Clinical trials: Illness, Critical
Pressure Injury, Critically Ill Patients
Construction and Application of Pressure Injury Risk Prediction Model for Critically Ill Patients
In the previous investigation, investigators found that when the risk factors of stress injury in critical patients changed, clinical nurses lacked the awareness of evaluating the risk of stress injury, and lacked the risk…
- Conditions
- Pressure Injury, Critically Ill Patients, Risk Factors, Machine Learning Algorithms
- Trial name
- NCT05564975
- Volunteers
- 350 people
- Sponsor
- Yang Chaonan
Gastrointestinal Injury
Biomarkers and Bowel Sounds in Patients With Acute Gastrointestinal Injury
The incidence of gastrointestinal diseases is high in intensive care unit (intensive care unit,ICU). In critically ill patients, the intestinal tract is the "engine" of multiple organ dysfunction syndrome (Multiple organ…
- Trial name
- BABSIPWAGI (NCT04769830)
- Testing
- Bowel sound
- Where
- China
- Volunteers
- 172 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Ventilator Associated Bacterial Pneumonia (VABP), Critical Illness
Effect of Ventilator Hyperinflation Combined With Body Positioning on ABG in VAP
This study aims to evaluate the effect of ventilator hyperinflation combined with body positioning on arterial blood gases in patients with ventilator-associated pneumonia.
- Trial name
- NCT07854730
- Testing
- Ventilator hyperinflation, Manual hyperinflation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Zaytoonah University of Jordan
Nutrition Disorders, Neurologic Disorder
The Effects of Enteral Whey Protein Supplement on Serum Albumin Level in Acute Critically Ill Neurological Patients
The incidence of malnutrition in patients with severe neurological diseases is approximately 37%, among which hypoproteinemia is a common manifestation.
- Trial name
- NCT04361357
- Testing
- whey protein
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Xuanwu Hospital, Beijing
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Neurocognitive Disorders, Surgery-Complications
Cerebrolysin in Prevention of Postoperative Delirium in Cardiac Surgery
Postoperative delirium (POD) and postoperative neuropsychological dysfunction are frequently noted in critically ill patients undergoing elective or emergency surgery and treated in the intensive care unit (ICU).
- Conditions
- Neurocognitive Disorders, Surgery-Complications, Critical Illness, Brain Damage
- Trial name
- Cereb-POD (NCT05864677)
- Testing
- Cerebrolysin
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lublin
Multiple Organ Failure
Feasibility Study of MicroKine Dx System in Critically-ill Pediatric Patients.
This study will enroll approximately 25 pediatric patients to assess the performance and real-world feasibility of multi-biomarker based prognostic and predictive algorithms to aid in the clinical management of pediatric…
- Trial name
- NCT04295278
- Testing
- MicroKine Dx system
- Volunteers
- 25 people
- Sponsor
- PreDxion Bio, Inc.
Severe COVID-19
Corticosteroids in Severe COVID-19(ASAP-C Study)
Administration of systemic corticosteroids for patients with severe forms of severe acute respiratory syndrome(SARS-Co-2) infection are recommended by several guidelines.
- Trial name
- ASAP-C (NCT04648410)
- Testing
- questionnaire
- Where
- Czechia
- Volunteers
- 2,000 people
- Sponsor
- Brno University Hospital
Sepsis, Infection
The Extended Study of Prevalence of Infection in Intensive Care IV
The goal of this observational study is to learn how common infections are in intensive care units (ICUs) around the world and how they are treated. The study will look at all adults in the ICU during a single 24-hour period.
- Trial name
- EPIC IV (NCT07309549)
- Volunteers
- 10,000 people
- Sponsor
- Universidad de la Sabana
Pain, Agitation, Emergence
Management of PADIS in Emergency Intensive Care Unit
Investigate the prevalence of PADIS in EICU, as well as the awareness and clinical implementation status of medical staff towards PADIS.
