Clinical trials: Illness, Critical
Gastrointestinal Motility
Clinical Evaluation Gastrointestinal Motility With PillCam
The purpose of this study is to evaluate the clinical usefulness of a video camera pill (PillCam) in assessing intestinal function in the small intestines of patients.
- Trial name
- NCT01158989
- Testing
- PillCam
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Louisville
Achievement of a Sufficient Thrombosis Prohpylaxis in Clitically Ill Patients With Heparin Resistance
Argatroban in Critically Ill Patients With Heparin Resistance
Critically ill patients with high risk for thrombosis or tromboembolic events with the presence of heparin resistance, treated at the Department for General and Surgical Critical Care Medicine of the Medical University Innsbruck…
- Trial name
- NCT01734252
- Testing
- Argatroban
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Medical University Innsbruck
Delirium, Acute Kidney Injury
Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury
Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality.
- Conditions
- Delirium, Acute Kidney Injury, Critical Illness, Cognitive Impairment
- Trial name
- INCOGNITOAKI (NCT04722939)
- Testing
- Cerebral oxygenation
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Dr. Gordon Boyd
Respiratory Failure, Tracheostomy Complication
Expert-Guided Early Tracheostomy Pathway
The optimal timing of tracheostomy insertion remains uncertain. We hypothesized that a clinical pathway including expert-informed risk assessment regarding predicted duration of mechanical (MV) would enhance the effectiveness of…
- Trial name
- NCT05595707
- Testing
- Expert-Guided Early Tracheostomy
- Where
- Jordan
- Volunteers
- 104 people
- Sponsor
- Denver Health and Hospital Authority
Systemic Lupus Erythematosus, Critical Illness
Accuracy, Feasibility and Acceptance of CGM Lupus
This is a prospective monocenter, non-randomised, open-lable single-group intervention diagnostic trial on the accuracy, reliability and feasibility of the continuous glucose monitoring system in critically systemic lupus…
- Conditions
- Systemic Lupus Erythematosus, Critical Illness, Diabetic Blood Glucose Monitoring
- Trial name
- NCT03296995
- Testing
- Flash glucose monitoring system
- Where
- China
- Volunteers
- 30 people
- Sponsor
- RenJi Hospital
Critical Illness, Intensive Care
Critical Illness Outcomes Study
We will test whether the way that an intensive care unit is organized can influence patient related outcomes such as mortality. We will test whether who works in the ICU, and how the ICU is managed will affect the care received…
- Conditions
- Critical Illness, Intensive Care, Intensive Care Unit
- Trial name
- CIOS (NCT01109719)
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Acute Respiratory Distress Syndrome, Cardiac Failure
Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients
Patients in end-stage cardiac failure and/or respiratory failure may be started on a rescue therapy known as Extracorporeal Membrane Oxygenation (ECMO).
- Conditions
- Acute Respiratory Distress Syndrome, Cardiac Failure, Extracorporeal Membrane Oxygenation Complication, Respiratory Failure
- Trial name
- IGNITE (NCT04669444)
- Testing
- Ventilator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Intra-Abdominal Hypertension
The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients
Intra-abdominal hypertension (IAH) is a frequent cause of organ dysfunction in critically ill patients. Secondary IAH is mainly caused by excessive fluid resuscitation.The World Society for the Abdominal Compartment Syndrome…
- Trial name
- NCT01072071
- Testing
- furosemide
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Ziekenhuis Netwerk Antwerpen (ZNA)
Sleep
The Effects of White Noise for Adult Patients' Sleep Quality in Intensive Care Unit.
Poor sleep quality is one of the most common problems among adult patients in the intensive care unit (ICU). The causes of sleep disturbance are complicated.
- Trial name
- NCT05785130
- Testing
- white noise
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Communication, Critical Illness
Improving Family Meetings in the Pediatric Cardiac Intensive Care Unit
This study aims to improve communication between medical teams, patients, and families in the pediatric cardiac intensive care unit.
- Trial name
- NCT03749330
- Testing
- CICU Team And Loved Ones Communicating (CICU TALC)
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Children's Hospital of Philadelphia
Any Condition Underlying Critical Illness
SWedish Intensive Care Biobank
The goal of this observational study is to understand the genetic and molecular risk factors for developing critical illness in adult intensive care unit (ICU) patients in Sweden.
