs) has decreased significantly in recent years, leading to a significant increase in the number of patients with high rehabilitation needs…
- Conditions
- Critical Illness, ICU Acquired Weakness, Malnutrition
- Trial name
- NutriPhyT (NCT05865314)
- Testing
- Optimisation of nutrition therapy coupled with early mobilisation, Standard care
- Where
- Switzerland
- Volunteers
- 164 people
- Sponsor
- HEIDEGGER CP
Critical Illness
Individualized Blood Glucose Control in ICU. The CONTROLING Study. A Double Blinded Multicentric Randomized Study.
During the last 2 decades, the management of hyperglycemia in critically ill patients has become one of the most discussed topics in the intensive-care field.
- Trial name
- CONTROLING (NCT02244073)
- Testing
- Human insulin - Insulin administration to control blood glucose level.
- Where
- 12 sites in France
- Volunteers
- 2,069 people
- Sponsor
- Hospices Civils de Lyon
Critical Illness
Bedside Air Quality in ICU and Clinical Outcome
There is a close relationship between air pollution and cardiovascular disease. Small particulate matter and inhalable particulate matter in the air are the main components of air pollution, which can enter the respiratory system…
- Trial name
- NCT06201754
- Testing
- Measure air quality
- Where
- 3 sites in China
- Sponsor
- First Affiliated Hospital of Zhejiang University
Antibiotic Resistant Infection, Critical Illness
Bolus Versus Continuous Infusion of Meropenem
This study arises from the need to optimize antibacterial drug usage to face increasing drug resistance among gram-negative pathogens in intensive care units.
- Trial name
- MERCY (NCT03452839)
- Testing
- Meropenem
- Where
- 26 sites in Croatia, Italy and 2 more
- Volunteers
- 607 people
- Sponsor
- Università Vita-Salute San Raffaele
Critical Illness, Communication
Communication With Mechanically Ventilated Intensive Care Patients
The overarching aim of this multicenter study is to develop a multimodule training intervention (COMMEC-ICU) for nurses working in ICUs, to increase nurses skills and knowledge and then improve communication for mechanically…
- Conditions
- Critical Illness, Communication, Intensive Care Unit Syndrome
- Trial name
- COMMEC-ICU (NCT06977555)
- Testing
- Communication Course and skills training
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Critical Illness, Hyperglycaemia
Intermittent Versus Continuous Glucose Monitoring in Intensive Care Unit
Glucose control is an important part of supportive care for critically ill patients. Achieving optimal glucose control in such situations is challenging due to frequent fluctuations in blood glucose levels.
- Conditions
- Critical Illness, Hyperglycaemia, Hypoglycaemia
- Trial name
- ICONS-ICU (NCT07088549)
- Testing
- Continuous glucose monitoring, Control Arm - standard of care
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Ljubljana
Hypomagnesemia, Critical Illness
Hypomagnesemia and Its Clinical Outcome
Magnesium is an essential electrolyte involved in numerous physiological processes, including maintaining cellular integrity, regulating muscle tone, supporting cardiovascular function, and modulating immune responses.
- Conditions
- Hypomagnesemia, Critical Illness, Intensive Care Unit (ICU) Patients, Scoring Systems
- Trial name
- Hypogamnesamia (NCT07089004)
- Testing
- No intervention (observational study)
- Where
- Bangladesh
- Volunteers
- 112 people
- Sponsor
- Bangladesh Bioscience Research Group
Critical Illness
Physical Therapist Inter-Rater Reliability in Neuro-Muscle Ultrasound in Critically Ill Patients
The goal of this observational study is to evaluate the feasibility and inter-rater reliability of muscle and peripheral nerve ultrasound for the early detection of ICU-acquired weakness (ICU-AW) in critically ill patients.
- Trial name
- NMusICU-R (NCT07032870)
- Where
- Chile
- Volunteers
- 37 people
- Sponsor
- University of Chile
Critical Illness, Delirium
Family Integration in Therapy Activities in the Intensive Care Unit: The FIT-ICU Feasibility Study
An ICU admission is stressful for not only patients but their families as well. Research has shown that involving family members during a loved one's ICU stay can be helpful for them, but there is not clear direction on the best…
- Trial name
- FIT-ICU (NCT06071793)
- Testing
- Family involvement
- Where
- 3 sites in Canada
- Volunteers
- 20 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Mechanical Ventilation, Critical Illness
Effect of Ventilation Mode in the Pupillary Light Reflex: A Crossover Study
The goal of this clinical trial is to explore whether different modes of mechanical ventilation affect pupillary constriction velocities in critically ill patients without brain injury.
- Trial name
- EYE-BREATH (NCT07082569)
- Testing
- Volume Control Ventilation, Pressure Control Ventilation, Pressure-Regulated Volume Control (PRVC)
- Where
- Greece
- Volunteers
- 36 people
- Sponsor
- Evangelismos Hospital
Critical Illness, Delirium
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge.
- Conditions
- Critical Illness, Delirium, Cognitive Impairment, Cognitive Decline
- Trial name
- SLEEP-COG (NCT06411561)
- Testing
- SLEEP + COG, COG, SLEEP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Palliative Care, Critical Illness
A Needs-focused Palliative Care Intervention for Older Adults in ICUs
The quality of intensive care unit (ICU)-based palliative care is highly variable, particularly for the 2 million older adults admitted annually to ICUs.
- Conditions
- Palliative Care, Critical Illness, Aging, Care Delivery Model
- Trial name
- PCplanner (NCT04414787)
- Testing
- PCplanner
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Duke University
Critical Illness
Effects of Positional Therapy on Pulmonary Physiology in Patients Undergoing Mechanical Ventilation.
The aim of this project is to evaluate the effects of positional changes in mechanically ventilated patients.
- Trial name
- NCT04471090
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa