Clinical trials: Illness, Critical
Cardiovascular Disease, Aortic Dissection
Additive Anti-inflammatory Action for Critically Ill Patients With Cardiovascular Surgery (Xuebijing) IV
XueBiJing, a Chinese herbal derived therapeutic, has been approved to treat severe infections (sepsis) in critically ill patients (China Food and Drug Administration; Beijing, China, Number Z20040033).
- Conditions
- Cardiovascular Disease, Aortic Dissection, Coronary Artery Disease, Valve Heart Disease
- Trial name
- NCT04993794
- Testing
- XueBiJing Injection, Normal saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Critical Illness, Sepsis, Severe
Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm
The inflammatory storm in critically ill patients releases cytokines, causing systemic immune damage, which may be an important cause of multiple organ failure and even death.
- Trial name
- NCT04850456
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Appropriate Startup of Acid Suppressive Therapy
Acid Suppressive Therapy - Review of Appropriateness
Acid suppressive therapy (AST) is used in a variety of indications in prevention and treatment of gastric acid related disorders. In recent years, an increase in the use of acid suppressive therapy has been documented.
- Trial name
- ASTRA (NCT02259270)
- Testing
- Record review, AST-history
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
COVID-19, Critical Illness
Interleukin-6 Antagonists in Critically-ill Covid-19 Patients
The emerging SARS-COV2 virus has shed a new light on the cross-talks between the immune and the hemostatic system. In this study we aim to evaluate the dynamic change in coagulation caused by the modulation of the inflammatory…
- Trial name
- HEMOCOV (NCT05218369)
- Testing
- IL6 Antagonist
- Where
- 3 sites in Hungary
- Volunteers
- 30 people
- Sponsor
- University of Pecs
Critical Illness, Anxiety
Self-management of Sedative Therapy by Ventilated Patients
The purpose of this randomized clinical trial is to test the efficacy of dexmedetomidine for the self-management of sedative therapy (SMST) in a sample of critically ill patients receiving mechanical ventilator support.
- Conditions
- Critical Illness, Anxiety, Respiratory Failure
- Trial name
- NCT02819141
- Testing
- Dexmedetomidine
- Where
- 2 sites in United States
- Volunteers
- 161 people
- Sponsor
- Mayo Clinic
Critical Illness, Palliative Care
Improving Needs Among Older Adults
Millions of older adults receive care in intensive care units (ICUs) annually. However, the quality and accessibility of ICU-based palliative care is highly variable across hospitals and clinicians, due in part to specialists'…
- Conditions
- Critical Illness, Palliative Care, Older Adults, Informal Caregivers
- Trial name
- ICUconnect 2 (NCT06588556)
- Testing
- ICUconnect, Usual care
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- Duke University
Post Intensive Care Syndrome, ARDS: Acute Respiratory Distress Syndrome
Combined Activity and Cognitive Intervention for ICU Survivors
This mixed-methods study comprising a 3-arm pilot RCT and a qualitative study aims to investigate the preliminary effects and feasibility of a home-based combined activity and cognitive intervention for ICU survivors…
- Conditions
- Post Intensive Care Syndrome, ARDS: Acute Respiratory Distress Syndrome, Delirium, Loss of Muscle Mass
- Trial name
- NCT06117761
- Testing
- Home-based exercises combined with cognitive training, Home-based exercises
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Acute Kidney Injury, COVID-19
Incidence of Acute Kidney Injury in Covid-19
Acute kidney injury (AKI) in Covid-19 patients is a topic that receives little attention in the literature, although being important in clinical practice in the ICU, particularly in Oman.
- Conditions
- Acute Kidney Injury, COVID-19, Critically Ill
- Trial name
- COVIDAKI (NCT05467956)
- Testing
- Covid-19
- Where
- Oman
- Volunteers
- 286 people
- Sponsor
- Sultan Qaboos University
Lung Collapse
Brochoscopic Intervention Versus Conventional Management in Acute Lung Collapse in the Pediatric Intensive Care Unit
This prospective RCT at Cairo University Children Hospitals enrolls critically ill pediatric patients (intubated, NIV, or post-extubation) with lung atelectasis unresponsive to 48 hours of conventional recruitment.
- Trial name
- picu (NCT07383129)
- Testing
- bronchoscope, chest physiotherapy and suction
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
ICU Ill Patients, Critical Illness
Evolution of Physical and Emotional Distress in ICU
Emotional distress is prevalent in ICU patients and may be influenced by physical symptoms such as dyspnea and pain, yet its evolution and interactions during ICU stay remain insufficiently explored.
- Trial name
- CARE-ICU (NCT07153380)
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Corporacion Parc Tauli
Critical Illness, Communication Disabilities
Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience Among Surrogate Decision-Makers of ICU Patients
Intensive Care Units (ICU) are stressful places where life-and-death medical decisions are made and patients' surrogate decision-makers are exposed to potentially traumatic experiences.
- Trial name
- EMPOWER (NCT03276559)
- Testing
- EMPOWER, Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Delirium, Aging
MIND-ICU Study: Delirium and Dementia in Veterans Surviving ICU Care
This will be the first large cohort study to define the epidemiology of and identify modifiable risk factors for long-term CI and functional deficits of ICU survivors.
- Conditions
- Delirium, Aging, Dementia
- Trial name
- NCT00400062
- Where
- 3 sites in United States
- Volunteers
- 800 people
- Sponsor
- VA Office of Research and Development
Bacterial Infection
Minocycline Pharmacokinetics (ACUMIN)
This is a Phase IV, multi-center open-label pharmacokinetic trial studying the pharmacokinetics and pharmacodynamics of a single dose of Minocin IV.
- Trial name
- NCT03369951
- Testing
- Minocycline
- Where
- 15 sites in United States
- Volunteers
- 58 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Agitation, Emergence
Efficacy of Dexmedetomidine vs Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning
Comparison of effect of dexmedetomidine and midazolam in icu patients who put on mechanical ventilation and show agitation on weaning.Selection of better agent minimises the drug related side effects like respiratory depression…
- Trial name
- NCT05264077
- Testing
- Dexmedetomidine Hydrochloride
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Medical College
Critical Illness
Adult Intensive Care Units Database of National Taiwan University Hospital
Australian and New Zealand Intensive Care Society (ANZICS) has built an Center of Outcome and Resource Evaluation (CORE) adult patients database (APD) of adult critically ill patients.
- Trial name
- NCT04541862
- Testing
- Intensive care
- Where
- Taiwan
- Volunteers
- 200,000 people
- Sponsor
- National Taiwan University Hospital
Malnutrition, Critical Illness
Assessment of Nutritional Status in Critically Ill Children in PICU
This prospective cohort study aims to assess the nutritional status of critically ill children aged 1 month to 5 years admitted to the pediatric intensive care unit using a comprehensive ABCD approach including anthropometric…
- Trial name
- NCT07830966
- Volunteers
- 103 people
- Sponsor
- Assiut University
Infection During Renal Replacement Therapy, Critically Ill
Ceftaroline Pharmacokinetics in Continuous Renal Replacement Therapy
Dosing of ceftaroline in patients with chronic kidney disease is defined, but there is no data on pharmacokinetics and pharmacodynamics of the drug in patients receiving continuous renal replacement therapy (CRRT).
- Trial name
- NCT04152694
- Testing
- Ceftaroline levels in CRRT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Maryland, Baltimore
Delirium Risk, Critical Illness in Coronary ICU Patients
THE EFFECTS OF VIRTUAL ART THERAPY ON PHYSIOLOGICAL PARAMETERS, DELIRIUM RISK, ANGER, ANXIETY, AND MENTAL AND SPIRITUAL RECOVERY IN INTENSIVE CARE PATIENTS.
Patients in intensive care units experience significant physiological and psychological stress due to life-threatening conditions and invasive treatments.
- Conditions
- Delirium Risk, Critical Illness in Coronary ICU Patients, Mental and Spiritual Recovery, Effects of Virtual Art Therapy
- Trial name
- NCT07562802
- Testing
- Virtual Art Therapy
- Volunteers
- 62 people
- Sponsor
- Inonu University
Muscle Wasting
Effects of Omega-3 Fatty Acids on Muscle Wasting
The risk of muscle wasting, and sarcopenia is high in the intensive care unit patients and associated with adverse clinical outcomes.
- Trial name
- NCT04582630
- Testing
- omega 3 fatty acid
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Karadeniz Technical University
Sepsis, Septic Shock
Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill
This study will test the feasibility of ultrasound-guided sterile blood sampling for critically ill patients with suspected sepsis requiring blood culture.
- Conditions
- Sepsis, Septic Shock, Infections, Diagnosis
- Trial name
- ECOVEN (NCT06156072)
- Testing
- Ultrasound-guided venipuncture
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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