Clinical trials: Illness, Critical
Critical Illness
Glucose Control in the ICU Using Continuous Glucose Monitoring
Stress hyperglycemia occurs in 50-85% of patients admitted to a medical intensive care unit (MICU) and is associated with increased morbidity and mortality.
- Trial name
- REGIMEN (NCT01799512)
- Testing
- experimental: real-time continuous glucose monitoring, Active comparator: blinded continuous glucose monitoring
- Where
- 2 sites in Belgium
- Volunteers
- 35 people
- Sponsor
- University Hospital, Antwerp
Cardiovascular Physiological Phenomena, Intensive Care Unit Syndrome
Echocardiographic Measurement of Myocardial Work
Echocardiography is recommended for the hemodynamic management of patients with shock. Recently, a new echocardiographic method has been proposed that provides a non-invasive measurement of myocardial work incorporating different…
- Trial name
- MYOLOAD (NCT06422481)
- Testing
- Fluid administration, Norepinephrine administration or increase in norepinephrine dosage
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Terminal Illness, Intensive Care Unit Syndrome
End Of Life in the Critically Ill patiEnt
The purpose of this multicentric study is to evaluate the perception of the quality of the end of life in intensive care units seen from the side of the caregivers, trough the CAESAR scale.
- Trial name
- EOLE (NCT03392857)
- Testing
- Assessment by caregivers of the quality of the end of life in intensive care units
- Where
- 112 sites in France
- Volunteers
- 514 people
- Sponsor
- French Society for Intensive Care
Critical Illness, Intensive Care
Critical Illness Outcomes Study
We will test whether the way that an intensive care unit is organized can influence patient related outcomes such as mortality. We will test whether who works in the ICU, and how the ICU is managed will affect the care received…
- Conditions
- Critical Illness, Intensive Care, Intensive Care Unit
- Trial name
- CIOS (NCT01109719)
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Sepsis, Morality
CRP Versus PCT as Bio-markers for Sepsis and in Guiding Antibiotics in Critically Ill Patients
Sepsis is a life threatening organ dysfunction caused by infection. Severe sepsis is expected to rise due to resistance to antibiotics.
- Trial name
- PCTCRP (NCT04049565)
- Testing
- Procalcitonin biomarker and CRP biomarker
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Delirium
Family ICU Delirium Detection Study
To evaluate the validity, reliability, and acceptability of employing family-administered delirium detection tools in the critically ill.
- Trial name
- FIDDS (NCT03379129)
- Where
- Canada
- Volunteers
- 147 people
- Sponsor
- University of Calgary
Critical Illness, Sepsis
Implementation of a Web Based Real Time Clinical Decision Support Tool.
In the developed world critical illness is routinely treated in an intensive care unit (ICU) by highly specialized physicians, nurses and support staff.
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, Shock
- Trial name
- CERTAINp (NCT02398981)
- Testing
- Clinical decision support tool
- Where
- 10 sites in China, Croatia and 4 more
- Volunteers
- 962 people
- Sponsor
- Mayo Clinic
ARDS, Sepsis
Drug Monitoring of Antibiotics in Critical Care Patients
Infections are critical factors for the survival of critically ill patients. A broad, high-dose and early initial therapy of antibiotics is of particular relevance.
- Trial name
- DRAK (NCT01793012)
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Ludwig-Maximilians - University of Munich
COVID19, Thromboembolism
Impact of an Intensified Thromboprofylaxis Protocol in COVID-19
The aim of this study is to investigate and compare the mortality, the incidence of DVT and the incidence of kidney and liver failure in patients admitted to the ICU before and after the implementation of an intensified…
- Trial name
- NCT04394000
- Testing
- thromboprofylaxis protocol, standard protocol
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Jessa Hospital
Renal Failure , Chronic, Intradialytic Hypotension
Ultrasound-Based Prediction of Hemodynamic Instability During CVVHDF Initiation
This prospective observational study aims to evaluate the ability of transthoracic echocardiographic and bedside ultrasonographic parameters to predict intradialytic hypotension and hemodynamic instability at the initiation of…
- Conditions
- Renal Failure , Chronic, Intradialytic Hypotension, Critical Illness
- Trial name
- US-CVVHDF (NCT07397663)
- Volunteers
- 80 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Any Condition Underlying Critical Illness
SWedish Intensive Care Biobank
The goal of this observational study is to understand the genetic and molecular risk factors for developing critical illness in adult intensive care unit (ICU) patients in Sweden.
