Clinical trials: Illness, Critical
Physician-Family Communication in Intensive Care Units, Surrogate Decision-making for Critically Ill Patients
Family Support Intervention in Intensive Care Units (The Four Supports Study)
The purpose of this study is to test the effectiveness of a multi-faceted communication intervention for family members of critically ill patients to reduce the family members' long-term symptoms of depression and anxiety.
- Trial name
- NCT01107704
- Testing
- Family Support Intervention
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- University of Pittsburgh
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Metabolic Acidosis, Acute Kidney Injury
High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy
Researchers are trying to determine which dialysis solution, low bicarbonate fluid (22 mmol/L) or high bicarbonate fluid (32 mmol/L), is better in subjects with acute kidney injury (acute kidney failure) and metabolic acidosis…
- Conditions
- Metabolic Acidosis, Acute Kidney Injury, Acute Kidney Failure
- Trial name
- NCT03846258
- Testing
- Low bicarbonate solution (22 mmol/L), High Bicarbonate solution (32 mmol/L)
- Where
- United States
- Sponsor
- Mayo Clinic
Coagulation Factor Deficiency, Coagulopathy, Consumption
Effect of Vitamin K in Critically Ill Patients
Critically ill patients with spontaneously prolonged pro-thrombin time, where administration of intravenous administration of phytomenadione (vitamin K) has been ordered by the treating physician will be identified.
- Conditions
- Coagulation Factor Deficiency, Coagulopathy, Consumption, Vitamin K Deficiency
- Trial name
- VITAKOAG (NCT03782025)
- Testing
- Phytomenadione
- Where
- 2 sites in Sweden
- Volunteers
- 52 people
- Sponsor
- Region Skane
Heparin Induced Thrombocytopenia (HIT)
Argatroban Versus Lepirudin in Critically Ill Patients
The purpose of this study is to test the hypotheses that argatroban significantly increases efficacy and safety of renal replacement therapy measured as life time of haemodialysis filters as compared to lepirudin
- Trial name
- ALiCia (NCT00798525)
- Testing
- Argatroban, Lepirudin
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Sepsis, Critical Illness
Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children
Multiple organ failure (MODS) is still the leading cause of death in children in ICU. The treatment of MODS is mainly organ function monitoring and organ replacement therapy.
- Conditions
- Sepsis, Critical Illness, MODS
- Trial name
- CELS (NCT03654287)
- Testing
- Treatment
- Where
- China
- Sponsor
- Guoping Lu
Central Line Complication, Thrombosis, Venous
The Use of Thrombin Generation Assay in Detection of Central Line Related Thrombosis (CRT) in Critically Ill Patients
To study thrombin generation parameters in critically ill patients with and without central line related thrombosis (CRT).
- Trial name
- THROM-CRIT (NCT06094387)
- Testing
- Thrombin generation assay
- Where
- Hong Kong
- Volunteers
- 2 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Impaired Oxygen Delivery, Critically Ill Patient
Non-Invasive Measurement of SjvO2 Using Near Infrared Spectroscopy in Critically Ill Patients
ScvO2 is an important parameter in the management of critically ill patient. The only way to measure it is to have an internal jugular or subclavian central venous catheter.
- Trial name
- NIRS-SCJVO2 (NCT04624009)
- Where
- 2 sites in Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Covid19, Left Ventricular Dysfunction
Cardiac Dysfunction in Critically Ill Patients With COVID-19
Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients infected with COVID-19.
- Conditions
- Covid19, Left Ventricular Dysfunction, Right Ventricular Dysfunction, Pulmonary Hypertension
- Trial name
- CARDYCOVID (NCT04524234)
- Testing
- Echocardiography
- Where
- 5 sites in Sweden
- Volunteers
- 132 people
- Sponsor
- Sahlgrenska University Hospital
Intensive Care Unit Delirium, Pain
Decreasing Delirium Through Music in Critically Ill Older Adults
Critically ill older adults admitted to the intensive care unit (ICU) are at a higher risk to develop delirium, which predisposes them to longer lengths of ICU and hospital stay, increased in-patient mortality, and higher risk of…
- Conditions
- Intensive Care Unit Delirium, Pain, Anxiety, Intensive Care Acquired Cognitive Impairment
- Trial name
- DDM (NCT04182334)
- Testing
- Slow Tempo Music, Attention Control
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Indiana University
Aneurysmal Subarachnoid Hemorrhage
FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage
A multi-centre, prospective, blinded, randomised clinical trial of fludrocortisone compared with placebo in patients presenting with aneurysmal subarachnoid haemorrhage.
