Clinical trials: Illness, Critical
Cuff Overinflation, Cuff Underinflation
Efficiency of a Mechanical Device in Controlling Tracheal Cuff Pressure in Intubated Critically Ill Patients
Despite intermittent control of tracheal cuff pressure using a manual manometer, cuff underinflation and overinflation frequently occur in critically ill patients, resulting in increased risk for microaspiration and tracheal…
- Trial name
- NCT02109003
- Testing
- Pressure easy® device, Manual control of Pcuff followed by continuous control.
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Corporacion Parc Tauli
Acute Respiratory Failure
INtubation With Sedation Only to Preserve Independent Respiratory Effort Trial
The INtubation with Sedation Only to Preserve Independent Respiratory Effort (INSPIRE) trial is a pragmatic, non-blinded, parallel-group, randomized clinical trial comparing the effect of intubation with sedation only…
- Trial name
- INSPIRE (NCT07845305)
- Testing
- Intubation with a sedative medication only, Intubation with a sedative medication and neuromuscular blockade agent
- Where
- United States
- Volunteers
- 228 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness
Effect of Immune-enhancing Enteral Nutrition on Immunomodulation in Critically Ill Patients
To determine whether high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients (eg, ω-3 fatty acids and antioxidants) enriched with β-glucan stimulates immune functions compared with…
- Trial name
- NCT02569203
- Testing
- standard enteral nutrition, high-protein enteral nutrition of immune modulating nutrients enriched with β-glucan, high-protein enteral nutrition of immune modulating nutrients without β-glucan
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Hyperglycemia
Hospital Management of Hyperglycemia Study of Insulin Glargine Plus Insulin Lispro Versus Human Regular Insulin
The purpose of this study is to compare the use of insulin glargine plus insulin lispro to human regular insulin for treatment of hyperglycemia in the hospital setting in patients without known prior history of diabetes.
- Trial name
- HMH (NCT01136746)
- Testing
- Human regular insulin, Insulin lispro, Insulin glargine
- Where
- 12 sites in United States
- Volunteers
- 16 people
- Sponsor
- Eli Lilly and Company
Cancer, Critical Illness
Cancer Patients Treated With Immunotherapy in Intensive Care Unit
This work aims to describe the characteristics and methods of management of patients suffering from a solid tumor treated with immunotherapy admitted to intensive care.
- Conditions
- Cancer, Critical Illness, Immunotherapy
- Trial name
- IMMUNO-REA (NCT03357861)
- Where
- 2 sites in Belgium, France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Critically Ill
Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients
The principal aim of this study is to establish if a polymorphism in a gene important for innate immunity to fungi represents a significant risk factor for the development of Candida colonisation and subsequent invasive…
- Trial name
- Dectin-1 (NCT01482988)
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Cardiff and Vale University Health Board
Heart Arrest, Out-Of-Hospital, Wounds and Injuries
Pediatric Prehospital Airway Resuscitation Trial
This study is a Phase 3, multi-center, Bayesian Adaptive Sequential Platform Trial testing the effectiveness of different prehospital airway management strategies in the care of critically ill children.
- Conditions
- Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only
- Trial name
- Pedi-PART (NCT06364280)
- Testing
- BVM, SGA, ETI
- Where
- 10 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Ohio State University
Gastroparesis, Shock
Gastric Emptying and Enteral Nutrition Tolerance According to Vasopressor Dose in ICU Patients
This study investigates whether the dose of vasopressor medications (drugs that maintain blood pressure in shock) affects gastric emptying during tube feeding in the intensive care unit (ICU).
- Conditions
- Gastroparesis, Shock, Critical Illness, Gastric Emptying
- Trial name
- NCT07802379
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Analgesia, Sedation
Surgical Stress Index as a Tool for Monitoring Analgesia and/or Sedation in Critically Ill Patients
The hypothesis of the study is: Does the Surgical Stress Index (SSI) correlate with the Behavioral Pain Scale (BPS), the Ramsay Sedation Scale (RSS)and/or the Behavioral Pain Scale(BPV) and can therefore be used to monitor the…
- Conditions
- Analgesia, Sedation, Mechanical Ventilation, Pain
- Trial name
- NCT00789412
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Schleswig-Holstein
Anemia, Critically Ill
Survey of Blood Transfusion Practices in Critically Ill Patients at High Altitude
The purpose of this study is to describe current practice on red blood cell transfusion in critically ill patients of intensive care units located in high altitude areas
- Trial name
- NCT03019900
- Testing
- Red blood cells transfusions
- Where
- Ecuador
- Volunteers
- 352 people
- Sponsor
- Universidad Tecnológica Equinoccial
Ascites Hepatic, Cirrhosis, Liver
Continuous Passive Paracentesis for Intra-abdominal Hypertension
Liver cirrhosis patients in Intensive Care present intra-abdominal hypertension and this is an independent risk factor for increased organ disfunction and mortality.
