Clinical trials: Illness, Critical
COVID-19, Critical Illness
Recovery of Patients From COVID-19 After Critical Illness
Patients who are critically ill with COVID-19 requiring life support in an intensive care unit (ICU) have increased risk of morbidity and mortality.
- Trial name
- NCT04401254
- Where
- 29 sites in Australia
- Volunteers
- 536 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Respiratory Failure
Lung Aeration After Flexible Bronchoscopy in Intubated Critically Ill Patients
In patients suffering from acute respiratory failure, ineffective cough and the consequent retention of secretions are common clinical problems, which often lead to the need for tracheostomy for the sole purpose of aspiration of…
- Trial name
- NCT05200494
- Testing
- Recruiting Maneuver
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University Magna Graecia
Mechanical Ventilation Complication, Ventilator Induced Lung Injury
Mechanical Power and Mortality in Mechanically Ventilated Adults
This prospective observational cohort study aims to investigate the relationship between mechanical power during the first 72 hours of invasive mechanical ventilation and 28-day mortality in mechanically ventilated adult patients…
- Conditions
- Mechanical Ventilation Complication, Ventilator Induced Lung Injury, ARDS, ICU Mortality (Survival Rate)
- Trial name
- NCT07836153
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Zagazig University
Cardiac Disease, Critically Ill
Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
OPTIC is a prospective, open-label, non-randomized study of multiple medications administered to approximately 2000 children in the pediatric cardiac intensive care unit (PCICU) per routine clinical car by their treating…
- Conditions
- Cardiac Disease, Critically Ill, Children, Adult
- Trial name
- OPTIC (NCT05055830)
- Testing
- The OPTIC study is collecting PK data on children prescribed understudied drugs of interest per standard of care.
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Duke University
Critical Ill Patients
Looking at the Physiological Response of Ergometry in Critical Care Patients
Exploring the physiological and metabolic demands of passive ergometry in the critical ill patient.
- Trial name
- NCT04383171
- Testing
- Motomed cycle ergometer (MOTOmed letto2 - Reck, Reckstr 1-5, Betzenweiler 88422, Germany).
- Volunteers
- 12 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Critical Illness, Mechanical Ventilation
Confirmation of Ventilation and Intubation by Determination With Ultrasonography
Chest radiography is the gold standard for confirming tracheal intubation. Bedside ultrasound can be a useful alternative. The investigators are conducting a multi-center, observational study from January 2019 to May 2020…
- Trial name
- COVID-US (NCT04419064)
- Testing
- Point of care ultrasound
- Where
- 4 sites in United States
- Volunteers
- 118 people
- Sponsor
- University of Pittsburgh
Fever, Critical Illness
Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults
The purpose of this study is to compare the effects of intravenous acetaminophen to placebo on body temperature and hemodynamic (heart rate and blood pressure) responses in febrile critically ill adult patients.
- Trial name
- ICUFeverAPAP (NCT01869699)
- Testing
- Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of California, San Francisco
Critical Illness
Consistency Between Measures of Renal Function in ICU Patients
This study aim to compare different measures of renal function (glomerular filtration rate) in ICU patients.
- Trial name
- NCT05385094
- Testing
- S Creatinine concentration, Serum Cystatin C concentration, Urinary Creatinine Clearance
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Karolinska University Hospital
Anemic, Critically Ill Patients
Efficacy of Enteral Iron Supplementation in Critical Illness
The purpose of this study is to investigate the efficacy of enteral iron supplementation for improving anemia, decreasing the risk of blood transfusion, and decreasing mortality in patients who are hospitalized in the intensive…
- Trial name
- NCT00450177
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Critical Illness, Microbiome
Alterations of the Microbiome During Critical Illness With Short and Long Term Clinical Outcomes
This study is designed to study the variations in the microbiome among critically ill patients and the effect of admission to the medical intensive care unit (MICU) at the University of Chicago.
- Trial name
- NCT04552834
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Chicago
Critical Illness, Communication
Time Limited Trials to Reduce Non-Beneficial Intensive Care Unit Treatments
Overutilization of intensive care unit (ICU) treatments among patients with advanced medical illnesses and poor prognosis places them at risk for prolonged suffering with minimal anticipated benefit.