- Trial name
- SWIC-B (NCT07582601)
- Volunteers
- 25,000 people
- Sponsor
- Uppsala University
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Critical Care, Phototherapy
HEaling LIght Algorithms for the ICU Patient
The purpose of this prospective, randomized controlled trial is to investigate if mechanically ventilated patients who are treated with a Light Scheduling Algorithm with high circadian effective irradiances are better able to…
- Trial name
- HELIA-ICU (NCT05556811)
- Testing
- Dynamic Light Therapy Device, LSA-1, Dynamic Light Therapy Device, LSA-2, Dynamic Light Therapy Device, LSA, 3
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Malnutrition or Risk of Malnutrition, Acute Respiratory Failure
Nutritional Intake in Patients on Noninvasive Ventilation: a Prospective Observational Study
The primary objective is to quantify the caloric and protein intake in adult participants with acute respiratory failure who start a noninvasive ventilation treatment.
- Trial name
- PRO-NUTRINIV (NCT06740981)
- Testing
- Food diary
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Critical Illness, Circadian Dysregulation
Effect of Sleep on the Recovery of Patients Admitted to the ICU
The investigators plan to create several sleep/circadian rhythm friendly rooms within the medical intensive care unit to determine if decreasing sleep fragmentation effects recovery in patients hospitalized in the ICU.
- Conditions
- Critical Illness, Circadian Dysregulation, Delirium
- Trial name
- NCT04111900
- Testing
- Sleep/Circadian Friendly
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Rush University Medical Center
Circulatory Failure, Shock
Brachial-radial Pressure Gradient Phenomenon in Critically Ill Patients Treated With Vasoactive Agents
The goal of this observational study is to observe brachial-to-radial pressure gradient in critically-ill patients receiving vasoactive agents. The main questions it aims to answer are: 1.
- Conditions
- Circulatory Failure, Shock, Vasopressor Agents, Blood Pressure
- Trial name
- NCT07061457
- Where
- 3 sites in Poland
- Volunteers
- 300 people
- Sponsor
- Jagiellonian University
Supraventricular Arrhythmia, Septic Shock
Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Controlled Trial
New-onset supraventricular arrhythmia (NOSVA) is reported in 40 % of patients with septic shock and is associated with hemodynamic alterations and mortality.
- Trial name
- CAFS (NCT04844801)
- Testing
- Risk control strategy, Heart-Rate control strategy:, Rhythm control strategy:
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Acute Respiratory Failure, Critical Illness
ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their Caregivers
This study will investigate whether a family-centered intervention that has been adapted for patients with critical illness and their caregivers is possible, acceptable, and helpful
- Conditions
- Acute Respiratory Failure, Critical Illness, Sepsis, Hypoxia
- Trial name
- ICU-SUCCEED (NCT07778004)
- Testing
- ICU-SUCCEED, Augmented Usual Care
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Circulatory Failure
Assessment of Agreement Between Two Measurement Methods of Left Ventricular Outflow Tract (LVOT) Velocity Time Integral (VTI)
Acute circulatory failure (ACF) is a common cause of admission in intensive care unit (ICU). Echocardiography is a widespread tool nowadays for the initial assessment and the hemodynamic monitoring.
- Trial name
- AUTO-VTI (NCT04360304)
- Testing
- Echocardiographic exam
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
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