- Conditions
- Ascites Hepatic, Cirrhosis, Liver, Hypertension, Intraabdominal, Critical Illness
- Trial name
- COPPTRIAHL (NCT04322201)
- Testing
- continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter, Ultrasound-guided intermittent large-volume paracentesis
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Fever
Anti-pyretic Therapy in Critically Ill Adults
The impact of fever and its management in different medical and surgical populations of critically ill patients has not been explained to date.
- Trial name
- NCT01173367
- Testing
- Aggressive Fever Treatment, Permissive Fever Treatment
- Where
- 2 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Mechanical Ventilation, Weaning Failure
Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients
Mechanical ventilation (MV) is essential in managing acute respiratory failure. Its duration is a crucial aspect since both, unnecessary prolongation and premature withdrawal have deleterious effects on patient outcomes in the…
- Conditions
- Mechanical Ventilation, Weaning Failure, Weaning Failure of Mechanical Ventilation, Intensive Care Unit ICU
- Trial name
- WEAN-FAIL (NCT06683781)
- Where
- Argentina
- Volunteers
- 1,077 people
- Sponsor
- Hospital Italiano de Buenos Aires
Critically Ill
The Effects of Nutritional Support of Critically Ill Patients Requiring Mechanical Ventilation
The purpose of this study is to assess the impact of different feeding solutions on patients with breathing difficulty being supported by a breathing machine.
- Trial name
- NCT00256074
- Testing
- Enteral feeding formula
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Infection Due to Resistant Bacteria, Acute Kidney Injury
Colistin Pharmacokinetics in Critically Ill Patients During Extended Dialysis
The emergence of multidrug-resistant bacteria has recently renewed interest in colistin. Data on dosing in critically ill patients undergoing extended dialysis are missing.
- Trial name
- NCT02556190
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Hannover Medical School
Pressure Sores, Intensive Care
The Effect of Antioxidants on the Immune Response and Wound Healing in Critically Ill Patients
The purpose of this study is to investigate whether the addition of omega-3 and antioxidants to nutritional support in critically ill patients in the intensive care unit influences the immune and anti-inflammatory systems and so…
- Trial name
- NCT00487097
- Testing
- Eicosapentanoic acid, docosahexaenoic acid
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Left Ventricular Dysfunction, Critically Ill
Left Ventricular Dysfunction in Critically Ill Patients
Left ventricular dysfunction is common in the critically ill. The aim of this study is to assess the incidence and prognosis of left ventricular dysfunction in critically ill patients.
- Conditions
- Left Ventricular Dysfunction, Critically Ill, Acute Coronary Syndrome, Cardiomyopathies
- Trial name
- LEVEDYCIP (NCT03787810)
- Testing
- Echocardiography
- Where
- Sweden
- Volunteers
- 428 people
- Sponsor
- Sahlgrenska University Hospital
Pediatric Asthma, Critical Illness
Azithromycin for Critical Asthma - Pediatrics
The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.
- Trial name
- CR-AZI Kids (NCT06223828)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins All Children's Hospital
Critically Ill
Frequency of Screening and SBT Technique Trial
The requirement for invasive mechanical ventilation is a defining feature of critical illness. Liberation or weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Trial name
- FAST (NCT02399267)
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 10 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Critical Illness
Effect of Different VV ECMO Flows on Lung Perfusion Monitored by EIT
The purpose of this study is to investigate the feasibility of using electric impedance tomography (EIT) to monitor lung perfusion during veno-venous (VV) extracopreal membrane oxygenation (ECMO) support, as well as the effect of…
- Trial name
- NCT05778292
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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