Clinical trials: Illness, Critical
Acute Kidney Injury, COVID-19
Incidence of Acute Kidney Injury in Covid-19
Acute kidney injury (AKI) in Covid-19 patients is a topic that receives little attention in the literature, although being important in clinical practice in the ICU, particularly in Oman.
- Conditions
- Acute Kidney Injury, COVID-19, Critically Ill
- Trial name
- COVIDAKI (NCT05467956)
- Testing
- Covid-19
- Where
- Oman
- Volunteers
- 286 people
- Sponsor
- Sultan Qaboos University
ICU Acquired Weakness, Quadriceps Muscle Atrophy
Ultrasound Measurement of Quadriceps Shortening During Neuromuscular Electrical Stimulation in Critically Ill Patients
ICU-Aw is highly prevalent (50%) among critically ill patients. Its diagnosis is usually delayed as it requires patients' awakening and collaboration to provide accurate measurement.
- Trial name
- DETECT (NCT04722445)
- Testing
- Early ultrasound measurement of quadriceps shortening during neuromuscular electrical stimulation (NMES)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Groupe Hospitalier du Havre
Critically Ill, Acute Kidney Injury
Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury
The purpose of this study is to assess the efficacy of calcifediol (25-hydroxyvitamin D) and calcitriol (1,25-dihydroxyvitamin D) in preventing and reducing the severity of acute kidney injury (AKI) in critically ill patients.
- Trial name
- ACTIVATE-AKI (NCT02962102)
- Testing
- Calcifediol, Calcitriol
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- David Leaf
Critical Illness
Lung Ultrasound Guided Protocol for Fluid Management for the Critically Ill Patient: a Randomized Study
In the Intensive Care Unit (ICU) this bedside method of assessing lung congestion could be useful in a better management of the critically ill patients with a wide range of respiratory failure causes (Acute Respiratory Distress…
- Trial name
- LUNG US ICU (NCT03393065)
- Testing
- Fluid management guided by BLS
- Where
- Romania
- Volunteers
- 10 people
- Sponsor
- Professor Adrian Covic
Pressure Ulcer, Critical Care
Prevalence of Pressure Ulcers Among Critically Ill Patients and Factors Associated With Their Occurrence in the ICU
The prevalence of and risk factors for pressure ulcers (PUs) in critically ill patients have been poorly studied. The main objective of this study was to describe the prevalence of PUs in critically ill patients.
- Conditions
- Pressure Ulcer, Critical Care, Intensive Care Unit Syndrome
- Trial name
- PRESSURE (NCT03912467)
- Testing
- Pressure Ulcer Evaluation
- Where
- 60 sites in France
- Volunteers
- 1,228 people
- Sponsor
- French Society for Intensive Care
Cardiac Failure, Critical Illness
Blender Biomarkers: A BLENDER Sub-study to Evaluate the Effect of Oxygen Dose on Oxidative Stress and Organ Injury
To compare the impact of liberal vs conservative oxygen doses on markers of oxidative stress in patients enrolled in the BLENDER trial.
- Trial name
- NCT05542966
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Metabolic Acidosis
Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients
An acid-base imbalance, called metabolic acidosis (acid-base disorder lasting from several minutes to several days, caused by a decrease in serum bicarbonate ion (HCO3) concentration), is often observed in critically ill patients…
- Trial name
- NCT05147051
- Testing
- Meglumine Sodium Succinate
- Where
- 6 sites in Russia
- Volunteers
- 140 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Tracheostomy, Critical Illness
Effect of Structured Education for Family Members of Intensive Care Patients Undergoing Tracheostomy
Family members of patients undergoing tracheostomy in the intensive care unit frequently experience anxiety, uncertainty, and concerns regarding the patient's care.
- Conditions
- Tracheostomy, Critical Illness, Intensive Care
- Trial name
- TRACH-FAMILY (NCT07737353)
- Testing
- Structured Education Program, Routine Information
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Giresun University
Post Intensive Care Unit Syndrome, Intensive Care Unit Acquired Weakness
Intensive Care Unit Recovery
Survival rates of patients with critical illness have increased due to improved facilities and treatment methods in the intensive care unit (ICU).