- Trial name
- FLASH (NCT06409364)
- Testing
- Fludrocortisone
- Where
- 16 sites in Australia, New Zealand
- Volunteers
- 524 people
- Sponsor
- The George Institute
Delirium, Cognition Disorders
The MIND Study: Modifying the INcidence of Delirium
Delirium is associated with increased risk of death, prolonged stay, higher cost of care, and likely long-term brain deficits in survivors.
- Trial name
- NCT00096863
- Testing
- Ziprasidone, Haloperidol
- Where
- 5 sites in United States
- Volunteers
- 102 people
- Sponsor
- Vanderbilt University
Intensive Care Unit Delirium
Prevention of Delirium in ICU Using Multimodal Interventions
This study was designed to evaluate the impact of non-pharmacological multimodal interventions including ongoing orientation, sensory correction, setting of familiar circumstance and promotion of sleep enviromnet for prevention…
- Trial name
- NCT05950958
- Testing
- Multimodal therapy for prevention of delirium
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Seoul National University Hospital
Critical Illness, Ventilation Perfusion Mismatch
Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients
Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured.
- Conditions
- Critical Illness, Ventilation Perfusion Mismatch, Shock, Pulmonary Embolism
- Trial name
- NCT05341258
- Testing
- EtCO2, PaCO2
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Side-effect of Antibiotic, Efficacy
Pharmacokinetics and Pharmacodynamics of Linezolid Continuous and Intermittent Administration
The purpose of this study is to evaluate the therapeutic efficacy expressed in pharmacokinetic/pharmacodynamic (PK/PD) indices, the clinical response and the risk of adverse reactions following the continuous and intermittent…
- Conditions
- Side-effect of Antibiotic, Efficacy, Pharmacokinetics, Critical Illness
- Trial name
- NCT05801484
- Testing
- Linezolid continuous infusion
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Cluj Municipal Clinical Hospital
Critically-ill Patients
Immunosuppression and Intensive Care Unit-acquired Multidrug-resistant Bacteria
Antimicrobial resistance AMR is an emerging global threat to human health, and intensive care units (ICUs) are a 'hot spot' for the emergence and diffusion of multidrug-resistant (MDR) bacteria.
- Trial name
- TANGERINE (NCT06652126)
- Testing
- Microbiological examinations.
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Lille
Critical Illness
Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients
In patients with critical illness, such as severe infections, heart attacks, or respiratory failure, most intensive care units (ICUs) measure magnesium levels and give supplemental doses of magnesium when levels are below certain…
- Trial name
- MAGNOLIA (NCT07173855)
- Testing
- Magnesium sulfate administration, Magnesium oxide, Magnesium glucoheptonate
- Where
- 6 sites in Canada
- Volunteers
- 3,853 people
- Sponsor
- Scarborough General Hospital
Sedation
Impact of a Nurse Implemented Sedation and Analgesia Algorithm in Surgical Intensive Care Unit
To show that the nurse implementation of a sedation and analgesia algorithm is beneficial to the patient in terms of sedative drugs reduction and thus overall decrease in duration of mechanical ventilation and the morbidity and…
- Trial name
- ALGOSEDA (NCT03186521)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
the Relationship Between Procalcitonin and 30-day Mortality in COVID Patients
Procalcitonin Level and the High Risk of Mortality in 30 Days in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patient , Cases Series.
Background: Procalcitonin (PCT) is a biomarker that has been proposed as a helpful tool in inflammatory Clinique cases specially patient with pulmonary bacterienne infection .
- Trial name
- NCT05008016
- Where
- Morocco
- Volunteers
- 582 people
- Sponsor
- Mohammed VI University Hospital
Jugular Venous Pulse Measurement in Critically Ill Patients
Measurement of Jugular Venous Pulse in Critically Ill Patients.
To assess the utility of clinical bedside examination for the measurement of jugular venous pulse in critically ill patients.
- Trial name
- NCT00303355
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Chicago
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