Clinical trials: Illness, Critical
Cerebral Embolism
Cerebral Microembolism in the Critically Ill With Acute Kidney Injury
The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill…
- Trial name
- COMET-AKI (NCT02621749)
- Testing
- Renal replacement therapy
- Where
- Switzerland
- Volunteers
- 66 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Critical Illness, Epidural Analgesia
Epidural Analgesia in Intensive Care Unit (APD-REA: Analgesie PeriDurale en REAnimation)
Epidural analgesia (EA) has been mainly investigated during the perioperative period. In the intensive care unit settings, EA should be proposed in critically ill patients, such as postoperative or trauma patients, typically.
- Trial name
- NCT01437358
- Testing
- Epidural analgesia
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP)
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients.
- Conditions
- Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
- Trial name
- IMP-VM (NCT07551258)
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Pressure Injury
The Effect of Norepinephrine on the Development of Pressure Injury
Norepinephrine mainly increases mean arterial pressure among intensive care patients. It may be an essential risk factor in developing pressure injuries. However, there are still conflicting findings in the literature.
- Trial name
- NCT06860308
- Where
- Turkey (Türkiye)
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- Koç University
Critical Illness
Tolerance of Early Exercise in Intensive Care Unit
Practice guidelines recommend early physical therapy in intensive care unit. Feasibility, safety and efficacy are confirmed by growing evidence based data.
- Trial name
- NCT02408250
- Testing
- Exercise program
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
COVID-19 Infections
Glucocorticoid Therapy for COVID-19 Critically Ill Patients With Severe Acute Respiratory Failure
In this multi-center, randomized, control study, the investigators will evaluate the efficacy and safety of glucocorticoid in combination with standard care for COVID-19 patents with Severe acute respiratory failure.
- Trial name
- NCT04244591
- Testing
- methylprednisolone therapy, Standard care
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Recovery From Critical Illness
Rehabilitating Muscle After Intensive Care
The study will examine the effect of amino acid supplements and enhanced physiotherapy on physical recovery following critical illness in intensive care.
- Trial name
- REMAIC (NCT01063738)
- Testing
- Amino acid supplement, PEPSE, Intensive Care Unit (ICU) Recovery Manual
- Where
- 2 sites in United Kingdom
- Volunteers
- 93 people
- Sponsor
- St Helens & Knowsley Teaching Hospitals NHS Trust
Critically Ill
Targeted Perfusion Based Haemodynamic Management in Critically Ill Patients Using Urethral Perfusion
To assess the safety and feasibility of the IKORUS device in critically ill patients and to gather exploratory data on haemodynamic coherence
- Trial name
- TARGET UP (NCT06158555)
- Testing
- 250 ML NaCl 4.5 MG/ML Injection
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
COPD Exacerbation
Non-inferiority Evaluation of Trimbow in Critically Ill Patients Admitted in ICU Compared to Standard of Care
Objective: To evaluate non-inferiority of Trimbow, an approved therapy for treatment of severe COPD, in ICU compared to the standard of care which is based on the same therapeutic approach.
- Trial name
- TRIMICU (NCT04737655)
- Testing
- TRIMBOW® pressurised inhalation solution: Beclometasone dipropionate / formoterol fumarate /glycopyrronium 87/5/9 µg per inhalation
- Volunteers
- 200 people
- Sponsor
- PARZIBUT Gilles
Acute Kidney Injury, VExUS
Doppler Evaluation for Congestive Acute Kidney Injury in Critical Illness
This study will evaluate the use of the Venous Excess Ultrasound (VExUS) score to guide fluid management in critically ill ICU patients through a prospective, multi-aim design combining observational and randomized components.
- Trial name
- DECONGEST-AKI (NCT07291778)
- Testing
- Fluid Management, No intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Critical Illness, Emergency Department Patient
Critical Care Admission Following Emergency Department's Resuscitation Room Care
This prospective multicenter observational study aims to describe resuscitation room activity in France and to compare critical care admission within 24 hours between patients directly admitted to the resuscitation room and those…
- Conditions
- Critical Illness, Emergency Department Patient, Shock, Trauma (Including Fractures)
- Trial name
- SAUV-IRU (NCT07411976)
- Testing
- Emergency resuscitation room management (observational)
- Where
- France
- Volunteers
- 1,629 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Conditions: Serious Mental Illness
Adapting a Model for Veterans on a Psychiatric Inpatient Unit
This randomized controlled study tests an adapted critical time intervention model for veterans discharged from a psychiatric inpatient unit.