- Conditions
- Pain, Agitation, Emergence, Delirium, Critical Illness
- Trial name
- NCT06339385
- Testing
- PADIS assessment
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Capital Medical University
Critical Illness, Acute Kidney Injury
Saline Against Lactated Ringers or Plasmalyte in the Emergency Department
This study will be a cluster-randomized, single-center trial comparing 0.9% saline (normal saline) vs physiologically-balanced crystalloid fluids (Lactated Ringers or Plasmalyte A) for intravenous fluid administration in the…
- Trial name
- SaLt-ED (NCT02614040)
- Testing
- 0.9% Saline, Physiologically-balanced isotonic crystalloid
- Where
- United States
- Volunteers
- 14,000 people
- Sponsor
- Vanderbilt University
Acute Kidney Injury, Fluid Overload
Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients
Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes.
- Conditions
- Acute Kidney Injury, Fluid Overload, Fluid Overload in Dialysis Patients, Critical Illness
- Trial name
- VINKO (NCT07643597)
- Where
- 10 sites in Brazil, Chile and 5 more
- Volunteers
- 128 people
- Sponsor
- Hospital Las Higueras
Shock
Effectiveness of Midodrine as an Adjuvant to Norepinephrine in Weaning Critically Ill Patients From Vasopressors
This study aims to evaluate the effectiveness of midodrine as an adjuvant to norepinephrine in weaning critically ill patients from vasopressors
- Trial name
- NCT06930235
- Testing
- Weaning critically ill patients from norepinephrine using midodrine as an adjuvant to norepinephrine, Weaning critically ill patients from norepinephrine without use of midodrine as an adjuvant
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Sohag University
Liver Diseases, Liver Cirrhosis
Sepsis, Endothelial Function, and Lipids in Critically Ill Patients With Liver Failure (the SELLIFA Study)
The purpose of the study is to determine the role of new biomarkers in the diagnosis of sepsis in critically-ill patients with liver failure and to correlate the prognosis of these patients with parameters of endothelial function…
- Conditions
- Liver Diseases, Liver Cirrhosis, Sepsis, Critical Illness
- Trial name
- SELLIFA (NCT00488917)
- Where
- Belgium
- Volunteers
- 167 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Critical Illness, PICS
ICU Follow-up After Prolonged Intensive Care Stay
Treatment in the intensive care unit (ICU) for more than five days often leads to chronic physical, cognitive and psychological complaints, such as post-traumatic stress disorders, muscle weakness, depression, anxiety and…
- Conditions
- Critical Illness, PICS, Post Intensive Care Syndrome
- Trial name
- PINA (NCT04186468)
- Testing
- ICU follow-up clinic
- Where
- 3 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Otto-von-Guericke University Magdeburg
Critically Ill, Liver Cirrhosis
The Influence of Paracentesis on Intra-abdominal Pressure and Kidney Function in Critically Ill Patients With Liver Cirrhosis and Ascites: an Observational Study
Patients with liver cirrhosis are at risk for development of renal failure, usually after a precipitating event such as infection or bleeding.
- Conditions
- Critically Ill, Liver Cirrhosis, Ascites
- Trial name
- NCT01091233
- Testing
- paracentesis
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Trauma, Critical Incident
The Resilient Minds Program in Fire Departments
The purpose of the study is to assess the impact of a mental health training program in volunteer and career firefighters.
- Conditions
- Trauma, Critical Incident, Mental Illness
- Trial name
- NCT03401684
- Testing
- Resilient Minds
- Where
- 5 sites in Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Critical Illness
Clinical and Economic Outcome of Simvastatin in Critically Ill Septic Patient
determination of the effectiveness and the cost-effectiveness of simvastatin(Zocor 40 mg) plus standard therapy (SSCG)versus standard therapy alone in critically ill septic patient from the societal perspective over one year.
- Trial name
- NCT02067949
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- sara mostafa amin eladawy
Delirium, Critical Illness
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs.
- Conditions
- Delirium, Critical Illness, Sedation Complication, Executive Dysfunction
- Trial name
- mini-MENDS (NCT04801589)
- Testing
- Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Vanderbilt University Medical Center
Sinus Rhythm
Cardiac Output Monitoring by Transpulmonary Thermodilution and Transthoracic Echocardiography in Critically Ill Patients
Cardiac output monitoring is a key component for the diagnosis and management of critically ill patients. The two less invasive methods commonly used in intensive care are transthoracic echocardiography and transpulmonary…
- Trial name
- TPTD-TTE-SR (NCT04637126)
- Testing
- Cardiac output measurement by transpulmonary thermodilution and transthoracic echocardiography
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Toulouse
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