- Trial name
- NCT04181294
- Testing
- Family meetings using time limited trials as default ICU communication and care planning approach, Usual practice
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Critical Illness
Self-Management Behaviors of Caregivers of the Chronically Critically Ill
For family members of chronically critically ill (CCI) patients, an ICU admission marks a significant milestone in the patient's illness trajectory that highlights the onset of end of-life issues and an abrupt need for family…
- Trial name
- ASSIST (NCT03065829)
- Testing
- ASSIST, Attention-Control
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Respiratory Failure
Multi-center Evaluation of the NEMO Gauge to Aid in Correct Positioning of the Endotracheal Tube
The aim of this study is to verify the safety and accuracy of an FDA-approved device called the NEMO™ Gauge to aide in the proper positioning of the endotracheal tube (ETT), inserted in the lungs of patients admitted to the…
- Trial name
- NCT02787681
- Testing
- NEMO Gauge
- Where
- 3 sites in United States
- Volunteers
- 71 people
- Sponsor
- Loma Linda University
Critically-ill Patients
Itopride in Feeding Intolerance of Critically-ill Patients Receiving Enteral Nutrition
The current study will compare the effectiveness as well as the safety of Itopride against metoclopramide as the first line treatment for feeding intolerance in critically ill patients.
- Trial name
- NCT03698292
- Testing
- Itopride, Metoclopramide 10mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Prophylactic Anticoagulation
Prophylactic ANTicoagulation With HEparine in Critically Ill Patients With Renal Impairment
Intensive care patients have an increased risk of venous thromboembolic events (deep vein thrombosis (DVT) and pulmonary embolism (PE)) due to the presence of general risk factors for thrombosis (age, immobilization, obesity…
- Trial name
- PANTHER (NCT07365644)
- Where
- 15 sites in France
- Volunteers
- 1,111 people
- Sponsor
- Centre Hospitalier le Mans
Critical Illness
Rehabilitation Gaming System for Intensive Care Units
Admission to an Intensive Care Unit (ICU) is a potentially traumatic experience for a mentally vulnerable person. Beyond the stress and anxiety associated with the ICU environment and medical procedures, survivors of critical…
- Trial name
- RGS-ICU (NCT06267911)
- Testing
- Cognitive stimulation and psychological support (RGS-ICU)
- Where
- 3 sites in Spain
- Volunteers
- 93 people
- Sponsor
- University of the Balearic Islands
Right Heart Failure, Unspecified, Critical Illness
Echocardiographic Evaluation of RV Injury in the ICU
The adequate characterization of RV injury is currently unknown. The hypothesis is that the best characterization of RV injury is the one with the most significant impact on the response to fluids and on the outcome.
- Conditions
- Right Heart Failure, Unspecified, Critical Illness, ARDS, Human, Septic Shock
- Trial name
- RECHOicu (NCT05525936)
- Testing
- Echocardiography and central venous pressure
- Volunteers
- 440 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness
Lormetazepam Versus Midazolam in Critically Ill Patients: a Retrospective Cohort Trial
The aim of this retrospective cohort study is to evaluate the effect of lormetazepam versus midazolam on hospital mortality, intensive care unit outcomes and sedation management.
- Trial name
- RetroLoveMi (NCT04408911)
- Testing
- Midazolam vs. Lormetazepam
- Volunteers
- 3,314 people
- Sponsor
- Charite University, Berlin, Germany
Critical Illness, Fever
Safety and Efficacy of Acetaminophen in the Intensive Care Unit.
The intensive care unit (ICU) team needs to know what effects acetaminophen has in critically ill patients. Acetaminophen is better known as Tylenol. It is the drug given to reduce fever.
- Trial name
- SEA-ICU (NCT02280239)
- Testing
- Acetaminophen
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome
EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure
We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF).
- Trial name
- EPIPHANY (NCT05150483)
- Where
- Greece
- Volunteers
- 350 people
- Sponsor
- Evangelismos Hospital
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