Clinical trials: Illness, Critical
Platelet Count Decline in Critically Ill, Metabolic Acidosis
Correlation Between Base Excess in Patients Upon Admission to the ICU and Platelet Count Trend in the Following Days
Several studies have revealed that a relative platelet count decline in patients after their admission to the intensive care unit (ICU) is a very reliable marker of the severity of their sickness.
- Conditions
- Platelet Count Decline in Critically Ill, Metabolic Acidosis, Metabolic Acidosis Severity, Platelet Count Decline in ICU Patients
- Trial name
- BE-Platelet (NCT06908408)
- Testing
- Corrrelation between metabolic acidosis severity in patients on admission to the ICU and platelet count trend in 2 days following admission was investigated
- Where
- Slovenia
- Volunteers
- 484 people
- Sponsor
- University Medical Centre Ljubljana
Recovery From Critical Illness
Rehabilitating Muscle After Intensive Care
The study will examine the effect of amino acid supplements and enhanced physiotherapy on physical recovery following critical illness in intensive care.
- Trial name
- REMAIC (NCT01063738)
- Testing
- Amino acid supplement, PEPSE, Intensive Care Unit (ICU) Recovery Manual
- Where
- 2 sites in United Kingdom
- Volunteers
- 93 people
- Sponsor
- St Helens & Knowsley Teaching Hospitals NHS Trust
Sepsis, ARDS (Acute Respiratory Distress Syndrome)
Research on Risk Assessment and Early Warning Models for Adverse Clinical Outcomes in Critically Ill Patients
This is a medical research study that uses information from past patient hospital records. It focuses on three serious conditions that often affect critically ill patients: sepsis (a life-threatening body-wide infection), ARDS (a…
- Conditions
- Sepsis, ARDS (Acute Respiratory Distress Syndrome), AKI - Acute Kidney Injury
- Trial name
- NCT07317817
- Testing
- No intervention (Observational study)
- Where
- China
- Volunteers
- 55,940 people
- Sponsor
- Chongqing Medical University
Invasive Candidiasis
Invasive Candidiasis in Saudi ICUs
Epidemiology and clinical outcomes of invasive candidiasis in critically ill patients in Saudi Arabia is not well studied. This observational study objectives include to determine the epidemiology, risk factors and outcomes of…
- Trial name
- ICIP-SA (NCT01490684)
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 162 people
- Sponsor
- Hasan Al-Dorzi
Tracheal Intubation
Endotracheal Intubation Among the Critically Ill: HEMAIR Pilot Study
In order to examine the current endotracheal intubation practice among critically ill patients, a prospective observational multicenter study of adult critically ill patients was conducted from July 2015 to January 2017 involving…
- Trial name
- HEMAIR (NCT02508948)
- Where
- 16 sites in United States
- Volunteers
- 1,288 people
- Sponsor
- Mayo Clinic
Venous Thromboembolism (VTE)
Collaborative Risk-stratified Investigation in Thrombosis-prone Inpatients With Critical Illness: Anticoagulation With LMWH in Teens for ThromboProphylaxis (CRITICAL-Teens-TP).
Critically ill adolescents are at greatest risk for developing hospital-acquired venous thromboembolism. To date, no phase 3 randomized controlled trials have been conducted for pharmacological thromboprophylaxis as primary…
- Trial name
- NCT06628778
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 802 people
- Sponsor
- Johns Hopkins All Children's Hospital
Critically Ill, Intensive Care Unit
High Protein Formula on Enteral Feeding in Clinical Improvement and Malnutrition at Intensive Care Unit Patients
Effectiveness of Early Enteral Feeding With High Protein Polymeric Formula Versus Oligomeric Formula Versus 5% Dextrose Solution in Clinical Improvement and Malnutrition on Intensive Care Unit Patients Background : Critically ill…
- Trial name
- NCT04150978
- Testing
- High Protein Polymeric Formula, Oligomeric Formula, 5% Dextrose
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Hasanuddin University
Critical Illness, Sleep Deprivation
Improving the Sleep and Circadian Rhythms of Mechanically Ventilated Patients
The goal of this project is to determine whether the sleep and circadian rhythms of critically ill patients undergoing mechanical ventilation can be improved through practical strategies that can be employed at the bedside.
- Conditions
- Critical Illness, Sleep Deprivation, Respiratory Failure, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT01284140
- Testing
- Sleep and circadian rhythm promotion, Usual care
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Brian Gehlbach
Gram-Negative Bacterial Infections
Evaluation of Extended Intravenous of Beta-lactams in the Treatment of Serious Gram-negative Infections in Critically Ill Patients
The purpose of this study is to evaluate the PK/PD parameters, safety and efficacy of extended infusion of beta-lactams in intensive care patients who are infected with Gram-negative bacteremia or pneumonia at National Taiwan…
- Trial name
- NCT01600768
- Testing
- Beta-Lactams
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Pediatric Critical Illness
Pediatric International Nutrition Study 2018
This is a multi-site study of how nutrition is delivered to critically ill patients in pediatric intensive care units (PICUs) around the world.