- Trial name
- SWIC-B (NCT07582601)
- Volunteers
- 25,000 people
- Sponsor
- Uppsala University
COVID-19, Venous Thromboembolism
Prevention of Arteriovenous Thrombotic Events in Critically-Ill COVID-19 Patients Trial
The researchers wanted to learn how to help sick patients who are in the hospital because of COVID-19. They are trying to find out the best way that is safe to stop blood clots that could be dangerous from forming in patients…
- Conditions
- COVID-19, Venous Thromboembolism, Arterial Thrombosis
- Trial name
- COVID-PACT (NCT04409834)
- Testing
- Unfractionated Heparin IV, Enoxaparin 1 mg/kg, Clopidogrel
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- The TIMI Study Group
Critical Illness, Near-Death Experience
Near-death Experience in ICU Survivors
This observational study aims to describe the incidence of near-death experience (NDE) in patients who survived a critical illness.
- Trial name
- NCT04279171
- Testing
- Greyson NDE scale, DES dissociation scale, WHOQOL-SRPB
- Where
- Belgium
- Volunteers
- 126 people
- Sponsor
- University of Liege
Extracorporeal Membrane Oxygenation, Children
Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation
The BEAM study is a multicenter, prospective, observational study in children supported on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Extracorporeal Membrane Oxygenation, Children, Neurologic Injury
- Trial name
- BEAM (NCT05041712)
- Where
- 11 sites in United States
- Volunteers
- 455 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Critical Illness
Assessing Accuracy of the Freestyle Libre Pro Glucose Monitoring in Patients With Diabetes in a Critical Care Setting
Currently, the standard of care for monitoring sugar levels in patients with diabetes in the intensive care unit is to use finger stick blood sugar monitoring.
- Conditions
- Diabetes Mellitus, Critical Illness, Continuous Glucose Monitoring
- Trial name
- NCT06800365
- Testing
- Sensor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hennepin Healthcare Research Institute
Critical Illness Polyneuromyopathy, Critical Illness Polyneuropathy
Critical Illness Weakness Outside the Intensive Care Unit.
When people become seriously ill, their bodies can be affected in many ways beyond the original disease. One well-known complication in patients treated in intensive care units (ICUs) is the development of severe muscle weakness…
- Conditions
- Critical Illness Polyneuromyopathy, Critical Illness Polyneuropathy, Critical Illness Myopathy
- Trial name
- CRI-WEAK-OUT (NCT07478367)
- Testing
- No Intervention: Observational Cohort
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Clinico Humanitas
Aneurysmal Subarachnoid Hemorrhage
FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage
A multi-centre, prospective, blinded, randomised clinical trial of fludrocortisone compared with placebo in patients presenting with aneurysmal subarachnoid haemorrhage.
- Trial name
- FLASH (NCT06409364)
- Testing
- Fludrocortisone
- Where
- 16 sites in Australia, New Zealand
- Volunteers
- 524 people
- Sponsor
- The George Institute
Critical Illness
Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children
The purpose of the study is 1) to determine whether administration of intravenous zinc to critically ill children is safe, and 2) to determine an appropriate dose of zinc supplementation.
- Trial name
- NCT01062009
- Testing
- Zinc sulfate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Acute Kidney Injury, Chronic Kidney Disease
Evaluating the Role of Cystatin C and Creatinine as Markers of Renal Recovery in Critically Ill Patients After Acute Kidney Injury.
This is a cohort study in which patients who survive Acute Kidney Injury (AKI) during intensive care unit (ICU) admission are recalled at 3-6 months and renal function tests are performed.
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Acute Kidney Disease
- Trial name
- NCT02894164
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 336 people
- Sponsor
- Karolinska Institutet
Critical Illness, Dietary Modification
Probiotics in Enteral Feeding in Critically Ill Patients
The purpose of this study is to investigate the effect of probiotics in enteral nutrition on improving gut function, inflammatory markers and clinical outcomes in critically ill patients admitted to the intensive care unit.
- Conditions
- Critical Illness, Dietary Modification, Probiotics, Gut Failure
- Trial name
- NCT01792401
- Testing
- Probiotics
- Where
- Malaysia
- Volunteers
- 49 people
- Sponsor
- University of Malaya
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