- Conditions
- Post Intensive Care Unit Syndrome, Intensive Care Unit Acquired Weakness, Critical Illness
- Trial name
- ICU-RE (NCT04154995)
- Testing
- Venipuncture, Ultrasound Quadriceps Muscles
- Where
- Netherlands
- Volunteers
- 81 people
- Sponsor
- Frisius Medisch Centrum
Sepsis, Hyperglycemia
Clinical Validation of Continuous Glucose Monitoring in Glycemic Management of Critically Ill Sepsis Patients
Poor glycemic control is common in critically ill patients with sepsis and is associated with increased morbidity and mortality; however, achieving safe and effective glucose management in the ICU remains challenging with…
- Conditions
- Sepsis, Hyperglycemia, Glycemic Control
- Trial name
- NCT07686939
- Testing
- Continuous Glucose Monitoring (CGM) with FreeStyle Libre II System
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Taizhou Hospital
Transpulmonary Pressure, Pressure.Rate Product
Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation
Typically doctors adjust the settings on the ventilator to ensure that children receive enough help to decrease the work they perform to breathe, receive enough oxygen through the machine to pass into the blood and to the organs…
- Conditions
- Transpulmonary Pressure, Pressure.Rate Product, Guide to Mechanical Ventilator Management, Extubation Readiness
- Trial name
- NCT02354365
- Testing
- Transpulmonary Pressure measurement
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Children's Hospital Los Angeles
Blood Transfusion; Hemoglobinemia, Hypoxia
The Role of Central Venous Oxygen Saturation (ScvO2) as an Indicator of Blood Transfusion in the Critically Ill
Transfusion of red blood cells is an everyday practice in critical care with the primary aim of restoring adequate tissue oxygenation.
- Conditions
- Blood Transfusion; Hemoglobinemia, Hypoxia, Anemia
- Trial name
- NCT03138200
- Testing
- Blood transfusion
- Where
- 2 sites in Hungary
- Volunteers
- 160 people
- Sponsor
- Szeged University
COVID-19
Co-infection Management in COVID-19 Critically Ill
International guidelines suggest the administration of empirical broad-spectrum antibiotics for suspected bacterial co-infection in COVID-19 critically ill.
- Trial name
- NCT04382092
- Testing
- FilmArray Pneumonia
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Nursing Caries, Satisfaction
In-Situ Simulation Different Debriefing Methods
The goal of this pre-test-post-test randomized controlled experimental study is to examined the effects of the learning conversation (LC)-based, 3D model-based, and standard debriefing methods on critical thinking, debriefing…
- Conditions
- Nursing Caries, Satisfaction, Simulation of Physical Illness
- Trial name
- NCT06052007
- Testing
- LC-Based Debriefing, 3D Model-Based Debriefing
- Where
- Turkey (Türkiye)
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Critical Illness, Enteral Nutrition Intolerance
Predictive Value of Gastrointestinal Blood Flow for Enteral Nutrition Intolerance in Critically Ill Patients
This study aims to explore the correlation between gastrointestinal blood flow and the incidence of enteral nutrition intolerance (ENI) and its symptoms in critically ill patients, construct and compare predictive models…
- Conditions
- Critical Illness, Enteral Nutrition Intolerance, Enteral Nutrition Feeding, Prediction Models
- Trial name
- NCT07521111
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Critical Illness, Cancer
Mean Platelet Volume (MPV) as an Early Predictor of Mortality in Intensive Care Patients With Cancer
This study aims to investigate whether Mean Platelet Volume (MPV) and other blood count parameters measured at admission can predict mortality in cancer patients admitted to the intensive care unit (ICU).
- Conditions
- Critical Illness, Cancer, Mortality
- Trial name
- MPV-CICU (NCT07656311)
- Where
- Turkey (Türkiye)
- Volunteers
- 425 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Tissue Hypoperfusion, Critical Illness
Fecal Lactate and Resuscitation Outcomes in Critical Illness
This study evaluates the prognostic value of fecal lactate and the fecal-to-serum lactate gradient as early biomarkers of tissue hypoperfusion in critically ill patients.
- Conditions
- Tissue Hypoperfusion, Critical Illness, Shock, Sepsis
- Trial name
- DELTA-LAC (NCT07658001)
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital H+ Queretaro
Septicemia
Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia
Molecular testing is a largely validated approach allowing rapid identification of positive blood cultures. However, due to its high cost and its limited information on susceptibility, it is considered as an add-on technique…
- Trial name
- SEPSIS2016 (NCT03943719)
- Testing
- FilmArray blood culture identification panel
- Where
- Belgium
- Volunteers
- 139 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Critically Ill, ICU Survivor
The ICU-recover Box, Using Smart Technology for Monitoring Health Status After ICU Admission
In this pilot study we will study the feasibility of providing and following ICU patients with smart technology for three months after discharge from a general ward of the Leiden University Medical Centre.
- Conditions
- Critically Ill, ICU Survivor, User Experience
- Trial name
- NCT05766319
- Testing
- Withings ScanWatch, Withings BPM Connect, Withings Body
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Leiden University Medical Center
Critical Illness, Acute Kidney Injury
The Association of Protein-Energy Adequacy With Mortality in Critically Ill Patients With Acute Kidney Injury.
This is a prospective observational single-center study in which the association of Protein-Energy Adequacy and 28-Days of Mortality among critically ill patients with Acute Kidney Injury, AKI will be investigated.
- Trial name
- NCT04533100
- Where
- Malaysia
- Volunteers
- 185 people
- Sponsor
- University of Malaya
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