- Trial name
- PINS 2018 (NCT03223038)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 1,944 people
- Sponsor
- Boston Children's Hospital
Euthyroid Sick Syndromes, Non-thyroidal Illness Syndrome
Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome
AQUA FONTIS is a unicentric, multidisciplinary, prospective cross-section and longitudinal study that aims at the development of a more clear-cut diagnostic definition and classification of non-thyroidal illness syndrome (NTIS).
- Conditions
- Euthyroid Sick Syndromes, Non-thyroidal Illness Syndrome, Low T3 Syndrome, TACITUS
- Trial name
- AQUA FONTIS (NCT00591032)
- Where
- 6 sites in Germany
- Volunteers
- 590 people
- Sponsor
- Ruhr University of Bochum
AKI - Acute Kidney Injury
The Relationship Between Measured Creatinine Clearance and Acute Kidney Injury in Critically Ill Patients
With this study, the investigators want to find out how well different stages of acute kidney injury (AKI), match with the actual filtering ability of the kidneys in very sick adults in the intensive care unit (ICU).
- Trial name
- NCT07624721
- Where
- Belgium
- Volunteers
- 1,416 people
- Sponsor
- University Hospital, Ghent
Critical Care, Critical Illness
Early Multimodal Therapy and Mechanical Ventilation
To assess the association between early multimodal therapy and the duration of invasive mechanical ventilation in the Intensive Care Unit at Fundación Santa Fe de Bogotá.
- Trial name
- NCT06133504
- Testing
- Early Multimodal Therapy, Late Multimodal Therapy
- Volunteers
- 74 people
- Sponsor
- Fundación Santa Fe de Bogota
Sepsis, Critical Illness
Metabolic and Functional Study of γδ T Cells in Critically Ill Patients
This prospective observational cohort study investigates the subset-specific metabolic adaptation and functional remodeling of cytotoxic γδ T cells in critically ill patients with and without sepsis.
- Conditions
- Sepsis, Critical Illness, Immunosuppression, MODS
- Trial name
- NCT07680816
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Infection, Sepsis
A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients
The goal of this clinical trial is to examine the success and safety of administering certain antibiotics (beta-lactams) given in a longer 3-hour infusion to children (0-17 years) who are critically ill and have severe infection.
- Conditions
- Infection, Sepsis, NICU, PICU
- Trial name
- PEBBLE (NCT07484633)
- Testing
- Extended infusion time of the following beta-lactam: meropenem, Short-term infusion time of the following beta-lactam: meropenem, Extended infusion time of the following beta-lactam: piperacillin/tazobactam
- Where
- 2 sites in Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Stress Ulcer Prophylaxis
Economic Outcomes of Enteral and Parenteral Proton Pump Inhibitor (PPI) Use in the Intensive Care Unit (ICU)
This study will be a retrospective electronic medical chart review of all patients admitted to adult intensive care medicine units (ICU) at The Nebraska Medical Center over a three-year period from January 2006 through December…
- Trial name
- NCT00919152
- Where
- United States
- Volunteers
- 534 people
- Sponsor
- University of Nebraska
Cardiovascular Disease
Retrospective Safety Study to Compare Mortality in Intensive Care Unite (ICU) Patients Undergoing Echocardiography With or Without DEFINITY®
Retrospective analysis to observe changes in short term mortality
- Trial name
- DEF-418 (NCT01299649)
- Where
- United States
- Volunteers
- 4,300,000 people
- Sponsor
- Lantheus Medical Imaging
ICU-acquired Weakness, Critical Illness Polyneuropathy
Shear Wave Elastography of Peripheral Nerves for Early Diagnosis of ICU-acquired Weakness
This study aims to determine whether shear wave elastography (SWE), a non-invasive ultrasound technique that measures nerve stiffness, can help detect ICU-acquired weakness (ICU-AW) early in critically ill patients.
- Conditions
- ICU-acquired Weakness, Critical Illness Polyneuropathy, Critical Illness Myopathy
- Trial name
- NCT07594249
- Testing
- Nerve Ultrasound with Shear Wave Elastography
- Where
- China
- Volunteers
- 98 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Critically Ill, Intensive Care Unit Delirium
Physical Restraints in Intensive Care Unit Patients
The use of physical restraints is common practice in Intensive Care Units (ICU). This medically prescribed procedure requires full attention of medical and paramedical teams for its implementation, monitoring and ending, as a…
- Conditions
- Critically Ill, Intensive Care Unit Delirium, Delirium Confusional State, Agitation,Psychomotor
- Trial name
- ARBORéa (NCT04957238)
- Testing
- ARBORea decision-making tool
- Where
- 19 sites in France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Kidney Injury, Kidney Replacement
Proactive Prescription-based Fluid Management vs Usual Care in Critically Ill Patients on Kidney Replacement Therapy
A pilot randomized clinical trial comparing a protocol-based fluid management strategy to usual care in critically ill patients receiving kidney replacement therapy.
- Conditions
- Acute Kidney Injury, Kidney Replacement, Critical Illness
- Trial name
- Probe-Fluid (NCT05473143)
- Testing
- Protocol-based fluid management, Usual care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
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