- Trial name
- NCT01820468
- Testing
- Adapted critical time intervention team
- Sponsor
- VA Connecticut Healthcare System
Critically Ill, Acute Circulatory Failure
FLOTRAC/VIGILEO in Acute Circulatory Failure
Acute circulatory failure may be related to hypovolemia. Fluid loading increases stroke volume in approximatively half of challenges. Determining fluid responsiveness prevents unnecessary fluid loading.
- Conditions
- Critically Ill, Acute Circulatory Failure, Fluid Loading
- Trial name
- FLOVAC (NCT01090791)
- Testing
- Flotrac/Vigileo third generation software, Transthoracic echocardiography
- Where
- 2 sites in France
- Volunteers
- 1 people
- Sponsor
- Hôpital Européen Marseille
Acute Kidney Injury
Investigating Different Anticoagulants for Renal Replacement Therapy
The aim of this study is to evaluate the effect of regional citrate anticoagulation within the scope of continuous renal replacement (CRRT) in critically ill patients with acute kidney injury (AKI) on filter life span and 90-day…
- Trial name
- RICH (NCT02669589)
- Testing
- Heparin, Citrate
- Where
- 31 sites in Germany
- Volunteers
- 638 people
- Sponsor
- University Hospital Muenster
Median Nerve Entrapement
Large Scale ICU Data Sharing for 1000 Critically Ill Patients With Severe Acute Respiratory Distress Syndrome Coronavirus (SARS.COV19) in Three Distinct Isolation Centers
Cohort study of patients with severe respiratory distress syndrome coronavirus2 in three different isolation hospitals recording data about outcome.
- Trial name
- NCT04779268
- Where
- Egypt
- Volunteers
- 1,000 people
- Sponsor
- Minia University
Aspergillosis Invasive
Liposomal Amphotericin B in Invasive Aspergillosis With Hepatic Dysfunction
Liposomal amphotericin B is an antifungal agent commonly used to treat invasive aspergillosis, a severe fungal infection associated with high mortality in critically ill patients.
- Trial name
- NCT07337720
- Testing
- LIposomal amphotericin B (L-AmB) treatment
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Covid-19, Critical Illness
Prospective Observational Cohort Study of Critically Ill Patients With Covid-19 in Sweden
The study will prospectively collect data from patients with Covid-19 admitted to the Västerås Intensive Care Unit, Västerås Hospital. Demographic, clinical, radiographic and laboratory characteristics will be recorded.
- Trial name
- NCT04382417
- Testing
- Observational study
- Where
- Sweden
- Volunteers
- 57 people
- Sponsor
- Region Västmanland
Sepsis, Septic Shock
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
The global burden of sepsis is substantial with an estimated 15 to 19 million cases per year; the vast majority of these cases occur in low income countries.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Fluid Overload
- Trial name
- NCT03335124
- Testing
- Vitamin C, Hydrocortisone, Thiamine
- Where
- Slovenia
- Volunteers
- 5 people
- Sponsor
- University Medical Centre Ljubljana
Critical Illness Myopathy, Critical Illness
Is Combined Respiratory Muscle Training, Incorporating Inspiratory and Expiratory Training, Feasible in Adult Critical-care Patients?
Background: Respiratory muscle weakness is a recognised consequence of mechanical ventilation in critical care. This weakness can have implications for patients, leading to prolonged mechanical ventilation (MV) and intensive care…
- Trial name
- NCT07055789
- Testing
- Combined respiratory muscle training, incorporating both inspiratory and expiratory muscle training
- Where
- Ireland
- Volunteers
- 22 people
- Sponsor
- Royal College of Surgeons, Ireland
Insufficient Breast Milk Syndrome
Comparison of Breast Pump Suction Patterns
Compare effectiveness of breast pump patterns on lactation outcomes of pump dependent mothers of critically ill infants
- Trial name
- NCT06061913
- Testing
- Breast Pump suction pattern
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Florida
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